Does Metacognitive Training Improve The Quality Of Life In Patients With Schizophrenia?, Amy Wei

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Does metacognitive training (MCT) improve the quality of life in patients with schizophrenia?”

Study Design: Systematic review of three randomized controlled trials (RCTs) published in peer-reviewed journals between 2010-2014, all in the English language; two of which were published in 2014 and one in 2010.

Data Sources: Three randomized controlled trials found using PubMed.

Outcomes Measured: Quality of life with a focus on social relationships was assessed using the Brief Quality of Life Questionnaire of the World Health Organization (WHOQOL-BREF) or Quality of Life Scale (QLS). …

Is Music Therapy Effective At Reducing Pain In Fibromyalgia Patients?, Amanda M. Vicznesky

PCOM Physician Assistant Studies Student Scholarship

The objective of this selective evidence based medicine (EBM) review is to determine whether or not music therapy is effective at treating pain in fibromyalgia patients.

STUDY DESIGN: This is a systematic review of three primary studies that were peer-reviewed published between the years of 2013-2016.

DATA SOURCES: Two randomized control trials and one cross-control study evaluating if music therapy is affective at treating pain in fibromyalgia patients. Data sources obtained for this review were found using PubMed Database.

OUTCOMES MEASURED: The outcome measured was the effectiveness of music therapy at reducing pain in fibromyalgia patients. Outcomes were measured via …

In Adult Patients With Obsessive Compulsive Disorder (Ocd), Is The Amino Acid N-Acetyl Cysteine (Nac) Effective In Reducing Severity Of Ocd?, Sabrina M. Toles

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “In adult patients with Obsessive Compulsive Disorder (OCD), is the amino acid N-Acetyl Cysteine (NAC) effective in reducing severity of OCD?”

STUDY DESIGN: Review of three English language primary studies, published between 2015-2017.

DATA SOURCES: Three randomized controlled trials (RCTs) were found using PubMed-NCBI. These studies analyzed the effectiveness in reducing the severity of OCD in adults with OCD. OUTCOME MEASURED: The main outcome measured was a reduction of OCD severity after taking N-Acetyl Cysteine. Outcomes were measured using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Participants …

Is The Use Of Methylcobalamin Alone Or In Combination With Lidocaine Clinically More Effective Than Lidocaine Alone In Relieving Herpes Zoster Related Neuropathic Pain With Subcutaneous Injections?, Rachel N. Todd

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Methylcobalamin alone or in combination with Lidocaine is clinically more effective than Lidocaine alone in relieving Herpes Zoster related neuropathic pain with subcutaneous injections.

STUDY DESIGN: This is a systematic review of three peer-reviewed primary studies. All were randomized, controlled trials published between the years of 2014 and 2016.

DATA SOURCES: Data sources obtained for this review were published in peer reviewed journals and selected from PubMed Database.

OUTCOME MEASURED: The outcomes measured reflected the effectiveness of incorporating subcutaneous Methylcobalamin in the treatment regimen for neuropathic …

Is Music Therapy Intervention Effective In Decreasing Pain After Standard Wound Care In Hospitalized Burn Patients?, Lindsay King

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence based medicine review is to determine whether or not music therapy intervention is effective in decreasing pain after standard wound care in hospitalized burn patients.

STUDY DESIGN: Systematic review compiling data from three randomized controlled trials in 2016, all in the English language.

DATA SOURCES: After a thorough search of PubMed and Cochrane, three pertinent studies were found to include in this review. The selected studies were evaluated to assess the effectiveness of music therapy in decreasing pain after wound care in hospitalized burn patients.

OUTCOMES MEASURED: Decrease in pain symptoms were measured …

Does Aerobic And Resistance Exercise Reduce Fatigue In Men With Prostate Cancer?, Rachel L. Metz

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not aerobic and resistance exercise reduces fatigue in men with prostate cancer.

STUDY DESIGN: Systematic review of three randomized controlled trials (RCT’s) published in peer reviewed journals between 2013-2017.

DATA SOURCES: Data sources obtained for this review were found in using PubMed and Cochrane Library and chosen based on their relevance to the clinical question and if they included patient oriented evidence that matters (POEMS).

OUTCOMES MEASURED: All three studies measured the effect aerobic and resistance exercise has on fatigue in men with prostate cancer undergoing androgen …

Is Electroacupuncture Effective In Improving Quality Of Life For Women With Urinary Incontinence?, Shelby Kaminsky

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence based medicine (EBM) review is to determine whether or not “Is electroacupuncture effective in improving quality of life for women with urinary incontinence?”

STUDY DESIGN: A systematic review of 3 peer-reviewed studies published between the years of 2014 and 2017.

DATA SOURCES: Two randomized placebo-controlled studies and one comparative study evaluating if electroacupuncture (EA) and/or the use of tolterodine improves the quality of life and therapeutic effects of those with urinary incontinence (UI). Sources were selected from PubMed and Cochrane Library based off of their relevance to the clinical question and the outcomes …

Is The Combined Oral Contraceptive Treatment Of 150 Mcg Levonorgestrel And 30 Mcg Ethinyl Estradiol Effective In Preventing Bothersome Unscheduled Uterine Bleeding?, Brandi L. Parker

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective evidence-based medicine (EBM) review is to determine whether or not the combined oral contraceptive treatment of 150 mcg levonorgestrel and 30 mcg ethinyl estradiol is effective in preventing unscheduled uterine bleeding.

Study Design: Review of two randomized controlled trials (RCTs) and one post hoc analysis, published after 2014 all in the English language.

Data Sources: Two randomized controlled trials (RCTs) and one post hoc analysis, all of which evaluate the efficacy of the combined oral contraceptive (COC) treatment of 150 mcg levonorgestrel and 30 mcg ethinyl estradiol in preventing bothersome unscheduled uterine bleeding. In …

Is Cannabis Effective In Reducing Muscle Spasticity And Body Pain Amongst Patients With Multiple Sclerosis?, William E. Johnson

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not cannabis is effective in reducing muscle spasticity and body pain amongst patients with Multiple Sclerosis (MS).

STUDY DESIGN: A systematic review of three peer-reviewed studies published between the years of 2003 and 2012.

DATA SOURCES: Three randomized control trials (RCTs) evaluating if cannabis can reduce muscle spasticity and body pain for patients diagnosed with Multiple Sclerosis. All three sources were selected from PubMed and examined for outcomes that were patient oriented.

OUTCOMES MEASURED: The two primary outcomes measured include: muscle spasticity measured by the Ashworth scale, …

Is Intranasal Oxytocin An Effective Treatment For Reducing Disruptive Behavior In Individuals With Prader-Willi Syndrome?, Anna C. Maraia

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not intranasal oxytocin is an effective treatment for reducing disruptive behavior in individuals with Prader-Willi Syndrome.

STUDY DESIGN: This is a systematic review of two randomized controlled crossover trials and one randomized controlled pilot study, all of which were double-blind and placebo-controlled. All articles were peer-reviewed, written in English and published between 2011 and 2016.

DATA SOURCES: The three articles used in this systematic review were found in PubMed based on their relevance to the objective of the study, the inclusion of patient-oriented problems and published within …

Does The Ligasure Vessel Sealing System Provide Benefit In Mortality In Regards To Hepatic Resections?, Samantha M. Kleiber

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not using the LigaSure device provides any benefit in morality in patients undergoing hepatic resection surgery.

STUDY DESIGN: Review of three English language randomized control trials published in 2007, 2009 and 2012.

DATA SOURCES: Data sources obtained for this review primary studies published in peerreviewed journals, found using PubMed.

OUTCOMES MEASURED: Patient mortality, defined as death within 30 days of the surgical procedure.

RESULTS: The study done by Doklestic and et al had 3 patient mortalities occur. The deaths occurred on post op days three, four and …

Does Adalimumab Improve Symptoms In Patients With Moderate To Severe Hidradenitis Suppurativa?, Eric A. Eck

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Does Adalimumab improve symptoms in patients with moderate to severe Hidradenitis Suppurativa?”

STUDY DESIGN: A systematic review of three peer-reviewed articles published between 2011 and 2016 which present patient oriented evidence.

DATA SOURCES: Review incorporated analysis of two randomized controlled trials (RCTs) and one open label prospective trial. Studies were selected based upon the relevance to the clinical question, does adalimumab usage improve symptoms in individuals with moderate to severe hidradenitis suppurativa.

OUTCOMES MEASURED: The outcomes measured focused on patient reported reduction in hidradenitis suppurativa symptoms. …

Does Light Therapy Improve The Quality Of Life For People With Acne?, Montana W. Banks

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Does light therapy improve the quality of life for people with acne?”

STUDY DESIGN: A systematic review of three peer-reviewed primary studies published between the years of 2016 and 2018. All articles were published in the English language and in peer-reviewed journals.

DATA SOURCES: One pilot study, one multicenter, randomized, split-face control study and one single-blind, randomized, split-face study evaluating if light therapy can improve the quality of life (QOL) of people with acne. Sources were selected from PubMed and Cochrane based off of the relevance …

Orthodontic Correction Of Transposed Maxillary Canine And First Premolar In Mixed Dentition, Lan-Tien Lin, Yi-Min Liu, Yuen-Yung Tsang

Taiwanese Journal of Orthodontics

Transposition is rare and occurred commonly on maxillary canine and premolar. To extract or not to extract, to correct or not to correct the dental transposition teeth, it’s a tough decision. A 12-year-old boy was referred for orthodontic correction because of bad alignment at upper dentition. His dental age was in late mixed dentition. Both upper deciduous canines were still retained. Left canine was buccally blocked-out, and first premolar was in palatal crossbite with the lower premolars. Panoramic film showed impacted upper right canine and transposed left canine and first premolar. The treatment duration took 3.5 years. The upper left …

To Do Or Not To Do? Slow Orthodontic Extrusion For Implant Site Development In Esthetic Zone At The Anterior Maxilla, Hui-Chen Tsai, Chung-Chen Jane Yao, Cheing-Meei Liu

Taiwanese Journal of Orthodontics

Slow orthodontic extrusion (SOE) for implant site development, was introduced in 1991. It has been more than 20 years since this treatment was applied in our clinical practice. In this paper, we investigate surgeon's expectation of SOE for special requirements of immediate implantation by a clinical case. We also review case reports/case series searched from PubMed and inspect the power of evidence of these reports from the integration of data collection, and try to define the value of SOE. If the SOE cannot eliminate at least one surgical procedure, we need to consider the necessity of SOE before implant surgery.

A Modified Surgery-First Approach For Mandibular Prognathism With Proclined Maxillary Incisor And Mandibular Spacing, Jutharath Chanruangvanich, Ellen Wen-Ching Ko, Ying-An Chen

Taiwanese Journal of Orthodontics

This case report describes the management of an adult patient presenting with a skeletal Class III malocclusion, mandibular protrusion, upper incisor proclination and mandibular arch spacing by a modified surgery-first approach. A 26-year-old man had skeletal Class III and dental Class III malocclusion with concave facial profile, midface deficiency and mandibular prognathism with chin deviation to left. His dental manifestation presented anterior crossbite, upper incisors proclination and spacing in his mandibular arch. Treatment was performed with a modified surgery-first approach, which included a short presurgical alignment phase. In the maxilla, the significant maxillary crowding was relieved by 14 and 24 …

Orthodontic Treatment Of Class Ii Malocclusion With Single Maxillary Incisor, Chien-Cheng Chen, Yi-Horng Chen

Taiwanese Journal of Orthodontics

Orthodontic treatment of a Class II malocclusion case with single maxillary central incisor was presented in the case report. The treatment plan consisted of removing one maxillary central incisor instead of premolars. Bilateral maxillary lateral incisors were mesialized for space closure and substitution for maxillary central incisors. The morphology of maxillary lateral incisors was modified to mimic the maxillary central incisors. After treatment, both occlusion and esthetics was improved, and the patient was satisfied with the results.

A Comprehensive Diagnostic System For Orthodontists- Beyond Angle’S Classification, Ib Leth Nielsen

Taiwanese Journal of Orthodontics

Traditionally orthodontists have used the classification system developed by Edward H. Angle in 1900 to describe the malocclusion of an orthodontic patient. This classification is very limited with respect to the information it provides and should be replaced by a more detailed and inclusive description of a patient’s malocclusion as well as the underlying biology. In this review article we propose a new technique that ensures all pertinent information gets considered and we suggest a systematic approach to a more differentiated orthodontic diagnosis. Our approach divides the diagnosis into clearly defined categories that bring together the clinical findings into a …

Mandibular Molar Protraction For Edentulous Space Closure: A Systematic Review, Yueh-Tse Lee, Proudchompoo Paungmalit, Eric Jein-Wein Liou

Taiwanese Journal of Orthodontics

Objective: Orthodontic molar protraction into the edentulous space is a treatment option for patients with missing mandibular molars or premolars. Space closure by moving the molars mesially into edentulous ridge is difficult, especially in the mandible. This systematic review aimed to evaluate the dental and periodontal changes after mandibular molar protraction into an edentulous ridge. Material and Methods: Literature search was conducted using PubMed, Medline (Ovid), Cochrane Library, Web of Science, and Scopus until September 2019 limited to English publications. Specific inclusion and exclusion criteria were extracted and analyzed. Study quality was objectively assessed. Results: In total, 490 studies were …

Factors Influencing Fixed Orthodontic Treatmentoutcomes In A University Dental Clinic, Zhan Yan Fang, Sneha Ravindranath, Allan Pau

Taiwanese Journal of Orthodontics

Objective: To assess the orthodontic treatment outcomes in a university dental clinic and to determine factors associated with the treatment outcomes. Methods and materials: Firstly, the records of all patients who have completed fixed orthodontic treatment from 2012 to 2017 were identified and included in the study. Age at start of treatment, gender, decayed, missing filled teeth (DMFT), malocclusion classification, type of appliance used and type of treatment (extraction or non-extraction) were recorded. The pre-treatment and post-treatment study models were assessed by the Peer Assessment Rating (PAR) Index. The treatment outcomes were tabulated in a nomogram to show the proportions …

Evaluating State Anxiety Levels In Nursing Students, Rachel Stevens, Rachel Nussbaum, Tyler Blake

Williams Honors College, Honors Research Projects

Anxiety, dependent upon the frequency and severity, can be a serious problem that reduces physical, cognitive, and clinical performance. Nursing students have been found to experience especially high levels of state and trait anxiety which, according to Dorothea Orem’s self-care deficit theory, causes a deficit in health promotion and the health of oneself. There is little evidence available about how progression through a baccalaureate nursing program in the United States impacts anxiety. This research investigates anxiety in baccalaureate nursing students and how progression through the program influences self-reported anxiety levels. A descriptive cross-sectional study was performed on a convenience sample …

Comparison Of Crnas With And Without Supervision On Cost And Safety Of Anesthesia, Kelly Mccurdy, Austin Phillips

Williams Honors College, Honors Research Projects

There has been controversy in the field of anesthesia regarding whether certified registered nurse anesthetists (CRNAs) or anesthesiologists provide safer and more cost-effective care. This study was done to compare CRNAs with and without supervision of an anesthesiologist and how it affects the cost and safety of anesthesia delivery. The results of this systematic review could provide information to affect policies regarding who is responsible for providing anesthesia, with safety and cost as the necessary variables. Twenty articles, published between the years 1999 and 2017, retrieved from the databases PubMed and Cinahl were analyzed and synthesized as part of this …

Fabrication And Characterization Of Nanofiber Nylon-6-Mwcnt As An Electrochemical Sensor For Sodium Ions Concentration Detection In Sweat, Kelsey Mills

Williams Honors College, Honors Research Projects

Fabrication and characterization nylon-6-MWCNT nanofiber as an electrochemical sensor to detect sodium ion concentrations specifically in sweat. Using contact angle to determine surface morphology and chronoamperometry testing to identify ideal sensor conditions, tests optimized parameters like weight percent of nylon or other polymers, carbon nanotube (CNT) isomer, and solution concentration to determine reproducibility of functional sensors. Utilizing the electric qualities of carbon nanotubes partnered with the sodium ion selectivity of calixarene treatment and polymers unique properties like flexibility and scalability create open an arena for optimizing sodium ion sensors for further development for functional prototypes. Morphology tests showed that the …

Long-Term Effects Of Breastfeeding Compared With Alternative Food Sources: A Systematic Review, Charlotte Bates

Williams Honors College, Honors Research Projects

The topic of the long-term impact of breast milk and alternative foods on the health status of children continues to be a focus of discussion and research. The aim of this systematic review was to describe and appraise evidence about the effects of breast feeding on health outcomes in children four years and older. Seventeen studies about on infant feeding were identified using Google Scholar and scholarly databases through The University of Akron. Google Scholar, CINAHL, and MEDLINE PLUS methods of searching were utilized, incorporating keywords, i.e., “breastfeeding” AND “cognitive development;” “obesity,”, “intelligence,”, and “immune system.” Based on appraisal of …

Leucine Supplementation In Cuprizone-Induced Oligodendrocyte Toxicity, Michael Ley

Williams Honors College, Honors Research Projects

Cuprizone is a copper chelator that induces demyelination in the central nervous system when fed to mice. This compound is thought to target Complex IV and disrupt mitochondrial metabolism leading to loss of myelin-producing oligodendrocytes. In this proposal, we further examine the chemical and toxicological properties of cuprizone. Immunofluorescence imaging and microarray data on MO3.13 cells treated with cuprizone revealed the possibility of alterations in lysosomal function, as well as mitochondrial disruption via mTOR and Electron Transport Chain (ETC) related pathways. Cell viability assays conducted suggest that addition of Branched-Chain Amino Acids, most commonly used from literature, leucine, can increase …

Assessing The Benefits Of A Collegiate-Run Wellness Program For Akron Inner City Residents, Alaina Gent

Williams Honors College, Honors Research Projects

This paper offers insight into the University of Akron Wellness Wednesday Program, an interprofessional organization of campus students and faculty that present wellness programming to three off-campus housing developments: Edgewood Village, Belcher Apartments, and Saferstein Towers I. The residents of these complexes receive wellness programming from many different disciplines for six months of the year, and then experience a large, four-month gap when the university breaks for summer. With this gap, residents often vocalized that they felt as if information was lost and that they were not able to remember as much when the program returned in the fall. In …

Total Laryngectomy Surgery In The United States And Spain: A Tale Of Two Healthcare Systems, Anna Nyszczy

Williams Honors College, Honors Research Projects

For individuals entering the field of health professions, an understanding of variation among global health systems can foster more informed viewpoints when working with multicultural populations. To investigate this relationship between the Spanish and U.S. systems, I analyzed the macro-structure of the healthcare systems in the United States and Spain to better understand plans of treatment, economic burden to patients and quality of life of patients undergoing total laryngectomy surgery in each country. A critical review of scholarly journals and studies relating to the healthcare systems of each country and total laryngectomy surgeries showed a unique picture of each system. …

Åstrand-Rhyming And Ymca: A Compare And Contrast Literature Review Of Two Submaximal Cycle Ergometer Tests, Sean Roberts

Williams Honors College, Honors Research Projects

In the world of exercise prescription there are two major protocols that are used to test an individual’s aerobic capacity at a submaximal intensity using a stationary bicycle. These protocols require participants to exercise at a constant work rate until a specified hear rate is reached. Data can then be analyzed to determine the participant’s aerobic capacity. The objective of this literature review is to look at these two tests – the Åstrand-Rhyming cycle ergometer test (ARCET) and the YMCA cycle ergometer test – and determine if one is better than the other for different populations and which one an …

Optimization Of Primary Cilia Detection In Musculoskeletal Tissue, Ragen Engel

Williams Honors College, Honors Research Projects

The objective of this research project was to optimize a laboratory technique for visualizing primary cilia in musculoskeletal tissue of young swine, specifically the growth plate of long bones. This was accomplished through varying fixation procedures, antigen retrieval methods, antibody concentrations, and incubation times. By varying these parameters, a reproducible procedure was developed to examine the primary cilia in multiple tissues including ligament, fascia, and growth plate. This experiment introduced variances in fixation methods, with methanol or formalin. Paraffin and frozen embedding techniques were also varied for comparison with regards to cilia visualization. Results from the acetylated alpha tubulin (aTUB) …

Effects Of Acute Hypoxia On Danio Rerio, Karly Crail

Williams Honors College, Honors Research Projects

The purpose of this research experiment was to determine the effects of acute hypoxia on the embryonic zebrafish (Danio rerio) cardiovascular system and assess the critical oxygen level at which embryonic function is compromised. This goal was achieved by exposing embryos to decreasing oxygen concentrations, (6.0 mg/L-0 mg/L) and observing the heart under an inverted microscope. Data analysis was conducted to determine end systolic volume, end diastolic volume, stroke volume, heart rate, and cardiac output. It was hypothesized that hypoxia would stimulate cardiac activity, because in early developmental stages, tissues are supplied with oxygen through bulk diffusion, and …