Medicine and Health Sciences Commons^™

Neurotransmitter, Fall 2019, George Washington Institute For Neuroscience Neurological Institute, George Washington University Hospital

Neurotransmitter

No abstract provided.

Leaving Ligand Effects On Reactivity And Solubility Of Monofunctional Platinum(Ii) Anticancer Complexes, Heidi Linn Hruska Millay

Masters Theses & Specialist Projects

Monofunctional platinum(II) complexes, such as phenanthriplatin and pyriplatin, have notably different characteristics from the bifunctional anticancer complexes, such as cisplatin and oxaliplatin, which have detrimental toxicities and resistance associated with them. The unique properties of the monofunctional complexes may be exploited to target cancer cells without producing the toxic side effects associated with the current FDA-approved platinum-based anticancer drugs. To advance the understanding of these monofunctional platinum(II) complexes, this study replaced the chloride leaving ligand with an acetate group, which should increase solubility and alter the rate of reactivity with key amino acid and nucleotide targets. Phenanthriplatin and pyriplatin compounds …

Interaction Of A Platinum Triamine Complex Having A Seven-Membered Chelate Ring With N-Acetyl-Lmethionine And Guanosine 5'-Monophosphate, Jae Ko

Masters Theses & Specialist Projects

In the 1960s, Rosenberg and his colleagues confirmed the anti-cancer activity of cisplatin. Although cisplatin was capable of killing testicular cancer cells there were also serious side effects. It was necessary to find alternate ways of overcoming side effects, and soon many researchers have discovered novel platinum compounds that show similar reactivity. Recently, replacing one chloride group to a heterocyclic amine group showed significant cytotoxicity with a different binding activity than cisplatin. Previously in our lab, [Pt(Me5dien)(NO3)]+ and [Pt(Et2dien)Cl]+ have been synthesized and reacted with NAcetyl- L-methionine (N-AcMet) and Guanosine 5’-monophosphate (5’-GMP) showed unusual reactivity. Unlike most previously studied platinum …

Evaluation Of Mitral Apparatus Blood Cyst: A Case Report And Review Of Literature, Dipesh Ludhwani, Belaal Sheikh, Yahya Sheikh

Publications and Research

Intracardiac blood cysts (ICBC) are cardiac pseudoneoplasm commonly seen in infants below two months of age. ICBC typically resolve spontaneously; however, they can sometimes persist in adults and can cause detrimental consequences. A 47-year-old female presented to our facility with complaints of chest pain and was found to have an incidental subvalvular chordal mitral apparatus echolucent mass on transthoracic echocardiogram (TTE). A stress echocardiography was performed, which revealed transient left ventricle outflow tract (LVOT) obstruction in the absence of anginal symptoms. A cardiac magnetic resonance imaging (MRI) showed no evidence of increased mass enhancement confirming the diagnosis of a benign …

Fall 2019 Fcs News Round-Up, College Of Education And Human Development

Family and Consumer Sciences News

• Presentations
• Publications
• Grants
• Other News

Differences In Duration Of Untreated Psychosis For Racial And Ethnic Minority Groups With First-Episode Psychosis: An Updated Systematic Review And Meta-Analysis., Nicole Schoer, Chen Wei Huang, Kelly K. Anderson

Epidemiology and Biostatistics Publications

PURPOSE: Ethnic minority groups with early psychosis may have longer treatment delays, potentially leading to poorer outcomes. We updated a previous systematic review of the literature on racial and ethnic differences in duration of untreated psychosis (DUP) among people with first-episode psychosis.

RESULTS: Six of 17 studies described significant differences across aggregated racial groups; however, the pooled estimates did not show differences across groups. Additional data from this update allowed for disaggregated analyses, finding that Black-African groups have a shorter DUP, whereas Black-Caribbean groups have longer DUP, relative to White groups.

CONCLUSIONS: These findings highlight the importance of in-depth research …

Machine Learning Groups Patients By Early Functional Improvement Likelihood Based On Wearable Sensor Instrumented Preoperative Timed-Up-And-Go Tests, Riley A. Bloomfield, Harley A. Williams, Jordan S. Broberg, Brent A. Lanting, Kenneth A. Mcisaac, Matthew G. Teeter

Bone and Joint Institute

© 2019 The Author(s) Background: Wearable sensors permit efficient data collection and unobtrusive systems can be used for instrumenting knee patients for objective assessment. Machine learning can be leveraged to parse the abundant information these systems provide and segment patients into relevant groups without specifying group membership criteria. The objective of this study is to examine functional parameters influencing favorable recovery outcomes by separating patients into functional groups and tracking them through clinical follow-ups. Methods: Patients undergoing primary unilateral total knee arthroplasty (n = 68) completed instrumented timed-up-and-go tests preoperatively and at their 2-, 6-, and 12-week follow-up appointments. A …

A Framework For Evaluating Correspondence Between Brain Images Using Anatomical Fiducials., Jonathan C Lau, Andrew G Parrent, John Demarco, Geetika Gupta, Jason Kai, Olivia W Stanley, Tristan Kuehn, Patrick J Park, Kayla Ferko, Ali R Khan, Terry M Peters

Brain and Mind Institute Researchers' Publications

Accurate spatial correspondence between template and subject images is a crucial step in neuroimaging studies and clinical applications like stereotactic neurosurgery. In the absence of a robust quantitative approach, we sought to propose and validate a set of point landmarks, anatomical fiducials (AFIDs), that could be quickly, accurately, and reliably placed on magnetic resonance images of the human brain. Using several publicly available brain templates and individual participant datasets, novice users could be trained to place a set of 32 AFIDs with millimetric accuracy. Furthermore, the utility of the AFIDs protocol is demonstrated for evaluating subject-to-template and template-to-template registration. Specifically, …

The Efficacy Of A Brief, School-Based Bystander Bullying Intervention On High School Student Alcohol Use, April D. Watts, Diana M. Doumas, Aida Midgett

Counselor Education Faculty Publications and Presentations

We examined the efficacy of a brief, bystander bullying intervention on reducing alcohol use among high school students (n = 61). As hypothesized, high-risk drinkers in the intervention group reported reduced drinking compared to control students at a 30-day follow-up.

Validity Evidence For The Littlears Early Speech Production Questionnaire: An English-Speaking, Canadian Sample, Olivia Daub, Janis Oram Cardy, Andrew M. Johnson, Marlene P. Bagatto

Communication Sciences and Disorders Publications

© 2019 American Speech-Language-Hearing Association. Purpose: This study reports validity evidence for an English translation of the LittlEARS Early Speech Production Questionnaire (LEESPQ). The LEESPQ was designed to support early spoken language outcome monitoring in young children who are deaf/hard of hearing. Methods: Data from 90 children with normal hearing, ages 0–18 months, are reported. Parents completed the LEESPQ in addition to a concurrent measure of spoken language development, the Receptive-Expressive Emergent Language Test–Third Edition. Normal hearing status and development were confirmed. Results: Traditional scale analyses, in addition to item parameters, are reported. The LEESPQ was highly correlated with the …

Quantifying Balance Control After Spinal Cord Injury: Reliability And Validity Of The Mini-Bestest, Katherine Chan, Janelle Unger, Jae Woung Lee, Gillian Johnston, Marissa Constand, Kei Masani, Kristin E Musselman

Physical Therapy Publications

Context/Objective: Incomplete spinal cord injury (iSCI) causes deficits in balance control. The Mini-Balance Evaluation Systems Test (mini-BESTest) is a comprehensive measure; however, further testing of its psychometric properties among the iSCI population is needed. We evaluated the mini-BESTest’s test-retest reliability, and concurrent and convergent validity among individuals living with iSCI for more than one year.

Design: Cross-sectional study.

Setting: Rehabilitation hospital.

Participants: Twenty-one individuals with chronic motor iSCI (14 females, mean age 56.8 ± 14.0 years).

Interventions: None.

Outcome Measures: Participants completed the mini-BESTest at two sessions spaced two weeks apart. At the second session, participants …

The Institutional Repository Landscape In Medical Schools And Academic Health Centers: A 2018 Snapshot View And Analysis, Daniel G. Kipnis, Lisa A. Palmer, Ramune K. Kubilius

Libraries Scholarship

Objective:

This study uses survey research methods to gain a deeper understanding of the institutional repository (IR) landscape in medical schools and academic health centers.

Methods:

Members of the Association of Academic Health Sciences Libraries (AAHSL) were surveyed about their IRs. The authors used a mixed-methods approach of a survey and qualitative content analysis to identify common themes.

Results:

Survey results indicate that a large majority of responding medical schools and academic health centers have or are implementing an IR (35 out of 50, 70%). Of these, 60% (21 institutions) participate in an institution-wide IR rather than administer their own …

A Quality Improvement Project To Determine The Incidence And Prevalence Of Obstructive Sleep Apnea, Best Practice Anesthesia Guidelines, And The Incidence Of Perioperative Cardiac And Respiratory Complications After The Implementation Of The Stop-Bang Questionnaire, Bradly Diamond, Gregory Guerrier, Cody Holliman, Robert Marrero, Tyler Nelson

Doctoral Projects

Patients with obstructive sleep apnea (OSA) are at risk for perioperative respiratory and cardiovascular compromise (Opperer et al., 2016). Unfortunately, almost 90% of patients with moderate-to-severe OSA are not diagnosed and unaware of their disorder; however, they remain at increased perioperative risks (Singh et al., 2015). The STOP-BANG questionnaire was developed to meet the need for a reliable, concise, and efficient screening tool for OSA risk. The facility at which this project was conducted did not utilize a prescreening OSA risk tool. The facility not using a prescreening OSA risk tool is especially important because the State of Mississippi currently …

Opioid Abuse Among Student Registered Nurse Anesthetists In The United States: A Policy Change Proposal, Ifeoma P. Anakor

Doctoral Projects

Opioid abuse among Certified Registered Nurse Anesthetists (CRNAs) and Student Registered Nurse Anesthetists (SRNAs) is an epidemic that is growing in numbers yearly. The number of deaths from opioid abuse is also increasing. The specialty of anesthesia primarily has increased instances of opioid abuse cases (Wright et al., 2012). The reason for the increase in opioid abuse occurrences is because anesthesia providers regularly administer opioids in patient care. Opioid abuse commonly results in injury or death. While abusing, anesthesia providers are not only putting their lives in jeopardy but also the lives of their patients.

The project observed the opioid …

Impact Of Best Practice Guideline Statement On Anesthesia Practice In Rural Mississippi Hospitals With Obese Patients Undergoing Total Knee Arthroplasty, Steven Hodnett

Doctoral Projects

The aim of this best practice guideline (BPG) was to be a resource for anesthesia providers practicing with obese patients undergoing total knee arthroplasty (TKA) and to measure the knowledge of these providers. After dissemination of an executive summary to anesthesia providers in two hospitals in rural Mississippi, an anonymous online survey was provided via Qualtrics software for voluntary participation. The survey consisted of 10 questions. The data collection period was five weeks. Respondents are noted at N=2, and the data was reviewed and categorized into one of three domains (i.e., knowledge, practice, and safety). In the domain of knowledge, …

Increasing Patient Satisfaction Survey Response Rate At An Ambulatory Surgery Center, Carlee Nicholson

Doctoral Projects

In an effort to increase distribution rate and response rate of the patient satisfaction survey at this ASC, adjustments were made to current processes. These interventions included accentuating the option of a paper or emailed survey, providing pre-operative and post-operative response prompts, as well as adding a cover letter to the existing survey. The purpose of these interventions was to ensure a 100% distribution rate of the survey as well as to increase the response rate by 20%.

Results were obtained by collecting forms to monitor distribution of the survey. The response rate was calculated by the number of responses …

Implementation Of A Psychiatric Admission Acuity Tool In The Pediatric Behavioral Health Unit, Tyler T. Wansley

Doctoral Projects

Staffing, patient ratios, and acuity are not new concepts in health care. While these are popular concepts in medical units, inpatient psychiatric facilities are lacking the tools to correctly quantify patient acuity. An even considerably larger gap exists in the literature regarding the quantification of acuity in pediatric behavioral health units.

A needs assessment was conducted to determine if an existing psychiatric acuity tool would prove useful after implementation in a pediatric behavioral health unit. A need for such a tool was found which led to the purpose of this doctoral project, which was to measure nurse satisfaction with the …

Developing A Local Anesthetic Systemic Toxicity Protocol In A Mississippi Hospital, James Dearman, Terry J. Tieman

Doctoral Projects

Local anesthetic systemic toxicity (LAST) is a rare complication of administering local anesthetic medications. However, this complication is potentially deadly, especially without prompt and correct treatment. Due to the rarity of LAST and the fact that its treatment differs from the conventional treatment of cardiac arrest, the authors sought a best practice recommendation to guide its treatment. While the most effective treatment for LAST has been well established, a thorough review of literature and survey of clinical preceptors demonstrated that most providers have not encountered LAST in clinical practice. Additionally, lipid emulsion therapy is a somewhat controversial treatment among some …

A Market Analysis Of Pay Rates For New Graduate Certified Registered Nurse Anesthetists, Zachary Halliwell

Doctoral Projects

The profession of Certified Registered Nurse Anesthetists (CRNA) is a thriving occupation. In their national Occupational Outlook Handbook, the Bureau of Labor Statistics (U.S. Department of Labor, 2018), reported the national market for CRNAs is predicted to continue its steady growth through 2026. The Bureau of Labor Statistics (BLS) provides numerous statistics, as previously mentioned, on their website. However, the stats available include CRNAs of varying experience levels. The Mississippi Department of Employment Security (MDES) has a few statistics, online, regarding the market for CRNAs. The data provided by MDES, while appreciated, is lacking in numerical significance, given the minuscule …

Himmelfarb Library Liaison Letter - October 2019, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Impressions, Nova Southeastern University

Newsletters

No abstract provided.

Multiple Primary Gists: Unusual Presentation As Jejuno-Jejunal Intussusception, Busaba Jiruppabha

Chulalongkorn Medical Journal

Gastrointestinal stromal tumors (GISTs) are rare, occurring in 10 - 15 per million, and 0.2% of all gastrointestinaltumors, and is generally considered a solitary tumor. This study presented a 57 year-old female with abdominalpain and intermittent vomiting for 6 months. Acute abdomen series did not show any evidence of a small bowelobstruction. Esophagogastroduodenoscopy (EGD) suggested partial small bowel obstruction. A contrast enhancedCT scan (CECT) of the abdomen demonstrated jejuno-jejunal intussusception induced by an intraluminal tumorand another two mesenteric tumors confirmed by histopathology and immunohistochemistry as GISTs. Thepatient had complete resection for treatment. She recovered without complication and remained well. This …

The Changing Role Of Rodenticides And Their Alternatives In The Management Of Commensal Rodents, Gary Witmer

United States Department of Agriculture Wildlife Services: Staff Publications

Rodents cause substantial damage and losses of foodstuffs around the world. They also transmit many diseases to humans and livestock. While various methods are used to reduce damage caused by rodents, rodenticides remain an important tool in the toolbox. However, like all tools, rodenticides have advantages and disadvantages. Several considerations are shaping the future of rodenticide use, including manufacturing and registration costs, concern about toxicity levels and nontarget animal hazards, potential hazards to children, reduced effectiveness of some formulations, and humaneness to the targeted rodents. Many of these disadvantages apply to anticoagulant rodenticides, and their use is being more restricted …

Creation Of A Health And Wellness And Self Care Tool For Mothers Of Infants Requiring A Neonatal Intensive Care Unit Stay, Genevieve Maccarthy

Doctor of Occupational Therapy Capstone Projects

Purpose: Despite occupational therapy’s established role in the neonatal intensive care unit (NICU) in providing family centered intervention, mothers continue to report lack of readiness to discharge home and emotional distress while in the NICU and upon discharge home. Occupational therapists have the unique skillset to promote engagement in meaningful activities and facilitate overall health and wellness for mother’s during and after their NICU stay.

Method: A qualitative survey was distributed to a convenience sample of fifteen participants to identify emotional experiences in the NICU, how these experiences impact each mother fulfilling her role as a primary caretaker, and the …

A Discharge Checklist To Combat Patient Readmission: A Case Study In A Skilled Nursing Facility, Shaylin O’Connell

Doctor of Occupational Therapy Capstone Projects

A Discharge Checklist to Combat Patient Readmission: A Case Study in a Skilled Nursing Facility focuses on the creation of a discharge checklist, as an intervention, to increase the competency for occupational therapists working in skilled nursing facilities discharging clients back to their home environment. A SNF (Skilled Nursing Facility) provides post-acute healthcare services and rehabilitation for patients following a hospitalization prior to discharging home (Burke et al., 2017). This case study for clinical improvement uses the DMAIC (define, measure, analyze, improve, control) quality model and a multiple case study research design for evaluation. The goal of the quality improvement …

Medicine + Health Magazine, Fall 2019, George Washington University, School Of Medicine And Health Sciences, Office Of Communications And Marketing

Medicine + Health Magazine

No abstract provided.

An Inquiry Of The Effects Of Stress Management On Recovery For Hospitalized Patients, Clair Walters

Fall Showcase for Research and Creative Inquiry

The premise of this research is to analyze stress management strategies that were implemented across prevalent populations that had a significant impact on either physical or mental health. Ultimately, it is anticipated that this research will inspire Longwood to reduce stress for all the various populations that reside in the town of Farmville.

Apolipoprotein L1 Associated Nephropathy; An Overview, Mohsen Akhavan Sepahi, Lvks Bhaskar, Audrey C. Tolouian, Ramin Tolouian

Nursing Faculty Publications

Genetic variants of apolipoprotein L1 (APOL1) have been recognized as a risk factor for kidney disease in people of African ancestry. APOL1 mediate renal damage in podocytes through necrosis, apoptosis and pyroptosis processes. APOL1 gene contains G1 and G2 alleles that mediate in increasing risk of renal disorders in African Americans. People who carry APOL1 risk alleles have a three to four-fold increase risk for non-diabetic renal disease (NDRD), Idiopathic focal segmental glomerulosclerosis (FSGS) and HIV-associated nephropathy (HIVAN). Therefore, identifying genetic factors involved in the pathogenesis of renal disorders, including APOL1 risk variants, may help to improve our understanding of …

The Innovator - Fall 2019, Allison Litera

Faculty Affairs & Research Newsletters - The Innovator

Newsletter published by the Offices of Faculty Affairs & Research

Implementing Screening To Assess Readiness To Change In Overweight And Obese Patients At A Patient-Centered Medical Home, Jarrod Gant

Doctoral Projects

Obesity is at epidemic levels within the United States (U.S.), but the Southern U.S. has some of the most obese states. Mississippi (MS) is the most obese state in the country (Robert Wood Johnson Foundation, 2018). Factors such as diet, sedentary lifestyle, cultural influences, and socioeconomic status contribute to the state’s citizens being overweight and obese.

Contributing to the state’s obesity is the fact that MS has more people living in poverty than any other state (Center for American Progress [CAP], 2018). Lacking the ability to afford healthy foods and the ability to afford quality healthcare adds to the state’s …