Medicine and Health Sciences Commons^™

A Comparison Of Pharmacologic Interventions In Pregnant Women With Opioid Use Disorder, Catherine M. Bopp

Physician Assistant Scholarly Project Papers

The purpose of this research and systematic literature review is to determine which pharmacotherapeutic agent, methadone or buprenorphine, leads to better outcomes in cases of pregnant mothers with opioid use disorder (OUD). Outcomes considered are maternal compliance, neonatal abstinence syndrome severity, and neonatal length of hospital stay. In the review, PubMed, Clinical Key, Cochrane Database of Systematic Reviews, and DynaMed Plus were searched. Key terms searched were “methadone, buprenorphine, pregnancy”, “opioids, pregnancy”, “neonatal abstinence syndrome” and “medication assisted treatment, pregnancy”. Articles were narrowed with applications of filters for articles in the past fifteen years and by use of the English …

Kinetic And Kinematic Analysis Of Landing A Grand Jeté Between Barefoot And Pointe Shoe Footwear For Dominant And Non-Dominant Legs, Cara Giordani Daybré

Honors Program Theses and Projects

Dancers wear pointe shoes while performing a Grand Jeté because the shoes produce an illusion that dancers are floating. Since dancers are required to absorb a significant amount of force in a small area on the toes during landing, this then causes a high incidence of injury. The question of how to perform a Grand Jeté safely for both feet remains unaddressed. Therefore, the purpose of this study was to examine the vertical ground reaction force and lower body joint angular displacements in the skill of a Grand Jeté between barefoot and pointe shoes for both dominant and non-dominant legs. …

Juul Like It?, Kim Petit

Senior Honors Projects

Juul is the most prominent producer of e-cigarettes, devices that vaporize nicotine for inhalation. These devices were developed to deliver nicotine in a tobacco-free vapor as a safer alternative to traditional cigarettes. The Juul, in particular among other e-cigarettes, delivers a much higher concentration of dissolved nicotine than a standard cigarette. Although many smokers use Juuls as a method of quitting cigarettes, the overwhelming majority of Juul users are 15-21 years old and have never before used cigarettes, but now have unknowingly become heavily addicted to the nicotine contents. Research has found that 63% of Juul users do not know …

Worcester Chamber Of Commerce: Recruiting Minority Business Owners, Ryan Dimaria, Alexander Hull, Xikun Lu, Haopeng Wang, Jiacheng Hou, Danning Zhao

School of Professional Studies

Our capstone project was to help the Worcester Regional Chamber of Commerce identify how to re-frame their marketing so it would be appealing to immigrant and minority owned businesses. Based on interviews and external research, our group was able to create a tangible and resourceful data set that provided justified recommendations and ideas on how the Chamber could make adjustments to their marketing plan to attract more businesses of this particular demographic in the city of Worcester. By implementing these recommendations, we believe the Chamber has the opportunity to create a more diverse group of Chamber members, add value to …

Service Now: Cmdb Research, Monika Patel, Smita Patil, Katerina Tzanavara, Manish Chauhan, Yuhao Wang, Houmin Xie, Lei Shi

School of Professional Studies

The MAPFRE Capstone team has been tasked with reviewing and recommending roadmap on the existing CMDB configuration. Paper discusses the team’s overall research on ServiceNow CMDB, Client’s deliverables and introduction to the latest technological innovations. Based on given objectives and team’s analysis we have recommended key solutions for the client to better understand the IT environment areas of business service impact, asset management, compliance, and configuration management. In addition, our research has covered all the majority of the technical and functional areas to provide greater visibility and insight into existing CMDB and IT environment.

For One Child, Zion Bereket, Xin Huang, Yitong Lin, Ruobing Pei, Rachel White, Ziyuan Li

School of Professional Studies

The entirety of this project was completed on the foundation of the three focus areas, which were identified by our client as areas of high need. The client wanted to prioritize these three areas as they believed that these three areas were the most integral to the successful achievement of their mission, as well as to the overall health and longevity of the organization.

The Relationship Between Human Trafficking And An Occupational Therapy Career, Lexie France

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Occupational therapy crosses physical-mental health boundaries. It has been stated that occupational therapists have an innate duty to work with not only individuals, but society as a whole when individuals experience social and occupational injustices. An example of a social/occupational injustice that an individual may experience is human trafficking. Human trafficking not only affects the individual physically and emotionally, but it also has a pervasive impact on the individual’s ability to function as an occupational being. These experiences have the potential to affect the individual in varied contexts and environments, and over the lifespan. Due to an occupational therapist's proficiency …

Hiv/Aids In The Latino Community Of San Francisco: Past And Present, Jessica Da Silva

School of Professional Studies

There are approximately 122,000 people of Latino origin in San Francisco, which account for 15% of the total population (Census, 2010). Historically, Latinos have and still face several barriers to access healthcare and improvements in health (Aguirre-Molina, Molina & Zambrana, 2001). When the world was exposed to the spread of a new and unknown virus, the broader population suffered from the epidemic. The Latino community in San Francisco was and still is one of the hardest hit by the virus.

Changing The Current Perception Of Affordable Housing In Worcester, Simone Mcguinness, William Roberts, Vaske Gjino, Tong Zhou, Mengxin Ma, Sarawadee Sonpuak

School of Professional Studies

One of Worcester Interfaith’s goals is to eradicate the stigma of affordable housing in Worcester. Currently, the perception of affordable housing is of an image of unkept and old residences filled with destitute citizens who cannot afford basic needs to live in a city, let alone housing. This image is perpetuated by media, stigma, and a lack of education of the true reality of affordable housing and who its recipients are. Affordable housing-qualified citizens represent a range of educations, professions, age, race, and income levels. Affordable housing units, too, represent a variety of homes, many of which are extremely well-kept …

The Modeling Assessment Of World Vision’S Water, Sanitation, And Hygiene Program In Southern Africa Countries, Malawi, Mozambique, And Zambia: Analyses Using Lives Saved Tool, Chulwoo Park, Armen Martirosyan, Seble Frehywot, Erin Jones, Ashley Labat, Yvonne Tam, Emmanuel Opong

Faculty Publications

Background: Since 2010, the humanitarian aid organization World Vision has implemented a community-based water, sanitation, and hygiene (WASH) program in 76 area development programs (ADPs) for a total target population of 2,831,535 in three Southern Africa countries: Malawi, Mozambique, and Zambia.

Methods: This study was conducted using the Lives Saved Tool (LiST) to analyze the isolated impact of World Vision WASH interventions on child morbidity and mortality during the four-year implementation period from 2010 to 2014. The combined effects of WASH interventions – improved water source, home water connection, improved sanitation, handwashing with soap, hygienic disposal of children’s stools – …

Education As Important Predictor For Successful Employment In Adults With Congenital Heart Disease Worldwide., Maayke Sluman, Maayke Sluman, Silke Apers, Judith Sluiter, Karen Nieuwenhuijsen, Philip Moons, Philip Moons, Koen Luyckx, Koen Luyckx, Adrienne Kovacs, Adrienne Kovacs, Corina Thomet, Werner Budts, Junko Enomoto, Hsiao-Ling Yang, Jamie Jackson, Paul Khairy, Stephen Cook, Raghavan Subramanyan, Luis Alday, Katrine Eriksen, Mikael Dellborg, Mikael Dellborg, Malin Berghammer, Malin Berghammer, Eva Mattsson, Andrew Mackie, Samuel Menahem, Maryanne Caruana, Kathy Gosney, Alexandra Soufi, Susan Fernandes, Kamila White, Edward Callus, Shelby Kutty, Berto Bouma, Barbara Mulder

Psychology Faculty Works

Background: Conflicting results have been reported regarding employment status and work ability in adults with congenital heart disease (CHD). Since this is an impor‐ tant determinant for quality of life, we assessed this in a large international adult CHD cohort. Methods: Data from 4028 adults with CHD (53% women) from 15 different countries were collected by a uniform survey in the cross‐sectional APPROACH International Study. Predictors for employment and work limitations were studied using general linear mixed models. Results: Median age was 32 years (IQR 25‐42) and 94% of patients had at least a high school degree. Overall employment rate …

The Impact Of A School-Based Program On Diabetes And Cardiovascular Risk Factors, Lindsey Thielman

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Obesity is an increasing health issue both in the United States and worldwide. Furthermore, childhood obesity is increasing in prevalence. Childhood obesity is associated with an increased risk of comorbidities in adulthood. Obesity in childhood and adolescence makes one more likely to become obese during adulthood. This study sought to determine the effect of a school-based obesity prevention program on diabetes and cardiovascular risk factors such as body mass index (BMI), blood pressure, waist circumference, and acanthosis nigricans. Measurements were taken before education in the fall semester, and again after two education sessions in the spring semester. Student and faculty …

Selling Childhood: How The Middle Class Used Children In The Anti-Tuberculosis Movement (1930s-1940s), Hannah Fisher

Senior Theses

During the anti-tuberculosis movement of the 1930s and 1940s, children were chosen as focal points, with their roles shaped by society’s changing view of childhood, the emergence of the middle class, and the socioeconomic and political climate. Children were used by middle-class reformers as conduits through which to disseminate information and enact controls on the working class. Health education in schools had two main goals: (1) for educated children to become educated adults, and (2) for educated children to transform the behaviors of adults around them. Although researchers have studied middle-class interventions into children’s health, few have analyzed the role …

Implementing An Early Progressive Mobility Protocol In The Intensive Care Unit, Jennifer Mattone

The Eleanor Mann School of Nursing DNP Capstone Projects

Background: More people are requiring intensive care unit stays for their illnesses due to the complexity of individuals care needs. Many patients remain in bed during their hospital stay due to the severity of their illness, resulting in increased time spent on the ventilator and increased length of stay in the intensive care unit (ICU). There are many risks to of being bed bound, including decreased muscle mass, development of pressure ulcers, increased hospital stay and increased time on the ventilator. All of these factors drive up hospital costs for the hospital and the consumer. Purpose of Project: The purpose …

Inpatient Diabetes Education To Improve Disease Knowledge, Jennifer Miles

The Eleanor Mann School of Nursing DNP Capstone Projects

Diabetes is a complex chronic disease currently affecting almost 25 million people in the United States (Ostling et al., 2017; Saccomano, 2014). The prevalence of diabetes is increasing yearly. Diabetes is a common comorbidity associated with hospitalizations and 30-day inpatient readmissions (Ostling et al., 2017; Chang, Kirby, Phelps, Rhee, Meneghine & Gunasekaran, 2017). Some retrospective studies have shown that inpatient diabetes education can reduce the readmission rate by up to 34% in this population (Healy et al., 2013). The Chronic Care Model (CCM) exemplifies the need to move the education to a proactive and preventative approach for further admissions instead …

A Dedicated Chaperone Mediates The Safe Transfer Of Mitoribosomal Proteins To Their Site Of Assembly, Gabrielle Ashley Hillman

Graduate School of Biomedical Sciences Theses and Dissertations

Mitochondrial ribosomes are functionally specialized for the synthesis of several essential inner membrane proteins of the respiratory chain. While remarkable progress has recently been made towards understanding the structure of mitoribosomes, the unique pathways and factors that facilitate their biogenesis remain largely unknown. This dissertation defines the physiological role of an evolutionarily conserved yeast protein called Mam33 in mitochondrial ribosome assembly. The biomedical relevance of this finding stems from the fact that mutations or changes in its expression of the human ortholog p32 result in mitochondrial dysfunction. In human patients, bi-allelic mutations cause severe multisystemic defects in mitochondrial energy metabolism, …

Risk For Maternal Infant Bonding Reduction In High Risk Deliveries And The Recovery Phases, Amanda M. Karimi, Corie Vanarsdale Msn

Anna Vaughn School of Nursing Undergraduate Work

Bonding is one of the first developmental tasks for infants and is imperative for successful growth. The bonding phase begins in the periods immediately following birth. Complications that inhibit bonding postpartum may delay this process. Breastfeeding barriers, maternal substance abuse, and poor maternal mental health are among the contributing factors to delayed bonding. The purpose of this research study was to answer the question, “What best practiced nursing interventions assist mothers to promote bonding with the newborn after high risk deliveries?” This research review included a sample size of 10 articles which provided a variety of interventions to promote bonding …

Detection Of Genetic Thrombophilia (Fa V Leiden & Pt20210 Mutation) Using Genexpert Technology With Iqcp Implementation, Mariegrace Saquilayan

Natural Sciences and Mathematics | Clinical Laboratory Sciences

Abstract

Individuals having Genetic Thrombophilia pose a higher risk of having a thrombotic event. It is crucial to determine these gene variants to prevent a possible episode of thromboembolism. With the current PCR method, it involves individual processing of DNA isolation, amplification, and detection using three (3) different instruments resulting to an increased turnaround time of 5 to 7 days and additional staff utilization. It is performed by repetitive manual sample pipetting and preparation of reagent master mixes in small vials. Results interpretations are entered manually to a worklist built initially for final verification. These processes increase the risk of …

Identification Of Anaerobes In Clinical Specimens Comparison Between The Rapid Ana Ii System And The Bruker Maldi-Tof Ms System Utilized In The Clinical Laboratory, Raymond Chow

Natural Sciences and Mathematics | Clinical Laboratory Sciences

Matrix-Assisted Laser Desorption and Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has been revealed as an invaluable platform for identifying anaerobic bacteria in the clinical laboratory over traditional methods such as the RapID ANA II System.

A qualitative comparison is made, through the analysis of methodologies and specifications, to determine whether the RapID ANA II system or Bruker MALDI-TOF MS is more suitable for identifying anaerobic organism in the clinical laboratory. Based on the data reviewed, the MALDI-TOF MS is a more intuitive platform within the clinical laboratory due to its increased specificity, cost-effectiveness, and shorten turnaround time for the identification …

The Effects Of Tracheal Occlusion On Wnt Signaling In A Rabbit Model Of Congenital Diaphragmatic Hernia, Martina Mudri, Shane A. Smith, Christina Vanderboor, Jacob Davidson, Timothy R.H. Regnault, Andreana Bütter

Paediatrics Publications

Purpose: Tracheal occlusion (TO)reverses pulmonary hypoplasia (PH)in congenital diaphragmatic hernia (CDH), but its mechanism of action remains poorly understood. Wnt signaling plays a critical role in lung development, but few studies exist. The purpose of our study was to a)confirm that our CDH rabbit model produced PH which was reversed by TO and b)determine the effects of CDH +/− TO on Wnt signaling. Methods: CDH was created in fetal rabbits at 23 days, TO at 28 days, and lung collection at 31 days. Lung body weight ratio (LBWR)and mean terminal bronchiole density (MTBD)were determined. mRNA and miRNA expression was determined …

Δ9-Tetrahydrocannabinol Leads To Endoplasmic Reticulum Stress And Mitochondrial Dysfunction In Human Bewo Trophoblasts., Tina Lojpur, Zachary Easton, Sergio Raez-Villanueva, Steven Laviolette, Alison C Holloway, Daniel B Hardy

Physiology and Pharmacology Publications

While studies have demonstrated that the main psychoactive component of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC) alone induces placental insufficiency and fetal growth restriction, the underlying mechanisms remain elusive. Given that both (i) endoplasmic reticulum (ER) stress in pregnancy and (ii) gestational exposure to Δ9-THC leads to placental deficiency, we hypothesized that Δ9-THC may directly induce placental ER stress, influencing trophoblast gene expression and mitochondrial function. BeWo human trophoblast cells treated with Δ9-THC (3-30 μM) led to a dose-dependent increase in all ER stress markers and CHOP; these effects could be blocked with CB1R/CB2R antagonists. Moreover, expression of ER stress-sensitive genes ERRγ, VEGFA, …

Perceptions Of Drones, Digital Adherence Monitoring Technologies And Educational Videos For Tuberculosis Control In Remote Madagascar: A Mixed-Method Study Protocol, Elysée Nouvet, Astrid M. Knoblauch, Ian Passe, Andry Andriamiadanarivo, Manualdo Ravelona, Faniry Ainanomena Ramtariharisoa, Kimmerling Razafimdriana, Patricia C. Wright, Jesse Mckinney, Peter M. Small, Niaina Rakotosamimanana, Simon Grandjean Lapierre

Health Studies Publications

© 2019 Author(s). Introduction Poor road and communication infrastructure pose major challenges to tuberculosis (TB) control in many regions of the world. TB surveillance and patient support often fall to community health workers (CHWs) who may lack the time or knowledge needed for this work. To meet the End TB Strategy goal of reducing TB incidence by 90% by 2035, the WHO calls for intensified research and innovation including the rapid uptake of new tools, interventions and strategies. Technologies that â € leapfrog' infrastructure challenges and support CHWs in TB control responsibilities have the potential to dramatically change TB outcomes …

Functional Network Resilience To Pathology In Presymptomatic Genetic Frontotemporal Dementia, Timothy Rittman, Robin Borchert, Simon Jones, John Van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Fabrizio Tagliavini, Giovanni B. Frisoni, Robert Laforce, Elizabeth Finger, Alexandre Mendonça, Sandro Sorbi, Jonathan D. Rohrer, James B. Rowe, Sónia Afonso, Maria Rosario Almeida, Sarah Anderl-Straub, Christin Andersson, Anna Antonell, Silvana Archetti, Andrea Arighi, Mircea Balasa, Myriam Barandiaran, Nuria Bargalló, Robart Bartha, Benjamin Bender, Luisa Benussi, Valentina Bessi, Giuliano Binetti

Medical Biophysics Publications

© 2019 The Authors The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despite loss of both brain volume and functional connections, there is maintenance of an efficient topological organization of the brain's functional network in the years leading up to the estimated age …

Effectiveness Of Home Fire Safety Interventions. A Systematic Review And Metaanalysis, Maya Senthilkumaran, Goris Nazari, Joy C. Macdermid, Karen Roche, Kim Sopko

Bone and Joint Institute

© 2019 Senthilkumaran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Purpose To assess the effectiveness of Home Fire Safety (HFS) interventions versus other interventions/ no interventions/controls on HFS knowledge and behaviour at short-, intermediateand long-term follow ups. Design Systematic review and meta-analysis of randomized controlled trials. Data sources MEDLINE, EMBASE and PubMed databases were searched from January 1998 to July 2018, and studies retrieved. Participants Toddlers, children (primary or secondary school), …

Mri T2 And T1Ρ Relaxation In Patients At Risk For Knee Osteoarthritis: A Systematic Review And Meta-Analysis, Hayden F. Atkinson, Trevor B. Birmingham, Rebecca F. Moyer, Daniel Yacoub, Lauren E. Kanko, Dianne M. Bryant, Jonathan D. Thiessen, R. Terry Thompson

Bone and Joint Institute

© 2019 The Author(s). Background: Magnetic resonance imaging (MRI) T2 and T1ρ relaxation are increasingly being proposed as imaging biomarkers potentially capable of detecting biochemical changes in articular cartilage before structural changes are evident. We aimed to: 1) summarize MRI methods of published studies investigating T2 and T1ρ relaxation time in participants at risk for but without radiographic knee OA; and 2) compare T2 and T1ρ relaxation between participants at-risk for knee OA and healthy controls. Methods: We conducted a systematic review of studies reporting T2 and T1ρ relaxation data that included both participants at risk for knee OA and …

Simple Random-Interval Generation Reveals The Irresistibly Periodic Structure Of Perceived Time, Jessica A. Grahn, J. Eric Taylor

Brain and Mind Institute Researchers' Publications

Whole-integer ratios in musical rhythm are culturally universal. The reliable periodicity of rhythm inspired us to determine whether time perception, which is foundational to and inherently less structured than rhythm, is subject to similar biases. We created a random-interval generation task that exploits the nonrandom tendencies in perception and action in order to uncover the structural biases underlying temporal duration perception. Participants listened to and watched an audiovisual suprasecond temporal cue and were asked to subdivide it as randomly as possible in a prescribed number of responses. The results showed that the subdivision probability distributions were distinctly nonrandom, and closely …

Addressing The Need For Establishment Of School-Based Health Centers To Provide Reproductive Health Care In Philadelphia: A Meta-Analysis, Annam Humayun

PCOM Capstone Projects

OBJECTIVE: Currently, the communities of Philadelphia, which have predominantly African American residents, suffer from massive racial and ethnic health disparities. Children in these communities are at high risk of dropping out of school while also lacking access to reproductive health care. This myriad of unfortunate circumstances perpetuates the cycle of poverty that residents in these lowincome communities have been experiencing for decades. School-based health centers are a potential answer to this problem. The objective of this meta-analysis is to review published studies and carry out a meta-analysis to assess potential benefits and feasibility of SBHCs in the Philadelphia public …

“Unprecedented Times”: The Impact Of Funding Structure On Grant Projects Through The Violence Against Women Act, Amanda Guiliano

GW Research Days 2016 - 2020

Millions of dollars in grants are awarded annually through the Violence Against Women Act (VAWA). This study examined the impact of the funding structure on program implementation, both for current program periods and over time. A dual-methods survey was sent to recipients of 2018 grants for three programs to identify any modifications made to the planned programs due the project period length and potentially unreliable funding. Anticipated results are that grant recipients with the shortest project periods will be more likely to have made program modifications due to project length, and organizations that have received VAWA grants over multiple years …

Intersex Wildlife As Sentinels For Human Health And Endocrine Disruption Near Superfund Sites: A Systematic Review, Olivia Anderson, Melissa Perry

GW Research Days 2016 - 2020

Fish and wildlife are often used as sentinels for human health. This systematic review examines one aspect of wildlife health, intersex (both ovarian and testicular tissue) animals and their prevalence or severity near Superfund sites (EPA designated toxic waste sites). The body of evidence demonstrates some evidence of this indicator and more research is needed, specifically a meta-analysis that is outside the scope of this study.

Low-Calorie Sweetened Beverage Consumption Does Not Reduce Total Energy Or Sugar Intake Among Children, Talia E. Zimmerman, Allison Sylvetsky Meni, Janet Figeuroa, Susan E. Swithers, Jean A. Welsh

GW Research Days 2016 - 2020

Beverages containing low-calories sweeteners (LCSB) are used as alternatives to sugar-sweetened beverages (SSBs), yet their effects on the overall diet and effectiveness for weight management are unclear. The objective of this analysis was to examine energy and macronutrient intake among children who report LCSB and SSB consumption. The findings of this analysis challenge the utility of LCSB consumption as a strategy for weight management in children.