Medicine and Health Sciences Commons^™

Insight - December 2019, Dugoni School Of Dentistry

Insight

Whether you are involved in clinical research, biomedical research, the scholarship of teaching and learning, improvement of the health care system, or professional partnerships that advance the field, we aim to spotlight the work of people at the Dugoni School.

Totally Robotic Vs Hybrid Abdominoperineal Resection: A Retrospective Multicenter Analysis, Jonathan Douissard, Vincent Obias, Craig S. Johnson, Monika E. Hagen, Deborah Keller, James R. Ouellette, Minia Hellan

Department of Surgery Faculty Publications

Introduction

Laparoscopic abdominoperineal resection (APR) for low rectal cancers is technically demanding. Robotic assistance may be of help and can be hybrid (HAPR) or totally robotic (RAPR). The present study describes outcomes of robotic APR and compares both approaches.

Material and methods

A multicentric retrospective analysis of rectal cancer patients undergoing either HAPR or RAPR was conducted. Patients' demographics, surgeons' experience, oncologic results, and intraoperative and postoperative outcomes were collected.

Results

One hundred twenty‐five patients were included, 48 in HAPR group and 77 in RAPR group. Demographics and comorbidities were comparable. Operative time was reduced in RAPR group (266.9 ± …

The Pulse: College Of Health Sciences E-Newsletter, Irvin B. Harrell (Editor)

Ellmer College of Health Sciences Newsletters

Special Holiday Edition December 2019 issue of Old Dominion University's College of Health Sciences Newsletter.

Working Together To Improve Outcomes: Physician-Pharmacist Collaborative Agreement For Uncontrolled Type 2 Diabetes, Frank Sperrazza Do, Laura M. Mauro Bs, Pharmd, Bcps, Lauren Geerlof Bcps, Jennifer Cicconetti Pharmd, Bcps, Bcgp, Michelle Omari-Okyere Bs, Pharmd, Bcps, Bcgp

Department of Pharmacy

No abstract provided.

10 Year Outcomes After Monitoring, Surgery, Or Radiotherapy For Localized Prostate Cancer, Taylor Schumacher, Jennifer Carraux

Physician Assistant Student Research Posters

Research review poster of article:
Hamdy FC, Donovan JL, Lane, JA et al. 10 Year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N Engl J Med. 2016; 375:1415 1424. doi: 10.1056/NEJMoa1606220

UNE Physician Assistant students reviewed research whose purpose was to compare active monitoring, radical prostatectomy, and external beam radiotherapy for the treatment of localized prostate cancer.

Gut Bacterial Tyrosine Decarboxylases Restrict Levels Of Levodopa In The Treatment Of Parkinson’S Disease, Bailey D'Antonio, Laura Yamagata

Physician Assistant Student Research Posters

Research review poster of article:
van Kessel, S.P., Frye, A.K., El-Gendy, A.O. et al. Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease. Nat Commun 10, 310 (2019) doi:10.1038/s41467-019-08294-y

UNE Physician Assistant students reviewed research whose purpose was to analyze the effect of levodopa-metabolizing bacteria at its primary site of absorption, the jejunum, and further use this information to understand the variability in L-DOPA dosage requirements for individual treatment of Parkinson’s Disease.

Oral Versus Intramuscular Cobalamin Treatment In Megaloblastic Anemia: A Single-Center, Prospective, Randomized, Open-Label Study, Tiara Bianco, John Wironen

Physician Assistant Student Research Posters

Research review poster of article:
Bolaman, Z., Kadikoylu, G., Yukselen, V., Yavasoglu, I., Barutca, S., & Senturk, T. (2003). Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clinical therapeutics, 25(12), 3124–3134. doi:10.1016/s0149-2918(03)90096-8

UNE Physician Assistant students reviewed research whose purpose was to compare the treatments of PO versus IM cobalamin for patients with megaloblastic anemia due to a cobalamin deficiency in terms of cost and effectiveness.

Comprehensive Physical Therapy Management Of Chronic Low Back Pain With Associated Remote Right Hamstring Injury: A Case Report, Emily Larson

Case Report Posters

Low back pain (LBP) is a health condition associated with back, core, and hip muscle dysfunction as well as reduced lumbar range of motion. Core muscle stabilization, hip abductor strengthening, and lumbar range of motion are all effective techniques for treating patients with chronic LBP. Lumbar muscular imbalance can lead to hamstring injury because of change in the functional load. The purpose of this case report was to review a therapeutic exercise approach to the treatment of chronic low back pain after a remote hamstring injury, including a focus on lumbar and core stabilization, lumbar and hamstring stretching and hamstring …

Functional Mobility In A Patient With Antiphospholipid Antibody Syndrome Following A Femoral Neck Fracture Surgical Repair: A Case Report, Mckenna Young

Case Report Posters

Antiphospholipid Antibody Syndrome is an autoimmune disease which causes the body to produce antibodies that attack phospholipids, a type of fat. It leads to high rates of blood clot formation in arteries and veins. High rates of blood clots cause stroke, which can lead to balance concerns and increased falls. Fall rates among individuals with chronic disease peak between age 45-64. Fall risk factors include reduced mobility level, imbalance, age, number of co-morbidities, duration of diagnosis, and sex. The purpose of this case report is to investigate a comprehensive physical therapy program that focused on increasing independence and reducing fall …

Combining A Comprehensive Physical Therapy Program And Electroshock Therapy For A Patient With Plantar Fasciitis: A Case Report, Kathryn Piersiak

Case Report Posters

Plantar fasciitis (PF) affects 2 million Americans per year and 10% of the population over a lifetime. PF is inflammation to the thick, fibrous connective tissue originating on the medial calcaneal tubercle extending to the metatarsal heads of the foot. A comprehensive physical therapy (PT) plan of care (POC) of proximal strengthening, distal stretching and soft tissue massage (STM) has been shown to improve PF symptoms. Extracorporeal shockwave therapy (ESWT) is a non-invasive modality that uses sound waves to create a controlled microtrauma to the impaired tissue to stimulate a healing response and microvascularization. ESWT has shown to be effective …

Conservative Management Of A Massive Rotator Cuff Tear And Partial Tear Of The Long Head Of The Biceps: A Case Report, Jessica Diggins

Case Report Posters

A rotator cuff tear (RCT) is a common injury to the shoulder musculature that increases in prevalence with age. RCT’s can be classified into five categories determined by the muscular involved: Type A: supraspinatus & superior subscapularis; Type B: supraspinatus & entire subscapularis; Type C: supraspinatus, superior subscapularis & infraspinatus; Type D: supraspinatus & infraspinatus tears; Type E: supraspinatus,infraspinatus & teres minor. Massive RCT is classified as >5cm in size, or complete tear of two or more tendons. Some massive tears may be considered irreparable due to the extent of tendon retraction, atrophy, arthritis and mobilization. Current literature supports the …

Blood Flow Restriction Therapy For The Treatment Of An Acl Reconstruction With A Meniscal Repair: A Case Report, Nicole Victor

Case Report Posters

ACL tears make up ~50% of all knee injuries. Meniscal tears are second to ACL injuries in regards to prevalence. Following an ACL reconstruction, high-load resistance training is often used to increase muscle strength. However, rehabilitation after a meniscal repair calls for a longer period of immobilization in order to prevent early loading of the meniscus. Blood Flow Restriction Therapy (BFRT) used in conjunction with low intensity resistance training can produce increased muscle mass of the quadriceps muscles without adding load and stress to the meniscus. While evidence has shown positive results with the use of BFRT after an ACLR, …

The Impact Of Income On Nutrition. A Case Study Of Northern Mozambique, Hunter Swanigan

Agricultural Economics and Agribusiness Undergraduate Honors Theses

In 2017, Mozambique ranked as one of the least-developed countries in the world by measures of health, education, and income, and had one of the lowest GDP per capita at $1,300. With a minimal income, purchasing adequate food to meet recommended levels of nutrients for a healthy diet is difficult, leaving almost half of the country’s population undernourished. This study researched what foods are available during the dry months (hungry season) of May through October in the Nampula province of Mozambique to analyze if it is possible to meet the National Institutes of Health’s recommended levels of nutrients from purchasing …

Implementing A Community-Based Breastfeeding And Infant Support Tent At University Of Arkansas Athletic Events, Moranda Clark

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Breastfeeding is such an important role in a mother and baby’s relationship as it establishes a unique bond while also providing health benefits for both parties involved. Unfortunately, many women are discriminated against for trying to breastfeed in public and with little to no designated breastfeeding areas or sanitary places in such spaces; they are left with very few viable options. During the last year I have been completing an internship surrounding the subject of breastfeeding and have helped to implement a breastfeeding and infant support tent at University of Arkansas athletic events. My work has included extensive research, lactation …

Downeast Maine Mat Expansion Project: Year 1 Data Summary, Mary Lindsey Smith Phd, Olivia Dooley Mpa, Evelyn Ali Bs

Substance Use Research & Evaluation

This report summarizes the Year 1 activities of the Healthy Acadia Downeast Maine MAT Expansion Project. Through a collaborative effort of Healthy Acadia, its providers, the Downeast Substance Treatment Network and Downeast Substance Use Response Coalition, the project utilized multiple evidence-based strategies to combat opioid use disorder (OUD) in Downeast Maine.

Key findings focused on:

• capacity building,
• stakeholder engagement,
• organizational and peer support,
• payment and reimbursement issues,
• the creation of low-barrier access to MAT,
• barriers, including stigma, to MAT
• patient-centered approaches
• auxiliary recovery supports

For more information, please contact M. LIndsey Smith, PhD at [email protected]

Progression Magazine, 2019 Fall/Winter, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.

Perseverance, Faith And Stoicism: A Qualitative Study Of Medical Student Perspectives On Managing Fatigue, Taryn S Taylor, Alexandra L Raynard, Lorelei Lingard

Obstetrics & Gynaecology Publications

CONTEXT: Fatigue risk management (FRM) strategies offer a potential solution to the widespread problem of fatigued trainees in the clinical workplace. These strategies assume a shared perception that fatigue is hazardous. Despite the growing body of evidence suggesting that fatigue leads to burnout and medical errors, previous research suggests that residents perceive fatigue as a personal, surmountable burden rather than an occupational hazard. Before we can implement FRM, we need a better understanding of when and how such problematic notions of fatigue are adopted by medical trainees. Thus, we sought to explore how third-year medical students understand and manage the …

Production Of Physician Services Under Fee-For-Service And Blended Fee-For-Service: Evidence From Ontario, Canada., Nibene H Somé, Rose Anne Devlin, Nirav Mehta, Greg Zaric, Lihua Li, Salimah Shariff, Bachir Belhadji, Amardeep Thind, Amit Garg, Sisira Sarma

Epidemiology and Biostatistics Publications

We examine family physicians' responses to financial incentives for medical services in Ontario, Canada. We use administrative data covering 2003-2008, a period during which family physicians could choose between the traditional fee for service (FFS) and blended FFS known as the Family Health Group (FHG) model. Under FHG, FFS physicians are incentivized to provide comprehensive care and after-hours services. A two-stage estimation strategy teases out the impact of switching from FFS to FHG on service production. We account for the selection into FHG using a propensity score matching model, and then we use panel-data regression models to account for observed …

Healthcare Utilization Costs Of Emerging Adults With Mood And Anxiety Disorders In An Early Intervention Treatment Program Compared To A Matched Cohort, Ava A. John-Baptiste, Lihua Li, Wanrudee Isaranuwatchai, Elizabeth Osuch, Kelly K. Anderson

Epidemiology and Biostatistics Publications

AIM: The First Episode Mood and Anxiety Disorder Program (FEMAP) provides treatment to emerging adults with mood and anxiety disorders in an accessible, youth-friendly environment. We sought to investigate FEMAP's impact on the costs of care.

METHODS: We conducted a retrospective observational study of one-year health service costs using linked administrative datasets to compare emerging adults treated at FEMAP (FEMAP users) to propensity-score matched controls (non-users). Costs from the perspective of the Ontario Ministry of Health and Long-Term Care, included drug benefit claims, inpatient, physician and ambulatory care services. We used bootstrapping to perform unadjusted comparisons between FEMAP users and …

Comparison Of Quality Control Methods For Automated Diffusion Tensor Imaging Analysis Pipelines, Seyyed M.H. Haddad, Christopher J.M. Scott, Miracle Ozzoude, Melissa F. Holmes, Stephen R. Arnott, Nuwan D. Nanayakkara, Joel Ramirez, Sandra E. Black, Dar Dowlatshahi, Stephen C. Strother, Richard H. Swartz, Sean Symons, Manuel Montero-Odasso, Robert Bartha

Medical Biophysics Publications

© 2019 Haddad et al. The processing of brain diffusion tensor imaging (DTI) data for large cohort studies requires fully automatic pipelines to perform quality control (QC) and artifact/outlier removal procedures on the raw DTI data prior to calculation of diffusion parameters. In this study, three automatic DTI processing pipelines, each complying with the general ENIGMA framework, were designed by uniquely combining multiple image processing software tools. Different QC procedures based on the RESTORE algorithm, the DTIPrep protocol, and a combination of both methods were compared using simulated ground truth and artifact containing DTI datasets modeling eddy current induced distortions, …

Mousebytes, An Open-Access High-Throughput Pipeline And Database For Rodent Touchscreen-Based Cognitive Assessment, Flavio H. Beraldo, Daniel Palmer, Sara Memar, David I. Wasserman, Wai Jane V. Lee, Shuai Liang, Samantha D. Creighton, Benjamin Kolisnyk, Matthew F. Cowan, Justin Mels, Talal S. Masood, Chris Fodor, Mohammed A. Al-Onaizi, Robert Bartha, Tom Gee, Lisa M. Saksida, Timothy J. Bussey, Stephen S. Strother, Vania F. Prado, Boyer D. Winters, Marco A.M. Prado

Medical Biophysics Publications

© 2019, eLife Sciences Publications Ltd. All rights reserved. Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the availability of tools to share and disseminate data is scarce. Automated touchscreen-based tests enable systematic cognitive assessment with easily standardised outputs that can facilitate data dissemination. Here we present an integration of touchscreen cognitive testing with an open-access database public repository (mousebytes.ca), as well as a Web platform for knowledge dissemination (https://touchscreencognition.org). We complement these resources with the largest dataset of age-dependent high-level cognitive assessment of …

Genome-Wide Association Analysis Of Hippocampal Volume Identifies Enrichment Of Neurogenesis-Related Pathways, Emrin Horgusluoglu-Moloch, Shannon L. Risacher, Paul K. Crane, Derrek Hibar, Paul M. Thompson, Andrew J. Saykin, Kwangsik Nho, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher

Medical Biophysics Publications

© 2019, The Author(s). Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set enrichment analysis using summary statistics from a large-scale genome-wide association study (N = 13,163) of hippocampal volume from the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium and two year hippocampal volume changes from baseline in cognitively normal individuals from Alzheimer’s Disease Neuroimaging Initiative Cohort (ADNI). Gene-set enrichment analysis of hippocampal volume identified 44 significantly enriched biological pathways (FDR corrected p-value < 0.05), of which 38 pathways were related to neurogenesis-related processes including neurogenesis, generation of new neurons, neuronal development, and neuronal migration and differentiation. For genes highly represented in the significantly enriched neurogenesis-related pathways, gene-based association analysis identified TESC, ACVR1, MSRB3, and DPP4 as significantly associated with hippocampal volume. Furthermore, co-expression network-based functional analysis of gene expression data in the hippocampal subfields, CA1 and CA3, from 32 normal controls showed that distinct co-expression modules were mostly enriched in neurogenesis related pathways. Our results suggest that neurogenesis-related pathways may be enriched for hippocampal volume and that hippocampal volume may serve as a potential phenotype for the investigation of human adult neurogenesis.

The Bin1 Rs744373 Snp Is Associated With Increased Tau-Pet Levels And Impaired Memory, Nicolai Franzmeier, Anna Rubinski, Julia Neitzel, Michael Ewers, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowski, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marcus Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, Marek M. Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue

Medical Biophysics Publications

© 2019, The Author(s). The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer’s disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown. Here we find in 89 older individuals without dementia, that BIN1 rs744373 risk-allele carriers show higher AV1451 tau-PET across brain regions corresponding to Braak stages II–VI. In contrast, the BIN1 rs744373 SNP was not associated …

Multimodal Hippocampal Subfield Grading For Alzheimer’S Disease Classification, Kilian Hett, Vinh Thong Ta, Gwenaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine

Medical Biophysics Publications

© 2019, The Author(s). Numerous studies have proposed biomarkers based on magnetic resonance imaging (MRI) to detect and predict the risk of evolution toward Alzheimer’s disease (AD). Most of these methods have focused on the hippocampus, which is known to be one of the earliest structures impacted by the disease. To date, patch-based grading approaches provide among the best biomarkers based on the hippocampus. However, this structure is complex and is divided into different subfields, not equally impacted by AD. Former in-vivo imaging studies mainly investigated structural alterations of these subfields using volumetric measurements and microstructural modifications with mean diffusivity …

3d Vessel-Wall Virtual Histology Of Whole-Body Perfused Mice Using A Novel Heavy Element Stain, P. Joy Dunmore-Buyze, Charmainne Cruje, Zengxuan Nong, Jason J. Lee, John A. Kiernan, J. Geoffrey Pickering, Maria Drangova

Medical Biophysics Publications

Virtual histology – utilizing high-resolution three-dimensional imaging – is becoming readily available. Micro-computed tomography (micro-CT) is widely available and is often coupled with x-ray attenuating histological stains that mark specific tissue components for 3D virtual histology. In this study we describe a new tri-element x-ray attenuating stain and perfusion protocol that provides micro-CT contrast of the entire vasculature of an intact mouse. The stain – derived from an established histology stain (Verhoeff’s) – is modified to enable perfusion through the vasculature; the attenuating elements of the stain are iodine, aluminum, and iron. After a 30-minute perfusion through the vasculature (10-minute …

Are Specific Learning Disorders Truly Specific, And Are They Disorders?, Lien Peters, Daniel Ansari

Brain and Mind Institute Researchers' Publications

© 2019 The Authors Specific learning disorders, such as dyslexia and dyscalculia, are frequently studied to inform our understanding of cognitive development, genetic mechanisms and brain function. In this Opinion Paper, we discuss limitations of this research approach, including the use of arbitrary criteria to select groups of children, heterogeneity within groups and overlap between domains of learning. By drawing on evidence from cognitive science, neuroscience and genetics, we propose an alternative, dimensional framework. We argue that we need to overcome the problems associated with a categorical approach by taking into account interacting factors at multiple levels of analysis that …

Altered Motor, Anxiety-Related And Attentional Task Performance At Baseline Associate With Multiple Gene Copies Of The Vesicular Acetylcholine Transporter And Related Protein Overexpression In Chat::Cre+ Rats, Craig P. Mantanona, Johan Alsiö, Joanna L. Elson, Beth M. Fisher, Jeffrey W. Dalley, Timothy Bussey, Ilse S. Pienaar

Brain and Mind Institute Researchers' Publications

© 2019, The Author(s). Transgenic rodents expressing Cre recombinase cell specifically are used for exploring mechanisms regulating behavior, including those mediated by cholinergic signaling. However, it was recently reported that transgenic mice overexpressing a bacterial artificial chromosome containing choline acetyltransferase (ChAT) gene, for synthesizing the neurotransmitter acetylcholine, present with multiple vesicular acetylcholine transporter (VAChT) gene copies, resulting in altered cholinergic tone and accompanying behavioral abnormalities. Since ChAT::Cre+ rats, used increasingly for understanding the biological basis of CNS disorders, utilize the mouse ChAT promotor to control Cre recombinase expression, we assessed for similar genotypical and phenotypical differences in such rats compared …

A Macaque Connectome For Large-Scale Network Simulations In Thevirtualbrain, Kelly Shen, Gleb Bezgin, Michael Schirner, Petra Ritter, Stefan Everling, Anthony R. Mcintosh

Brain and Mind Institute Researchers' Publications

© 2019, The Author(s). Models of large-scale brain networks that are informed by the underlying anatomical connectivity contribute to our understanding of the mapping between the structure of the brain and its dynamical function. Connectome-based modelling is a promising approach to a more comprehensive understanding of brain function across spatial and temporal scales, but it must be constrained by multi-scale empirical data from animal models. Here we describe the construction of a macaque (Macaca mulatta and Macaca fascicularis) connectome for whole-cortex simulations in TheVirtualBrain, an open-source simulation platform. We take advantage of available axonal tract-tracing datasets and enhance the existing …

Predator-Induced Fear Causes Ptsd-Like Changes In The Brains And Behaviour Of Wild Animals, Liana Y. Zanette, Emma C. Hobbs, Lauren E. Witterick, Scott A. Macdougall-Shackleton, Michael Clinchy

Brain and Mind Institute Researchers' Publications

© 2019, The Author(s). Predator-induced fear is both, one of the most common stressors employed in animal model studies of post-traumatic stress disorder (PTSD), and a major focus of research in ecology. There has been a growing discourse between these disciplines but no direct empirical linkage. We endeavoured to provide this empirical linkage by conducting experiments drawing upon the strengths of both disciplines. Exposure to a natural cue of predator danger (predator vocalizations), had enduring effects of at least 7 days duration involving both, a heightened sensitivity to predator danger (indicative of an enduring memory of fear), and elevated neuronal …

Consciousness-Specific Dynamic Interactions Of Brain Integration And Functional Diversity, Andrea I. Luppi, Michael M. Craig, Ioannis Pappas, Paola Finoia, Guy B. Williams, Judith Allanson, John D. Pickard, Adrian M. Owen, Lorina Naci, David K. Menon, Emmanuel A. Stamatakis

Brain and Mind Institute Researchers' Publications

Prominent theories of consciousness emphasise different aspects of neurobiology, such as the integration and diversity of information processing within the brain. Here, we combine graph theory and dynamic functional connectivity to compare resting-state functional MRI data from awake volunteers, propofol-anaesthetised volunteers, and patients with disorders of consciousness, in order to identify consciousness-specific patterns of brain function. We demonstrate that cortical networks are especially affected by loss of consciousness during temporal states of high integration, exhibiting reduced functional diversity and compromised informational capacity, whereas thalamo-cortical functional disconnections emerge during states of higher segregation. Spatially, posterior regions of the brain’s default mode …