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2019

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Articles 2041 - 2070 of 16114

Full-Text Articles in Medicine and Health Sciences

Genetic Medical Clinic In Kentucky: A Needs Assessment Of Anabaptist Households, Matthew M. Hunt, Susan L. Jones Oct 2019

Genetic Medical Clinic In Kentucky: A Needs Assessment Of Anabaptist Households, Matthew M. Hunt, Susan L. Jones

Journal of Amish and Plain Anabaptist Studies

The purposes of this study are to (a) describe the process of collecting survey data related to un/diagnosed genetic disorders in Anabaptist households, and (b) determine the need for a genetic medical clinic in Kentucky. A six-page adapted survey questionnaire was utilized to collect family status, un/diagnosed genetic conditions, reproductive history, history of deceased children, and demographics. The questionnaire was mailed to over 2,000 households; addresses were collected from Anabaptist directories. Data suggest that more than one-third of households include a family member with an un/diagnosed genetic condition. Collectively, 120 diagnosed conditions and 90 undiagnosed conditions were reported. Half of …


Amish And Mennonite Lay Caregivers' Experiences Using The B&W Burdock Leaf Treatment On Burns And Wounds: A Qualitative Study, Rosanna Hess Oct 2019

Amish And Mennonite Lay Caregivers' Experiences Using The B&W Burdock Leaf Treatment On Burns And Wounds: A Qualitative Study, Rosanna Hess

Journal of Amish and Plain Anabaptist Studies

Amish and Mennonites have a long standing heritage of caring for each other within the community and family setting using natural, herbal medicines and therapies. For several decades, in numerous Anabaptist communities across the United States, a burns and wounds treatment has been popularized by the training of hundreds of lay caregivers. Little is known outside these communities about the experiences of these caregivers dedicated to providing burns and wounds care. The aim of this study was to describe the lived experience of caregivers who use the Burns & Wounds ointment (B&W) and burdock leaf treatment. Twelve caregivers (eight women …


Anabaptist Community Members' Perceptions And Preferences Related To Healthcare, Dawn Garrett-Wright, M. Eve Main, M. Susan Jones Oct 2019

Anabaptist Community Members' Perceptions And Preferences Related To Healthcare, Dawn Garrett-Wright, M. Eve Main, M. Susan Jones

Journal of Amish and Plain Anabaptist Studies

The plain Anabaptists are thought to differ from mainstream U.S. health care beliefs and practices. Many non-Anabaptist health care providers have limited knowledge of the specific health beliefs and preferences of Anabaptists, which can lead to misunderstandings. The purpose of this descriptive qualitative study was to collect information from Anabaptist community members related to health care beliefs and preferences in their communities. Participants, who were members of various plain Anabaptist communities, completed a questionnaire containing open-ended questions about health issues. Seven themes emerged in results: (1) health viewed as a gift from God that provides the ability to work; (2) …


Child Weight And Feeding Patterns In An Old Order Mennonite Community, Dawn Garrett-Wright, M. Eve Main, M. Susan Jones Oct 2019

Child Weight And Feeding Patterns In An Old Order Mennonite Community, Dawn Garrett-Wright, M. Eve Main, M. Susan Jones

Journal of Amish and Plain Anabaptist Studies

Purpose: Feeding practices in some religious communities may decrease childhood obesity. However, there is limited research in these communities to assess maternal perceptions of their children’s weight and feeding patterns. The purpose of this study was to ascertain Old Order Mennonite mothers’ perceptions of their children’s body weight and to examine feeding patterns for their children. Sample: Participants for this descriptive, correlational study were recruited from an Old Order Mennonite community in south central Kentucky. Sampling was achieved using a snowball sampling strategy and the use of a community insider. Methods: Body Mass Index was measured for mothers and child …


Thriving After Pediatric Sci: Two Life Stories, Samantha Betz, Otd, Otr/L, Caitlin Cadematori, Otd, Otr/L, Mj Mulcahey, Phd, Otr/L Oct 2019

Thriving After Pediatric Sci: Two Life Stories, Samantha Betz, Otd, Otr/L, Caitlin Cadematori, Otd, Otr/L, Mj Mulcahey, Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

  • To understand the lived experiences of spinal cord injury (SCI) as described by two people with SCI through life story interviewing.
  • Narrative inquiry is a useful method to study the experience of living with a disability because story-telling allows individuals to explain how their conditions have influenced their everyday lives.1,3,7,12,13,14
  • Existing narrative studies have explored lived experiences of SCI and the distinct perspectives of men and women, athletes with SCI, and caregivers of persons with SCI.3,9,12,13,15
  • This study may be among the first accounts of life stories of adults with pediatric onset SCI. *The two participant’s names have been changed …


Community-Based Participatory Research In Diabetes Prevention Programs, Raihan Khan, Ranjita Misra Oct 2019

Community-Based Participatory Research In Diabetes Prevention Programs, Raihan Khan, Ranjita Misra

Department of Health Sciences - Faculty Scholarship

Background: The purpose of this study was to determine how community-based diabetes prevention programs utilized the concept and contents of the Community Based Participatory Research approach. Methods: Keyword search in PubMed and Scopus electronic databases from January 1, 2000, to December 31, 2019, was conducted to search and extract peer-reviewed articles that included words “Community-Based Participatory Research (CBPR)” and “diabetes mellitus” in the title, abstract or in the main article. The initial search yielded 1122 articles. After the final screening, a total of 67 articles were extracted for review. Results: Findings suggested that an advisory board was used by most …


Health Coaching In Context: A Descriptive Case Study, Caitlin Cadematori, Otd, Otr/L, Samantha Betz, Otd, Otr/L, Winnie Dunn, Phd, Otr/L, Faota, Mj Mulcahey, Phd, Otr/L Oct 2019

Health Coaching In Context: A Descriptive Case Study, Caitlin Cadematori, Otd, Otr/L, Samantha Betz, Otd, Otr/L, Winnie Dunn, Phd, Otr/L, Faota, Mj Mulcahey, Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

Persons with spinal cord injury (SCI) often report challenges with accessing employment, reliable transportation and opportunities for social engagement, resulting in decreased independence and self-efficacy.1 When challenges with access are addressed, participation in valued activities is possible and supports social-emotional health, physical health, and quality of life.2,3

“Health Coaching in Context” is a skillful dialogue that adheres to coaching competencies and draws from the tenets of health coaching and positive psychology. “Health Coaching in Context” reflects authentic client centeredness, and develops problem solving skills that address solutions that lead to meaningful engagement in everyday living despite the presence …


Occupational Therapy Students’ Perception Of Types Of Class Preparation Activities, Caitlin Taylor, Margaret A. Ryan, Marie-Christine Potvin, Phd, Otr/L Oct 2019

Occupational Therapy Students’ Perception Of Types Of Class Preparation Activities, Caitlin Taylor, Margaret A. Ryan, Marie-Christine Potvin, Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

This mixed-methods pilot study examined OT student perceptions of the practicality and perceived benefits of 4 class preparation activities used in 3 occupational therapy courses.


Understanding Participation In A Community-Based Art Program, Melody Taban, Otd, Otr, Gabrielle Kains, Otd, Otr/L, Lydia Navarro-Walker, Otd, Otr/L, Namrata Grampurohit, Phd, Otr/L Oct 2019

Understanding Participation In A Community-Based Art Program, Melody Taban, Otd, Otr, Gabrielle Kains, Otd, Otr/L, Lydia Navarro-Walker, Otd, Otr/L, Namrata Grampurohit, Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

Objectives

  1. To understand the perceived benefits of occupational engagement with art for people with dementia and their informal caregivers
  2. To understand the art program’s influence on interpersonal relationships


Third-Wave Cognitive Behavioral Therapy, Mindfulness, And Behavioral Activation, Sonny Misa, Mary Muhlenhaupt, Otd, Otr/L, Faota Oct 2019

Third-Wave Cognitive Behavioral Therapy, Mindfulness, And Behavioral Activation, Sonny Misa, Mary Muhlenhaupt, Otd, Otr/L, Faota

Department of Occupational Therapy Posters and Presentations

Learning Objectives

  • Restate Active Participation, Just-right Challenge, Motivating and Rewarding, and Therapist as Coach in their own words
  • Differentiate between Cognitive Behavioral Therapy and Third-wave Cognitive Behavioral Therapy
  • Illustrate the difference between meditation and mindfulness
  • Discuss the implication of extended Behavioral Activation for occupational therapy practice


Does Perioperative Use Of Renin-Angiotensin System Inhibitors Improve Patient Outcomes In Cardiac Surgery?, Qian Ding, Mark Berguson, Zugui Zhang, Hong Liu, Huang Nie, Jordan E. Goldhammer, Rohinton J. Morris, Jianzhong Sun Oct 2019

Does Perioperative Use Of Renin-Angiotensin System Inhibitors Improve Patient Outcomes In Cardiac Surgery?, Qian Ding, Mark Berguson, Zugui Zhang, Hong Liu, Huang Nie, Jordan E. Goldhammer, Rohinton J. Morris, Jianzhong Sun

Department of Anesthesiology Posters

  • 2011 ACCF/AHA Guidelines for CABG: Uncertain about the safety of the preoperative administration of ACE inhibitors or ARBs in patients on chronic therapy and the safety of initiating ACE inhibitors or ARBs before hospital discharge
  • 2014 ESC Guidelines: ACE inhibitors might be stopped 1 to 2 days before CABG to avoid the potential deleterious consequences of perioperative hypotension
  • Guidelines state that ACE inhibitors or ARBs should be initiated postoperatively in CABG patients who were not receiving them preoperatively if they have an LVEF ≤40%, hypertension, diabetes, or CKD (Level of Evidence: A)
  • There is still a lack of large clinical …


Anesthetic Management Without The Use Of Neuromuscular Blocking Agents In Myasthenia Gravis Patient Undergoing Coronary Artery Bypass Grafting And Thymectomy, Katarina Kapisoda, Ettore Crimi Md, Omeni Osian Oct 2019

Anesthetic Management Without The Use Of Neuromuscular Blocking Agents In Myasthenia Gravis Patient Undergoing Coronary Artery Bypass Grafting And Thymectomy, Katarina Kapisoda, Ettore Crimi Md, Omeni Osian

Anesthesiology

We describe a novel and effective anesthetic management of a 67 year old male with myasthenia gravis (MG) who underwent combined coronary artery bypass graft and thymectomy. Induction of general anesthesia with endotracheal intubation was performed with propofol and remifentanyl without use of any neuromuscular blocking agents (NMBA). General anesthesia was then maintained with inhaled isoflurane and continuous intravenous infusion of sufentanyl and dexmedetomidine. In ICU, trachea was extubated within two hours from admission and no complications occurred during the following 24 hours ICU stay. Avoidance of NMBA may improve outcomes by decreasing the risks associated with their use.


Just Another Labor Epidural, Whitney King Do, William B. Smith Oct 2019

Just Another Labor Epidural, Whitney King Do, William B. Smith

Anesthesiology

A 32 year-old healthy pregnant patient with no significant past medical history who presented to the hospital for delivery of fetus status post intrauterine fetal death. Vaginal delivery with epidural placement was initially the mother’s preference. Fetal movement last felt 4 days prior. The patients H&P and laboratory findings revealed early stages DIC. Patient underwent Caesarean delivery with general anesthesia, the OB physician found the patient to have Couvelaire uterus, a form of placental abruption. The patient’s uterus was atonic requiring multiple units of blood products. Case assessed indications for epidural placement versus general anesthesia.


Expanded Access (Compassionate Use) For Investigational Drugs Or Biologics, Lukas Gilmore Oct 2019

Expanded Access (Compassionate Use) For Investigational Drugs Or Biologics, Lukas Gilmore

Parkview Pharmacy Department

A presentation given at the Parkview Cancer Institute (PCI) Oncology Research Committee meeting in October 22, 2019.

Investigational Drug Service Department of Parkview Health


Clinician Evaluators: Take Your Mark!, Jodi Polaha, William Lusenhop, Mckenzie Highsmith, Deepu George, Adrian Sandoval Oct 2019

Clinician Evaluators: Take Your Mark!, Jodi Polaha, William Lusenhop, Mckenzie Highsmith, Deepu George, Adrian Sandoval

ETSU Faculty Works

  • Discuss two implementation outcomes (adoption and reach) and explain why they are important for clinicians to measure and report, with application to own work.
  • Name sources of data that are accessible to clinicians in health care settings, with consideration of own setting.
  • Describe a range of dissemination strategies used to create impact, including new ideas for dissemination of own work.

References

  • Proctor, E. K., Silmere, H., Raghavan, R., Hovmand, P., Aarons, G. A., Bunger, A., . . . Hensley, M. (2011). Outcomes for implementation research: Conceptual distinctions, measurement challenges, and research agenda. Administration and Policy in Mental Health and Mental …


Severe Bradycardia During A Spinal Cord Stimulator Procedure, Marc Blanchard Md, Ettore Crimi Md, Stephen Pyles Md Oct 2019

Severe Bradycardia During A Spinal Cord Stimulator Procedure, Marc Blanchard Md, Ettore Crimi Md, Stephen Pyles Md

Anesthesiology

We report a case of severe bradycardia during spinal cord implantation. A 43 year old female with a history of chronic refractory lumbar back pain presented for revision of spinal cord stimulator. Preoperative assessment was positive only for bilateral lower extremity radiculopathy. During the procedure, surgeon’s attempt to advance the lead through scar tissue elicited severe bradycardia (HR 28) resolved with glycopyrrolate. Compression of spinal cord secondary to difficult lead placement could be the cause of this cardiovascular event. Anesthesiologists need to be aware that severe bradycardia can occur during spinal cord implantation.


Revealing The Optimal Thresholds For Movement Performance: A Systematic Review And Meta-Analysis To Benchmark Pathological Walking Behaviour, Deepak K. Ravi, Michelle Gwerder, Niklas König Ignasiak, Christian R. Baumann, Mechtild Uhl, Jaap H. Dieën, William R. Taylor, Navrag B. Singh Oct 2019

Revealing The Optimal Thresholds For Movement Performance: A Systematic Review And Meta-Analysis To Benchmark Pathological Walking Behaviour, Deepak K. Ravi, Michelle Gwerder, Niklas König Ignasiak, Christian R. Baumann, Mechtild Uhl, Jaap H. Dieën, William R. Taylor, Navrag B. Singh

Physical Therapy Faculty Articles and Research

In order to address whether increased levels of movement output variability indicate pathological performance, we systematically reviewed and synthesized meta-analysis data on healthy and pathological motor behavior. After screening up to 24’000 reports from four databases, 85 studies were included containing 2409 patients and 2523 healthy asymptomatic controls. The optimal thresholds of variability with uncertainty boundaries (in % Coefficient of Variation ± Standard Error) were estimated in 7 parameters: stride time (2.34 ± 0.21), stride length (2.99 ± 0.37), step length (3.34 ± 0.84), swing time (2.94 ± 0.60), step time (3.35 ± 0.23), step width (15.87 ± 1.86), …


Caffeine And Sodium Bicarbonate Supplementation Alone Or Together Improve Karate Performance, Sajjad Rezaei, Kazem Akbari, Daniel E. Gahreman, Amir Sarshin, Montassar Tabben, Mojtaba Kaviani, Alireza Sadeghinikoo, Majid S. Koozehchian, Alireza Naderi Oct 2019

Caffeine And Sodium Bicarbonate Supplementation Alone Or Together Improve Karate Performance, Sajjad Rezaei, Kazem Akbari, Daniel E. Gahreman, Amir Sarshin, Montassar Tabben, Mojtaba Kaviani, Alireza Sadeghinikoo, Majid S. Koozehchian, Alireza Naderi

Research, Publications & Creative Work

Background: The ergogenic properties of acute caffeine (CAF) and sodium bicarbonate (NaHCO3) ingestion on athletic performance have been previously investigated. However, each sport has unique physiological and technical characteristics which warrants optimizing supplementations strategies for maximizing performance. This study examined the effects of CAF and NaHCO3 ingestion on physiological responses and rate of perceived exertion during a Karate-specific aerobic test (KSAT) in competitive karatekas.

Methods: In a double-blind, crossover, randomized placebo-controlled trial, eight Karatekas underwent five experimental conditions including control (CON), placebo (PLA), CAF, NaHCO3, and CAF + NaHCO3 before completing KSAT. Capsules containing 6 mg/kg BW CAF …


Heart Rate Variability, Neuromuscular And Perceptual Recovery Following Resistance Training, Andrew A. Flatt, Liam Globensky, Evan Bass, Brooke L. Sapp, Bryan Riemann Oct 2019

Heart Rate Variability, Neuromuscular And Perceptual Recovery Following Resistance Training, Andrew A. Flatt, Liam Globensky, Evan Bass, Brooke L. Sapp, Bryan Riemann

Health Sciences & Kinesiology: Faculty Publications

We quantified associations between changes in heart rate variability (HRV), neuromuscular and perceptual recovery following intense resistance training (RT). Adult males (n = 10) with >1 year RT experience performed six sets to failure with 90% of 10 repetition maximum in the squat, bench press, and pull-down. Changes (∆) from pre- to immediately (IP), 24 and 48 h post-RT were calculated for neuromuscular performance markers (counter-movement jump peak power and mean concentric bench press and squat velocity with load corresponding to 1.0 m∙s−1) and perceived recovery and soreness scales. Post-waking natural logarithm of the root-mean square of successive …


Rapidly Progressive Rheumatoid Lung Disease, Alaynna C. Kears Do, Nathan Brewster Do, Andrea M. Soliman Do, Stacey Smith Md, Facp, James Ross Md, Facp Oct 2019

Rapidly Progressive Rheumatoid Lung Disease, Alaynna C. Kears Do, Nathan Brewster Do, Andrea M. Soliman Do, Stacey Smith Md, Facp, James Ross Md, Facp

Department of Medicine

No abstract provided.


Rash Provokes Catastrophic Antiphospholid Syndrome, Alaynna C. Kears Do, Nathan Brewster Do, Breanna S. Goldner Do, Kareem Godil Md, Aaron J. Czysz Md Oct 2019

Rash Provokes Catastrophic Antiphospholid Syndrome, Alaynna C. Kears Do, Nathan Brewster Do, Breanna S. Goldner Do, Kareem Godil Md, Aaron J. Czysz Md

Department of Medicine

No abstract provided.


Where Have All The Female Md, Phd Applicants Gone?, Kathryn Behling Oct 2019

Where Have All The Female Md, Phd Applicants Gone?, Kathryn Behling

Cooper Rowan Medical Journal

Letter to the Editor: In Reply to "Factors Influencing Graduate Program Choice Among Undergraduate Women," Cooper Rowan Medical Journal: Vol. 1 : Iss. 1 , Article 5.


Welcome Readers, Barbara Aranda-Naranjo, Phd Oct 2019

Welcome Readers, Barbara Aranda-Naranjo, Phd

Optometric Clinical Practice

Interim provost would like to welcome you as readers to our new journal, Optometric Clinical Practice.


Crises In The Aquatic Profession, Robert Keig Stallman Oct 2019

Crises In The Aquatic Profession, Robert Keig Stallman

International Journal of Aquatic Research and Education

In this paper, I propose there are several crises in the aquatic profession and I explain what they are and how to address them using research and my own observations. I use an innovative questioning process to do this by asking you the reader a series of questions after which I explain each. The first crisis has to do with the quantity of trained swimming instructors relative to the population that they serve. In many western European and North American high income countries (HICs), the teacher:student ratios are declining and it is getting increasingly difficult to hire trained swim instructors. …


Functional Profiling Of Single Crispr/Cas9-Edited Human Long-Term Hematopoietic Stem Cells., Elvin Wagenblast, Maria Azkanaz, Sabrina A Smith, Lorien Shakib, Jessica L Mcleod, Gabriela Krivdova, Joana Araújo, Leonard D. Shultz, Olga I Gan, John E Dick, Eric R Lechman Oct 2019

Functional Profiling Of Single Crispr/Cas9-Edited Human Long-Term Hematopoietic Stem Cells., Elvin Wagenblast, Maria Azkanaz, Sabrina A Smith, Lorien Shakib, Jessica L Mcleod, Gabriela Krivdova, Joana Araújo, Leonard D. Shultz, Olga I Gan, John E Dick, Eric R Lechman

Faculty Research 2019

In the human hematopoietic system, rare self-renewing multipotent long-term hematopoietic stem cells (LT-HSCs) are responsible for the lifelong production of mature blood cells and are the rational target for clinical regenerative therapies. However, the heterogeneity in the hematopoietic stem cell compartment and variable outcomes of CRISPR/Cas9 editing make functional interrogation of rare LT-HSCs challenging. Here, we report high efficiency LT-HSC editing at single-cell resolution using electroporation of modified synthetic gRNAs and Cas9 protein. Targeted short isoform expression of the GATA1 transcription factor elicit distinct differentiation and proliferation effects in single highly purified LT-HSC when analyzed with functional in vitro differentiation …


Towards A People’S Social Epidemiology: Envisioning A More Inclusive And Equitable Future For Social Epi Research And Practice In The 21st Century, Ryan J. Petteway, Mahasin Mujahid, Rachel Morello-Frosch, Amani Allen Oct 2019

Towards A People’S Social Epidemiology: Envisioning A More Inclusive And Equitable Future For Social Epi Research And Practice In The 21st Century, Ryan J. Petteway, Mahasin Mujahid, Rachel Morello-Frosch, Amani Allen

OHSU-PSU School of Public Health Faculty Publications and Presentations

Social epidemiology has made critical contributions to understanding population health. However, translation of social epidemiology science into action remains a challenge, raising concerns about the impacts of the field beyond academia. With so much focus on issues related to social position, discrimination, racism, power, and privilege, there has been surprisingly little deliberation about the extent and value of social inclusion and equity within the field itself. Indeed, the challenge of translation/action might be more readily met through re-envisioning the role of the people within the research/practice enterprise—reimagining what “social” could, or even should, mean for the future of the field. …


Barefoot Running: Effects On Emg Activity Of Gluteus Medius And Tensor Fascia Latae In Habitually Shod Runners, Bailey Neubauer, Zach Drevlow, Alexandra Gerlach Oct 2019

Barefoot Running: Effects On Emg Activity Of Gluteus Medius And Tensor Fascia Latae In Habitually Shod Runners, Bailey Neubauer, Zach Drevlow, Alexandra Gerlach

Physical Therapy Scholarly Projects

Purpose/Hypothesis: Running has been a common practice in humans since the species’ dawn. Due to its relative ease and low cost, running continues to be one of the most popular forms of exercise today. Although running provides many benefits such as disease prevention, injury prevalence in running is high. The trend of minimalist shoes and barefoot training has gained popularity over the decade as a return to a more natural form of running. Some researchers hypothesize that barefoot running can reduce injury rate by changing the biomechanics of the runner. In this study we propose a different hypothesis: barefoot running …


The Case For Revamping New Faculty Orientation: Integrating Case-Based Learning Into Faculty Onboarding., Mansoor Siddiqui, Dimitrios Papanagnou, Samantha Bruno, Karen Novielli Oct 2019

The Case For Revamping New Faculty Orientation: Integrating Case-Based Learning Into Faculty Onboarding., Mansoor Siddiqui, Dimitrios Papanagnou, Samantha Bruno, Karen Novielli

Department of Emergency Medicine Faculty Papers

Introduction: New faculty orientation (NFO) for onboarding faculty members is replete with critical information and resources. Most NFO sessions are facilitated through lecture-based slide presentations. We employed a case-based learning (CBL) format to promote learner engagement through active use of the content being taught. We hypothesized that a CBL format would lead to improved learner satisfaction.

Methods: An inventory of topics presented at NFO was generated by reviewing previous orientation sessions. Cases and discussion questions were developed to link to specific content areas from previously delivered lectures. Participants were assigned cases with discussion questions, followed by a large-group debriefing. In …


Harmonizing Clinical, Research, And Teaching Aims: Team Care For Patients With Complex Needs, Alicia Williams, Millie Wykoff, Ryan Tewell, Jodi Polaha, Jim Holt Oct 2019

Harmonizing Clinical, Research, And Teaching Aims: Team Care For Patients With Complex Needs, Alicia Williams, Millie Wykoff, Ryan Tewell, Jodi Polaha, Jim Holt

ETSU Faculty Works

At the conclusion of this session, the participants will be able to:
1. Describe a team-based approach to addressing complex patients’ needs.
2. Develop engaged and experiential methods for teaching interprofessional learners about team-care for complex patients.
3. Demonstrate familiarity with an evaluation strategy and preliminary outcomes data for a team approach for complex patients.


Alpha Synuclein In Hematopoiesis And Immunity, Robert W. Maitta Oct 2019

Alpha Synuclein In Hematopoiesis And Immunity, Robert W. Maitta

Faculty Scholarship

Parkinson's disease (PD) is the second most common neurodegenerative condition and intracellular deposition of Lewy bodies in the substantia nigra (SN), which can cause dopaminergic neuronal death, is the hallmark of this syndrome. α-synuclein (syn) is a small protein expressed mainly in neurons but can also be found in a number of tissues. It can be present as a soluble monomer under normal physiological conditions, but can be toxic in its oligomeric or fibrillary forms. Most of the available literature has focused on the effects of α-syn pathology in the mechanisms leading to PD. However, the normal functions of α-syn …