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Articles 15931 - 15960 of 16114
Full-Text Articles in Medicine and Health Sciences
Obesity Prevention And The Role Of Hospital And Community-Based Health Services: A Scoping Review, Claire Pearce, Lucie Rychetnik, Sonia Wutzke, Andrew Wilson
Obesity Prevention And The Role Of Hospital And Community-Based Health Services: A Scoping Review, Claire Pearce, Lucie Rychetnik, Sonia Wutzke, Andrew Wilson
Medical Papers and Journal Articles
Background: Control of obesity is an important priority to reduce the burden of chronic disease. Clinical guidelines focus on the role of primary healthcare in obesity prevention. The purpose of this scoping review is to examine what the published literature indicates about the role of hospital and community based health services in adult obesity prevention in order to map the evidence and identify gaps in existing research.
Methods: Databases were searched for articles published in English between 2006 and 2016 and screened against inclusion and exclusion criteria. Further papers were highlighted through a manual search of the reference lists. Included …
Genetic Influence On Scar Height And Pliability After Burn Injury In Individuals Of European Ancestry: A Prospective Cohort Study, Hilary J. Wallace, Gemma Cadby, Phillip E. Melton, Fiona M. Wood, Sian Falder, Margaret M. Crowe, Lisa J. Martin, Karen Marlow, Sarah V. Ward, Mark W. Fear
Genetic Influence On Scar Height And Pliability After Burn Injury In Individuals Of European Ancestry: A Prospective Cohort Study, Hilary J. Wallace, Gemma Cadby, Phillip E. Melton, Fiona M. Wood, Sian Falder, Margaret M. Crowe, Lisa J. Martin, Karen Marlow, Sarah V. Ward, Mark W. Fear
Medical Papers and Journal Articles
After similar extent of injury there is considerable variability in scarring between individuals, in part due to genetic factors. This study aimed to identify genetic variants associated with scar height and pliability after burn injury. An exome-wide array association study and gene pathway analysis were performed on a prospective cohort of 665 patients treated for burn injury. Outcomes were scar height (SH) and scar pliability (SP) sub-scores of the modified Vancouver Scar Scale (mVSS). DNA was genotyped using the Infinium® HumanCoreExome-24 BeadChip. Associations between genetic variants (single nucleotide polymorphisms) and SH and SP were estimated using an additive genetic …
Trans-Generational Stress Regulation: Mother-Infant Cortisol And Maternal Mental Health Across The Perinatal Period, Megan Galbally, Elisabeth F.C Van Rossum, Stuart J. Watson, Edo Ronald De Kloet, Andrew J. Lewis
Trans-Generational Stress Regulation: Mother-Infant Cortisol And Maternal Mental Health Across The Perinatal Period, Megan Galbally, Elisabeth F.C Van Rossum, Stuart J. Watson, Edo Ronald De Kloet, Andrew J. Lewis
Medical Papers and Journal Articles
Understanding maternal mental health and cortisol regulation across pregnancy and the relationship to the development of the offspring’s stress regulation is critical to a range of health outcomes. The aim of this study was to investigate infant and maternal cortisol in women with depression. Data were obtained from 241 pregnant women within the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS), a selected pregnancy cohort study. Depression was measured using the Structured Clinical Interview for DSM-IV (SCID-IV) and repeat Edinburgh Postnatal Depression Scale (EPDS). Repeated measures of antidepressant use, stressful events, anxiety symptoms and maternal hair cortisol concentrations (HCC) and infant …
Adrenal Crisis, R Louise Rushworth, David J. Torpy, Henrik Falhammar
Adrenal Crisis, R Louise Rushworth, David J. Torpy, Henrik Falhammar
Medical Papers and Journal Articles
Glucocorticoid replacement therapy, available since the 1950s, has prolonged the survival of patients with adrenal insufficiency. However, adrenal crises, which are life-threatening medical emergencies, still develop in many affected patients. Adrenal crisis appears to be increasing in frequency, despite the availability of effective preventive strategies. This review examines the definitions, pathophysiology, epidemiology, and treatment of adrenal crises.
Reducing Stroke Risk In Atrial Fibrillation: Adherence To Guidelines Has Improved, But Patient Persistence With Anticoagulant Therapy Remains Suboptimal., Nicole Lowres, Katrina Giskes, Charlotte Hespe, Ben Freedman
Reducing Stroke Risk In Atrial Fibrillation: Adherence To Guidelines Has Improved, But Patient Persistence With Anticoagulant Therapy Remains Suboptimal., Nicole Lowres, Katrina Giskes, Charlotte Hespe, Ben Freedman
Medical Papers and Journal Articles
Atrial fibrillation (AF) is a significant risk factor for avoidable stroke. Among high-risk patients with AF, stroke risk can be mitigated using oral anticoagulants (OACs), however reduction is largely contingent on physician prescription and patient persistence with OAC therapy. Over the past decade significant advances have occurred, with revisions to clinical practice guidelines relating to management of stroke risk in AF in several countries, and the introduction of non-vitamin K antagonist OACs (NOACs). This paper summarises the evolving body of research examining guideline-based clinician prescription over the past decade, and patient-level factors associated with OAC persistence. The review shows clinicians' …
Machine Learning Classification Of Human Joint Tissue From Diffuse Reflectance Spectroscopy Data, Rajitha Gunaratne, Issac Monteath, Joshua Goncalves, Raymond Sheh, Charles N. Ironside, Michael Kapfer, Richard Chipper, Brett Robertson, Riaz Khan, Daniel Fick
Machine Learning Classification Of Human Joint Tissue From Diffuse Reflectance Spectroscopy Data, Rajitha Gunaratne, Issac Monteath, Joshua Goncalves, Raymond Sheh, Charles N. Ironside, Michael Kapfer, Richard Chipper, Brett Robertson, Riaz Khan, Daniel Fick
Medical Papers and Journal Articles
Objective: To assess if incorporation of DRS sensing into real-time robotic surgery systems has merit. DRS as a technology is relatively simple, cost-effective and provides a non-contact approach to tissue differentiation.
Methods: Supervised machine learning analysis of diffuse reflectance spectra was performed to classify human joint tissue that was collected from surgical procedures.
Results: We have used supervised machine learning in the classification of a DRS human joint tissue data set and achieved classification accuracy in excess of 99%. Sensitivity for the various classes were; cartilage 99.7%, subchondral 99.2%, meniscus 100% and cancellous 100%. Full wavelength range is required for …
A Randomized Controlled Trial Of Peek Versus Titanium Interference Screws For Anterior Cruciate Ligament Reconstruction With 2-Year Follow-Up, Sarah Shumborski, Emma Heath, Lucy J. Salmon, Justin P. Roe, James P. Linklater, Michael Facek, Leo Pinczewski
A Randomized Controlled Trial Of Peek Versus Titanium Interference Screws For Anterior Cruciate Ligament Reconstruction With 2-Year Follow-Up, Sarah Shumborski, Emma Heath, Lucy J. Salmon, Justin P. Roe, James P. Linklater, Michael Facek, Leo Pinczewski
Medical Papers and Journal Articles
Purpose: To compare the clinical performance of ACL reconstruction with PEEK and titanium interference screws at 2 years and to evaluate a novel method of measuring tunnel volume.
Study Design: Randomized controlled trial; Level of evidence, 1.
Methods: A total of 133 patients underwent arthroscopic ACL reconstruction with 4-strand hamstring autografts and were randomized to have titanium or PEEK interference screws for femoral and tibial tunnel fixation. At 2 years, subjective Lysholm and International Knee Documentation Committee scores were assessed and clinical examination performed. At 12 months, MRI was performed to assess graft incorporation and cyst formation, and a novel …
Cyanoacrylate Closure For Peripheral Veins: Consensus Document Of The Australasian College Of Phlebology, Kurosh Parsi, Stefania Roberts, Mina Kang, Stephen Benson, Luke Baker, Ivor Berman, Lourens J. Bester, David E. Connor, Paul Dinnen, Joseph Grace, Andrew Stirling, Nabeel Ibrahim, Christopher Lekich, Adrian Lim, Luke Matar, Sanjay Nadkarni, Peter Paraskevas, Christopher Rogan, Paul K. Thibault, Simon Thibault, Andre Van Rij, Anes Yang
Cyanoacrylate Closure For Peripheral Veins: Consensus Document Of The Australasian College Of Phlebology, Kurosh Parsi, Stefania Roberts, Mina Kang, Stephen Benson, Luke Baker, Ivor Berman, Lourens J. Bester, David E. Connor, Paul Dinnen, Joseph Grace, Andrew Stirling, Nabeel Ibrahim, Christopher Lekich, Adrian Lim, Luke Matar, Sanjay Nadkarni, Peter Paraskevas, Christopher Rogan, Paul K. Thibault, Simon Thibault, Andre Van Rij, Anes Yang
Medical Papers and Journal Articles
Background: Cyanoacrylates are fast-acting adhesives used in procedural medicine including closure of superficial wounds, embolization of truncal vessels pre-operatively, vascular anomalies, visceral false aneurysms, endoleaks, gastrointestinal varices and gastrointestinal bleeding. More recently, catheter-directed cyanoacrylate adhesive closure was introduced as an alternative to endovenous thermal ablation (ETA) to occlude superficial veins of the lower limbs.
Objectives: To formulate policies for the safe and effective delivery of cyanoacrylate adhesive closure procedures in Australasia, based on current experience and evidence.
Methods: A panel of phlebologists including vascular surgeons, interventional radiologists, dermatologists and research scientists systematically reviewed the available data on cyanoacrylate products used …
Using Participatory Design Methodologies To Co-Design And Culturally Adapt The Spanish Version Of The Mental Health Eclinic: Qualitative Study, Laura Ospina-Pinillos, Tracey Davenport, Antonio Mendoza Diaz, Alvaro Navarro-Mancilla, Elizabeth M. Scott, Ian B. Hickie
Using Participatory Design Methodologies To Co-Design And Culturally Adapt The Spanish Version Of The Mental Health Eclinic: Qualitative Study, Laura Ospina-Pinillos, Tracey Davenport, Antonio Mendoza Diaz, Alvaro Navarro-Mancilla, Elizabeth M. Scott, Ian B. Hickie
Medical Papers and Journal Articles
Background: The Mental Health eClinic (MHeC) aims to deliver best-practice clinical services to young people experiencing mental health problems by making clinical care accessible, affordable, and available to young people whenever and wherever they need it most. The original MHeC consists of home page with a visible triage system for those requiring urgent help; a online physical and mental health self-report assessment; a results dashboard; a booking and videoconferencing system; and the generation of a personalized well-being plan. Populations who do not speak English and reside in English-speaking countries are less likely to receive mental health care. In Australia, international …
Pre-Hospital Management Of Acute Addison’S Disease – Audit Of Patients Attending A Referral Hospital In A Regional Area, Thomas Goubar, David J. Torpy, Shaun Mcgrath, R Louise Rushworth
Pre-Hospital Management Of Acute Addison’S Disease – Audit Of Patients Attending A Referral Hospital In A Regional Area, Thomas Goubar, David J. Torpy, Shaun Mcgrath, R Louise Rushworth
Medical Papers and Journal Articles
Context: Adrenal crises (AC) cause morbidity and mortality in patients with Addison’s disease [primary adrenal insufficiency (PAI)]. Patient-initiated oral stress dosing, with parenteral hydrocortisone, is recommended to avert ACs. While these should be effective, the continued incidence of ACs remains largely unexplained.
Methods: Audit of all attendances between 2000 and 2017 by adult patients with treated PAI to one large regional referral centre in New South Wales, Australia. Measurements were those taken on arrival at hospital.
Results: There were 252 attendances by 56 patients with treated PAI during the study period. Women comprised 60.7% (n=34) of the patients. The mean …
Prevalence Of Sexual Harassment Of Nurses And Nursing Students In China: A Meta-Analysis Of Observational Studies, Liang-Nan Zeng, Qian-Qian Zong, Ji-Wen Zhang, Li Lu, Feng-Rong An, Chee H. Ng, Gabor S. Ungvari, Fang-Yu Yang, Teris Cheung, Ligang Chen, Yu-Tao Xiang
Prevalence Of Sexual Harassment Of Nurses And Nursing Students In China: A Meta-Analysis Of Observational Studies, Liang-Nan Zeng, Qian-Qian Zong, Ji-Wen Zhang, Li Lu, Feng-Rong An, Chee H. Ng, Gabor S. Ungvari, Fang-Yu Yang, Teris Cheung, Ligang Chen, Yu-Tao Xiang
Medical Papers and Journal Articles
Sexual harassment experienced by nurses and nursing students is common and significantly associated with negative consequences. This study is a meta-analysis of the pooled prevalence of sexual harassment of nurses and nursing students in China. Electronic databases (PubMed, EMBASE, PsycINFO, Web of Science and Ovid, China National Knowledge Internet, WanFang, SinoMed and Chinese VIP Information) were independently and systematically searched by two reviewers from their commencement date to 12 March 2018. Forty-one studies that reported the prevalence of sexual harassment were analyzed using the random-effects model. The pooled prevalence of sexual harassment was 7.5% (95% CI: 5.5%-10.1%), with 7.5% (5.5%-10.2%) …
Patients’ And Caregivers’ Contested Perspectives On Spiritual Care For Those Affected By Advanced Illnesses: A Qualitative Descriptive Study, Clare O'Callaghan, Joanne Brooker, William De Silva, David Glenister, Adelaide Melia, Xavier Symons, David Kissane, Natasha Michael
Patients’ And Caregivers’ Contested Perspectives On Spiritual Care For Those Affected By Advanced Illnesses: A Qualitative Descriptive Study, Clare O'Callaghan, Joanne Brooker, William De Silva, David Glenister, Adelaide Melia, Xavier Symons, David Kissane, Natasha Michael
Medical Papers and Journal Articles
Context; Spiritual care refers to practices and rituals addressing spiritual/religious concerns. It supports coping with loss and finding hope, meaning, and peace. Although integral to palliative care, its implementation is challenging.
Objective: To understand an Australian cohort of patients’ and caregivers’ perspectives about experiencing and optimizing spiritual care in the context of advanced illness.
Methods: Patients and caregivers of patients with #12 month prognosis were recruited from a broader spiritual study via criterion sampling and agreed to opt-in interviews. Participants from an Australian, metropolitan health service received a spiritual care definition and were interviewed. Transcripts were analyzed using qualitative description. …
How Does The Duration Of Consults Vary For Upper Respiratory Tract Infections In General Practice Where An Antibiotic Has Been Prescribed?, Phoebe R. Darlison Shepherd, Catherine J. Krejany, Moyez Jiwa
How Does The Duration Of Consults Vary For Upper Respiratory Tract Infections In General Practice Where An Antibiotic Has Been Prescribed?, Phoebe R. Darlison Shepherd, Catherine J. Krejany, Moyez Jiwa
Medical Papers and Journal Articles
Background: There is limited data on the duration of consults resulting in the prescription of antibiotics for upper respiratory tract infections (URTIs) in general practice.
Objective: To explore how demographic factors influence consult duration where antibiotics have been prescribed for URTI in Australian general practice.
Methods: 2985 URTI-specific presentations were identified from a national study of patients who were prescribed an antibiotic after presenting to general practice between June and September 2017. Consult duration was analysed to assess for any variation in visit length based on demographic factors.
Results: The overall median consult duration was 11.42 minutes [interquartile range (IQR) …
Impulse Control Disorders In Dopamine Agonist-Treated Hyperprolactinemia: Prevalence And Risk Factors, Sunita M.C De Sousa, John Baranoff, R Louise Rushworth, Jessica Butler, Jane Sorbello, Juanita Vorster, Tanya Thompson, Ann I. Mccormack, Warrick J. Inder, David J. Torpy
Impulse Control Disorders In Dopamine Agonist-Treated Hyperprolactinemia: Prevalence And Risk Factors, Sunita M.C De Sousa, John Baranoff, R Louise Rushworth, Jessica Butler, Jane Sorbello, Juanita Vorster, Tanya Thompson, Ann I. Mccormack, Warrick J. Inder, David J. Torpy
Medical Papers and Journal Articles
Context: There are growing reports of dopamine agonist (DA)-induced impulse control disorders (ICDs) in hyperprolactinemic patients. However, the magnitude of this risk and predictive factors remain uncertain.
Objective: To determine ICD prevalence and risk factors in DA-treated hyperprolactinemic patients compared to community controls.
Design, Setting and Participants: Multicenter cross-sectional analysis of 113 patients and 99 healthy controls.
Main Outcome Measures: Participants completed a neuropsychological questionnaire consisting of the Depression Anxiety Stress Scale (DASS21), Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s disease (QUIP-S), Hypersexual Behavior Inventory (HBI), Hypersexual Behavior Consequences Scale and Social Desirability Response Set Scale. Demographic and clinical data were …
A Sex-Specific Evaluation Of Predicted Lean And Fat Mass Composition And Cardiovascular Disease Onset And Progression: A Combined Analysis Of The Attica And Greecs Prospective Epidemiological Studies, Matina Kouvari, Demosthenes B. Panagiotakos, Christina Chrysohoou, Venetia Notara, Ekavi N. Georgousopoulou, Mary Yannakoulia, Dimitrios Tousoulis, Christos Pitsavos
A Sex-Specific Evaluation Of Predicted Lean And Fat Mass Composition And Cardiovascular Disease Onset And Progression: A Combined Analysis Of The Attica And Greecs Prospective Epidemiological Studies, Matina Kouvari, Demosthenes B. Panagiotakos, Christina Chrysohoou, Venetia Notara, Ekavi N. Georgousopoulou, Mary Yannakoulia, Dimitrios Tousoulis, Christos Pitsavos
Medical Papers and Journal Articles
Objectives: To evaluate the association of predicted lean and fat mass on 10-year first and recurrent CVD incidence separately for men and women.
Methods: Two prospective studies, ATTICA (2002-2012, n = 3042 subjects free-of-CVD, n = 1514 men (46 ± 13 years) and n = 1528 women (45 ± 14 years)) and GREECS (2004-2014, n = 2172 subjects with acute coronary syndrome (ACS), n = 1649 men (65 ± 13 years) and n = 523 women (62 ± 11 years)) were used. Lean mass index (LMI) and fat mass index (FMI) were created through total body lean and fat mass …
Exposure To Second Hand Smoke And 10-Year (2002–2012) Incidence Of Cardiovascular Disease In Never Smokers: The Attica Cohort Study, Elena Critselis, Demosthenes B. Panagiotakos, Ekavi N. Georgousopoulou, Paraskevi Katsaounou, Christina Chrysohoou, Christos Pitsavos
Exposure To Second Hand Smoke And 10-Year (2002–2012) Incidence Of Cardiovascular Disease In Never Smokers: The Attica Cohort Study, Elena Critselis, Demosthenes B. Panagiotakos, Ekavi N. Georgousopoulou, Paraskevi Katsaounou, Christina Chrysohoou, Christos Pitsavos
Medical Papers and Journal Articles
Background: Despite WHO Framework Convention of Tobacco Control (FCTC) adoption, effective implementation of national smoking bans remains pending in several countries. This study quantified the association of second hand smoke (SHS) exposure and 10-year cardiovascular disease (CVD) among never smokers in such settings.
Methods: In 2001–2002, a sample of 1514 males and 1528 females (range: 18–89 years old) were randomly selected in Greece. Frequency and duration of SHS exposure (i.e. exposure extending >30 min/day) within the home and/or workplace were assessed by interview. Following a 10-year follow-up period (2002–2012), incidence of non-fatal and fatal CVD (ICD-10) was evaluated among n …
Lipoprotein (A) And 10-Year Cardiovascular Disease Incidence In Apparently Healthy Individuals: A Sex-Based Sensitivity Analysis From Attica Cohort Study, Matina Kouvari, Demosthenes B. Panagiotakos, Christina Chrysohoou, Ekavi N. Georgousopoulou, Mary Yannakoulia, Dimitrios Tousoulis, Christos Pitsavos
Lipoprotein (A) And 10-Year Cardiovascular Disease Incidence In Apparently Healthy Individuals: A Sex-Based Sensitivity Analysis From Attica Cohort Study, Matina Kouvari, Demosthenes B. Panagiotakos, Christina Chrysohoou, Ekavi N. Georgousopoulou, Mary Yannakoulia, Dimitrios Tousoulis, Christos Pitsavos
Medical Papers and Journal Articles
The association between lipoprotein (a) (Lp(a)) and 10-year first fatal/nonfatal cardiovascular disease (CVD) risk in apparently healthy men and women was evaluated. The ATTICA prospective study was conducted during 2001-2012 and included n = 1514 men and n = 1528 women (age >18 years) from the greater Athens area, Greece. Follow-up CVD assessment (2011-2012) was achieved in n = 2020 participants (n = 317 cases); baseline Lp(a) was measured in n = 1890 participants. The recommended threshold of 50 mg/dL was used to define abnormal Lp(a) status. Ten-year CVD-event rate was 14% and 24% in participants with Lp(a)Lp(a) ≥50 mg/dL, …
Investigating Risk Factors And Predicting Complications In Deep Brain Stimulation Surgery With Machine Learning Algorithms, Farrokh Farrokhi, Quinlan D. Buchlak, Matt Sikora, Nazanin Esmaili, Maria Marsans, Pamela Mcleod, Jamie Mark, Emily Cox, Christine Bennett, Jonathan Carlson
Investigating Risk Factors And Predicting Complications In Deep Brain Stimulation Surgery With Machine Learning Algorithms, Farrokh Farrokhi, Quinlan D. Buchlak, Matt Sikora, Nazanin Esmaili, Maria Marsans, Pamela Mcleod, Jamie Mark, Emily Cox, Christine Bennett, Jonathan Carlson
Medical Papers and Journal Articles
Background: Deep brain stimulation (DBS) surgery is an option for patients experiencing medically resistant neurological symptoms. DBS complications are rare; finding significant predictors requires a large number of surgeries. Machine learning algorithms may be used to effectively predict these outcomes. The aims of this study were to (1) investigate preoperative clinical risk factors, and (2) build machine learning models to predict adverse outcomes.
Methods: This multicenter registry collected clinical and demographic characteristics of patients undergoing DBS surgery (n=501) and tabulated occurrence of complications. Logistic regression was used to evaluate risk factors. Supervised learning algorithms were trained and validated on 70% …
Primary Open Abductor Reconstruction - A 5-10 Year Study, Olivia J.K Fox, Graeme Wertheimer, Michael Walsh
Primary Open Abductor Reconstruction - A 5-10 Year Study, Olivia J.K Fox, Graeme Wertheimer, Michael Walsh
Medical Papers and Journal Articles
Background: Gluteal tears are recognised as the source of pain over the greater trochanter. We investigated the outcome of primary open abductor tendon reconstruction with a 5 year follow-up.
Methods: 165 consecutive hips underwent an open abductor tendon reconstruction, with all tears confirmed pre-operatively by MRI. Oxford hip scores (OHS) were assessed at the initial visit, and at 5 to 10 years.
Results: The average pre-operative OHS was 22 (r: 7y – 34y) and average post-operative OHS was 40 a difference of 18 (p<0.0001).
Conclusion: Surgical reconstruction of degenerate abductor tendons should be considered in the presence of an MRI …
'Through The Eyes Of The Dying' - Identifying Who May Benefit From Bereavement Follow-Up: A Qualitative Study, Jane L. Phillips, Elizabeth A. Lobb, Francis Bellemore, Terrence Hays, David C. Currow
'Through The Eyes Of The Dying' - Identifying Who May Benefit From Bereavement Follow-Up: A Qualitative Study, Jane L. Phillips, Elizabeth A. Lobb, Francis Bellemore, Terrence Hays, David C. Currow
Medical Papers and Journal Articles
Introduction: Bereavement support is an integral element of palliative care. Emerging evidence stipulates that bereavement support should be reserved for those most at risk of poor outcomes. While this evidence makes identifying those at risk of experiencing a complex bereavement a necessary first step, it has been difficult to arrive at a consensus as to whom that should be.
Aim: To explore whether palliative care in-patients with advanced disease are concerned about the bereavement needs of others and, if so, is it their next-of-kin.
Design: A qualitative study using semi-structured interviews, and thematic analysis using a constant comparative method.
Setting/participants: …
My Patients Prepared Me Well, Meagan E. Brennan
My Patients Prepared Me Well, Meagan E. Brennan
Medical Papers and Journal Articles
“When doctors become patients, they shouldn’t be surprised that the experience is frightening, undignified and disempowering.”
Stories of doctors experiencing illness are common. Major illness is life-changing for most people, and the impact on doctors can be particularly profound.1–5 But why do so many doctors seemingly have to experience a life-threatening illness before they truly develop empathy? Despite years spent caring for patients, why is it that it takes their own illness to realise that being unwell can be frightening and demoralising for the soul as well as wreaking havoc on the body?
P450 Oxidoreductase Deficiency: A Systematic Review And Meta-Analysis Of Genotypes, Phenotypes And Their Relationships, Benjamin Dean, Georgina L. Chrisp, Maria Quartararo, Ann M. Maguire, Shihab Hameed, Bruce R. King, Craig F. Munns, David J. Torpy, Henrik Falhammar, R Louise Rushworth
P450 Oxidoreductase Deficiency: A Systematic Review And Meta-Analysis Of Genotypes, Phenotypes And Their Relationships, Benjamin Dean, Georgina L. Chrisp, Maria Quartararo, Ann M. Maguire, Shihab Hameed, Bruce R. King, Craig F. Munns, David J. Torpy, Henrik Falhammar, R Louise Rushworth
Medical Papers and Journal Articles
Context: P450 oxidoreductase deficiency (PORD) is a rare genetic disorder that is associated with significant morbidity. However there has been limited analysis of reported PORD cases.
Objective: To determine, based on the cohort of reported PORD cases, genotype-phenotype relationships for skeletal malformations, maternal virilisation in pregnancy, adrenal insufficiency and disorders of sexual development (DSD).
Data Sources: PubMed and Web of Science from January 2004 to February 2018.
Study Selection: Published case reports/series of patients with PORD. Eligible patients were unique, had biallelic mutations and their clinical features reported.
Data Extraction: Patient data were manually extracted from the text of case …
Combining Unassisted And Robot-Guided Practice Benefits Motor Learning For A Golf Putting Task, Stephen R. Bested, Gerome A. Manson, Luc Tremblay
Combining Unassisted And Robot-Guided Practice Benefits Motor Learning For A Golf Putting Task, Stephen R. Bested, Gerome A. Manson, Luc Tremblay
Medical Papers and Journal Articles
Robotic guidance has been employed with limited effectiveness in neurologically intact and patient populations. For example, our lab has effectively used robotic guidance to acutely improve movement smoothness of a discrete trajectory without influencing movement endpoint distributions. The purpose of the current study was to investigate the efficacy of combining robotic guidance and unassisted trials in the learning of a golf putting task. Participants completed a pre-test, an acquisition phase, and an immediate and delayed (24-hour) post-test. During the pre-test, kinematic data from the putter was converted into highly accurate, consistent, and smooth trajectories delivered by a robot arm. During …
Familial Hypercholesterolaemia In 2020: A Leading Tier 1 Genomic Application, Jing Pang, David R. Sullivan, Tom Brett, Karam M. Kostner, David L. Hare, Gerald F. Watts
Familial Hypercholesterolaemia In 2020: A Leading Tier 1 Genomic Application, Jing Pang, David R. Sullivan, Tom Brett, Karam M. Kostner, David L. Hare, Gerald F. Watts
Medical Papers and Journal Articles
Familial hypercholesterolemia (FH) is caused by a major genetic defect in the low-density lipoprotein (LDL) clearance pathway. Characterised by LDL-cholesterol elevation from birth, FH confers a significant risk for premature coronary artery disease (CAD) if overlooked and untreated. With risk exposure beginning at birth, early detection and intervention is crucial for the prevention of CAD. Lowering LDL-cholesterol with lifestyle and statin therapy can reduce the risk of CAD. However, most individuals with FH will not reach guideline recommended LDL-cholesterol targets. FH has an estimated prevalence of approximately 1:250 in the community. Multiple strategies are required for screening, diagnosing and treating …
Eliminating Hepatitis C: Part 2. Assessing Your Patient For Antiviral Treatment, Chloe Layton, Jacqui Richmond, David Baker, Louise Owen, Gail Matthews, Erin Oliver-Landry, Jessica Howell, Joseph Doyle
Eliminating Hepatitis C: Part 2. Assessing Your Patient For Antiviral Treatment, Chloe Layton, Jacqui Richmond, David Baker, Louise Owen, Gail Matthews, Erin Oliver-Landry, Jessica Howell, Joseph Doyle
Medical Papers and Journal Articles
With the introduction of direct-acting antivirals (DAAs) in Australia in 2016, most people with chronic hepatitis C can be cured of this infection. GPs and suitably qualified nurse practitioners working in all areas of primary care have a key role in identifying, testing and treating their patients with hepatitis C. The previous article in this series discussed how to identify your patients with hepatitis C. This article provides practical advice on assessing a patient after diagnosis in preparation for DAA therapy. This includes determining whether they can be safely treated in general practice or require specialist referral.
Managing Anxiety Disorders In Adults, Gregory Wilkins, Gavin Andrews, Caroline Bell, Philip Boyce, Christopher Gale, Ronald Rapee, Lisa Lampe
Managing Anxiety Disorders In Adults, Gregory Wilkins, Gavin Andrews, Caroline Bell, Philip Boyce, Christopher Gale, Ronald Rapee, Lisa Lampe
Medical Papers and Journal Articles
The GP has a key role in identifying patients presenting with anxiety symptoms and ensuring appropriate acute and long-term management. There are two key messages for GPs to follow: once you have made a diagnosis of an anxiety disorder, tell the patient you have a treatment for it. Second, do not let your anxiety lead you to prescribe inappropriately or overinvestigate for all possible differential diagnoses.
The Potential Therapeutic Effects Of Creatine Supplementation On Body Composition And Muscle Function In Cancer, C M. Fairman, K L. Kendall, Nicolas H. Hart, D R. Taaffe, D A. Galvao, R U. Newton
The Potential Therapeutic Effects Of Creatine Supplementation On Body Composition And Muscle Function In Cancer, C M. Fairman, K L. Kendall, Nicolas H. Hart, D R. Taaffe, D A. Galvao, R U. Newton
Health Sciences Papers and Journal Articles
Low muscle mass in individuals with cancer has a profound impact on quality of life and independence and is associated with greater treatment toxicity and poorer prognosis. Exercise interventions are regularly being investigated as a means to ameliorate treatment-related adverse effects, and nutritional/supplementation strategies to augment adaptations to exercise are highly valuable. Creatine (Cr) is a naturally-occurring substance in the human body that plays a critical role in energy provision during muscle contraction. Given the beneficial effects of Cr supplementation on lean body mass, strength, and physical function in a variety of clinical populations, there is therapeutic potential in individuals …
Vitamin D Enzymes (Cyp27a1, Cyp27b1 And Cyp24a1) And Receptor Expression In Non-Melanoma Skin Cancer, Natalie Nemazannikova, Gregory L. Blatch, Crispin R. Dass, Rodney Sinclair, Vasso Apostolopoulos
Vitamin D Enzymes (Cyp27a1, Cyp27b1 And Cyp24a1) And Receptor Expression In Non-Melanoma Skin Cancer, Natalie Nemazannikova, Gregory L. Blatch, Crispin R. Dass, Rodney Sinclair, Vasso Apostolopoulos
Health Sciences Papers and Journal Articles
No abstract available for this paper.
Treatment, Prevention And Public Health Management Of Impetigo, Scabies, Crusted Scabies And Fungal Skin Infections In Endemic Populations: A Systematic Review, Philippa J. May, Steven Y.C Tong, Andrew C. Steer, Bart J. Currie, Ross M. Andrews, Jonathan R. Carapetis, Asha C. Bowen
Treatment, Prevention And Public Health Management Of Impetigo, Scabies, Crusted Scabies And Fungal Skin Infections In Endemic Populations: A Systematic Review, Philippa J. May, Steven Y.C Tong, Andrew C. Steer, Bart J. Currie, Ross M. Andrews, Jonathan R. Carapetis, Asha C. Bowen
Health Sciences Papers and Journal Articles
We conducted a systematic review of the treatment, prevention and public health control of skin infections including impetigo, scabies, crusted scabies and tinea in resource-limited settings where skin infections are endemic. The aim is to inform strategies, guidelines and research to improve skin health in populations that are inequitably affected by infections of the skin and the downstream consequences of these. The systematic review is reported according to the PRISMA statement. From
1759 titles identified, 81 full text studies were reviewed and key findings outlined for impetigo, scabies, crusted scabies and tinea. Improvements in primary care and public health management …
In Their Own Words: A Qualitative Study Exploring Influences On The Food Choices Of University Students, Michelle Lambert, Paola Chivers, Fiona Farringdon
In Their Own Words: A Qualitative Study Exploring Influences On The Food Choices Of University Students, Michelle Lambert, Paola Chivers, Fiona Farringdon
Health Sciences Papers and Journal Articles
Issue addressed: University students generally make independent decisions regarding food choices. Current research about knowledge of Australian Dietary Guidelines (ADG), sources of nutrition information and influences on food choices for this group is scarce.
Methods: Qualitative data were collected from gender‐separated focus groups comprising four female (n = 31) and four male (n = 18) to identify: knowledge of ADG; sources of nutrition information; factors that influence food choices; perceived relevant nutrition messages and how best to deliver them.
Results: Gaps in knowledge were identified particularly regarding number of serves and serving size for food groups. Social media was the …