Medicine and Health Sciences Commons^™

The Influence Of Action Video Gaming Experience On The Perception Of Emotional Faces And Emotional Word Meaning, Yuening Yan, Yi Li, Xinyu Lou, Senqi Li, Yutong Yao, Diankun Gong, Weiyi Ma, Guojian Yan

General Human Environmental Sciences Faculty Publications and Presentations

Action video gaming (AVG) experience has been found related to sensorimotor and attentional development. However, the influence of AVG experience on the development of emotional perception skills is still unclear. Using behavioral and ERP measures, this study examined the relationship between AVG experience and the ability to decode emotional faces and emotional word meanings. AVG experts and amateurs completed an emotional word-face Stroop task prior to (the pregaming phase) and after (the postgaming phase) a 1 h AVG session. Within-group comparisons showed that after the 1 h AVG session, a more negative N400 was observed in both groups of participants, …

Administrator Training At The Laurels Of Mount Vernon Skilled Nursing Facility, Lance Stambaugh

Masters Theses/Capstone Projects

The job duties of a Licensed Nursing Home Administrator exist in a great multitude, and require those aspiring to obtain the position to complete training in all areas of focus. The focus of this practicum is to gain exposure to the job duties of a Licensed Nursing Home Administrator, while also gaining experience in a multitude of departments that function within a skilled nursing facility. This practicum was completed amidst the COVID-19 pandemic, and therefore emphasis was placed on infection control and procedures that allow for a safe environment for those residing in this nursing facility. This increased emphasis is …

Nationwide Children's Hospital Sports Performance, Mackenzie Meyers

Masters Theses/Capstone Projects

During the Advanced Clinical Practicum experience, the student will be exposed to a variety of clinical experiences. The sports performance interns will have the opportunity to work with high school, collegiate and private sector athletes (ranging from 6 to 22 years of age) and also be involved in leading small group sessions and coaching large group sessions. Administratively, the intern will have the opportunity to participate in several teaching/learning sessions per week and be involved in research, data collection and program design.

A Framework To Guide Planetary Health Education., Carlos A. Faerron Guzmán, A. Alonso Aguirre, Barbara Astle, Enrique Barros, Brett R. Bayles, Moses Chimbari, Naglaa El-Abbadi, Jessica Evert, Finola Hackett, Courtney Howard, Jonathan Jennings, Amy Krzyzek, Jessica Leclair, Filip Maric, Olwenn Martin, Odipo Osano, Jonathan Patz, Teddie Potter, Nicole Redvers, Noortje Trienekens, Sarah Walpole, Lynda Wilson, Chenchen Xu, Matthew Zylstra

Global Public Health | Faculty Scholarship

People around the world are increasingly facing the pressing challenges of today’s interconnected environmental, social, and health crises. The COVID-19 pandemic has been an important wake-up call reminding us that we need a healthy planet to ensure the health of all people.¹ The emerging field of planetary health is a framework for understanding these interconnections and identifying solutions to the complex challenges confronting our civilization. Building on the unique role and responsibility of education institutions in shaping our futures, embedding planetary health education in curricula is an essential step to achieving the transformative change needed. Planetary health education across …

Biopharmaceutical Characteristics Of Nifurtimox Tablets For Age- And Body Weight-Adjusted Dosing In Patients With Chagas Disease., Heino Stass, Ethel Feleder, Facundo Garcia-Bournissen, Johannes Nagelschmitz, Boris Weimann, Gustavo Yerino, Jaime Altcheh

Paediatrics Publications

Treatment of Chagas disease with nifurtimox requires age- and body weight-adjusted dosing, resulting in complex dosing instructions. Appropriate formulations are needed for precise and compliant dosing, especially in pediatric patients. We characterized the biopharmaceutical features of a standard nifurtimox 120-mg tablet and a 30-mg tablet developed to improve dose accuracy. Two open-label, randomized crossover studies were conducted in adult outpatients with Chagas disease. One study investigated whether 4 × 30-mg tablets and 1 × 120-mg tablet were bioequivalent and whether tablets can be administered as an aqueous slurry without affecting bioavailability. The second study investigated the effect of a high-calorie/high-fat …

Exploring Canadian Children's Social Media Use, Digital Literacy, And Quality Of Life: Pilot Cross-Sectional Survey Study, Lorie Donelle, Danica Facca, Shauna Burke, Bradley Hiebert, Emma Bender, Stephen Ling

Nursing Publications

Background: Understanding social media use and digital literacy among young Canadian children is an increasing area of concern, given the importance of digital inclusion for full and informed participation in evolving educational, civic, corporate, social, and economic spaces. Objective: The aim of this study was to explore internet and social media knowledge as well as social media use among Canadian children aged between 6 and 10 years. Methods: We conducted interview surveys with 42 children aged between 6 and 10 years who participated in an after-school health promotion program in an urban community in Southwestern Ontario to understand their digital …

Muting, Not Fragmentation, Of Functional Brain Networks Under General Anesthesia, Corson N. Areshenkoff, Joseph Y. Nashed, R. Matthew Hutchison, Melina Hutchison, Ron Levy, Douglas J. Cook, Ravi S. Menon, Stefan Everling, Jason P. Gallivan

Brain and Mind Institute Researchers' Publications

© 2021 Changes in resting-state functional connectivity (rs-FC) under general anesthesia have been widely studied with the goal of identifying neural signatures of consciousness. This work has commonly revealed an apparent fragmentation of whole-brain network structure during unconsciousness, which has been interpreted as reflecting a break-down in connectivity and a disruption of the brain's ability to integrate information. Here we show, by studying rs-FC under varying depths of isoflurane-induced anesthesia in nonhuman primates, that this apparent fragmentation, rather than reflecting an actual change in network structure, can be simply explained as the result of a global reduction in FC. Specifically, …

Shared Neural Circuits For Visuospatial Working Memory And Arithmetic In Children And Adults, Anna A. Matejko, Daniel Ansari

Brain and Mind Institute Researchers' Publications

Visuospatial working memory (VSWM) plays an important role in arithmetic problem solving, and the relationship between these two skills is thought to change over development. Even though neuroimaging studies have demonstrated that VSWM and arithmetic both recruit frontoparietal networks, inferences about common neural substrates have largely been made by comparisons across studies. Little work has examined how brain activation for VSWM and arithmetic converge within the same participants and whether there are age-related changes in the overlap of these neural networks. In this study, we examined how brain activity for VSWM and arithmetic overlap in 38 children and 26 adults. …

Acute Conceptual Disorganization In Untreated First-Episode Psychosis: A Combined Magnetic Resonance Spectroscopy And Diffusion Imaging Study Of The Cingulum, Yunzhi Pan, Kara Dempster, Peter Jeon, Jean Théberge, Ali R. Khan, Lena Palaniyappan

Department of Medicine Publications

Background: Disorganized thinking is a core feature of acute psychotic episodes that is linked to social and vocational functioning. Several lines of evidence implicate disrupted cognitive control, excitatory overdrive and oxidative stress relating to the anterior cingulate cortex as mechanisms of conceptual disorganization (CD). We examined 3 candidate mechanistic markers related to CD in firstepisode psychosis: glutamate excess, cortical antioxidant (glutathione) status and the integrity of the cingulum bundle that connects regions implicated in cognitive control. Methods: We used fractional anisotropy maps from 7 T diffusion-weighted imaging to investigate the bilateral cingulum based on a probabilistic white matter atlas. We …

Predictors Of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis, Marian C. Brady, Release Collaborators, Jackie Hinckley

HPD Articles

Background and Purpose:

The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset.

Methods:

Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all …

Incorporating Adverse Childhood Experiences In Medical Student Trauma-Informed Training, Mary Catherine Minke

PCOM Capstone Projects

One of the emerging fields in public health has become how behavior and personal experiences shape the health experience. Particularly, there is interest in understanding how the environment that one lives in changes one’s biology, causing disease, and how interventions can combat this change. A 1998 study conducted by the CDC and Kaiser Health first characterized negative household environments that suffered from dysfunction or abuse and showed how this could be a leading cause of death in adults (Vincent, et al., 1998). Researchers termed these Adverse Childhood Experiences (ACEs). Since that time, additional studies have found that those who suffered …

An Analysis Of Information Requirements For Passengers Of (Autonomous) Urban Air Mobility Vehicles, Dennis B. Beringer

International Symposium on Aviation Psychology - 2021

Much effort has been put into examining control/monitoring strategies for semiautonomous/autonomous urban air mobility vehicles (UAMVs). Less has been done to define information requirements for passengers to facilitate their cognitive comfort. Similarities and differences between driverless automobiles (and transport-category aircraft) and UAMVs will both affect what information is needed and what operational factors influence that need, including; perceived locus of control, shared fate, ambient visibility, familiarity with the area to be traversed, and operational status of the vehicle. Information impacted includes route/progress (location, estimated time of arrival), phase of flight, and system status as well as communications between passenger and …

The Impacts On The Flight Crew With The Implementation Of The Airborne Image Recorder System (Airs) In The Cockpit, Tatiana Lícia Da Silva Rangel, Marcelo Fernandes Da Costa

International Symposium on Aviation Psychology - 2021

The technological resources used in aviation are widely used in the occurrence investigations process. However, they present technical-operational limitations, mainly regarding the reliable reproduction of the information that the flight crew really has. The implantation proposal of the Airborne Image Recording System (AIRs) arises to overcome these technical limitations presented by other technologies. Thus, this study aimed to verify if the implantation of AIRs in the cockpit could affect the pilot’s perception, behavior and performance during flight. Preliminary results with ten volunteer pilots performing in a flight simulator in Brazil pointed to a series of behavioral and performance changes when …

System-Theoretic Requirements Definition For Human Interactions On Future Rotary-Wing Aircraft, Sam M. Yoo, Andrew N. Kopeikin, Dro J. Gregorian, Adam T. Munekata, John P. Thomas, Nancy G. Leveson

International Symposium on Aviation Psychology - 2021

Future rotary-wing aircraft designs are highly complex, optionally manned, and include advanced teaming concepts that create unknown human-automation interaction safety risks. System-Theoretic Process Analysis (STPA) enables analysis of hazards on these complex systems. This paper demonstrates how to apply STPA in future helicopters' early concept development to prevent unacceptable losses. The system is modeled as a hierarchical control structure to capture interactions between components, including human and software controllers. Unsafe control actions are identified from these relationships and are used to systematically derive causal scenarios that arise from both hazardous interactions between system components and component failures. System requirements are …

Training Airline Pilots For Improved Flight Path Monitoring: The Sensemaking Model Framework, Dorrit Billman, Peter Zaal, Randall Mumaw, Thomas Lombaerts, Isabel Torron, Saad Jamal, Michael Feary

International Symposium on Aviation Psychology - 2021

The importance and benefit of improved monitoring is increasingly recognized. Improved training may be a valuable intervention. Our study (conducted 2019) assessed and trained airline First Officers on flight path monitoring skills. The exploratory study assessed monitoring pre-training in a simulator session that included monitoring challenges (8 or 7 events). A 1-hour interactive training followed, based on the Sensemaking Model of Monitoring; it presented concepts and examples using a slide deck, discussion, and simple activities. Post-training assessment used scenarios with analogous monitoring challenges (7 or 8 events) but a different setting. Performance showed significant and relatively consistent improvement. Training monitoring …

What We Know About Teamwork And Multiteam Coordination In Aviation: Contextual Factors Affecting Teamwork In Aviation, Andrea M. Georgiou, Glenn E. Littlepage, Michael B. Hein

International Symposium on Aviation Psychology - 2021

Technology and culture are two major influences that play a role in team processes and performance. Technology can lessen the cognitive workload; however, the use of technology has the potential to undermine shared cognition and teamwork. Aviation technology has been developed to support individual performance, without sufficient analysis of the impact on team performance. Due to the international nature of aviation, cultural differences can play a role in teamwork. Dimensions of national culture, such as power distance and gender roles, along with inadequate English proficiency may impact the effectiveness of communication and teamwork. Status barriers and physical barriers such as …

Survey Of Ticks And Tick-Borne Pathogens Associated With Feral Swine (Sus Scrofa) In Arkansas, Haylee Campbell

Graduate Theses and Dissertations

Feral hogs (Sus scrofa L.) are an invasive species throughout the southeast United States and found in every Arkansas county. As feral hogs invade new habitat, they can disrupt ecosystems, damage agriculture systems, and bring ticks and tick-borne pathogens with them. There are no surveys of the tick species parasitizing the Arkansas feral hog populations or the pathogens they carry. This is a public health concern because feral hogs occupy often same geographical regions as humans and livestock and can harbor over 45 animal diseases and parasites. The ticks carried by feral hogs can carry tick-borne pathogens that can cause …

User Testing Of A Diagnostic Decision Support System With Machine-Assisted Chart Review To Facilitate Clinical Genomic Diagnosis., Alanna Kulchak Rahm, Nephi A Walton, Lynn K Feldman, Conner Jenkins, Troy Jenkins, Thomas N Person, Joeseph Peterson, Jonathon C Reynolds, Peter N Robinson, Makenzie A Woltz, Marc S Williams, Michael M Segal

Faculty Research 2021

OBJECTIVES: There is a need in clinical genomics for systems that assist in clinical diagnosis, analysis of genomic information and periodic reanalysis of results, and can use information from the electronic health record to do so. Such systems should be built using the concepts of human-centred design, fit within clinical workflows and provide solutions to priority problems.

METHODS: We adapted a commercially available diagnostic decision support system (DDSS) to use extracted findings from a patient record and combine them with genomic variant information in the DDSS interface. Three representative patient cases were created in a simulated clinical environment for user …

Body Positivity On Social Media, Bellas

Body Positivity

No abstract provided.

Carpal Tunnel Syndrome, Haley Rodriguez '22

Human Diseases Graphic Novels

No abstract provided.

Pneumonia, Marcail Mcbride '21

Human Diseases Graphic Novels

No abstract provided.

Covid-19-The American Perspective., Karl Saardi, Vesna Petronic-Rosic

Dermatology Faculty Publications

No abstract provided.

The Pa Title: Is A Change The Best Way Forward?, Bettie Coplan, Tami Ritsema, James F Cawley

Physician Assistant Studies Faculty Publications

No abstract provided.

Early Bird Caregiver Education: A Program To Support Caregivers Of Individuals Living With Early Stage Dementia Or Memory Loss Or Other Cognitive Impairments, Mia Lopez, Tyler Trees, Brock Albee

Occupational Therapy | MSOT Capstone Projects

The number of individuals living with dementia continues to rise every year, with the need for caregiver education increasing as a result. Occupational therapists (OTs) have the skills and training needed to educate caregivers on how to care for not only themselves, but their loved one as well. The Early-Bird Caregiver Education Program was created to support caregivers of individuals living with early-stage dementia, memory loss, or other cognitive impairments in providing the highest quality of care possible, while also maintaining their own well-being. The program is intended to be led by an occupational therapy practitioner and aims to provide …

Occupation-Based Volunteer Training Program To Increase Social Engagement For Residents With Dementia In Skilled Nursing Facilities, Kiyomi Kuroda, Nhat Hoang, Victoria Ramia, Kelsy Wallace

Occupational Therapy | MSOT Capstone Projects

The population of individuals with dementia (IwD) is increasing, and IwD are often admitted into skilled nursing facilities (SNFs) due to greater need for care (Alzheimer’s Association, 2020b). Admittance leads to social isolation as a result of decreased engagement in co-occupations. Co-occupations are occupations, or meaningful activities necessary for wellbeing and survival, that are performed with others (American Occupational Therapy Association [AOTA], 2014). IwD exhibit behaviors and symptoms that create challenges for family caregivers to engage in co-occupations (Ono et al., 2014). Without guidance or support, family members or volunteers may be less likely to visit or facilitate quality visits, …

The Association Between Age And Unrecognized And Untreated Hypertension In Children With Chronic Kidney Disease, Chloe Douglas, J Roem, Joseph Flynn, Susan Furth, Bradley A. Warady, Susan Halbach

Presentations

Background: Younger age has been associated with unrecognized hypertension (HTN) in both the general pediatric population and in children on dialysis. An increased lifetime risk of cardiovascular disease and the association of HTN with chronic kidney disease (CKD) progression make optimal treatment of elevated blood pressure (BP) a key component of CKD management. However, the role of age in the recognition and treatment of HTN in non-dialysis pediatric CKD remains unknown.

Objective: Using data from the Chronic Kidney Disease in Children (CKiD) Cohort Study, we examined the relationship between age and recognized vs. unrecognized HTN, and the frequency with which …

Neonatal Neurobehavior, Medical Risk, And 2-Year Developmental Outcomes In Infants Born <30 Weeks Gestation, Elizabeth Mcgowan, Marie Camerota, Julie A. Hofheimer, Michael O'Shea, Brian S. Carter, Howard Kilbride, Steven Pastyrnak, Charles R. Neal, Lynne Smith, Jennifer Helderman, Jennifer Check, Lynne Dansereau, Sheri A. Dellagrotta, Barry Lester

Presentations

Background: Among preterm infants, risk of poor outcomes has been linked to neonatal medical illness and neurobehavior. The combined contribution of neonatal medical morbidities and neonatal neurobehavior to 2 year outcomes has yet to be studied.

Objective: To determine associations between NICU Network Neurobehavioral Scale (NNNS) profiles, medical risk, and 2 year developmental outcomes.

Design/Methods: Multi-center study of 704 infants born <30 weeks gestation enrolled in the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) Study. NNNS were completed prior to NICU discharge and six profiles of neonatal neurobehavior were calculated by latent profile analysis. Two profiles (5 and 6) were considered atypical. Medical risk included brain injury, CLD, ROP, and NEC/sepsis. Outcomes at 2 years were Bayley Scales of Infant and Toddler Development-III (BSID-III) composite scores and Child Behavior Checklist (CBCL) T-scores. Generalized estimating equation (GEE) models were used to test the associations among NNNS profiles, neonatal medical risk, and 2 year developmental outcomes. GEE models accounted for multiple births. Covariates were research site, maternal socioeconomic status (SES), race or ethnicity, maternal primary language, partner status, maternal psychopathology, and infant sex.

Results: Follow-up data were available for 556/704 (78.9%) infants, of which 157 (28.2%) were Profile 5-6. Mother of Profile 5-6 infants were more likely to be non-English speaking and lower SES compared to Profiles 1-4 mothers (Table 1). In …

Using Machine Learning To Identify Metabolomic Signatures Based On Pediatric Chronic Kidney Disease Etiology, Arthur Lee, Alison Abraham, Yunwen Xu, Jian Hu, Xia Or, Josef Coresh, Casey Rebholz, J Chen, Eugene Ree, Harold Feldman, Paul Kimmel, Bradley A. Warady, Susan Furth, Michelle Denburg

Presentations

Background: Untargeted plasma metabolomic profiling combined with novel machine learning (ML) tools may lead to the discovery of metabolic profiles that inform our understanding of pediatric chronic kidney disease (CKD) etiologies and identify potential therapeutic targets.

Objective: We sought to identify metabolomic signatures in pediatric CKD based on etiology: focal segmental glomerular sclerosis (FSGS), obstructive uropathy (OU), aplasia/dysplasia/hypoplasia (A/D/H), & reflux nephropathy (RN).

Design/Methods: Untargeted GC/MS2 and LC/MS2-based metabolomics quantification (Metabolon) was performed on baseline plasma samples from 702 Chronic Kidney Disease in Children (CKiD) participants. Participants per etiology were: FSGS (n=63), OU (n=122), A/D/H (n=109), & RN (n=86). Lasso …

Preserving Safety While Upholding The Integrity Of Medical Education And Practical Skills: The Impact Of Covid-19 On Teaching Human Anatomy, Anna Cowan

Undergraduate Honors Theses

The global pandemic caused by COVID-19 placed constraints on several aspects of normal life, especially those of higher level education. While many programs moved to teaching in a strictly online format, there are some courses in which this structure was not appropriate. This study observed the outcome of the adapted course structure employed at Quillen College of Medicine during their Gross Human Anatomy course. Through a voluntary survey and multiple independent t-tests, it was demonstrated that the students who took the adapted course performed, on average, 2 points lower on each exam than previous classes. Also, this study showed that …

The Experts Speak: A New Feature In The Jicr, Michael Gale, Ram Savan, Adolfo Garcia-Sastre, Ludmila Prokunina-Olsso, Kuppusamy Balamurugan, Howard A. Young

United States Public Health Resources

This month we launch a new feature in the JICR: The Experts Speak. This feature is designed to provide first-hand insight from topical experts in the fields of interferon, cytokines, innate immunity, and adaptive immune actions of cytokine biology in disease. We start by asking experts to comment on interferon, cytokines, and SARS-CoV-2.