Medicine and Health Sciences Commons^™

7-Epi-Clusianone, A Multi-Targeting Natural Product With Potential Chemotherapeutic, Immune-Modulating, And Anti-Angiogenic Properties, Wesley F. Taylor, Maria Yanez, Sara E. Moghadam, Mahdi Moridi Farimani, Sara Soroury, Samad N. Ebrahimi, Marzieh Tabefam, Ehsan Jabbarzadeh

Faculty Publications

Targeted therapies have changed the treatment of cancer, giving new hope to many patients in recent years. The shortcomings of targeted therapies including acquired resistance, limited susceptible patients, high cost, and high toxicities, have led to the necessity of combining these therapies with other targeted or chemotherapeutic treatments. Natural products are uniquely capable of synergizing with targeted and non-targeted anticancer regimens due to their ability to affect multiple cellular pathways simultaneously. Compounds which provide an additive effect to the often combined immune therapies and cytotoxic chemotherapies, are exceedingly rare. These compounds would however provide a strengthening bridge between the two …

Bone Mineral Density Of The Common Bottlenose Dolphin, Tursiops Truncatus: A Proposed Model For Monitoring Osteological And Ecosystem Health, James Wright Burrus Powell

Dissertations and Theses

Bone mineral density (BMD) in the pectoral flipper of the common bottlenose dolphin, Tursiops truncatus, was examined to address the need to define a comprehensive target site for clinical osteodensitometric assessment and to establish ranges of observed bone density values for this species. Radii were analyzed using dual energy X-ray absorptiometry (DXA), the accepted standard in human medical studies. Multiple loci within the radius were identified and assessed for their correlation to BMD of the entire bone. Radii BMD were also examined for differences based on sex, age, total body length, handedness, geographical affinity, and nutritional status at time …

Exploring Knowledge, Attitudes And Practices Of Physical Therapists Regarding Lateral Wedge Insoles In Patients With Mild To Moderate Knee Osteoarthritis, Mashael Ghazi Alsobhi

Seton Hall University Dissertations and Theses (ETDs)

Statementof the problem: The implementation of lateral wedge insole (LWI) as a conservative treatment strategy for knee Osteoarthritis (OA) may be influenced by the knowledge, attitudes and practices ofhealthcareproviders, including physical therapists (PTs). Although the literature has identified thebiomechanicalfunction of insoles, little is known about the PTs’ knowledge, attitudes and practices and the likelihood of LWI adoption in their clinical practices. Therefore, the purpose of this study was to identify and understand the relationships that might exist between PTs’ knowledge, attitudes and practices andlikelihoodof LWI adoption as a cost-effective treatment approach.

Methods: The study design was descriptive, cross-sectional andcorrelational, utilizing …

Alzheimer's And Amyloid Beta: Amyloidogenicity And Tauopathy Via Dyshomeostatic Interactions Of Amyloid Beta, Jordan Tillinghast

Senior Honors Theses

This paper reviews functions of Amyloid-β (Aβ) in healthy individuals compared to the consequences of aberrant Aβ in Alzheimer’s disease (AD). As extraneuronal Aβ accumulation and plaque formation are characteristics of AD, it is reasonable to infer a pivotal role for Aβ in AD pathogenesis. Establishing progress of the disease as well as the mechanism of neurodegeneration from AD have proven difficult (Selkoe, 1994). This thesis provides evidence suggesting the pathogenesis of AD is due to dysfunctional neuronal processes involving Aβ’s synaptic malfunction, abnormal interaction with tau, and disruption of neuronal homeostasis. Significant evidence demonstrates that AD symptoms are partially …

Veru-111 Suppresses Tumor Growth And Metastatic Phenotypes Of Cervical Cancer Cells Through The Activation Of P53 Signaling Pathway, Vivek Kumar Kashyap, Nirnoy Dan, Neeraj Chauhan, Qinghai Wang, Saini Setua, Prashanth K. B. Nagesh, Shabnam Malik, Vivek Batra, Murali M. Yallapu, Duane D. Miller, Bilal B. Hafeez, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

In this study, we investigated the therapeutic efficacy of VERU-111 in vitro and in vivo model systems of cervical cancer. VERU-111 treatment inhibited cell proliferation and, clonogenic potential, induce accumulation of p53 and down regulated the expression of HPV E6/E7 expression in cervical cancer cells. In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727. VERU-111 treatment arrested cell cycle in the G2/M phase and modulated cell cycle regulatory proteins (cyclin B1, p21 p34cdc2 and pcdk1). Moreover, VERU-111 treatment induced apoptosis and modulated the expression of Bid, Bcl-xl, Survivin, Bax, Bcl2 …

Off-Label, On Brand: How Psychiatric Drugs Reached Unsuspecting Youths, Charles J. May, Danielle Hyams, Larisa Karr

Capstones

This capstone project takes a deep dive into the world of off-label medicine, specifically focusing on psychiatric drugs for children. Off-label medicine is common practice, but not many people understand the potential dangers of this practice if doctors are not forthcoming and honest with their patients about potential side effects. Throughout this report, we detail the experiences of youths who took antipsychotics and antidepressants for off-label purposes, and the life-changing side effects the experienced as a result.

https://medium.com/@charlie.may/off-label-on-brand-how-psychiatric-drugs-reached-unsuspecting-youths-cdcb22315789

Inside Out, Spring 2019

Inside Out

Contents:

Spiderweb of Lights, Erica Westlake - Cover

Morning Commute - La Molina, Peru, Sarah Roselli - Inside Cover

Untitled Constellations Kevin Tang - Following Page

Desire, Daisy Zhang - 1

The Cliffs, Kevin Tang - 2

Fish Tails, Sean Considine - 3

Fisherman’s Nook, Boglarka Jordan - 4

Moratorium, Harnoor Kaur - 4

Cain and Abel, Sean Considine - 5

Sunset Outside Philly, Cara Mergner - 5

Abstract Anatomy: Umbilical Cord, Jordyn Tumas - 6

Daughterhood, Danielle Crabtree - 7

Al Kabsa, Sh’Rae Marshall -8

Thinking in Circles, Kerry …

Using Lifestyle Educational Intervention To Decrease Blood Pressure Reading Amongst African American Adults, Catherine Madu

Dissertations

Hypertension or high blood pressure is a global epidemic and a major public health challenge in the United States. Hypertension increases the risk of cardiovascular disease, stroke, and renal failure. The disease disproportionately affects African Americans (AAs) and is a leading cause of morbidity and mortality in this ethnic group. Effective management of hypertension decreases complications from the disease. The purpose of the clinical scholarly project (CSP) was to decrease blood pressure readings amongst AA adults, ages 18 to 65 years old using educational intervention on lifestyle modifications. A convenience sampling of 20 AA (n = 20) adult participants was …

Clinical And Therapeutic Sciences Ii Php 328, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Clinical And Therapeutic Sciences Iii Php 427, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Clinical And Therapeutic Sciences V Php 527, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Effectiveness Of Individual Nutrition Education Compared To Group Education, In Improving Anthropometric And Biochemical Indices Among Hypertensive Adults With Excessive Body Weight: A Randomized Controlled Trial, Danuta Gajewska, Alicja Kucharska, Marcin Kozak, Shahla M. Wunderlich, Joanna Niegowska

Department of Nutrition and Food Studies Scholarship and Creative Works

Objective: The study aims to compare the effectiveness of individual and group nutrition education methods in improving key anthropometric and biochemical markers in drug-treated, overweight-obese hypertensive adults. Methods: The randomized trial included 170 patients with pharmacologically well-controlled primary hypertension and body mass index (BMI) ≥ 25 kg/m². For six months, the patients received six sessions, either one-to-one individual nutrition education (IE, n = 89) or group education (GE, n= 81), developed by dietitians. Anthropometric measurements, body composition, and fasting measures of biochemical parameters were obtained at baseline and after six months of intervention. Results: 150 patients completed the …

What's Happening: December 2, 2019, Maine Medical Center

What's Happening

No abstract provided.

Clinical And Therapeutic Sciences Iv Php 428, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Ontrack: A Program Evaluation, Justin Mynatt

Doctoral Projects

OnTrack is a program that provides coordinated specialty care (CSC) services for patients who have experienced their first episode of psychosis (FEP). Appropriately identifying and aggressively treating this vulnerable population, while providing support to both them and their families is critical for improved outcomes. Appropriate treatment of FEP patients can improve their quality of life, preserve brain matter, improve overall functioning, and lessen the burden of the clients’ family who may be involved in their care, such as caregiver strain or financial hardship. The purpose of this project is to evaluate the success of OnTrack, a FEP program, at improving …

Differential Qualitative Analysis: A Pragmatic Qualitative Methodology To Support Personalised Healthcare Research In Heterogenous Samples, Freda N. Gonot-Schoupinsky, Gulcan Garip

The Qualitative Report

Differential qualitative analysis (DQA) was developed as a pragmatic qualitative health methodology for the exploration of individual differences, behaviours, and needs within heterogeneous samples. Existing qualitative methodologies tend to emphasise the identification of general principles, an approach that can lead to standardised treatment, care, and medicine. DQA emphasises the identification of individual variation, in order to inform personalised healthcare. DQA comprises an accessible three-stage approach: first individual profiles are explored and differentiated into research-relevant subgroups; then each subgroup is analysed, and findings identified; finally, the data is analysed in its entirety and overall and subgroup findings are presented. DQA was …

Fracture Repair Requires Trka Signaling By Skeletal Sensory Nerves., Zhu Li, Carolyn A Meyers, Leslie Chang, Seungyong Lee, Zhi Li, Ryan Tomlinson, Ahmet Hoke, Thomas L Clemens, Aaron W James

Department of Orthopaedic Surgery Faculty Papers

Bone is richly innervated by nerve growth factor-responsive (NGF-responsive) tropomyosin receptor kinase A-expressing (TrKa-expressing) sensory nerve fibers, which are required for osteochondral progenitor expansion during mammalian skeletal development. Aside from pain sensation, little is known regarding the role of sensory innervation in bone repair. Here, we characterized the reinnervation of tissue following experimental ulnar stress fracture and assessed the impact of loss of TrkA signaling in this process. Sequential histological data obtained in reporter mice subjected to fracture demonstrated a marked upregulation of NGF expression in periosteal stromal progenitors and fracture-associated macrophages. Sprouting and arborization of CGRP+TrkA+ sensory nerve fibers …

Operating Room First Case Start Times: A Metric To Assess Systems-Based Practice Milestones?, Christopher Ryan Hoffman, Jay Horrow, Shreyas Ranganna, Michael Stuart Green

Department of Anesthesiology Faculty Papers

BACKGROUND: Resident competence in peri-operative care is a reflection on education and cost-efficiency. Inspecting pre-existing operating room metrics for performance outliers may be a potential solution for assessing competence. Statistical correlation of problematic benchmarks may reveal future opportunities for educational intervention.

METHODS: Case-log database review yielded 3071 surgical cases involving residents over the course of 5 years. Surgery anticipated and actual start times were evaluated for delays and residents were assessed using the days of resident training performed at the time of each corresponding case. Other variables recorded included day of week, attending anesthesiologist name, attending surgeon name, patient age, …

Allele-Specific Rna Interference Prevents Neuropathy In Charcot-Marie-Tooth Disease Type 2d Mouse Models., Kathryn H Morelli, Laurie B Griffin, Nettie K Pyne, Lindsay M Wallace, Allison M Fowler, Stephanie N Oprescu, Ryuichi Takase, Na Wei, Rebecca Meyer-Schuman, Dattatreya Mellacheruvu, Jacob O Kitzman, Samuel G Kocen, Timothy J Hines, Emily L Spaulding, James R Lupski, Alexey Nesvizhskii, Pedro Mancias, Ian J Butler, Xiang-Lei Yang, Ya-Ming Hou, Anthony Antonellis, Scott Q Harper, Robert W Burgess

Department of Biochemistry and Molecular Biology Faculty Papers

Gene therapy approaches are being deployed to treat recessive genetic disorders by restoring the expression of mutated genes. However, the feasibility of these approaches for dominantly inherited diseases - where treatment may require reduction in the expression of a toxic mutant protein resulting from a gain-of-function allele - is unclear. Here we show the efficacy of allele-specific RNAi as a potential therapy for Charcot-Marie-Tooth disease type 2D (CMT2D), caused by dominant mutations in glycyl-tRNA synthetase (GARS). A de novo mutation in GARS was identified in a patient with a severe peripheral neuropathy, and a mouse model precisely recreating the mutation …

An Electronic Medical Records-Based Approach To Identify Idiosyncratic Drug-Induced Liver Injury In Children., Tracy L. Sandritter, Jennifer Goldman, Clayton J Habiger, James F. Daniel, Jennifer Lowry, Ryan T. Fischer

Manuscripts, Articles, Book Chapters and Other Papers

Drug-induced liver injury (DILI) is the leading cause of liver failure in the United States and the most common cause of drug recall. As opposed to the recognized direct toxicity of super-therapeutic acetaminophen or chemotherapeutic agents in children, limited data exists for pediatric populations on the incidence of idiosyncratic DILI (iDILI) that may develop independently of drug dose or duration of administration. To improve the detection of adverse drug reactions at our hospital, we utilized electronic medical records-based automated trigger tools to alert providers of potential iDILI. Clinical criteria concerning for iDILI were defined as serum ALT > 5x or serum …

Expanding Services Of A Pharmacist-Led Rural Mobile Health Clinic To School-Aged Children And Working Class Parents, Megan Stephan, Karen Kier, Michael Rush

Pharmacy Faculty Scholarship

No abstract provided.

Increasing Adult Annual Wellness Visits, Martha Caceres

Doctor of Nursing Practice

The purpose of this quality improvement project was to increase adult annual wellness visits in a high-volume family practice clinic. The significance of an adult annual wellness exam is health maintenance, disease prevention, early disease detection, and management of chronic diseases. Approximately 133 million Americans are diagnosed with at least 1 chronic disease, including cancer, diabetes, and heart disease, and 1 in 4 adults are diagnosed with multiple chronic diseases (Raghupathi & Raghupathi, 2018). In 2011, the Affordable Care Act mandated insurance companies to remove deductibles for preventative health services, relieving the financial burden of out-of-pocket expenses (Borsky et al., …

Medication Management In A Primary Care Practice, Melissa Fowler

Doctor of Nursing Practice

Improving medication management has become the 3rd National Patient Safety Goal. Medication errors cost $42 billion annually. A 5-month quality improvement project was conducted in a primary care clinic located in a south Texas metropolitan city to address medication reconciliation problems. The project improved medication management by implementing 7 tools to decrease preventable medication errors: One Source Medication List, staff knowledge pre- and post-tests, visual signs and staff badges, staff templates, Beers Criteria pocket guide, patient brochure, and a quality improvement tracking form. There were two objectives: 1. Staff would improve medication reconciliation documentation by 50%. 2. For patients 65 …

Cellular Corrosion Of Cocrmo Total Knee Implants: Understanding Underlying Mechanisms Through Retrieval Analysis And Simulated Inflammatory Conditions, Griffin Heise

Theses and Dissertations (ETD)

Introduction. Total joint arthroplasty is considered one of the most beneficial aspects of modern orthopedic surgery. Due to the increase in population, obesity rates, and medical advances, total joint replacements have become more commonplace in the United States. Recently, a unique type of damage has been investigated in cobalt-chrome (CoCr) implants that remains poorly understood and highly controversial. Originally, it was believed that this damage type was caused by inflammatory cells directly attacking the metal surface, leading to damage of the oxide layer. However, damage caused by electrocautery tools has shown identical characteristics, leading some to believe this is the …

Validation Testing Of A Synthetic Spine And Upgraded Protocol For A Biomechanical Evaluation Of A Lumbar Spinal Orthosis, Daniel Hoyer

Theses and Dissertations (ETD)

Low back pain (LBP) is highly prevalent in all walks of life. Standard conservative treatment methods may work for some, but others go on to have spinal injections, opioids, or surgical procedures to alleviate pain. The Distractive and Mobility-Enabling Orthosis (DMO) was developed to meet the need for a conservative, drug-free treatment method. In this research, the low back support test protocol for evaluating DMO success was upgraded with a new synthetic lumbar spine model. The latest generation of the DMO project was then evaluated using the new system in a laboratory setting and on a pilot physical therapy patient.First, …

Implementation Of Liberate Protocol With Focus On Delirium In An Acute Care Community Hospital’S Medical And Cardiovascular Intensive Care Units, Jasmine M. Hossler, Emily A. Sedio, Karen L. Kier

Pharmacy Faculty Scholarship

No abstract provided.

Evaluation Of A Perioperative Multi-Modal Analgesia Approach In Regards To Enhanced Recovery After Surgery, Seth Wollenhaupt, Jeremy Ebert, Karen Kier

Pharmacy Faculty Scholarship

No abstract provided.

Implementation Of A Pharmacist-Driven Prescription Delivery And Home Visitation Service In A Rural Community, Clayton L. Miller, Katie Westgerdes, Michael Rush, Karen L. Kier, Megan Stephan

Pharmacy Faculty Scholarship

No abstract provided.

Analysis Of Ashp Pgy1 Residency Placement Rates With Student Pharmacist Characteristics, Bradley S. Troyer, Karen L. Kier, Heather P. Roecker

Pharmacy Student Scholarship

No abstract provided.

Integrating Pharmacist Involvement Into A Student-Led, Peer-Reviewed Journal, Crystal Zheng, Nicole A. Mcelroy, Karen L. Kier

Pharmacy Student Scholarship

No abstract provided.