Medicine and Health Sciences Commons^™

Himmelfarb Library Liaison Letter - January 2019, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

A Note From The Executive Editor, Yolander Youngblood

Pursue: Undergraduate Research Journal

No abstract provided.

Occupational Therapy Practitioners' Knowledge And Perception Of The Value Of Environmental Adaptations For Nursing Home Residents With Neurocognitive Disorders, Hannah Fiser

Occupational Therapy Capstones

The purpose of this independent study was to evaluate occupational therapy practitioners’ perceptions of the efficacy of certain environment-based intervention types when utilized with nursing home residents who present with neurocognitive disorders. A non-experimental research design in an online survey format was utilized. An invitation to take the online survey was submitted to 56 occupational therapy (OT) practitioners working in skilled nursing facilities. The online survey was comprised of questions addressing awareness/use and perception of efficacy of environment-based intervention methods. Seventeen responses were received. The majority of respondents reported awareness and use of the 20 environment-based intervention methods. Overall, respondents …

Using Leisure As A Therapeutic Activity To Enhance Health, Well-Being, And Quality Of Life Among Long Term Care Residents, Olivia Mayasich, Alexis Tyce

Occupational Therapy Capstones

Purpose The purpose of this scholarly project is to address health, well-being, and quality of life with the use of leisure activities as modalities with residents in long term care (LTC) facilities.

Methodology The results of a thorough literature review supported the need for a program to address leisure participation in residents in LTC facilities. An abundance of literature supporting participation in leisure to enhance health, well-being, and quality of life emerged from the literature review, revealing an obvious gap between literature and practice. The information gathered in the literature review helped guide the development of a program manual to …

Spinal Kappa Opioid Receptor Activity Inhibits Adenylyl Cyclase-1 Dependent Mechanisms Of Chronic Postoperative Pain, Lilian Custodio

Theses and Dissertations--Physiology

Chronic postoperative pain impacts millions of individuals worldwide that undergo a variety of surgical procedures. Opioids remain the mainstay analgesics of acute and perioperative pain; however, prolonged opioid therapy may lead to life-threating adverse effects, tolerance, dependence, and addiction. Therefore, unraveling the cellular mechanisms that drive persistent pain states and opposing endogenous analgesia provided by opioid receptor signaling, may lead to novel analgesics. Evidence suggests that tissue injury leads to increased sensitization of the spinal cord nociceptive neurons which increases susceptibility to chronic pain via an N-methyl-D-aspartate (NMDA) receptor activation of calcium-sensitive adenylyl cyclase isoform 1 (AC1). This phenomenon, named …

Targeting Maladaptive Plasticity After Spinal Cord Injury To Prevent The Development Of Autonomic Dysreflexia, Khalid C. Eldahan

Theses and Dissertations--Physiology

Vital autonomic and cardiovascular functions are susceptible to dysfunction after spinal cord injury (SCI), with cardiovascular dysregulation contributing to morbidity and mortality in the SCI population. Autonomic dysreflexia (AD) is a condition that develops after injury to the sixth thoracic spinal segment or higher and is characterized by potentially dangerous and volatile surges in arterial pressure often accompanied with irregular heart rate, headache, sweating, flushing of the skin, and nasal congestion. These symptoms occur in response to abnormal outflow of sympathetic activity from the decentralized spinal cord typically triggered by noxious, yet unperceived nociceptive stimulation beneath the level of lesion. …

Preclinical Targeting Of Trem2 For The Treatment Of Alzheimer's Disease-Type Pathology In A Transgenic Mouse Model, Brittani Rae Price

Theses and Dissertations--Physiology

Alzheimer's disease (AD) is defined as a progressive neurodegenerative disorder and is characterized by a devastating mental decline. There are three pathological hallmarks of the disease necessary for its diagnosis, these are extracellular amyloid plaques comprised of the beta-amyloid (Aβ) protein, intracellular neurofibrillary tangles comprised of hyperphosphorylated tau protein, and marked neuronal loss. Active immunization against Aβ_1-42 or passive immunization with monoclonal anti-Aβ antibodies has been shown to reduce amyloid deposition and improve cognition in transgenic mouse models of AD, aged beagles, and nonhuman primates. Unfortunately, due to cerebrovascular adverse events, both active and passive immunization strategies targeting Aβ …

Variability In Plasma Concentrations Of Methylprednisolone 6 Days After Intrasynovial Injection Of Methylprednisolone Acetate In Racing Horses: A Field Study, Jacob Machin, W. Duer, G. Maylin, C. K. Fenger, D. Wilson, M. Ivey, B. Berthold, S. Allison, Thomas Tobin

Veterinary Science Faculty Publications

Background: Methylprednisolone (MP) acetate is a commonly used corticosteroid for suppression of inflammation in synovial structures in horses. Its use is often regulated in equine sports by plasma MP concentrations. Objectives: To describe variability in MP plasma concentrations after MP acetate injection in different synovial structures and with co-administration with hyaluronic acid (HA). Study design: Field study in actively racing horses in three disciplines (Thoroughbred, Standardbred and Quarter Horse). Methods: Seventy-six horses (15 Thoroughbreds, 20 Standardbreds and 41 Quarter Horses) were included in the study. Injection of any synovial structure with a total body dose of 100 mg MP acetate …

Monocytes And Monocyte-Derived Antigen-Presenting Cells Have Distinct Gene Signatures In Experimental Model Of Multiple Sclerosis, Kelly L. Monaghan, Wen Zheng, Gangqing Hu, Edwin C. K. Wan

Faculty & Staff Scholarship

Multiple sclerosis (MS) is a chronic inflammatory disease mediated by a complex interaction between the autoreactive lymphocytes and the effector myeloid cells within the central nervous system (CNS). In a murine model of MS, experimental autoimmune encephalomyelitis (EAE), Ly6Chi monocytes migrate into the CNS and further differentiate into antigen-presenting cells (APCs) during disease progression. Currently, there is no information about gene signatures that can distinguish between monocytes and the monocyte-derived APCs. We developed a surface marker-based strategy to distinguish between these two cell types during the stage of EAE when the clinical symptoms were most severe, and performed transcriptome analysis …

College Of Dental Medicine 2019, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Implicit Attitudes Of Asian American Older Adults Toward Aging, Anita Ho

Scripps Senior Theses

Greenwald, McGhee, and Schwartz (1998) developed the Implicit Association Test (IAT), a measure of mental associations between target pairs and positive or negative attributes. Highly associative categories yield faster responses than the reverse mental associations, which is thought to reflect implicit attitudes toward stereotypes. The present study investigated the effect of ethnic group on one’s implicit attitudes toward aging and gender stereotypes by comparing two groups of older adults, Asian Americans and Caucasian Americans, that likely hold different culture values. Past qualitative studies have established the existence of mental health stigma in Asian American populations, including negative Asian American perceptions …

Academy Presidents And Institutional Members List, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Table Of Contents, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Business Meeting Report (Secretary's And Treasurer's Report), Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Journal Acknowledgments And Editorial Board, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

The Experience Of Female Veterans’ Transitioning To Post—Active— Duty Health Care, Sarah A. Bradwisch

Theses & Dissertations

Problem Statement: Female veterans are growing in record numbers and are the fastest growing segment of the veteran population in the United States(U.S.). After discharge from the military, female veterans face a difficult challenge in finding quality, efficient, and gender-specific health care following active duty. The growing number of female veterans in the Department of Veterans Affairs (VA) health care facilities has highlighted gaps in access to care and quality of care for female veterans. Methodology: Interpretive phenomenology was used to better understand the meaning of 11 U.S. female veterans’ experiences. Semi-structured telephone interviews and the analytic approach of Martin …

Eyelid Cosmetic Enhancements And Their Associated Ocular Adverse Effects, Maliha Masud, Majid Moshirfar, Tirth J. Shah, Aaron T. Gomez, Michele R. Avila, Yasmyne C. Ronquillo

School of Medicine Publications

Numerous cosmetic enhancements and augmentations to the natural appearance of the periorbital area are readily available today. Due to the increasing popularity of these cosmetic procedures, it is important for ophthalmologists to be aware of their potential risks, complications and adverse effects. The aim of this literature review was to introduce some of the most common ocular cosmetic enhancements and provide a comprehensive overview of their associated adverse effects reported in various medical journals. PubMed, Embase, and Google Scholar were used to identify articles related to the following ocular cosmetic procedures; eyelash extensions, permanent eyelid tattooing, and eyelash dyeing. The …

Facile Synthesis Of Diverse N-Acyl Anthranilamides And Quinazolin-4-Ones As Hmg-Coa Reductase Inhibitor Via Pd-Catalyzed Cascade Reaction, Pathan Sultan Ismail, Irfan Khan, Vivek Kumar, Ved Prakash Verma, Monika Shukla, Anupam Dhasmana, Shashi Pandey, Girdhar Pal Singh, Jaybir Singh, Shahnawaz Khan

School of Medicine Publications

This manuscript describes the design and synthesis of a series of diverse N-Acyl Anthranilamides and quinazolin-4-ones derivatives (3a-3n, and 4a-4d) inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. A series of N-Acyl Anthranilamides and quinazolin-4-ones derivatives (3a-3n, and 4a-4d) were synthesized and their chemical structures were confirmed by 1 H, 13C NMR and mass spectral data. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 4b and 3d, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a vitro model.

Diversity-Oriented Synthesis Of Novel Benzimidazoles As Antimalarial Agents Via Post Ugi Mcr, Anshu Dandia, Pankaj Potlia, Irfan Khan, Vivek Kumar Kashyap, Ved Prakash Verma, Mankiva Karnatak, Anupam Dhasmana, Shashi Pandey, Tarun Shrimali, Vijay Parewa, Shahnawaz Khan, Jaybir Singh

School of Medicine Publications

An efficient strategy for the syntheses of highly diverse benzimidazoles in exceptional yields via post Ugi reactions has been described. In our methodology we have utilized isocyanide based Ugi-reaction followed by acid catalyzed condensation cyclization reaction under microwave irradiations. All benzimidazole derivatives showed moderate to good antimalarial activity when compared with chloroquine as reference compound. Among these compounds, three of them (8b), (8c), (8d) were found to be most potent towards antimalarial activity. The synthesized hybrids were examined for their purity with the help of thin layer chromatography. Different analytical techniques were employed for further characterization like Mass studies, NMRs …

Synthesis And Biological Evaluation Of 2,4-Diaminopyrimidine-5-Carbonitrile And N-(2-Amino-5-Cyanopyrimidin-4-Yl)Benzamide Derivatives As Egfr Inhibitors, Pathan Sultan Ismail, Irfan Khan, Vivek Kumar Kashyap, Ved Prakash Verma, Monika Shukla, Anupam Dhasmana, Shashi Pandey, Girdhar Pal Singh, Shahnawaz Khan, Jaybir Singh

School of Medicine Publications

A series of 2,4-diaminopyrimidine-5-carbonitrile and N-(2-amino-5-cyanopyrimidin-4-yl) benzamide derivatives (5–14) were synthesized and their chemical structures were confirmed by 1 H, 13C NMR and mass spectral data. Anticancer activity of all the synthesized compounds were evaluated for in vitro cytotoxic activity against a panel of four human cancer cell lines i.e., human breast (MCF-7,), cervical cancer (C33A), oral (KB) and prostrate (DU-145). All the examined compounds, demonstrated potent to moderate anticancer activity. Among all the synthesized compounds, 6 and 11 were exhibited more potent activity. Docking studies for 6 and 11 into EGFR active site was carried out to investigate their …

A Rare Presentation Of Cardiac Aspergilloma In An Immunocompetent Host: Case Report And Literature Review, Abdullah M. Pervaiz, Salman A. Bangash, Raheel Akhtar, Zain Wahab, Hyder Bangash

School of Medicine Publications

Cardiac aspergilloma is exceptionally rare with only a handful of cases reported and majority of them being in immunocompromised patients. Here, we present a case of cardiac aspergilloma involving the right and left ventricle in an immunocompetent patient that initially presented with acute limb ischemia. He was later found to have a cardiac mass with histopathological diagnosis confirming Aspergillus species. Despite aggressive medical and surgical interventions, the patient had an unfavorable outcome due to low suspicion of invasive fungal endocarditis given his immunocompetent status. Cardiac aspergilloma should remain in the differential diagnosis of immunocompetent patients as early clinical suspicion will …

Evaluation Of A Palliative Care Initiative On The African Continent: Responsibly Improving Access To Pain Treatment, J. Spencer Hirschi

MPA/MPP/MPFM Capstone Projects

The African continent today faces a crisis of inadequate palliative care, in spite of the growing level of suffering of its citizens who are faced with debilitating diseases and injuries. Much of this problem stems from deeply ingrained attitudes towards opioids: while the American continent grapples with the effects of opioid overprescribing, physicians trained in Africa are taught that opioids are inappropriate for virtually all scenarios, and therefore they come to fear and avoid their use or simply remain untrained on them altogether. Patients fail to advocate for themselves out of submission to the doctor’s authority, governments remain apathetic to …

Evaluating The Impact Of Fine Particulate Matter Pollution Standards On Mortality Rates In The Southeastern United States, Lauren Wice

MPA/MPP/MPFM Capstone Projects

The Environmental Protection Agency (EPA) continuously monitors six criteria pollutants that are known to have impacts on public health and welfare. One of these pollutants, fine particulate matter, or PM_2.5 (which includes particles that are smaller than 2.5 micrometers in diameter), is easily inhalable and can enter the lining of the lungs and the bloodstream, posing a great risk to human health. Standards for allowable concentrations of PM_2.5 were amended in 1997, 2006, and again in 2012, becoming increasingly stringent each time. According to the EPA, health organizations, and other research studies, these particles can specifically contribute to …

Efficient Region-Based Test Strategy Uncovers Genetic Risk Factors For Functional Outcome In Bipolar Disorder, Monika Budde, Stefanie Friedrichs, Ney Alliey-Rodriguez, Seth Ament, Judith A. Badner

School of Medicine Publications

Genome-wide association studies of case-control status have advanced the understanding of the genetic basis of psychiatric disorders. Further progress may be gained by increasing sample size but also by new analysis strategies that advance the exploitation of existing data, especially for clinically important quantitative phenotypes. The functionally-informed efficient region-based test strategy (FIERS) introduced herein uses prior knowledge on biological function and dependence of genotypes within a powerful statistical framework with improved sensitivity and specificity for detecting consistent genetic effects across studies. As proof of concept, FIERS was used for the first genome-wide single nucleotide polymorphism (SNP)-based investigation on bipolar disorder …

Cardiovascular Magnetic Resonance Imaging Feature Tracking: Impact Of Training On Observer Performance And Reproducibility, Sören J. Backhaus, Georg Metschies, Marcus Billing, Johannes T. Kowallick, Roman J. Gertz, Tomas Lapinskas, Burkert Pieske, Joachim Lotz, Boris Bigalke, Shelby Kutty, Gerd Hasenfuß, Philipp Beerbaum, Sebastian Kelle, Andreas Schuster

Journal Articles: Pediatrics

BACKGROUND: Cardiovascular magnetic resonance feature tracking (CMR-FT) is increasingly used for myocardial deformation assessment including ventricular strain, showing prognostic value beyond established risk markers if used in experienced centres. Little is known about the impact of appropriate training on CMR-FT performance. Consequently, this study aimed to evaluate the impact of training on observer variance using different commercially available CMR-FT software.

METHODS: Intra- and inter-observer reproducibility was assessed prior to and after dedicated one-hour observer training. Employed FT software included 3 different commercially available platforms (TomTec, Medis, Circle). Left (LV) and right (RV) ventricular global longitudinal as well as LV circumferential …

Societal Pressures And Procreative Preferences For Gay Fathers Successfully Pursuing Parenthood Through Ivf And Gestational Carriers, Steven R. Lindheim Md, Jody L. Madeira, Artur Ludwin, Emily Kemmer, J. Preston Parry, Georges Sylvestre, Guido Pennings

Articles by Maurer Faculty

This retrospective study surveyed decision-making and challenges among 78 gay cisgender male couples utilizing in-vitro fertilization (IVF) and a gestational carrier. While most couples (67.1%) found the decision to actively pursue fertility treatment ‘not difficult’, 32.9% felt that it was ‘somewhat difficult’ or ‘very or extremely difficult’. Almost 30% of couples had not undertaken financial planning for treatment, which introduced delays of N2 years for 25.3% of participants. Conceiving twins was ‘important to very important’ in 52.3% of couples, and 84.2% of couples chose to transfer two embryos to ‘increase the odds’ or reach an ideal family size in a …

Anti-Inflammatory, Anti-Nociceptive And Antipyretic Activity Of Young And Old Leaves Of Vernonia Amygdalina, Du-Bois Asante, Isaac Tabiri Henneh, Desmond Omane Acheampong, Foster Kyei, Christian Kweku Adokoh, Eric Gyamerah Ofori, Nelson Kwabla Domey, Emmanuel Adakudugu, Lokeswari Prathyusha Tangella, Elvis Ofori Ameyaw

Research outputs 2014 to 2021

Background

Both young and old leaves of Vernonia amygdalina (VA) are traditionally used to treat inflammation, pain and fever. However, the efficacy of young and old leaves for treating these ailments have not been compared till date.

Aim

To ascertain the effect of young and old leaves of VA in managing inflammation, pain and fever.

Methods

Both quantitative and qualitative phytochemical screening of ethanol extracts of young (EthYL) and old (EthOL) leaves of VA were performed. The anti-inflammatory activity of orally administered EthYL and EthOL (50–200 mg/kg) and Diclofenac (10 mg/kg) were evaluated in carrageenan-induced inflammation model in rats. Antipyretic …

Diets High In N-3 Fatty Acids Are Associated With Lower Arterial Stiffness In Patients With Rheumatoid Arthritis: A Latent Profile Analysis, Richard J. Woodman, Leena R. Baghdadi, E Michael Shanahan, Inushi De Silva, Jonathan M. Hodgson, Arduino A. Mangoni

Research outputs 2014 to 2021

Supplementation with n-3 fatty acids can influence inflammation and markers of arterial stiffness that are increased in patients with rheumatoid arthritis (RA). However, it is unknown whether specific patterns of dietary fatty acid intake are similarly associated. In a longitudinal study, eighty-six RA patients reported their dietary intake and had arterial stiffness measured using the augmentation index (AIx) at baseline and 8 months. Latent profile analysis (LPA) was performed to characterise patterns of fatty acid intake using sixteen major fatty acids. Models for two to six profiles were compared using the Akaike and Bayesian information criteria. Associations between AIx and …

Monitoring Melanoma Recurrence With Circulating Tumor Dna: A Proof Of Concept From Three Case Studies, Ashleigh C. Mcevoy, Michelle R. Pereira, Anna Reid, Robert Pearce, Lester Cowell, Zeyad Al-Ogaili, Muhammad A. Khattak, Michael Millward, Tarek M. Meniawy, Elin S. Gray, Melanie R. Ziman

Research outputs 2014 to 2021

Background: A significant number of melanoma patients experience recurrence to distant sites, despite having had surgical treatment of the primary lesion, with curative intent. Monitoring of patients for early evidence of disease recurrence would significantly improve management of the disease, allowing timely therapeutic intervention. Circulating tumor DNA (ctDNA) is becoming a well-recognized biomarker for monitoring malignancies and has, in a few studies, been shown to signify disease recurrence earlier than conventional methods.

Methods: We performed a retrospective analysis of plasma ctDNA using droplet digital PCR (ddPCR) in 30 primary melanoma patients with tumors harboring BRAF, NRAS or TERT promoter mutations. …

Using The Trajectory Of The Shuttlecock As A Measure Of Performance Accuracy In The Badminton Short Serve, Shayne Vial, Jodie Cochrane, Anthony J. Blazevich, James L. Croft

Research outputs 2014 to 2021

Accuracy of a projectile is typically quantified as the proportion of successful target hits, or the distance an object finishes from the target. Serving in sports such as badminton differs since the shuttlecock is usually intercepted by the opponent before landing on the target (i.e. court surface). Therefore, landing accuracy measures are inappropriate and a new method of determining accuracy of the serve is needed. During interviews, elite coaches and players described an accurate short serve as crossing the net with low clearance and having an apex before the net. Three-dimensional trajectory of the shuttlecock was therefore tracked from eight …