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2019

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Articles 12811 - 12840 of 16112

Full-Text Articles in Medicine and Health Sciences

Ua66/13/1 Ogden College Of Science & Engineering Public Health Administration, Wku Archives Jan 2019

Ua66/13/1 Ogden College Of Science & Engineering Public Health Administration, Wku Archives

WKU Archives Collection Inventories

Administrative records created by Public Health.


Ua61/11/1 Health & Human Services Dental Hygiene & Clinic Student Organizations, Wku Archives Jan 2019

Ua61/11/1 Health & Human Services Dental Hygiene & Clinic Student Organizations, Wku Archives

WKU Archives Collection Inventories

Records created by and about Dental Hygiene student organizations.


Preoperative Mental Health Scores And Achieving Patient Acceptable Symptom State Are Predictive Of Return To Work After Arthroscopic Rotator Cuff Repair, Anirudh K. Gowd, Gregory L. Cvetanovich, Joseph N. Liu, Benedict U. Nwachukwu, Brandon C. Cabarcas, Brian J. Cole, Brian Forsythe, Anthony A. Romeo, Nikhil N. Verma Jan 2019

Preoperative Mental Health Scores And Achieving Patient Acceptable Symptom State Are Predictive Of Return To Work After Arthroscopic Rotator Cuff Repair, Anirudh K. Gowd, Gregory L. Cvetanovich, Joseph N. Liu, Benedict U. Nwachukwu, Brandon C. Cabarcas, Brian J. Cole, Brian Forsythe, Anthony A. Romeo, Nikhil N. Verma

Orthopaedics and Sports Medicine Faculty Publications

Background: The incidence of rotator cuff repairs has risen dramatically over the past 10 years, most notably in the working-class population. Return to work (RTW) is a valuable outcome measure to set patient expectations before surgery.

Purpose: To establish the rate of RTW after rotator cuff repair with respect to stratified levels of occupational demand (sedentary, light, moderate, and heavy) and to identify clinical factors significantly associated with postoperative RTW.

Study Design: Cohort study; Level of evidence, 3.

Methods: Patients who received rotator cuff repair between 2014 and 2017 were queried from a prospectively maintained institutional registry. Work status was …


Iact Undergraduate Certificate In Applied Creativity (Year 2 - 2019), Brian Laduca Jan 2019

Iact Undergraduate Certificate In Applied Creativity (Year 2 - 2019), Brian Laduca

IACT Certificate Program

At the Institute of Applied Creativity for Transformation (IACT) at ArtStreet, we seek to empower a creatively confident 21st-century student with the ability to discover, invent and innovate ambiguous ideas through a disruptive design process that will impact today’s ever-changing global world regardless of degree focus.

IACT is home to the nation’s first undergraduate certificate in Applied Creativity for Transformation. Open to undergraduate students of any major, the certificate is a first step in achieving the University of Dayton’s vision of innovation, applied creativity, entrepreneurship and community engagement for the common good.


Impact Of Tumor Size On Local Control And Pneumonitis After Stereotactic Body Radiation Therapy For Lung Tumors, Sean M. Parker, R. Alfredo Siochi, Sijin Wen, Malcolm D. Mattes Jan 2019

Impact Of Tumor Size On Local Control And Pneumonitis After Stereotactic Body Radiation Therapy For Lung Tumors, Sean M. Parker, R. Alfredo Siochi, Sijin Wen, Malcolm D. Mattes

Clinical and Translational Science Institute

Purpose Stereotactic body radiation therapy (SBRT) is commonly used to treat primary or oligometastatic malignancies in the lung, but most of the available data that describe the safety and efficacy of SBRT are for smaller tumors. The purpose of this study was to evaluate the impact of tumor size, among other factors, on local control (LC) and radiation pneumonitis (RP) in patients who received lung SBRT. Methods and materials This retrospective study included 144 patients with 100 primary (57.1%) and 75 metastatic (42.9%) lung tumors treated with SBRT between 2012 and 2018. Measurements of tumor size, treatment volume, histology, and …


Understanding Diabetes Through Pathway Analysis Evaluation, London Cavaletto Jan 2019

Understanding Diabetes Through Pathway Analysis Evaluation, London Cavaletto

Research Opportunities for Engineering Undergraduates (ROEU) Program 2018-19

Metabolic disorders affect many people and identifying significantly perturbed biological processes in a metabolic disease can provide valuable insight into the disease’s mechanisms. Evaluating the proposed Metabolic Pathway Analysis Method (RAMP) will enable us to reliably use it to identify significantly perturbed metabolic pathways that could help identify disease mechanisms and potential therapy targets or disease bio-markers of a metabolic disorder.


Elevating Student Understanding: Irish Occupational Therapy Students’ Experience Of A Service Learning Project, Karen Mccarthy, Marian Mccarthy Jan 2019

Elevating Student Understanding: Irish Occupational Therapy Students’ Experience Of A Service Learning Project, Karen Mccarthy, Marian Mccarthy

Occupational Therapy | Faculty Scholarship

Service learning is a pedagogy that embraces learning in action and addresses community needs. Since the adoption of the Occupational Therapy Competencies in 2008 and the launch of national occupational therapist registration in Ireland in 2015, there has been limited research on the effectiveness of service learning pedagogies in Irish higher education for meeting core competencies. The majority of research focusing on evaluating service learning have been North American studies which brings to question the relevance of these service learning outcomes beyond North America and specifically Ireland. This qualitative study examined 11 occupational therapy students’ journal reflections, portfolio entries, and …


Assessing Knowledge, Attitude And Practices Of Hand Hygiene Among University Students, Linda Afia Mbroh Jan 2019

Assessing Knowledge, Attitude And Practices Of Hand Hygiene Among University Students, Linda Afia Mbroh

All Graduate Theses, Dissertations, and Other Capstone Projects

Objective: Proper hand hygiene is the key to reducing occurrence of infectious diseases in many different types of communities, including the healthcare settings, daycare centers, and grade schools. College students have been found to inadequately wash their hands, which increases their chances of contracting infectious diseases. The purpose of this research is to assess the knowledge, attitude and practices of hand hygiene among students at a large midwestern university.

Participants and Methods: Using a cross- sectional survey, and three self-reported questionnaires, data were collected from 406 undergraduate students, ages 18 years of age and above enrolled at Minnesota State University, …


Preparation And Characterization Of Multimodal Hybrid Organic And Inorganic Nanocrystals Of Camptothecin And Gold, Christin P. Hollis, Alan K. Dozier, Barbara L. Knutson, Tonglei Li Jan 2019

Preparation And Characterization Of Multimodal Hybrid Organic And Inorganic Nanocrystals Of Camptothecin And Gold, Christin P. Hollis, Alan K. Dozier, Barbara L. Knutson, Tonglei Li

Pharmaceutical Sciences Faculty Publications

We demonstrate a novel inorganic-organic crystalline nanoconstruct, where gold atoms were imbedded in the crystal lattices as defects of camptothecin nanocrystals, suggesting its potential use as simultaneous agents for cancer therapy and bioimaging. The incorporation of gold, a potential computed tomography (CT) contrast agent, in the nanocrystals of camptothecin was detected by transmission electron microscope (TEM) and further quantified by energy dispersive X-ray spectrometry (EDS) and inductively coupled plasma-optical emission spectrometers (ICP-OES). Due to gold's high attenuation coefficient, only a relatively small amount needs to be present in order to create a good noise-to-contrast ratio in CT imaging. The imbedded …


Methods To Quantify Nanomaterial Association With, And Distribution Across, The Blood-Brain Barrier In Vivo, Robert A. Yokel Jan 2019

Methods To Quantify Nanomaterial Association With, And Distribution Across, The Blood-Brain Barrier In Vivo, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

The role and functional anatomy of the blood-brain barrier (BBB) is summarized to enable the investigator to appropriately address evaluation of nanomaterial interaction with, and distribution across, it into brain tissue (parenchyma). Transport mechanisms across the BBB are presented, in relation to nanomaterial physicochemical properties. Measures and test substances to assess BBB integrity/disruption/permeation are introduced, along with how they are used to interpret the results obtained with the presented methods. Experimental pitfalls and misinterpretation of results of studies of brain nanomaterial uptake are briefly summarized, that can be avoided with the methods presented in this chapter. Two methods are presented. …


The Positional Technical And Running Performance Of Sub-Elite Gaelic Football, Shane Mangan, Kieran Collins, Con Burns, Cian O Neill Phd Jan 2019

The Positional Technical And Running Performance Of Sub-Elite Gaelic Football, Shane Mangan, Kieran Collins, Con Burns, Cian O Neill Phd

Articles

Introduction The current research examines the positional technical and running performance of sub-elite Gaelic football match-play and compares technical and running performance between Division 1 and Division 2 teams.

Methods Sixty eight sub-elite Gaelic football players from two teams were monitored via global positioning system (GPS) microtechnology (GPEXE LT 18 Hz, Exelio, Udine, Italy) and a video camera across 30 competitive matches (n = 336). Comparisons between teams and playing positions were examined for selected technical and running performance variables.

Results Playing position had large effects on several variables including number of possessions (ES = 0.18), number of shots (ES …


The Impact On Cost, Quality, And Patient Satisfaction When Delivering Care To Acutely Ill Adults In An At-Home Care Model Versus An Inpatient Hospital Setting., Franchesca M. Adams Jan 2019

The Impact On Cost, Quality, And Patient Satisfaction When Delivering Care To Acutely Ill Adults In An At-Home Care Model Versus An Inpatient Hospital Setting., Franchesca M. Adams

Honors Theses and Capstones

The impact on cost, quality, and patient satisfaction when delivering care to acutely ill adults in an at-home care model versus an inpatient hospital setting. Hospital level care for certain acute conditions can be safely delivered in the patient’s home while lowering the cost per episode of care, maintaining or improving patient experience, and improving safety and patient/care giver education as well as care coordination, at the Critical Access Hospital (CAH) level.


Three-Dimensional Echocardiographic Analysis Of The Equine Aortic Valve, Amber Mcelhinney Jan 2019

Three-Dimensional Echocardiographic Analysis Of The Equine Aortic Valve, Amber Mcelhinney

Honors Theses and Capstones

This research focused on 3D echocardiography of the aortic valve (AV) in horses. Aortic regurgitation (AR) can be a common finding in older horses, and in severe cases can result in decreased performance and even sudden cardiac death. Standard AR diagnosis includes 2D echocardiography from the right side of the horse. Three-dimensional echocardiography (3DE) records a pyramid of tissue, showing structures in the heart difficult to visualize in 2D methods, and can be more accurate as it does not rely as heavily on placement of the transducer. Nine images of normal AV’s were assessed, and still frames of anatomical structures …


A Developmental Study Of Apoptotic Markers And Histamine In Cephalopod Statocysts, Samantha Nicole Leef Jan 2019

A Developmental Study Of Apoptotic Markers And Histamine In Cephalopod Statocysts, Samantha Nicole Leef

Honors Theses and Capstones

Cephalopods can participate in complex navigation using landmarks that show context due to their statocysts. Statocysts are analogous to the vertebrate vestibular and auditory system encased in cartilage rather than bone making them more easily accessible. Age and anatomical dysfunctions are the reasons for many human vestibular malfunctions. Two of these sources are endolymph hydrops and aging. In the past, endolymph pressure changes were attributed to the ineffectual ion transport. Recent studies have illuminated the possibility of histamine receptors in the semicircular canal could be responsible for patients’ endolymph pressure changes rather than the previous belief that the pressure changes …


Sunshine In Our Soul, Susan Halchishak Allen Jan 2019

Sunshine In Our Soul, Susan Halchishak Allen

Lake Union Herald

No abstract provided.


Impact Of Serratus Plane Block On Pain Scores And Incentive Spirometry Volumes After Chest Trauma, Nadia Hernandez, Johanna De Haan, Dallis Clendeninn, David E Meyer, Semhar Ghebremichael, Carlos Artime, George Williams, Holger Eltzschig, Sudipta Sen Jan 2019

Impact Of Serratus Plane Block On Pain Scores And Incentive Spirometry Volumes After Chest Trauma, Nadia Hernandez, Johanna De Haan, Dallis Clendeninn, David E Meyer, Semhar Ghebremichael, Carlos Artime, George Williams, Holger Eltzschig, Sudipta Sen

Faculty, Staff and Student Publications

Background: Adequate pain control is difficult to achieve in patients with multiple rib fractures (MRF). Serratus plane block (SPB) is a novel technique for alleviating rib fracture pain. Several published case reports support this hypothesis.

Purpose: The purpose of this study was to evaluate the use of SPB in MRF at our level 1 trauma center.

Methods: Our hospital’s Regional Anesthesia Registry was queried for all trauma patients with MRF who underwent SPB between August 2014 and January 2018. Data were compared in each patient as a matched pair for the time periods before and after undergoing SPB. Thirty-four patients …


Amplification Vs The Natural Ear: A Test On The Effectiveness Of The Natural Ear On Adults Ability To Match Pitch In Song, Celeste Orozco Jan 2019

Amplification Vs The Natural Ear: A Test On The Effectiveness Of The Natural Ear On Adults Ability To Match Pitch In Song, Celeste Orozco

Open Access Theses & Dissertations

Background: Singing is a natural enjoyment of life; however, individuals tend to isolate themselves from this enjoyment due to their inability to match pitch accurately. A new technology, the Natural Ear provides altered auditory feedback to the user while singing. It is hypothesized that this feedback may aid in the userâ??s ability to match pitch.

Purpose: The purpose of this study is to compare the effects of the Natural Ear to amplification and no amplification conditions on pitch matching accuracy in song.

Study Design: This study used a complex counterbalance within-subjects design.

Methods: 50 adults from the El Paso Metropolitan …


The Role Of P62/Imp2 In Hepatocellular Carcinoma Progression, Mengtao Xing Jan 2019

The Role Of P62/Imp2 In Hepatocellular Carcinoma Progression, Mengtao Xing

Open Access Theses & Dissertations

The family of insulin- like growth factor 2 mRNA binding proteins (IMPs) contains three members: IMP1, p62/IMP2 and IMP3. All these proteins are oncofetal proteins, expressed during embryogenesis and lost in most tissues in adults. However, p62/IMP2 were found overexpressed in various cancers but its function in carcinogenesis remains to be investigated. Our previous studies found that p62/IMP2 was not only overexpressed in hepatocellular carcinoma (HCC) tissues, but also overexpressed in HCC cell lines. To explore the biological roles of p62/IMP2 in HCC progression, p62/IMP2 was knockout in two p62/IMP2 positive HCC cell lines (SNU449, HepG2). Due to the low …


Towards A Learning System For University Campuses As Living Labs For Sustainability, L.A. Verhoef, M. Bossert, J. Newman, Filipa Ferraz, Z.P. Robinson, Y. Agarwala, P. Wolff, P. Jiranek, C. Hellinga Jan 2019

Towards A Learning System For University Campuses As Living Labs For Sustainability, L.A. Verhoef, M. Bossert, J. Newman, Filipa Ferraz, Z.P. Robinson, Y. Agarwala, P. Wolff, P. Jiranek, C. Hellinga

Articles

Universities, due to their sizeable estates and populations of staff and students, as well as their connections with, and impact within, their local and wider communities, have significant environmental, social and economic impacts. There is a strong movement for universities to become leaders in driving society towards a more sustainable future, through improving the sustainability of the built environment and the universities’ practices and operations, and through their educational, research and wider community engagement missions. Around the globe the concept of ‘Living Labs’ has emerged as an instrument to integrate these different aspects to deliver sustainability improvements, through engaging multiple …


Assessment Of Physicochemical Characteristics, Thermal Stability And Release Profile Of Ascorbic Acid Microcapsules Obtained By Complex Coacervation, Michele Cristina Rodrigues Da Cruz, João Luiz Andreotti Dagostin, Camila Augusto Perussello, Maria Lúcia Masson Jan 2019

Assessment Of Physicochemical Characteristics, Thermal Stability And Release Profile Of Ascorbic Acid Microcapsules Obtained By Complex Coacervation, Michele Cristina Rodrigues Da Cruz, João Luiz Andreotti Dagostin, Camila Augusto Perussello, Maria Lúcia Masson

Articles

The aim of this study was to determine the physicochemical characteristics, thermal stability and release profile of ascorbic acid (AA) microcapsules obtained by complex coacervation. Gelatin and gum arabic were used as wall materials in concentrations of 2.5, 5.0 and 7.5 g% (w/v). The coacervate microcapsules were freeze-dried and assessed for physicochemical characteristics, thermal behavior and stability during 60 days of storage. The release profile was evaluated at different pH values (1.1, 2.2, 5.4, 7.4, 9.6 and 12). The encapsulation efficiency ranged from 27.3 to 93.8%. The microcapsules of AA presented good characteristics for application in food matrices, such as …


Harnessing Smart Technology For Private Well Risk Assessment And Communication, Tanner Hoffman, Paul Hynds, Corinne Schuster-Wallace, Sarah Dickson-Anderson, Anna Majury Jan 2019

Harnessing Smart Technology For Private Well Risk Assessment And Communication, Tanner Hoffman, Paul Hynds, Corinne Schuster-Wallace, Sarah Dickson-Anderson, Anna Majury

Articles

Unregulated, privately owned water supplies, including groundwater wells, are relied upon extensively, particularly in rural and remote regions. While adequate stewardship behaviors (water testing, treatment, and maintenance) have been shown to decrease the incidence and frequency of faecal indicator organism (FIO) presence and, by extension, the risk of pathogenic ingress, contaminated private water supplies continue to constitute a significant public health risk. Recognizing that innovative approaches are needed to bolster well stewardship, this paper identifies and assesses 35 tools (smartphone and web-based applications) to better understand components, functionality, strengths, and weaknesses. Applications for both data collection and risk communication were …


Predicting Quality Attributes Of Strawberry Packed Under Modified Atmosphere Throughout The Cold Chain, Kompal Joshi, Brijesh Tiwari, P. J. Cullen, Jesus Maria Frias Jan 2019

Predicting Quality Attributes Of Strawberry Packed Under Modified Atmosphere Throughout The Cold Chain, Kompal Joshi, Brijesh Tiwari, P. J. Cullen, Jesus Maria Frias

Articles

Modified Atmosphere Packaging (MAP) is used commercially to extend the shelf life of strawberries. The attainment of desired gas (O2, CO2) concentrations inside MAP relies on the product respiration and the mass transfer through packaging and will affect the quality. The objective of this work is to build a mathematical model for strawberries to assess the effect of the uncertainties on headspace gas concentration and quality: 1) cold chain related temperature and relative humidity variations and 2) variability associated to product respiration and quality based on literature. Weight loss was more influenced by the cold chain storage conditions (temperature and …


Assessment Of Two Behavioural Models (Hbm And Ranas) For Predicting Health Behaviours In Response To Environmental Threats: Surface Water Flooding As A Source Of Groundwater Contamination And Subsequent Waterborne Infection In The Republic Of Ireland, L. Andrade, K. O'Malley, Paul Hynds, E. O'Neill, J. O'Dwyer Jan 2019

Assessment Of Two Behavioural Models (Hbm And Ranas) For Predicting Health Behaviours In Response To Environmental Threats: Surface Water Flooding As A Source Of Groundwater Contamination And Subsequent Waterborne Infection In The Republic Of Ireland, L. Andrade, K. O'Malley, Paul Hynds, E. O'Neill, J. O'Dwyer

Articles

Extreme weather events (EWEs) are increasing in frequency, posing a greater risk of adverse human health effects. As such, developing sociological and psychological based interventions is paramount to empowering individuals and communities to actively protect their own health. Accordingly, this study compared the efficacy of two established social-cognitive models, namely the Health Beliefs Model (HBM) and Risks-Attitudes-Norms-Abilities-Self-regulation (RANAS) framework, in predicting health behaviours following EWEs. Surface water flooding was used as the exemplar EWE in the current study, due to the increasing incidence of these events in the Republic of Ireland over the past decade. Levels of prior experience with …


Nuclear Frames In The Irish Media: Implications For Conversations On Nuclear Power Generation In The Age Of Climate Change, Catherine Devitt, Finbarr Brereton, Simon Mooney, David Conway, Eoin O'Neill Jan 2019

Nuclear Frames In The Irish Media: Implications For Conversations On Nuclear Power Generation In The Age Of Climate Change, Catherine Devitt, Finbarr Brereton, Simon Mooney, David Conway, Eoin O'Neill

Articles

Keeping within the temperature limits set by the Paris Agreement on climate action will be a significant challenge. Nuclear power generation may contribute to achieving these targets, however, there are significant environmental, economic and health risks attached. Using qualitative and quantitative methods, this paper explores how nuclear power generation is framed in the Irish print media, and discusses the implications of these frames for how nuclear power is perceived within the context of climate change mitigation in Ireland. Two Irish broadsheet papers, the Irish Times and the Irish Independent were selected for data collection, focusing on Chernobyl and Fukushima incidents. …


Spirit Checklist, Myopia Outcome Study Of Atropine In Children (Mosaic): Design And Methodology, Saoirse Mccrann, Daniel Ian Flitcroft, John S. Butler, James Loughman Jan 2019

Spirit Checklist, Myopia Outcome Study Of Atropine In Children (Mosaic): Design And Methodology, Saoirse Mccrann, Daniel Ian Flitcroft, John S. Butler, James Loughman

Articles

Purpose

The Myopia Outcome Study of Atropine in Children (MOSAIC) aims to explore the efficacy, safety, acceptability and mechanisms of action of 0.01% atropine for myopia control in a European population.

Methods

MOSAIC is an investigator-led, double-masked, placebo-controlled, randomised clinical trial (RCT) investigating the efficacy, safety and mechanisms of action of 0.01% atropine in myopia progression management. During Phase 1 of the trial, 250 children aged 6-16 years with progressive myopia apply eye drops once nightly in both eyes from randomisation to month 24. No treatment is given during Phase 2 from month 24 to 36 (washout period) for those …


Coreq Checklist: Is Optometry Ready For Myopia Control? Education And Other Barriers To The Treatment Of Myopia., Saoirse Mccrann, Daniel Ian Flitcroft, James Loughman Jan 2019

Coreq Checklist: Is Optometry Ready For Myopia Control? Education And Other Barriers To The Treatment Of Myopia., Saoirse Mccrann, Daniel Ian Flitcroft, James Loughman

Other Resources

Background

With the increasing prevalence of myopia there is growing interest in active myopia control. However, the majority of progressive myopes are still prescribed single vision spectacles. This prospective study aims to elucidate the knowledge and attitudes of optometrists toward myopia control, and thereby identify perceived barriers to the implementation of a risk focused model of myopia management.


Is Optometry Ready For Myopia Control? Education And Other Barriers To The Treatment Of Myopia, Saoirse Mccrann, Daniel Ian Flitcroft, James Loughman Jan 2019

Is Optometry Ready For Myopia Control? Education And Other Barriers To The Treatment Of Myopia, Saoirse Mccrann, Daniel Ian Flitcroft, James Loughman

Other Resources

Background

With the increasing prevalence of myopia there is growing interest in active myopia control. However, the majority of progressive myopes are still prescribed single vision spectacles. This prospective study aims to elucidate the knowledge and attitudes of optometrists toward myopia control, and thereby identify perceived barriers to the implementation of a risk focussed model of myopia management.

Methods

A series of four focus group discussions were conducted involving optometrists in different settings and career stages.

Results

The key finding to emerge is a clear disconnect between academic optometrists, optometry students and clinicians in practice. Academic faculty considered themselves competent …


Myopia Outcome Study Of Atropine In Children (Mosaic): Design And Methodology, Saoirse Mccrann, Daniel Ian Flitcroft, John Butler, James Loughman Jan 2019

Myopia Outcome Study Of Atropine In Children (Mosaic): Design And Methodology, Saoirse Mccrann, Daniel Ian Flitcroft, John Butler, James Loughman

Articles

Purpose

The Myopia Outcome Study of Atropine in Children (MOSAIC) aims to explore the efficacy, safety, acceptability and mechanisms of action of 0.01% atropine for myopia control in a European population.

Methods

MOSAIC is an investigator-led, double-masked, placebo-controlled, randomised clinical trial investigating the efficacy, safety and mechanisms of action of 0.01% atropine eyedrops in myopic progression management. During phase 1 of the trial, 250 children aged 6-16 years with progressive myopia apply eye drops once nightly in both eyes from randomisation to month 24. No treatment is given during phase 2 from month 24 to 36 (washout period) for those …


Improved Performance Of Near Infrared Excitation Raman Spectroscopy Using Reflective Thin-Film Gold On Glass Substrates For Cytology Samples, Sinead J. Barton, Kevin O'Dwyer, Marion Butler, Adam Dignam, Hugh Byrne, Luke O'Neill, Bryan M. Hennelly Jan 2019

Improved Performance Of Near Infrared Excitation Raman Spectroscopy Using Reflective Thin-Film Gold On Glass Substrates For Cytology Samples, Sinead J. Barton, Kevin O'Dwyer, Marion Butler, Adam Dignam, Hugh Byrne, Luke O'Neill, Bryan M. Hennelly

Articles

Confocal near-infrared Raman spectroscopy has been shown to have applications in the area of clinical biology. A source wavelength in the near infrared is preferred over visible wavelengths for inspecting biological samples due to superior wavenumber resolution and reduced photodamage. However, these excitation sources have a number of drawbacks when compared to lasers in the visible wavelength region, including the requirement to use expensive highly pure crystal substrates such as Raman grade calcium fluoride as well as long acquisition times due to the lower Raman scattering efficiency. This paper investigates the use of a reflective substrate comprising a low cost …


The Potential Of Biobanked Liquid Based Cytology Samples For Cervical Cancer Screening Using Raman Spectroscopy., D. Traynor, S. Duraipandian, R. Bhatia, K. Cuschieri, C. M. Martin, J. J. O'Leary, Fiona Lyng Jan 2019

The Potential Of Biobanked Liquid Based Cytology Samples For Cervical Cancer Screening Using Raman Spectroscopy., D. Traynor, S. Duraipandian, R. Bhatia, K. Cuschieri, C. M. Martin, J. J. O'Leary, Fiona Lyng

Articles

Patient samples are unique and often irreplaceable. This allows biobanks to be a valuable source of material. The aim of this study was to assess the ability of Raman spectroscopy to screen for histologically confirmed cases of Cervical Intraepithelial neoplasia (CIN) using biobanked liquid based cytology (LBC) samples. Two temperatures for long term storage were assessed; 80°C and -25°C. The utility of Raman spectroscopy for the detection of CIN was compared for fresh LBC samples and biobanked LBC samples. Two groups of samples were used for the study with one group associated with disease (CIN 3) and the other associated …