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Articles 13801 - 13830 of 16112
Full-Text Articles in Medicine and Health Sciences
Validity Of The Falls Risk For Older People In The Community (Frop‑Com) Tool To Predict Falls And Fall Injuries For Older People Presenting To The Emergency Department After Falling, Marlon Mascarenhas, Keith D. Hill, Anna Barker, Elissa Burton
Validity Of The Falls Risk For Older People In The Community (Frop‑Com) Tool To Predict Falls And Fall Injuries For Older People Presenting To The Emergency Department After Falling, Marlon Mascarenhas, Keith D. Hill, Anna Barker, Elissa Burton
Health Sciences Papers and Journal Articles
The aims of this study were to (1) externally validate the accuracy of the Falls Risk for Older People in the Community (FROP-Com) falls risk assessment tool in predicting falls and (2) undertake initial validation of the accuracy of the FROPCom to predict injurious falls (requiring medical attention) in people aged ≥ 60 years presenting to emergency departments (EDs) after falling. Two hundred and thirteen participants (mean age = 72.4 years; 59.2% women) were recruited (control group of a randomised controlled trial). A FROP-Com assessment was completed at a home visit within 2 weeks of ED discharge. Data on falls …
The Peer Experience For Older People Encouraging Other Older People To Engage In Resistance Training: A Qualitative Study, Elissa Burton
The Peer Experience For Older People Encouraging Other Older People To Engage In Resistance Training: A Qualitative Study, Elissa Burton
Health Sciences Papers and Journal Articles
Resistance training (RT) can maintain and improve physical and mental health in 2 older adults, but this population has low levels of participation in RT. Linking older people 3 already participating in RT (i.e. peers) with those who have not may promote and maintain 4 adherence to RT participation. This qualitative study explored the experience of peers in 5 encouraging participation in RT among older community-dwelling adults. Data were collected 6 using focus groups, researcher observations, and semi-structured interviews. Thematic 7 analysis was conducted. Older people (n=8) who had engaged in RT for at least two months 8 prior to …
The Association Between Hysterectomy And Ovarian Cancer Risk: A Population-Based Record-Linkage Study, Suzanne C. Dixon-Suen, Penelope M. Webb, Louise F. Wilson, Karen Tuesley, Louise M. Stewart, Susan J. Jordan
The Association Between Hysterectomy And Ovarian Cancer Risk: A Population-Based Record-Linkage Study, Suzanne C. Dixon-Suen, Penelope M. Webb, Louise F. Wilson, Karen Tuesley, Louise M. Stewart, Susan J. Jordan
Health Sciences Papers and Journal Articles
Background: Recent studies have called into question the long-held belief that hysterectomy without oophorectomy protects against ovarian cancer. This population-based longitudinal record-linkage study aimed to explore this relationship, overall and by age at hysterectomy, time period, surgery type, and indication for hysterectomy.
Methods: We followed the female adult Western Australian population (837 942 women) across a 27-year period using linked electoral, hospital, births, deaths, and cancer records. Surgery dates were determined from hospital records, and ovarian cancer diagnoses (n¼1640) were ascertained from cancer registry records.We used Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the …
Does Exercise Impact Gut Microbiota Composition In Men Receiving Androgen Deprivation Therapy For Prostate Cancer? A Single-Blinded, Two-Armed Randomised Controlled Trial, Robert U. Newton, Claus T. Christophersen, Ciaran M. Fairman, Nicolas H. Hart, Dennis R. Taaffe, David Broadhurst, Amanda Devine, Raphael Chee, Colin I. Tang, Nigel Spry, Daniel A. Galvao
Does Exercise Impact Gut Microbiota Composition In Men Receiving Androgen Deprivation Therapy For Prostate Cancer? A Single-Blinded, Two-Armed Randomised Controlled Trial, Robert U. Newton, Claus T. Christophersen, Ciaran M. Fairman, Nicolas H. Hart, Dennis R. Taaffe, David Broadhurst, Amanda Devine, Raphael Chee, Colin I. Tang, Nigel Spry, Daniel A. Galvao
Health Sciences Papers and Journal Articles
Introduction: A potential link exists between prostate cancer (PCa) disease and treatment and increased inflammatory levels from gut dysbiosis. This study aims to examine if exercise favourably alters gut microbiota in men receiving androgen deprivation therapy (ADT) for PCa. Specifically, this study will explore whether: (1) exercise improves the composition of gut microbiota and increases the abundance of bacteria associated with health promotion and (2) whether gut health correlates with favourable inflammatory status, bowel function, continence and nausea among patients participating in the exercise intervention.
Methods and analysis: A single-blinded, two-armed, randomised controlled trial will explore the influence …
A Randomized Trial Of Prenatal N-3 Fatty Acid Supplementation And Preterm Delivery, Maria Makrides, Karen Best, Lisa Yelland, Andrew Mcphee, Shao Zhou, Julie Quinlivan, Jodie Dodd, Elinor Atkinson, Huda Safa, Jacqueline Van Dam, Gustaaf Dekker, Monika Skubisz, Amanda Anderson, Beth Kean, Anneka Bowman, Carly Mccallum, Kara Cashman, Robert Gibson
A Randomized Trial Of Prenatal N-3 Fatty Acid Supplementation And Preterm Delivery, Maria Makrides, Karen Best, Lisa Yelland, Andrew Mcphee, Shao Zhou, Julie Quinlivan, Jodie Dodd, Elinor Atkinson, Huda Safa, Jacqueline Van Dam, Gustaaf Dekker, Monika Skubisz, Amanda Anderson, Beth Kean, Anneka Bowman, Carly Mccallum, Kara Cashman, Robert Gibson
Health Sciences Papers and Journal Articles
Background: Previous studies have suggested that maternal supplementation with n−3 long-chain polyunsaturated fatty acids may reduce the incidence of preterm delivery but may also prolong gestation beyond term; however, more data are needed regarding the role of n−3 long-chain polyunsaturated fatty acids in pregnancy.
Methods: We performed a multicenter, double-blind, randomized trial in which women who were pregnant with single or multiple fetuses were assigned to receive either fish-oil capsules that contained 900 mg of n−3 long-chain polyunsaturated fatty acids (n−3 group) or vegetable-oil capsules that contained trace n−3 long-chain polyunsaturated fatty acids (control group) daily, beginning before 20 weeks …
Reliability Of Mechanical Sprint Profiles In State U16 Female Basketball Athletes, Toby Edwards, Jacob Joseph, Brendon Lewis, Ashley Cripps
Reliability Of Mechanical Sprint Profiles In State U16 Female Basketball Athletes, Toby Edwards, Jacob Joseph, Brendon Lewis, Ashley Cripps
Health Sciences Papers and Journal Articles
BLUF: Mechanical sprint characteristics produce acceptable trial to trial reliability in state U16 female basketball athletes.
INTRODUCTION: Sprint acceleration is a key component of basketball performance that occurs frequently during competition that is commonly measured over various distances using timing gates. Sprint profiling is a topical area of research that provides practitioners an insight into the underlying mechanical characteristics that contributed to the performance. These include theoretical maximal force, theoretical maximal velocity, maximum power, slope of the force velocity relationship, maximum ratio of force, decrease in ratio of force and max speed. This study aimed to investigate the reliability of …
Study To Assess The Prevalence Of Breakfast Skipping And Its Associated Factors Among Nursing Students In Selected College, Mangaluru, Derina Benny Ms, Anu Varghese Ms, Ashly Susan Baby Ms, Aishwarya Roy Ms
Study To Assess The Prevalence Of Breakfast Skipping And Its Associated Factors Among Nursing Students In Selected College, Mangaluru, Derina Benny Ms, Anu Varghese Ms, Ashly Susan Baby Ms, Aishwarya Roy Ms
Manipal Journal of Nursing and Health Sciences
Introduction: Nowadays breakfast skipping is a tradition in the adolescent group. Breakfast actually means breaking the fast over the night. One of the most important meals which is required for a normal growth is breakfast. If we fail to have breakfast it can lead to the poor concentration, obesity, high blood pressure, irritability, fatigue, etc. Objectives: The objective of the study was to identify the prevalence among nursing students in relation to their breakfast skipping pattern and find out the factors associated with it. Methods: The approach used was a descriptive survey design. The sample comprised of 349 students. The …
Management In Paediatric Burns: A Case Report, Sangeetha Priyadarshini Ms, Pramod Kumar Dr, Elsa Sanatombi Devi Dr, Anice George Dr
Management In Paediatric Burns: A Case Report, Sangeetha Priyadarshini Ms, Pramod Kumar Dr, Elsa Sanatombi Devi Dr, Anice George Dr
Manipal Journal of Nursing and Health Sciences
Burns are common childhood injuries among children, mainly caused by scald, fire or abuse. The authors presented the case of a one-year child who presented with second degree thermal burns due to fall of hot liquid on the child. Most of the burn injuries, which occur in the early ages of life, are mostly due to the negligence or lack of supervision of the child during the growing period. So, proper management of burn injury and adequate education of parents should be considered as an important aspect in prevention of burns in children. Further, the classification of burns injury helps …
Activities Of Daily Living, Peter F. Edemekong, Deb Bomgaars, Sukesh Sukumaran, Shoshana B. Levy
Activities Of Daily Living, Peter F. Edemekong, Deb Bomgaars, Sukesh Sukumaran, Shoshana B. Levy
Faculty Work Comprehensive List
The activities of daily living (ADLs) is a term used to collectively describe fundamental skills that are required to independently care for oneself such as eating, bathing, and mobility. The term activities of daily living was first coined by Sidney Katz in 1950. ADL is used as an indicator of a person’s functional status. The inability to perform ADLs results in the dependence of other individuals and/or mechanical devices. The inability to accomplish essential activities of daily living may lead to unsafe conditions and poor quality of life. Measurement of an individual’s ADL is important as these are predictors of …
Well-Being And Health Promotion Template, Nichole Arn, Cody Mach
Well-Being And Health Promotion Template, Nichole Arn, Cody Mach
Occupational Therapy Capstones
Purpose: The purpose of this scholarly project was to develop an occupational therapy intervention template that could be utilized at LaGrave on First. LaGrave on First is a new Housing First facility that opened in Grand Forks, ND during the summer of 2018. Literature reviews regarding occupational therapy and its' role with the homeless population were limited and challenging to find, especially with a Housing First emphasis. Within this scholarly project, the reviewed literature was used to develop an intervention guide that could be implemented in conjunction with other occupational therapy interventions for this population. The interventions were created for …
Therapeutic Use Of Self: A Guide To Integrate The 5 Love Languages Into Practice, Haley Folkens, Emily Roberts
Therapeutic Use Of Self: A Guide To Integrate The 5 Love Languages Into Practice, Haley Folkens, Emily Roberts
Occupational Therapy Capstones
Healthcare institutions have become businesses and, subsequently, these institutions are oftentimes structured to maximize profits consequently leading to a sacrifice in quality of care (Beltrán-Salazar, 2014). The emphasis on business in healthcare results in a push for productivity and reimbursement consequently decreasing attention to the therapeutic relationship. There are many definitions that offer a better understanding to the idea of therapeutic use of self, but they offer little to guide therapists in what using therapeutic use of self looks like in everyday practice (Solman & Clouston, 2016). Additionally, a vast majority of occupational therapists perceive the therapeutic relationship to be …
An Occupational Therapy Referral Screening Tool For Children In Adoptive And Foster Care Placements, Alli Fox, Emily Kollodge
An Occupational Therapy Referral Screening Tool For Children In Adoptive And Foster Care Placements, Alli Fox, Emily Kollodge
Occupational Therapy Capstones
The purpose of this scholarly project was to identify the needs of children in the adoption and foster care systems (AFCS) by creating a screening tool to refer them to occupational therapy services. In the United States (US), the number of adopted children has grown to 1.8 million (Vandivere, Malm, & Radel, 2009), and to 400,000 children in the foster care system at any given time (Bramlett & Radel, 2017). These children are considered an at-risk population due to their life experiences. Occupational therapists (OTs) are uniquely qualified to work with this population. Due to stress and adversity, children who …
Occupational Therapy’S Role In Post Cva Education, Sadie Larson, Brooke Westrich
Occupational Therapy’S Role In Post Cva Education, Sadie Larson, Brooke Westrich
Occupational Therapy Capstones
The average literacy rate for healthcare client education materials is currently 11th-16th grade (Dignan & Hunter, 2015). Due to cognitive impairments, difficulty understanding healthcare education materials increases after experiencing a stroke (Danzl et al., 2016). Poor health education results in lower adherence to treatment and limited participation in everyday activities at home (DeMarco, Nystrom, & Salvatore, 2011). Clients and caregivers specifically reported a lack of understanding of post-stroke impairments (O'Connell, Baker, & Prosser, 2003).
A literature review was conducted on topics related to health literacy, post-stroke residual deficits, client education, and occupational therapy’s role in client education. There was an …
Life History Of Provost Beth Cada, Ed.D., Otr/L, Faota, Janice Finley, Emily Utech
Life History Of Provost Beth Cada, Ed.D., Otr/L, Faota, Janice Finley, Emily Utech
Oral History Posters
The life history of Provost Beth Cada was one of 9 life history interview which are a part of a larger project of Life Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) in North Dakota and Wyoming. The purpose of the project is to obtain information about the history and evolution of OT practice in North Dakota and Wyoming. This study intends to provide current and future generations of occupational therapists a view of the history and how OT practice has evolved. The life history of Beth Cada is a case study that examined her life …
Life History Of Elizabeth Crepeau, Phd, Otr/L, Faota, Nathina Crabtree, Sara Gregoire
Life History Of Elizabeth Crepeau, Phd, Otr/L, Faota, Nathina Crabtree, Sara Gregoire
Oral History Posters
The purpose of the study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond. It is anticipated that the life history process will be a powerful way to gather this information. This life history is part of the larger study consisting of 30 occupational therapists. The larger project is Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) at …
Evolution Of Occupational Therapy Practice: Life History Of Anne Macrae, Phd, Otr/L, Bcmh, Faota, Danielle Cox, Brock Wahlert
Evolution Of Occupational Therapy Practice: Life History Of Anne Macrae, Phd, Otr/L, Bcmh, Faota, Danielle Cox, Brock Wahlert
Oral History Posters
This life history is one of 30 life history interviews which are part of a larger project, Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) at the National Level and Beyond. The purpose of study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond. It is anticipated that the life history process will be a powerful way to …
Evolution Of Occupational Therapy Practice: Life History Of Kuzhilethu “Shep” Kshepakaran, M. Ed., Otr/S, Caps, Faota, Roxana Chirinos, Carly Derouin
Evolution Of Occupational Therapy Practice: Life History Of Kuzhilethu “Shep” Kshepakaran, M. Ed., Otr/S, Caps, Faota, Roxana Chirinos, Carly Derouin
Oral History Posters
The purpose of study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond. It is anticipated that the life history process will be a powerful way to gather this information. An in-depth interview with the selected participant, Kuzhilethu “Shep” Kshepakaran, as well as his resume and the internet were used to gather information. The categories created symbolized Shep’s life history which included …
Evolution Of Occupational Therapy Practice: Life History Of Paula Kramer, Phd, Otr/L, Faota, Shelby Wittenberg, Lexie Coalwell
Evolution Of Occupational Therapy Practice: Life History Of Paula Kramer, Phd, Otr/L, Faota, Shelby Wittenberg, Lexie Coalwell
Oral History Posters
Objective: The purpose of this study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond. It is anticipated that the life history process will be a powerful way to gather this information.
Method: A life history qualitative approach was used by conducting two, 60-minutes semi-structured interviews at the University of North Dakota’s School of Medicine and Health Sciences. The interviews …
Evolution Of Occupational Therapy Practice: Life History Of Suzanne Peloquin, Phd, Otr, Faota, Alexandra Grosser, Kelsey Knutson
Evolution Of Occupational Therapy Practice: Life History Of Suzanne Peloquin, Phd, Otr, Faota, Alexandra Grosser, Kelsey Knutson
Oral History Posters
Objective: This life history of Dr. Suzanne Peloquin is one of 30 life history interviews, which are part of a larger project. The purpose of study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond.
Method: A two-hour, semi-structured interview was conducted via Zoom video conferencing technology. The interview was video and audio recorded and later transcribed. The transcription was analyzed …
The Use Of Dhea In The Treatment Of Depression, Bryan Tipton
The Use Of Dhea In The Treatment Of Depression, Bryan Tipton
Physician Assistant Scholarly Project Posters
Dehydroepiandrosterone (DHEA) and its sulfated ester (DHEA-S) are important pre-hormones that also have direct neurohormonal effects on the central nervous system. Over the last twenty years, data have revealed that serum DHEA peaks in a person’s mid-20s and steadily declines throughout their lifetime. In addition, women tend to have lower values than men. This is of note because lower serum values tend to be correlated with increased risk of depression, worse depressive symptoms, and increased risk of relapse into depression. A review of literature concerning DHEA’s age related values, its association with depression, and its use in the treatment of …
Embolus Prevention: Anticoagulant Therapy In Comparison To Watchman’S Procedure In Patients With Atrial Fibrillation, Erik Fladmo
Embolus Prevention: Anticoagulant Therapy In Comparison To Watchman’S Procedure In Patients With Atrial Fibrillation, Erik Fladmo
Physician Assistant Scholarly Project Posters
• Atrial fibrillation or A-fib is a common cardiac disease that occurs as individuals get older.
• A risk factor of atrial fibrillation is blood clot formation and dislodgement or ‘embolus’ in the left atrium.
• Current treatment methods to prevent clot formation include anticoagulants, as well as a left atrial appendage closure device, The Watchman’s device is the only FDA approved left atrial appendage closure device.
• Study results confirm the rising efficacy and cost effectiveness of Watchman’s device versus long term anticoagulant therapy as well as their adverse effects regarding placement and post procedure; however further randomized control …
Comparing Rates Of Macrosomia And Neonatal Hypoglycemia Of Differing Treatment Modalities Of Gestational Diabetes Mellitus, Ashleigh Milbrath
Comparing Rates Of Macrosomia And Neonatal Hypoglycemia Of Differing Treatment Modalities Of Gestational Diabetes Mellitus, Ashleigh Milbrath
Physician Assistant Scholarly Project Posters
Gestational diabetes mellitus (GDM) is a known potential complication that can occur during pregnancy. Unmanaged GDM can result in maternal hyperglycemia, which can cause increased neonatal complications, two of which are macrosomia and neonatal hypoglycemia. To prevent maternal hyperglycemia, treatment of GDM typically begins with dietary changes, home glucose monitoring, increased exercise patterns and other lifestyle modifications. However, if maternal hyperglycemia persists after two weeks of maternal lifestyle modifications, there are not current best practice guidelines established for the treatment of GDM. Historically, subcutaneous multiple daily dosed insulin (MDI) has been the gold standard for treatment after lifestyle modification. However, …
Managing Anxiety With Pharmacogenomic Testing, Ashley Pommer
Managing Anxiety With Pharmacogenomic Testing, Ashley Pommer
Physician Assistant Scholarly Project Posters
Anxiety affects approximately three to seven percent of the United States population, and nearly 50% of the diagnosed patients fail to respond to first line treatment regimens (Boland, Duffy, & Meyer 2018). Traditional first line treatments include medication therapy, cognitive behavioral therapy (CBT), or the combination of both. With such a high initial failure rate, recent studies indicate promising results in managing anxiety with pharmacogenomic testing. Pharmacogenomic testing is allowing providers to prescribe medication based on individual genetic makeup, focusing on how each patient metabolizes certain medications. The purpose of this literature review was to determine if first line methods …
Fertility Options For Women With Endometriosis: In Vitro Fertilization Versus Surgical Excision Or Ablation, Jenny Brown
Fertility Options For Women With Endometriosis: In Vitro Fertilization Versus Surgical Excision Or Ablation, Jenny Brown
Physician Assistant Scholarly Project Posters
Endometriosis negatively affects the fertility of many women of reproductive age worldwide. Some women with endometriosis are able to conceive without reproduction assistance, while others require medical intervention. In vitro fertilization and surgical management are available and widely used in the treatment of endometriosis associated infertility. In vitro fertilization has been found to be effective in women with stages I-IV endometriosis, with varying degrees of success at each stage. These varying results may be due to oocyte quality and availability as well as endometriosis location. Surgical excision and/or surgical ablation of endometriosis/endometriomas may also improve chance of successful pregnancy but …
Autonomy, Intimate Partner Violence, And Maternal Health-Seeking Behavior: Findings From Mixed-Methods Analysis In Nigeria, Pooja Sripad, Charity Ndwiga, Charlotte E. Warren
Autonomy, Intimate Partner Violence, And Maternal Health-Seeking Behavior: Findings From Mixed-Methods Analysis In Nigeria, Pooja Sripad, Charity Ndwiga, Charlotte E. Warren
Reproductive Health
Gendered norms and discriminatory practices often limit women’s decision-making power, which over time can lead to social norms that systematically subordinate women. Aspects of empowerment were explored in a global evaluation of Demographic and Health Survey data that measured how gendered social norms influenced maternal health-seeking behaviors. Analysis specifically explored associations of women’s autonomy and acceptability of intimate partner violence against women (IPVAW) on antenatal care use and facility delivery in 63 low- and middle-income countries. Service utilization is positively associated with increased autonomy and negatively associated with increased acceptability of IPVAW, but variability exists across countries and regions. In …
Practice-Based Learning: Integrating Sgbv Screening Into Health Facilities In Refugee Contexts, Chi-Chi Undie, Josephine Ngebeh, Joanina Karugaba, Harriet Birungi, Michael Mbizvo
Practice-Based Learning: Integrating Sgbv Screening Into Health Facilities In Refugee Contexts, Chi-Chi Undie, Josephine Ngebeh, Joanina Karugaba, Harriet Birungi, Michael Mbizvo
Reproductive Health
Sexual and gender-based violence (SGBV) “screening” refers to the standardized assessment of clients for SGBV incidents, regardless of reasons for presenting at a health facility. This practice has been shown to be feasible and effective in various countries and contexts in the East and Southern African region, resulting in proactive identification of female survivors, and their successful referrals for comprehensive SGBV care. In the last decade, health facilities in the region have been increasingly eager to incorporate such screening within the normal protocols of their health-care providers. In collaboration with the Population Council-led Africa Regional SGBV Network, the UNHCR East, …
Examining Nurse Resiliency & A Mindfulness-Based Stress Reduction Intervention To Prevent Nurse Burnout, Allegra Grannell
Examining Nurse Resiliency & A Mindfulness-Based Stress Reduction Intervention To Prevent Nurse Burnout, Allegra Grannell
Posters
Nurses continually give of themselves at work, as well as outside of work. This results in extensive stress, physiological distress, and ultimately burnout for individuals in the nursing profession. Nurses that work in high-stress environments, such as critical care, pediatrics, and oncology, are at a significantly increased risk of manifesting physical and psychological symptoms of burnout syndrome, compassion fatigue, and post-traumatic stress disorder (PTSD). Many of these factors are leading to nurses leaving the profession prematurely, resulting in significantly high turnover rates. High burnout and turnover rates of nurses result in the lack of adequate nursing staff in hospitals, which …
Creating Staff Engagement In Transition Planning Through The Use Of Data, Teresa Hickam, Michelle Bozarth
Creating Staff Engagement In Transition Planning Through The Use Of Data, Teresa Hickam, Michelle Bozarth
Posters
In 2017 the Children's Mercy Kansas City Transition Program provided 14 Divisions and 28 programs with data to support their hard work. 2,160 of 3,768 patients (61%) completed readiness assessments and held transition-related discussions with their health care team.
Data reports providing timely, routine feedback on staff success and missed opportunities helps keep staff engaged, their efforts visible and transition planning on a conscious level.
Efficacy And Effectiveness Of Treatment Studies, Manish Rami
Efficacy And Effectiveness Of Treatment Studies, Manish Rami
Communication Sciences & Disorders Faculty Publications
Professionals in the discipline of communication sciences and disorders primarily assess and treat speech, language, and hearing disorders. Speech–language pathologists and audiologists are the two professions. These professionals constantly search for ways to improve services for people who have speech, language, or hearing disorders. To do so, these professionals conduct research to figure out the best treatment options for their clients. Two types of research methods, efficacy of treatment studies (efficacy studies) and effectiveness of treatment studies (effectiveness studies), help establish the certainty and practicality of new treatment approaches. Evidence from such studies advances the discipline of communication sciences and …
Advances In Chimeric Antigen Receptor T-Cell Therapies For Solid Tumors., Trevor R. Baybutt, John C. Flickinger, Ellen M. Caparosa, Adam E. Snook
Advances In Chimeric Antigen Receptor T-Cell Therapies For Solid Tumors., Trevor R. Baybutt, John C. Flickinger, Ellen M. Caparosa, Adam E. Snook
Department of Pharmacology and Experimental Therapeutics Faculty Papers
In 2017, the US Food and Drug Administration approved the first two novel cellular immunotherapies using synthetic, engineered receptors known as chimeric antigen receptors (CARs), tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (Yescarta), expressed by patient-derived T cells for the treatment of hematological malignancies expressing the B-cell surface antigen CD19 in both pediatric and adult patients. This approval marked a major milestone in the use of antigen-directed "living drugs" for the treatment of relapsed or refractory blood cancers, and with these two approvals, there is increased impetus to expand not only the target antigens but also the tumor types that can be …