Medicine and Health Sciences Commons^™

Harnessing Nature For Occupational Therapy: Interventions And Health Promotion, Gina Ferra Kaplanis

Occupational Therapy Program Student Theses, Dissertations and Capstones

Literature is beginning to emerge which states that participation in natural environments can be restorative, provide much needed physical activity and assist with health promotion and prevention of illness. Theories such as Attention Restoration Theory (Kaplan, 1995) and Biophilia Hypothesis (Wilson, 1993) support the benefits for participation in natural outdoor environments. Health benefits of participation in nature including accessing Vitamin D, improving balance, attention restoration, reduced myopia, stress reduction are widely present in literature. Despite the health benefits of participation in nature, occupational therapists rarely complete interventions in the natural environment. Principles of adult learning and occupational adaptation were used …

Impact Of Shoulder Pathology On Individuals With Distal Radius Fracture: A Mixed Methods Study, Sarah Beth Doerrer

Occupational Therapy Program Student Theses, Dissertations and Capstones

The purpose of this convergent parallel mixed methods study was to expand the understanding of the impact of shoulder pathology on individuals with distal radius fracture (DRF). This included describing the population that had shoulder pathology, comparing participants who had shoulder pathology with participants who did not, and exploring their experiences. The occupational adaptation model guided this study. Recruitment for this study included 45 patients post DRF. Each participant completed a short questionnaire after informed consent was obtained which asked demographic information such as age, gender, race, date of injury, and if the dominant hand was fractured. Over 9 weeks, …

Development Of A Caregiver Education Support Tool For Family Caregivers Of Older Adults With Dementia, Sarah Guariglia

Occupational Therapy Program Student Theses, Dissertations and Capstones

For every person diagnosed with dementia, four family members are affected and burdened with providing care. Providing familial care is associated with greater psychological, social, and emotional burden on the caregiver. Caregivers are not provided with adequate education to support successful caregiving and aging in place. This capstone project developed and piloted a caregiver education support tool to simplify the process of finding caregiver education. Five caregivers participated in interviews to guide the development of the support tool, next completed the Likert questionnaire, and tested the caregiver education support tool. Four themes were identified: (1) burden, (2) loss, (3) unmet …

Occupational Therapy Practitioner Knowledge And Use Of Medicaid Home And Community Based Service Waivers, Alyssa Zaffos

Occupational Therapy Program Student Theses, Dissertations and Capstones

Medicaid Home and Community Based Service (HCBS) waivers have allowed adults with intellectual and developmental disabilities (IDD) to remain in the community rather than transition to institutionalization. HCBS waivers vary drastically from state to state limiting consistency in services offered to adults with IDD within the community. Majority of HCBS waivers offered to adults with IDD do not fund occupational therapy as a habilitative service due to a variety of reasons. Many adults with IDD are negatively impacted by not receiving necessary services. After preliminary research, it was noted that there is limited information regarding occupational therapy practitioner knowledge of …

An Oasis In The Hospital Desert – General Aviation Meets Medicine, Ariel Braverman

International Journal of Aviation, Aeronautics, and Aerospace

Use of General Aviation and to support medical services is not novel. However, this paper is an attempt to establish a concept of a framework of using aviation, especially relatively low-operational cost fixed-wing aircraft as a convenient high-speed transport to bring medical staff to the rural and remote areas. Operating flight network will also be more efficient from the financial point of view - better than attracting medical personnel with high salaries. Existing regional and local airport system can be a feasible basis for airport-based medical network. This article is just an initial one and additional work needs to evaluate …

Rethinking Consumer Protection: Escaping Death By Regulation, Thomas L. Tacker

Publications

This book is designed to appeal to anyone who is at all interested in topics related to making life better and safer—for all us consumers. Our current approach to consumer protection is extremely flawed; sometimes costing lives rather than saving them. There are better ways to protect ourselves and the people we love.

Consort Checklist, Myopia Outcome Study Of Atropine In Children (Mosaic): Design And Methodology, Saoirse Mccrann, Daniel Ian Flitcroft, John Butler, James Loughman

Articles

Purpose

The Myopia Outcome Study of Atropine in Children (MOSAIC) aims to explore the efficacy, safety, acceptability and mechanisms of action of 0.01% atropine for myopia control in a European population.

Methods

MOSAIC is an investigator-led, double-masked, placebo-controlled, randomised clinical trial (RCT) investigating the efficacy, safety and mechanisms of action of 0.01% atropine in myopia progression management. During Phase 1 of the trial, 250 children aged 6-16 years with progressive myopia apply eye drops once nightly in both eyes from randomisation to month 24. No treatment is given during Phase 2 from month 24 to 36 (washout period) for those …

Ensuring Quality Standards And Reproducible Research For Data Analysis Services In Oncology: A Cooperative Service Model., Frank Emmert-Streib, Matthias Dehmer, Olli Yli-Harja

Articles, Abstracts, and Reports

Modern molecular high-throughput devices, e.g., next-generation sequencing, have transformed medical research. Resulting data sets are usually high-dimensional on a genomic-scale providing multi-factorial information from intertwined molecular and cellular activities of genes and their products. This genomics-revolution installed precision medicine offering breathtaking opportunities for patient's diagnosis and treatment. However, due to the speed of these developments the quality standards of the involved data analyses are lacking behind, as exemplified by the infamous Duke Saga. In this paper, we argue in favor of a two-stage cooperative serve model that couples data generation and data analysis in the most beneficial way from the …

Down Syndrome Associated Moyamoya May Worsen Epilepsy Control And Can Benefit From Surgical Revascularization., Sarah R Garson, Stephen J Monteith, Sheila D Smith, Bart P Keogh, Ryder P Gwinn, Michael J Doherty

Articles, Abstracts, and Reports

Objectives: To examine outcome of bilateral extracranial to intracranial (EC-IC) bypass surgeries for a Down syndrome patient with hard-to-treat epilepsy and moyamoya.

Materials and methods: Superficial temporal arteries were anastamosed using an indirect bypass technique to middle cerebral arteries bilaterally to help limit perfusion deficits and seizure controls.

Results: Two superficial temporal to middle cerebral artery indirect bypass surgeries were performed within 3 months. Post-revascularization improvements included seizure control, gait, perfusion, wakefulness, language and quality of life.

Conclusion: In patients with Down syndrome and moyamoya, improvements in seizure control and quality of life may occur with EC-IC bypass procedures.

Regeneration Enhances Metastasis: A Novel Role For Neurovascular Signaling In Promoting Melanoma Brain Metastasis., Roshini Prakash, Sivan Izraely, Nikita S Thareja, Rex H Lee, Maya Rappaport, Riki Kawaguchi, Orit Sagi-Assif, Shlomit Ben-Menachem, Tsipi Meshel, Michal Machnicki, Shuichi Ohe, Dave S B Hoon, Giovanni Coppola, Isaac P Witz, S Thomas Carmichael

Articles, Abstracts, and Reports

Neural repair after stroke involves initiation of a cellular proliferative program in the form of angiogenesis, neurogenesis, and molecular growth signals in the surrounding tissue elements. This cellular environment constitutes a niche in which regeneration of new blood vessels and new neurons leads to partial tissue repair after stroke. Cancer metastasis has similar proliferative cellular events in the brain and other organs. Do cancer and CNS tissue repair share similar cellular processes? In this study, we identify a novel role of the regenerative neurovascular niche induced by stroke in promoting brain melanoma metastasis through enhancing cellular interactions with surrounding niche …

Glioblastoma Mimicking Viral Encephalitis Responds To Acyclovir: A Case Series And Literature Review., Keenan J Piper, Haidn Foster, Brandon Gabel, Burt Nabors, Charles Cobbs

Articles, Abstracts, and Reports

Viral encephalitis and glioblastoma are both relatively rare conditions with poor prognoses. While the clinical and radiographic presentations of these diseases are often distinctly different, viral encephalitis can sometimes masquerade as glioblastoma. Rarely, glioblastoma can also be misdiagnosed as viral encephalitis. In some cases where a high-grade glioma was initially diagnosed as viral encephalitis, antiviral administration has proven effective for relieving early symptoms. We present three cases in which patients presented with symptoms and radiographic findings suggestive of viral encephalitis and experienced dramatic clinical improvement following treatment with acyclovir, only to later be diagnosed with glioblastoma in the region of …

Addressing Climate Change: We Can’T Afford Not To, Elizabeth Schenk

Articles, Abstracts, and Reports

No abstract provided.

Serum Amyloid A And Janus Kinase 2 In A Mouse Model Of Diabetic Kidney Disease., Brad P Dieter, Rick L Meek, Robert J Anderberg, Sheryl K Cooney, Jen L Bergin, Hongyu Zhang, Viji Nair, Matthias Kretzler, Frank C Brosius, Katherine Tuttle

Articles, Abstracts, and Reports

BACKGROUND: Serum amyloid A (SAA), a potent inflammatory mediator, and Janus kinase 2 (JAK2), an intracellular signaling kinase, are increased by diabetes. The aims were to elucidate: 1) a JAK2-mediated pathway for increased SAA in the kidneys of diabetic mice; 2) a JAK2-SAA pathway for inflammation in podocytes.

METHODS: Akita diabetic mice (129S6) with podocyte JAK2 overexpression and angiotensin II infusion (4 weeks) were given a JAK1,2 inhibitor (LY03103801, 3 mg/kg/day orally for the last two weeks). Kidneys were immunostained for SAA isoform 3 (SAA3). SAA3 knockout and control mouse podocytes were exposed to advanced glycation end products (AGE) or …

Understanding The Association Between Skin Involvement And Joint Activity In Patients With Psoriatic Arthritis: Experience From The Corrona Registry., Philip Mease, Carol J Etzel, William J Huster, Talia M Muram, April W Armstrong, Jeffrey R Lisse, Sabrina Rebello, Rhiannon Dodge, Mwangi James Murage, Jeffrey D Greenberg, William N Malatestinic

Articles, Abstracts, and Reports

Objective: To compare the characteristics of patients with psoriatic arthritis among patient groups stratified by degree of skin and joint involvement, and to evaluate the relationship between skin severity and joint activity.

Methods: Body surface area (BSA) and Clinical Disease Activity Index (CDAI) at enrolment were analysed. Patient characteristics were stratified by skin severity and joint activity. Baseline patient characteristics, clinical and disease characteristics and patient-reported outcomes were compared. The strength of the relationship of skin severity and joint activity was evaluated using methods for categorical variables (χ

Results: 1542 adult patients in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry enrolled between …

Body Mass Index And Treatment Response To Subcutaneous Abatacept In Patients With Psoriatic Arthritis: A, Iain B Mcinnes, Gianfranco Ferraccioli, Maria-Antonietta D'Agostino, Manuela Le Bars, Subhashis Banerjee, Harris A Ahmad, Yedid Elbez, Philip Mease

Articles, Abstracts, and Reports

Objective: This

Methods: In ASTRAEA, patients with active PsA were randomised (1:1) to receive blinded weekly SC abatacept 125 mg or placebo for 24 weeks. Treatment response at week 24 was assessed by the proportions of patients achieving American College of Rheumatology 20% improvement response, Disease Activity Score in 28 joints (DAS28 (C reactive protein (CRP))) ≤3.6 and

Results: Of 212/213 and 210/211 patients with baseline BMI data in the abatacept and placebo groups, respectively, 15% and 19% were underweight/normal, 36% and 27% were overweight, and 49% and 54% were obese. After adjusting for baseline characteristics, there were no significant …

Validations Of Apomorphine-Induced Bold Activation Correlations In Hemiparkinsonian Rhesus Macaques, Jorge E. Quintero, Yi Ai, Anders H. Andersen, Peter A. Hardy, Richard Grondin, Zain Guduru, Don M. Gash, Greg A. Gerhardt, Zhiming Zhang

Neuroscience Faculty Publications

Identification of Parkinson's disease at the earliest possible stage of the disease may provide the best opportunity for the use of disease modifying treatments. However, diagnosing the disease during the pre-symptomatic period remains an unmet goal. To that end, we used pharmacological MRI (phMRI) to assess the function of the cortico-basal ganglia circuit in a non-human primate model of dopamine deficiency to determine the possible relationships between phMRI signals with behavioral, neurochemical, and histological measurements. Animals with unilateral treatments with the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), that expressed stable, long-term hemiparkinsonism were challenged with the dopaminergic receptor agonist, apomorphine, and structure-specific phMRI …

Effectiveness Of Prophylactic Lingual Strengthening Exercises For Patients With Head And Neck Cancer A Systematic Review, Cassidy Pickens

Theses and Dissertations--Communication Sciences and Disorders

Radiation treatment for head and neck cancer has devastating effects on swallowing ability. Prophylactic swallowing exercises are often recommended. However, the evidence for these exercises is equivocal and information regarding critical components of an exercise program is lacking. The purpose of this systematic review was to examine the evidence regarding lingual strengthening exercises as a component of a prophylactic swallowing program.

The Medicalisation Of Female Genital Mutilation/Cutting In Kenya: Perspectives Of Families And Health Care Providers, Population Council

Reproductive Health

This evidence brief summarizes key findings from a study that sought to understand the shifts in FGM/C including medicalization among several communities Kenya. The study finds that medicalization is increasing because: 1) it is perceived to be safer because the procedure is reportedly performed under sterile conditions by trained health professionals; 2) it is believed to shorten the recovery period; and 3) it is a response to the law prohibiting the practice because it allows FGM/C to be performed in secret. These findings indicate that medicalization is an adaptation to awareness of the health complications associated with FGM/C and the …

Irreversible Chorea As The Initial Presentation Of Polycythemia Rubra Vera In An Elderly Woman, Shakya Bhattacharjee

Neurosciences

No abstract provided.

Assessment Of Perceived Levels Of Stress And Coping Mechanisms Among University Students, Nancy Adomako-Saahene

All Graduate Theses, Dissertations, and Other Capstone Projects

Majority of researchers have documented stress among college students. This study contributes to the existing literature on stress by assessing the relationship between perceived stress levels and the coping strategies utilized by university students. The study was conducted using a descriptive, inferential, cross-sectional, and correlational research design. The population for this study was students at a large, Midwestern university. A convenience sampling technique was used to select the students for the study. Perceived Stress Scale (PSS) was used to assess the participant’s perceived level of stress, whereas COPE Inventory was used to examine strategies participants use in coping with stress. …

The Relationship Between Adverse Childhood Experiences And Social Communication: A Survey Study, Chey Maree Robertson

All Graduate Theses, Dissertations, and Other Capstone Projects

Speech-language pathologists work with individuals who have experienced various levels of adversity. The title of this thesis is The Relationship between Adverse Childhood Experiences (ACEs) and Social Communication: A Survey study. The researcher, Chey Robertson, from the communication sciences and disorders program from a university in the Midwest investigated the relationship between ACEs and social communication such as social cognition, social interaction, and pragmatics. ACEs includes physical, emotional, and sexual abuse, and physical and emotional neglect. ACEs also includes household dysfunction such as a household member with mental illness, witnessing domestic violence, incarceration of a household member, household member who …

Human Islet Response To Selected Type 1 Diabetes-Associated Bacteria: A Transcriptome-Based Study, Ahmed M. Abdellatif, Heather Jensen Smith, Robert Z. Harms, Nora Sarvetnick

Journal Articles: Eppley Institute

Type 1 diabetes (T1D) is a chronic autoimmune disease that results from destruction of pancreatic β-cells. T1D subjects were recently shown to harbor distinct intestinal microbiome profiles. Based on these findings, the role of gut bacteria in T1D is being intensively investigated. The mechanism connecting intestinal microbial homeostasis with the development of T1D is unknown. Specific gut bacteria such as Bacteroides dorei (BD) and Ruminococcus gnavus (RG) show markedly increased abundance prior to the development of autoimmunity. One hypothesis is that these bacteria might traverse the damaged gut barrier, and their constituents elicit a response from human islets that causes …

Cash Transfers And Hiv/Hsv-2 Prevalence: A Replication Of A Cluster Randomized Trial In Malawi, Lynette M. Smith, Nicholas A. Hein, Danstan Bagenda

Journal Articles: Anesthesiology

INTRODUCTION: In this paper we perform a replication analysis of "Effect of a cash transfer programme for schooling on prevalence of HIV and herpes simplex type 2 in Malawi: a cluster randomised trial" by Sarah Baird and others published in "The Lancet" in 2012. The original study was a two-year cluster randomized intervention trial of never married girls aged 13-22 in Malawi. Enumeration areas were randomized to either an intervention involving cash transfer (conditional or unconditional of school enrollment) or control. The study included 1708 Malawian girls, who were enrolled at baseline and had biological testing for HIV and herpes …

The Metaphysics Of The Collective Unconscious, Oscar B. Jablon

Honors Undergraduate Theses

This thesis shows how the metaphysical features of the Jungian collective unconscious can be demystified by viewing the collective unconscious through the lens of functionalism. The features of the collective unconscious that will be investigated in this thesis are the possibility of the collective unconscious being present in every person, the archetypes as being the formal feature of some of our modes of perception, psychic energy, and synchronicity. By admitting functionalism, Jung doesn't need to posit synchronicity to explain how it is possible for the archetypes to interact with the body. This is because functionalism can view mental states as …

Artful Bionics: Pushing The Limits Of Visual Expression In Prosthetic Design, Anna Kester

Honors Undergraduate Theses

Traditional prosthetic design revolves around functionality, aiming to hide and downplay an individual's limb difference as much as possible. This may not only negatively affect the user's desire to wear their prosthetic but may also negatively affect their self-confidence and sense of identity. Expression is a primary way to communicate identity, yet some traditional prosthetics may deny expression, leaving users without an immediate means to express themselves apart from the stigmatizing label of 'disability'. This study examines the ability of art when combined with bionic prosthetic technology to change the perception of disability, empower self confidence in prosthetics users, and …

Vocal Function Exercises For Normal Voice: The Effects Of Maximally Sustained Phonation, Mariah Elaine Morton

Theses and Dissertations--Communication Sciences and Disorders

Vocal Function Exercises (VFEs) is a well-known treatment program that consists of four exercises, in which the first and fourth tasks require maximally sustained phonation. However, the active ingredients responsible for treatment efficacy are still unknown. The primary purpose of this investigation was the explore the effects of maximally sustained phonation on the VFE outcome measure of maximum phonation time (MPT) in individuals between the ages of 18-40 with normal voice. Participants were randomized into three experimental groups that completed VFEs for six weeks. The baseline group sustained tasks one and four for as long as was achieved at the …

Acceptability And Feasibility Of A Pharmacist-Led Hiv Pre-Exposure Prophylaxis (Prep) Program In The Midwestern United States, Joshua P. Havens, Kimberly Scarsi, Harlan Sayles, Donald G. Klepser, Susan Swindells, Sara H. Bares

Journal Articles: Infectious Diseases

BACKGROUND: HIV pre-exposure prophylaxis (PrEP) substantially reduces the risk of HIV acquisition, yet significant barriers exist to its prescription and use. Incorporating pharmacists in the PrEP care process may help increase access to PrEP services.

METHODS: Our pharmacist-led PrEP program (P-PrEP) included pharmacists from a university-based HIV clinic, a community pharmacy, and two community-based clinics. Through a collaborative practice agreement, pharmacists conducted PrEP visits with potential candidates for PrEP, according to the recommended CDC guidelines, and authorized emtricitabine-tenofovir disoproxil fumarate prescriptions. Demographics and retention in care over 12 months were summarized and participant satisfaction and pharmacist acceptability with the P-PrEP …

Lipophagy And Alcohol-Induced Fatty Liver, Li Yang, Changqing Yang, Paul G. Thomes, Kusum K. Kharbanda, Carol A. Casey, Mark A. Mcniven, Terrence M. Donohue

Journal Articles: Internal Medicine

This review describes the influence of ethanol consumption on hepatic lipophagy, a selective form of autophagy during which fat-storing organelles known as lipid droplets (LDs) are degraded in lysosomes. During classical autophagy, also known as macroautophagy, all forms of macromolecules and organelles are sequestered in autophagosomes, which, with their cargo, fuse with lysosomes, forming autolysosomes in which the cargo is degraded. It is well established that excessive drinking accelerates intrahepatic lipid biosynthesis, enhances uptake of fatty acids by the liver from the plasma and impairs hepatic secretion of lipoproteins. All the latter contribute to alcohol-induced fatty liver (steatosis). Here, our …

Stress Response And Performance Changes Of Law Enforcement Officers’ Marksmanship Under Varied Levels Of Stress, Brandon Michael Male

Graduate Research Theses & Dissertations

Objective: To investigate changes in physiological stress response and shooting performance of law enforcement officers under varying levels of stress. More specifically, the purpose of this study was to determine how increasing levels of stress from operating a firearm on static targets changes when law enforcement officers are subjected to a simulated life-threatening or dangerous situation.

Background: Performance changes associated with high levels of stress have been well documented in disciplines such as sports psychology, medicine, and military/law enforcement fields. However, little work has been done to draw comparisons between firearm training methods and qualification procedures which closely mimic armed …

Bioinformatics Haracterisation Of The (Mutated) Proteins Related To Andersen–Tawil Syndrome, Carlos Polanco, Vladimir N. Uversky, Manlio F. Márquez, Thomas Buhse, Miguel Arias Estrada, Alberto Huberman

Molecular Medicine Faculty Publications

In the last two decades, a group of proteins whose mutations are associated with a disease manifested by episodes of muscle weakness (periodic paralysis), changes in heart rhythm (arrhythmia), and developmental abnormalities has been under constant study. This malady is known as Andersen–Tawil syndrome, with ~60% of cases of this syndrome being caused by 16 mutations in the KCNJ2 gene [UniProt ID: P63252-01—P63252-17]. In this work, we present a computational study designed to obtain a fingerprint of Andersen–Tawil mutated proteins and differentiate them from mutated proteins associated with Brugada syndrome and from functional groups of proteins belonging to APD3, UniProt, …