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Articles 14701 - 14730 of 16114
Full-Text Articles in Medicine and Health Sciences
The Effect Of Technical Details Of Percutaneous Catheter Drainage On The Clinical Outcomes Of Infected Necrotizing Pancreatitis Patients, Zhi-Hua Zhang, Yi-Xuan Ding, Yu-Duo Wu, Chong-Chong Gao, Fei Li
The Effect Of Technical Details Of Percutaneous Catheter Drainage On The Clinical Outcomes Of Infected Necrotizing Pancreatitis Patients, Zhi-Hua Zhang, Yi-Xuan Ding, Yu-Duo Wu, Chong-Chong Gao, Fei Li
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effect of technical details of percutaneous catheter drainage (PCD) on the clinical outcomes of patients with infected necrotizing pancreatitis (INP).Materials and methods: A total of 44 INP patients treated in our hospital from October 2013 to October 2015 were included. The correlations of the first PCD treatment data and the clinical outcomes were analyzed.Results: The number of catheters was positively correlated with hospital readmission (r = 0.335, P = 0.032). Receiver operating characteristic curve analysis showed that patients with ? 3 catheters were more likely to have hospital readmission. Patients with pleural effusion …
Reference Values And Prediction Equation For The 6-Minute Walk Test In Healthy Children Aged 6?12 Years Old, Buse Özcan Kahraman, Ertuğrul Yüksel, Abdurrahman Nalbant, Umut Zi̇ya Koçak, Bayram Ünver
Reference Values And Prediction Equation For The 6-Minute Walk Test In Healthy Children Aged 6?12 Years Old, Buse Özcan Kahraman, Ertuğrul Yüksel, Abdurrahman Nalbant, Umut Zi̇ya Koçak, Bayram Ünver
Turkish Journal of Medical Sciences
Background/aim: The 6-minute walk test (6MWT) is the most commonly used and well-established test to measure functional exercise capacity in research and clinical settings. Country-specific reference values are important to interpret the results of 6MWT. However, no reference values have been reported for healthy Turkish children aged between 6 and 12 years old. The aim of this study was to determine normal reference values for the 6MWT test of healthy Turkish children aged between 6 and 12 years old. Materials and methods: Two hundred and sixty-two healthy children aged between 6 and 12 years old were included in this cross-sectional …
The Relationship With Clinical Course And Prognosis Of Serum Endothelin-1, Angiopoietin-2, And Tie-2 Levels In Crimean-Congo Hemorrhagic Fever, Ferhan Kerget, Zülal Özkurt, Nuri̇nni̇sa Öztürk, Si̇nan Yilmaz
The Relationship With Clinical Course And Prognosis Of Serum Endothelin-1, Angiopoietin-2, And Tie-2 Levels In Crimean-Congo Hemorrhagic Fever, Ferhan Kerget, Zülal Özkurt, Nuri̇nni̇sa Öztürk, Si̇nan Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Crimean-Congo hemorrhagic fever (CCHF) is a serious illness characterized by fever and hemorrhage. Endothelin-1 (ET-1), angiopoietin-2 (Ang-2), and endothelial cell-specific receptor tyrosine kinase (Tie-2) are believed to be important markers of the pathogenesis, clinical course, and prognosis of the disease. The aim of this study was to determine ET-1, Ang-2, and Tie-2 levels in adults with CCHF and investigate the associations between these markers and pathogenesis and disease course.Materials and methods: Sixty CCHF patients were included in the study. The patients were classified according to disease severity criteria and Ang-2, Tie-2, and ET-1 levels were compared.Results: Mean serum ET-1 …
Relationship Between Headache And Internet Addiction In Children, İlknur Böyükbaş Tepeci̇k, Ayşegül Neşe Çitak Kurt, Selma Tural Hesapçioğlu, Mehmet Uğurlu
Relationship Between Headache And Internet Addiction In Children, İlknur Böyükbaş Tepeci̇k, Ayşegül Neşe Çitak Kurt, Selma Tural Hesapçioğlu, Mehmet Uğurlu
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate Internet addiction in pediatric patients with migraine- and tension-type headache in this study. Materials and methods: Among our 200 subjects, 103 had migraine-type headache and 97 had tension-type headache. Results: Headache triggered by computer use was more common in the migraine-type headache group. There was no difference between the Internet addiction scale score of the two groups. The Internet addiction scale scores of the patients were found to differ depending on the aim and duration of computer use. Internet addiction was found in six (6%) patients. Internet addiction prevalence was 3.7% and 8.5% in the …
Is The Version Angle Of The Glenoid Different In Bone And Cartilage? An Mri Study, Alper Deveci̇, Yahya Can Dura, Deni̇z Sözmen Ciliz, Güzelali̇ Özdemi̇r, Enver Kiliç, Erman Ceyhan, Burak Kulakoğlu, Sualp Turan
Is The Version Angle Of The Glenoid Different In Bone And Cartilage? An Mri Study, Alper Deveci̇, Yahya Can Dura, Deni̇z Sözmen Ciliz, Güzelali̇ Özdemi̇r, Enver Kiliç, Erman Ceyhan, Burak Kulakoğlu, Sualp Turan
Turkish Journal of Medical Sciences
Background/aim: To determine whether or not there is a difference between the version of the bone and cartilage surfaces of the glenoid. Axial magnetic resonance imaging (MRI) slices were examined in order to evaluate the measurements taken based on both the cartilage and bone joint surfaces.Materials and methods: A retrospective evaluation was made of the MRI scans of 182 patients. All of the reviewers independently measured the glenoid version angles of all of the patients from 1-182. The process was then repeated, with each reviewer taking second measurements of the angles from 1-182. Pearson correlation coefficient analysis was applied to …
Kinesiophobia And Related Factors In Systemic Lupus Erythematosus Patients, Songül Bağlan Yentür, Sali̇ha Karatay, Deran Oskay, Abdurrahman Tufan, Hami̇t Küçük, Şemi̇nur Haznedaroğlu
Kinesiophobia And Related Factors In Systemic Lupus Erythematosus Patients, Songül Bağlan Yentür, Sali̇ha Karatay, Deran Oskay, Abdurrahman Tufan, Hami̇t Küçük, Şemi̇nur Haznedaroğlu
Turkish Journal of Medical Sciences
Background/aim: This study was designed to investigate the relationship between kinesiophobia and the level of physical activity, depression, disease activity, fatigue, pain, and quality of life in female patients with systemic lupus erythematosus (SLE).Materials and methods: Seventy volunteer female patients were included in the study. Kinesiophobia, physical activity level, disease activity, fatigue, depression, pain, and quality of life were assessed using the Tampa Scale for Kinesiophobia (TSK), International Physical Activity Questionnaire- Short Form (IPAQ), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), McGill Pain Questionnaire- Short Form (MPQ-SF) and Nottingham Health Profile (NHP), …
The Combination Of Fatty Liver And Increased Gamma-Glutamyl Transpeptidase Levels As A Risk Factor For Atherosclerotic Plaque Development In Apparently Healthy People, Kaori Kinoshita, Nobuyuki Toshikuni, Takashi Saito, Nobuhiko Hayashi, Takahiro Minato, Yasuhiro Matsue, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi
The Combination Of Fatty Liver And Increased Gamma-Glutamyl Transpeptidase Levels As A Risk Factor For Atherosclerotic Plaque Development In Apparently Healthy People, Kaori Kinoshita, Nobuyuki Toshikuni, Takashi Saito, Nobuhiko Hayashi, Takahiro Minato, Yasuhiro Matsue, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi
Turkish Journal of Medical Sciences
Background/aim: To elucidate how the combination of fatty liver and increased serum gamma-glutamyl transpeptidase (GGT) levels influences atherosclerotic plaque development in apparently healthy people.Materials and methods: The study population included people who had received an annual health checkup for more than 7 years and had no evidence of carotid plaque at baseline. We investigated the risk factors for carotid plaque occurrence using the Cox proportional hazards model.Results: A total of 107 people (76 men and 31 women; median age, 49 years) were enrolled. At baseline, fatty liver and a serum GGT level ≥50 U/L were observed in 13 and 38 …
The Relationship Between Serum Nt-Probnp Levels And Severity Of Coronary Artery Disease Assessed By Syntax Score In Patients With Acute Myocardial Infarction, Taner Sarak, Muhammed Karadeni̇z
The Relationship Between Serum Nt-Probnp Levels And Severity Of Coronary Artery Disease Assessed By Syntax Score In Patients With Acute Myocardial Infarction, Taner Sarak, Muhammed Karadeni̇z
Turkish Journal of Medical Sciences
Background/aim: In the present study, we aimed to investigate the relationship between NT-proBNP and SYNTAX score, which is a measure of the complexity of coronary artery disease. Materials and methods: We enrolled 405 consecutive patients with myocardial infarction who underwent coronary angiographic examination. Patients were divided into 3 groups according to their SYNTAX scores. Those with SYNTAX score ≤22 were included in the low SYNTAX score group (LSTX), those with a score of 23-32 were included in the intermediate SYNTAX score group (ISTX), and those with a score of ≥33 were included in the high SYNTAX score group (HSTX). Results: …
Comparison Of Ultrasound-Guided Transversus Abdominis Plane Block, Quadratus Lumborum Block, And Caudal Epidural Block For Perioperative Analgesia In Pediatric Lower Abdominal Surgery, Celal Bulut İpek, Deni̇z Kara, Si̇nan Yilmaz, Serdar Yeşi̇ltaş, Asim Esen, Shai̇naaz Dooply Su Sander Lwi̇n, Kazi̇m Karaaslan, Ayda Türköz
Comparison Of Ultrasound-Guided Transversus Abdominis Plane Block, Quadratus Lumborum Block, And Caudal Epidural Block For Perioperative Analgesia In Pediatric Lower Abdominal Surgery, Celal Bulut İpek, Deni̇z Kara, Si̇nan Yilmaz, Serdar Yeşi̇ltaş, Asim Esen, Shai̇naaz Dooply Su Sander Lwi̇n, Kazi̇m Karaaslan, Ayda Türköz
Turkish Journal of Medical Sciences
Background/aim: Despite different regional anesthesia techniques used to provide intraoperative and postoperative analgesia in pediatric patients, the analgesic effectiveness of peripheral nerve blockades with minimal side effect profiles have not yet been fully determined.We aimed to compare the efficacy of ultrasound-guided transversus abdominis plane (TAP) block, quadratus lumborum (QL) block, and caudal epidural block on perioperative analgesia in pediatric patients aged between 6 months and 14 years who underwent elective unilateral lower abdominal wall surgery.Materials and methods: Ninety-four patients classified under the American Society of Anesthesiologists physical status classification system as ASA I or ASA II were randomly divided into …
Does Different Subfertility Etiology Affect Pregnancy Rates In Intrauterineinsemination Cycles?, Batuhan Turgay, Yavuz Emre Şükür, Batuhan Özmen, Ruhşen Aytaç, Cem Somer Atabekoğlu, Bülent Berker, Murat Sönmezer
Does Different Subfertility Etiology Affect Pregnancy Rates In Intrauterineinsemination Cycles?, Batuhan Turgay, Yavuz Emre Şükür, Batuhan Özmen, Ruhşen Aytaç, Cem Somer Atabekoğlu, Bülent Berker, Murat Sönmezer
Turkish Journal of Medical Sciences
Background/aim: To investigate the relationship between subfertility etiologies and success rates in controlled ovarian stimulation and intrauterine insemination (COS?IUI) cycles.Materials and methods: The medical records of 218 couples who applied to a university-based fertility center were analyzed retrospectively. Detailed infertility examination data and pregnancy outcomes were compared according to different subfertility etiologies. The study groups with regard to subfertility etiologies were minimal?mild endometriosis, unexplained infertility, and mild male infertility. The primary outcome measure was live birth rate.Results: There were no statistically significant differences between the groups regarding demographics except for total motile sperm count. Live birth rates in the male …
Nicotinamide N-Methyltransferase Expression And Its Association With Phospho-Akt, P53 Expression, And Survival In High-Grade Endometrial Cancer, Serra Akar, İsmai̇l Harmankaya, Serdar Ugras, Çeti̇n Çeli̇k
Nicotinamide N-Methyltransferase Expression And Its Association With Phospho-Akt, P53 Expression, And Survival In High-Grade Endometrial Cancer, Serra Akar, İsmai̇l Harmankaya, Serdar Ugras, Çeti̇n Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Nicotinamide N-methyltransferase (NNMT) is an enzyme that is overexpressed in malignancies. NNMT expression has not been previously studied in endometrial cancer (EC). Increased phospho-Akt (pAkt) levels in response to NNMT overexpression have been reported in in vitro studies of different cancer types. We assayed NNMT expression in primary and metastatic high-grade EC and investigated the relationship of NNMT with p53, pAkt, and survival. Materials and methods: NNMT, pAkt, and p53 expressions were assayed in 100 tissue samples of benign endometria, primary EC, and metastatic EC by immunohistochemistry. Results: The NNMT immunoreactivity score was significantly higher in primary high-grade EC …
Unclassifiable Non-Cml Classical Myeloproliferative Diseases With Microcytosis: Findings Indicating Diagnosis Of Polycythemia Vera Masked By Iron Deficiency, Eli̇fcan Aladağ Karakulak, Sali̇h Aksu, Haluk Demi̇roğlu, Ni̇lgün Sayinalp, Hakan Göker, İbrahi̇m Celaletti̇n Haznedaroğlu, Osman İlhami̇ Özcebe, Yahya Büyükaşik
Unclassifiable Non-Cml Classical Myeloproliferative Diseases With Microcytosis: Findings Indicating Diagnosis Of Polycythemia Vera Masked By Iron Deficiency, Eli̇fcan Aladağ Karakulak, Sali̇h Aksu, Haluk Demi̇roğlu, Ni̇lgün Sayinalp, Hakan Göker, İbrahi̇m Celaletti̇n Haznedaroğlu, Osman İlhami̇ Özcebe, Yahya Büyükaşik
Turkish Journal of Medical Sciences
Background/aim: Polycythemia Vera (PV) is a myeloproliferative disorder characterized by overproduction of morphologically normal red blood cells (RBCs), granulocytes, and platelets, a phenotype that is caused by a mutation (V617F) in Janus kinase 2 (JAK2). However, JAK2 V617F is also found in approximately 50% of patients with essential thrombocytosis and primary myelofibrosis, rendering its presence nonspecific as a diagnostic test. An increased red cell mass is a major criterion for the diagnosis of PV according to World Health Organization (WHO) 2016 criteria. High hemoglobin (Hgb) or Hematocrit (Hct) are universally used as indicators of an increased red cell mass for …
Protective Effect Of Cyclosporine A In The Treatment Of Severe Hydronephrosis In A Rabbit Renal Pelvic Perfusion Model, Ben Zheng Zhou, Da Hu Zhang, Wei Min Yu, Jin Zhuo Ning
Protective Effect Of Cyclosporine A In The Treatment Of Severe Hydronephrosis In A Rabbit Renal Pelvic Perfusion Model, Ben Zheng Zhou, Da Hu Zhang, Wei Min Yu, Jin Zhuo Ning
Turkish Journal of Medical Sciences
Background/aim: Cyclosporine A (CsA), a traditional immunosuppressive compound, has been reported to specifically prevent isch-emia reperfusion tissue injury via apoptosis pathway. This study aimed to explore the renoprotective effects of CsA on the kidneys of rabbits undergoing renal pelvic perfusion.Materials and methods: A total of 30 rabbits were randomly assigned into a control group (n = 6) and an experimental group (n = 24). The experimental group underwent a surgical procedure that induced severe hydronephrosis and was then stochastically divided into 4 groups (S1, S1?, S2, and S2?), consisting of 6 rabbits each. Groups S1 and S1? were perfused with …
The Role Of Right Ventricular Volumes And Inferior Vena Cava Diameters In The Evaluation Of Volume Status Before Colonoscopy, Şule Arican, Ramazan Dertli̇, Çağdaş Dağli, Gülçi̇n Hacibeyoğlu, Mustafa Koyuncu, Ahmet Topal, Sema Tuncer Uzun, Mehmet Asil
The Role Of Right Ventricular Volumes And Inferior Vena Cava Diameters In The Evaluation Of Volume Status Before Colonoscopy, Şule Arican, Ramazan Dertli̇, Çağdaş Dağli, Gülçi̇n Hacibeyoğlu, Mustafa Koyuncu, Ahmet Topal, Sema Tuncer Uzun, Mehmet Asil
Turkish Journal of Medical Sciences
Background/aim: Ultrasonographic measurements of inferior vena cava (IVC) diameters and right ventricle (RV) volumes are important tools for the evaluation of intravascular volume. The current study investigates the association of IVC diameters and RV volumes before colonoscopy in prediction of postanesthesia hypotension.Materials and methods: Seventy patients scheduled for colonoscopy were included in the study. Preoperatively, expirium (dIVC max) and inspirium (dIVC min) IVC diameters were measured using M-mode ultrasonography and the collapsibility index (IVC-CI) was calculated. Ventricular volumes and areas were also measured using transthoracic echocardiography. Postanesthesia hypotension was defined as mean arterial blood pressure of 30% in the mean …
Radiographic Comparison Of Cervical Spine Motion Using Lma Fastrach, Lma Ctrach, And The Macintosh Laryngoscope, Gözde İnan, Nurdan Bedi̇rli̇, Zerri̇n Özköse Şatirlar
Radiographic Comparison Of Cervical Spine Motion Using Lma Fastrach, Lma Ctrach, And The Macintosh Laryngoscope, Gözde İnan, Nurdan Bedi̇rli̇, Zerri̇n Özköse Şatirlar
Turkish Journal of Medical Sciences
Background/aim: The optimal technique for airway management in patients with cervical pathology remains unclear. Intubating laryngeal mask airway devices such as LMA CTrach and LMA Fastrach have not been compared for cervical spine (C-spine) movements in the context of cervical pathology. The present study aimed to determine upper C-spine movements by radiography during intubation with different devices as well as comparing the duration and success of intubation in cervical surgery.Materials and methods: Sixty patients scheduled for elective cervical surgery were registered in this prospective, randomized study. Patients with cervical trauma/injury, previous neck surgery, and body mass index (BMI) of >35 …
Disruption Of Immune Homeostasis In Human Dendritic Cells Via Regulation Of Autophagy And Apoptosis By Porphyromonas Gingivalis, Mohamed M Meghil, Omnia K Tawfik, Mahmoud Elashiry, Mythilypriya Rajendran, Roger M Arce, David J Fulton, Patricia V Schoenlein, Christopher W Cutler
Disruption Of Immune Homeostasis In Human Dendritic Cells Via Regulation Of Autophagy And Apoptosis By Porphyromonas Gingivalis, Mohamed M Meghil, Omnia K Tawfik, Mahmoud Elashiry, Mythilypriya Rajendran, Roger M Arce, David J Fulton, Patricia V Schoenlein, Christopher W Cutler
Faculty, Staff and Student Publications
As fundamental processes of immune homeostasis, autophagy, and apoptosis must be maintained to mitigate risk of chronic inflammation and autoimmune diseases. Periodontitis is a chronic inflammatory disease characterized by oral microbial dysbiosis, and dysregulation of dendritic cell (DC) and T cell responses. The aim of this study was to elucidate the underlying mechanisms by which the oral microbe
Interpreting And Reporting Principal Component Analysis In Food Science Analysis And Beyond, D. Cozzolino, A. Power, J. Chapman
Interpreting And Reporting Principal Component Analysis In Food Science Analysis And Beyond, D. Cozzolino, A. Power, J. Chapman
Articles
Principal component analysis (PCA) is one of the most widely used data mining techniques in sciences and applied to a wide type of datasets (e.g. sensory, instrumental methods, chemical data). However, several questions and doubts on how to interpret and report the results are still asked every day from students and researchers. This brief communication is inspired in relation to those questions asked by colleagues and students. Please note that this article is a focus on the practical aspects, use and interpretation of the PCA to analyse multiple or varied data sets. In summary, the application of the PCA provides …
A Custom Radiopaque Thermoresponsive Chemotherapy-Loaded Hydrogel For Intratumoural Injection: An In Vitro And Ex Vivo Assessment Of Imaging Characteristics And Material Properties, Seóna M. Rossi, Timothy E. Murray, John Cassidy, Michael J. Lee, Helena M. Kelly
A Custom Radiopaque Thermoresponsive Chemotherapy-Loaded Hydrogel For Intratumoural Injection: An In Vitro And Ex Vivo Assessment Of Imaging Characteristics And Material Properties, Seóna M. Rossi, Timothy E. Murray, John Cassidy, Michael J. Lee, Helena M. Kelly
Articles
Purpose Thermoresponsive hydrogels are gels which have different properties at varying temperatures. The objective of this study was to assess the material characteristics, imaging properties and chemotherapeutic drug release profile of a novel radiopaque thermoresponsive hydrogel in vitro, which is liquid at room temperature but solidifies at body temperature, to determine potential suitability for intratumoural delivery. Materials and Methods An iodinated radiopaque thermoresponsive hydrogel was formulated using iodixanol at a range of concentrations and assessed for sol–gel transition, radiopacity and imaging using CT and US. A lead formulation containing iodixanol at a concentration of 9.22% weight by weight (w/w, g …
Developing A Rational Peptide Ligand Design Method Using Cd13 As A Prototype Target Receptor, Md Zahir Uddin
Developing A Rational Peptide Ligand Design Method Using Cd13 As A Prototype Target Receptor, Md Zahir Uddin
University of the Pacific Theses and Dissertations
Structure based computational peptide design methods have gained significant interest in recent years with the availability of structural insights of protein-protein interactions obtained from the crystal structures. Most of these approaches design new peptide ligands by connecting the crucial amino acid residues from the protein interface and are generally not based on any predicted receptor-ligand interaction. In this work, a peptide design method based on the Knob-Socket model was used to identify the specific ligand residues packing into the receptor interface. This method enables rational peptide ligand design by predicting amino acid residues that will fit best at the binding …
Fliposomes With A Ph-Sensitive Conformational Switch For Anticancer Drug Delivery Against Triple Negative Breast Cancer, Yifan Lu
University of the Pacific Theses and Dissertations
Cancer is the second leading cause of death in the US and worldwide, accounting for 16% of deaths worldwide in 2015. Of more than 100 types of cancers affecting humans, breast cancer is the most common cancer among women and is the second leading cause of death in women. Triple negative breast cancer (TNBC) is a subtype of breast carcinomas defined by the lack of the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2 /neu). The prognosis and survival of TNBC patients remains the poor due to the lack of effective targeted therapy. …
Saudi Arabian Students In Postgraduate Dental Programs: Investigating Factors Associated With Burnout, Asiri Amal
Saudi Arabian Students In Postgraduate Dental Programs: Investigating Factors Associated With Burnout, Asiri Amal
University of the Pacific Theses and Dissertations
Burnout related to emotional and physical study or work demands affects an individual’s performance and well being. This study focused on Saudi Arabian dental residents studying in the United States and the United Kingdom who are faced with many challenges in pursuit of a higher education degree. A survey including demographic and MBI questions was distributed to assess this population’s level of burnout. The Maslach Burnout inventory (MBI) was has been widely used in the literature to assess three components of burnout: emotional exhaustion (EE), depersonalization (DEP), and (diminished) personal accomplishment (PA). Potential predictors of burnout level, tested for statistical …
Synthesis And Conformational Studies Of Various Amides, Marcos Beltran-Sanchez
Synthesis And Conformational Studies Of Various Amides, Marcos Beltran-Sanchez
University of the Pacific Theses and Dissertations
In the past, aminocyclohexanol rings have been successfully utilized as pH-triggered molecular switches in various trans-2-aminocyclohexanol derivatives. By changing the groups on the amine nitrogen, these models provided a wide pH range in which a switch can occur. The pH-induced switch of conformation was monitored by 1H-NMR spectroscopy. The models were also incorporated into the bilayer membrane of liposome structures and tested for their ability to disrupt their membrane upon their conformational flip induced by a decrease in pH.
In this work, the amide bond has been studied as a molecular switch and various amide derivatives have been tested for …
Volume 11, Jacob Carney, Ryan White, Joseph Hyman, Jenny Raven, Megan Garrett, Ibrahim Kante, Summer Meinhard, Lauren Johnson, William "Editha" Dean Howells, Laura Gottschalk, Christopher Siefke, Pink Powell, Natasha Woodmancy, Katharine Colley, Abbey Mays, Charlotte Potts
Volume 11, Jacob Carney, Ryan White, Joseph Hyman, Jenny Raven, Megan Garrett, Ibrahim Kante, Summer Meinhard, Lauren Johnson, William "Editha" Dean Howells, Laura Gottschalk, Christopher Siefke, Pink Powell, Natasha Woodmancy, Katharine Colley, Abbey Mays, Charlotte Potts
Incite: The Journal of Undergraduate Scholarship
Table of Contents:
Introduction, Dr. Roger A. Byrne, Dean
From the Editor, Dr. Larissa "Kat" Tracy
From the Designers, Rachel English, Rachel Hanson
Synthesis of 3,5-substituted Parabens and their Antimicrobial Properties, Jacob Coarney, Ryan White
Chernobyl: Putting "Perestroika" and "Glasnot" to the Test, Joseph Hyman
Art by Jenny Raven
Watering Down Accessibility: The Issue with Public Access to Alaska's Federal Waterways, Meagan Garrett
Why Has the Democratic Republic of the Congo outsourced its Responsibility to Educate its Citizens? Ibrahim Kante
Art by Summer Meinhard
A Computational Study of Single Molecule Diodes, Lauren Johnson
Satire of …
Differences In Sexual Delay Discounting Among In-Treatment Adults With Opioid Use Disorder, Jonathan J.K. Stoltman
Differences In Sexual Delay Discounting Among In-Treatment Adults With Opioid Use Disorder, Jonathan J.K. Stoltman
Graduate Theses, Dissertations, and Problem Reports (ETD)
Previous research has found impulsive decision-making to be a core component of addiction (Moody, Franck, Hatz, & Bickel, 2016). One way to measure impulsive choice is through the use of a delay discounting task. The delay discounting task provides a way to measure choice of immediate, smaller rewards compared to delayed, larger rewards (Odum, 2011b). An emerging area of research in addiction science is the intersection of addiction and sexual health. Previous sexual delay discounting research has focused on whether attractiveness or STD risk can shift the likelihood of waiting until a condom was available (Johnson & Bruner, 2012). This …
Investigation Of Bovine Conceptus Galectins And The Effect Of Bovine Conceptus Secretory Proteins On The Endometrial Epithelial Transcriptome, Heather Lynn Baldwin
Investigation Of Bovine Conceptus Galectins And The Effect Of Bovine Conceptus Secretory Proteins On The Endometrial Epithelial Transcriptome, Heather Lynn Baldwin
Graduate Theses, Dissertations, and Problem Reports (ETD)
Pregnancy loss in cattle is greatest in the first 30 days of gestation. Near d15 of gestation, bovine conceptuses elongate and express LGALS1, an immunosuppressive glycan-binding protein believed to be essential for implantation. However, other members of the bovine galectin family, including LGALS3, LGALS4, LGALS7, LGALS8, LGALS9 and a galectin-13-like gene (LGALS13L), also may be expressed by the elongating conceptus. Therefore, galectin expression in elongating, d16 bovine conceptuses and intercaruncular endometrium as well as elongating, d14 ovine conceptuses and intercaruncular endometrium was assessed by RT-qPCR. Angus heifer and Texel ewes underwent estrous cycle synchronization and either inseminated or not bred. …
Systematic Control Of Aged Skeletal Muscle Following High-Intensity Stretch-Shortening Contraction Exercise Training: Epigenomic Regulation And Signaling Factors Underpinning Adaptation, Marshall Alan Naimo Jr.
Systematic Control Of Aged Skeletal Muscle Following High-Intensity Stretch-Shortening Contraction Exercise Training: Epigenomic Regulation And Signaling Factors Underpinning Adaptation, Marshall Alan Naimo Jr.
Graduate Theses, Dissertations, and Problem Reports (ETD)
Sarcopenia, the age-related decline in skeletal muscle mass, results in a loss of strength and functional capacity, which subsequently increases the risk of disease, disability, frailty, and all-cause mortality. Exercise is known to be an efficacious paradigm for improving health and attenuating or preventing many chronic diseases. For the previous two decades, our laboratory has established an in vivo rodent dynamometer model to explore the effects of various skeletal muscle training paradigms following stretch-shortening contractions (SSCs).The responses tohigh-intensity resistance-type exercise training (RTET) using this physiological model ranges from adaptation, characterized by enhanced skeletal muscle performance along with increased muscle mass, …
A Video Decision Aid To Influence Advance Care Planning, Angela Petry
A Video Decision Aid To Influence Advance Care Planning, Angela Petry
Graduate Theses, Dissertations, and Problem Reports (ETD)
The best mechanism to achieve successful advance care planning has yet to be identified. A randomized, controlled, experimental study was performed with a sample of 54 men and women who met inclusion criteria and were randomized into the intervention versus the control group in an outpatient clinical setting in rural West Virginia (WV) from December 2018 to March 2019. Participant mean age was 72.4 years. For those who chose to participate (n=42), the intervention group received the usual standard of care, which was a face to face advance care planning (ACP) discussion with the new intervention of a video decision …
Environmental Regulation Of The Heart: The Role Of Non-Coding Rna And Epigenetics In Influencing Mitochondrial And Cellular Health, Quincy Alexander Hathaway
Environmental Regulation Of The Heart: The Role Of Non-Coding Rna And Epigenetics In Influencing Mitochondrial And Cellular Health, Quincy Alexander Hathaway
Graduate Theses, Dissertations, and Problem Reports (ETD)
The mitochondrion, a small but ubiquitously distributed organelle in the cell, continues to be the focus of many disease pathogeneses, tissue and organ dysfunctions, and other morbidities that occur throughout the body. The purpose of this work was to understand how cardiac mitochondrion are altered in disease and pathological states, specifically in their adaptation to environmentally stimulated regulatory networks, such as epigenetic modifications and promotion/inhibition of non-coding RNAs. Acute stress to mitochondrial regulation (inhalation toxicology) as well as chronic (type 2 diabetes mellitus) was examined. Using a FVB transgenic microRNA-378a mouse knockout model, the cardiovascular impact derived from altering the …
Differentiating Pre-Capillary And Post-Capillary Pulmonary Hypertension By Doppler Echocardiography In A Large Realworld Database, Pyi Naing
Theses
Background: Pulmonary hypertension (PH) is common, dangerous and has multiple causes. Vasodilator therapy has significantly improved the prognosis of patients with pulmonary arterial hypertension (PAH), but the diagnosis can be challenging, requiring right heart catheterisation (RHC). Differentiating pre-capillary PH (prePH) and postcapillary PH (postPH) and measuring pulmonary vascular resistance (PVR) are key steps for diagnosing PAH. A novel echocardiographic parameter, the pulmonary to left atrial ratio (ePLAR), which is derived from the tricuspid regurgitation velocity (TRV) divided by the ratio between the early diastolic filling velocity and the early mitral annulus velocity (E/e’), i.e., ePLAR=TRV/E/e’, has been described as a …
The Course Changes In Maximal Strength Velocity Following A Traditional Strength- Or Power Orientated Training Session, Alexander Vernon
The Course Changes In Maximal Strength Velocity Following A Traditional Strength- Or Power Orientated Training Session, Alexander Vernon
Theses
The primary aim of this study was to investigate the return to baseline of movement velocity and maximal strength following a typical strength-orientated and power-orientated session in the full depth, free-weight back squat performed with maximal concentric velocity. Fourteen strength-trained males completed a power-orientated session (3-sets of 6-repetitions @50% of a one-repetition maximum [1RM]) and a strength-orientated session (5-sets of 5-repetitions @80%1RM) in randomised order over two weeks. At 24, 48, 72 and 96-hours following the training session stimulus, sessions were completed with loads of 20%, 40%, 60%, 80%, 90% and 100%1RM lifted. Prior to the completion of the training …