Medicine and Health Sciences Commons^™

Hiv/Aids Research Insights: Impacts, Trends, Opportunities, Analytical Services, Elsevier

Public Reports

The United States is the top producer of HIV/AIDS related research, followed by the UK, South Africa and China. In terms of the relative activity in HIV/AIDS research, output is highest in Uganda, Kenya, South Africa and Nigeria, reflecting the high priority of this research in countries where the disability-adjusted life years lost due to HIV/AIDS per 100,000 individuals is high, along with the strong research culture in these countries.

Alzheimer's Disease Research Insights: Impacts, Trends, Opportunities, Analytical Services, Elsevier

Public Reports

Alzheimer’s disease research represents a steady share of global output. There is a focus on the peptide, amyloid-β, but interesting behavioral topics are emerging. To understand the landscape of Alzheimer’s disease research, we queried Scopus, the largest abstract and citation database of peer-reviewed literature.

Research on Alzheimer’s disease has increased steadily in volume since 1980 and 50,614 items related to Alzheimer’s disease were published from 2014-2018. Compared with global research output, Alzheimer’s disease research has grown at the same pace as research overall and has represented 0.35- 0.4% of all research done globally between 2012 and 2018.

Dna Damage And Cytokine Production In Non-Target Irradiated Lymphocytes, Jane Bryant, Laura Shields, Christopher Hynes, Orla L. Howe, Brendan Mcclean, Fiona Lyng

Articles

In advanced radiotherapy, treatment of the tumor with high-intensity modulated fields is balanced with normal tissue sparing. However, the non-target dose delivered to surrounding healthy tissue within the irradiated volume is a potential cause for concern. Whether the effects observed are caused after exposure to out-of-field radiation or bystander effects through neighboring irradiated cells is not fully understood. The goal of this study was to determine the effect of exposure to out-of-field radiation in lymphocyte cell lines and primary blood cells. The role of cellular radiosensitivity in altering bystander responses in out-of-field exposed cells was also investigated. Target cells were …

Intranasal Delivery Of Insulin By Nanoemulsion System, Darshana Mahendrakumar Shah

Theses and Dissertations

The main objective of this research was to develop an o/w nanoemulsion dosage form of insulin for intranasal delivery where insulin is loaded into the oil phase of the nanoemulsion for enhanced absorption. When loaded into the lipid droplets (oil phase), insulin can be protected from enzymatic degradation, can permeate through the mucus gel barrier in a comparatively efficient manner and can be absorbed through transcellular permeation along with paracellular route. To incorporate lipophilicity to insulin molecule, several complexes of insulin with various amphiphiles were developed to load it into the oil phase. The cytotoxicity of these amphiphiles and the …

Liquid Mosquito Repellent Ingestion In Children, Saptharishi Lalgudi Ganesan, Mounika V. Reddy, Karthik Narayanan Ramalingam, Muralidharan Jayashree, Sunit C. Singhi, Karthi Nallasamy, Arun Bansal, Arun K. Baranwal

Data and Test Instruments

No abstract provided.

Electrographic Seizure Burden And Outcomes Following Pediatric Status Epilepticus, Saptharishi Lalgudi Ganesan, Cecil Hahn

Data and Test Instruments

No abstract provided.

Community-Acquired Methicillin-Resistant Staphylococcus Aureus Infections In Acutely Ill Children: A Retrospective Case-Control Study, Saptharishi Lalgudi Ganesan, Ankita Mehta, Md, Keshavmurthy Lakshmikantha, Muralidharan Jayashree, Vikas Gautam, Pallab Ray

Data and Test Instruments

No abstract provided.

Enhancing Access For Student Nurse Athletes: Office Hours On The Road, Lorretta Krautscheid, Samuel Williams, Benjamin Kahn

Faculty Publications - College of Nursing

The purpose of this education innovation was to facilitate office hour (OH) instruction for student nurse athletes due to training schedules and off-campus travel. Effective integration of technology, learning theory, and multimedia resources provide strategies to enhance student athlete access to faculty OH and associated learning opportunities. Explain Everything™ software, a digital interactive whiteboard space, enables students and faculty to collaborate and learn across distance. This innovative approach enriches learning, ensuring OH access among student athletes.

Antibodies In The Diagnosis, Prognosis, And Prediction Of Psychotic Disorders., Thomas A Pollak, Jonathan P Rogers, Robert G Nagele, Mark Peakman, James M Stone, Anthony S David, Philip Mcguire

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Blood-based biomarker discovery for psychotic disorders has yet to impact upon routine clinical practice. In physical disorders antibodies have established roles as diagnostic, prognostic and predictive (theranostic) biomarkers, particularly in disorders thought to have a substantial autoimmune or infective aetiology. Two approaches to antibody biomarker identification are distinguished: a "top-down" approach, in which antibodies to specific antigens are sought based on the known function of the antigen and its putative role in the disorder, and emerging "bottom-up" or "omics" approaches that are agnostic as to the significance of any one antigen, using high-throughput arrays to identify distinctive components of the …

Urban Aerobiological Risk Mapping Of Ornamental Trees Using A New Index Based On Lidar And Kriging: A Case Study Of Plane Trees, Raúl Pecero-Casimiro, Santiago Fernández-Rodríguez, Rafael Tormo-Molina, Alejandro Monroy-Colín, Inmaculada Silva-Palacios, Juan Pedro Cortés-Pérez, Ángela Gonzalo-Garijo, J. M. Maya-Manzano

Articles

Ornamental trees bring benefits for human health, including reducing urban pollution. However, some species, such as plane trees (Platanus sp.), produce allergenic pollen. Consequently, urban maps are a valuable tool for allergic patients and allergists, but they often fail to include variables that contribute to the “building downwash effect”, such as the width and shape of streets and the height of buildings. Other factors that directly influence pollen dispersion (slopes and other geographical features) also have not traditionally been discussed. The LiDAR (Laser Imaging Detection and Ranging) technique enables one to consider these variables with high accuracy. This work proposes …

Evolution Of Occupational Therapy Practice: Life History Of Karen Jacobs Edd, Otr/L, Cpe, Faota, Katelyn Jennings, Abby Wendel

Oral History Posters

This life history is one of 30 life history interviews which are part of a larger project,Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) at the National Level and Beyond. The purpose of study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond. It is anticipated that the life history process will be a powerful way to gather …

The Evolution Of Occupational Therapy Practice: Life History Of Susan Haiman, Mps, Ot/L, Faota, Jacey Savage, Meaghan Wolfgram

Oral History Posters

Objective: This life history is one of 30 life history interviews, which are part of a larger project, Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) at the National Level and Beyond. The purpose of this qualitative study is to provide current and future generations of occupational therapists a view of the history of occupational therapy and how the practice has evolved from the beginning to its current practice through the life history stories of accomplished occupational therapists.

Method: An in-depth, semi-structured, 120-minute interview was conducted with Susan Haiman via telephone from the University of North …

Evolution Of Occupational Therapy Practice: Life History Of Patricia Scott Phd, Mph, Ot, Faota, Bethany Easthouse, Samantha Plutko

Oral History Posters

Purpose: The purpose of the study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond. It is anticipated that the life history process will be a powerful way to gather this information.

Methods: Data was collected from one semi-structured interview with Dr. Scott. The interview was conducted via teleconference through the program Zoom and lasted approximately two hours. The questions asked during …

Evolution Of Occupational Therapy Practice: Life History Of Mary Hager, Allison Moran, Grace Spanos

Oral History Posters

Objective: The purpose of this qualitative study using a life history approach is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond.

Method: A semi-structured phone interview was conducted between the student researchers and Mary Hager, a retired occupational therapist. The interview was audio-recorded and transcribed verbatim prior to data analysis. Codes, categories, and themes were synthesized from the interview to comprehend a …

Evolution Of Occupational Therapy Practice: Life History Of Lela Llorens, Ph.D., Otr/Ret, Faota., Rylee Skyberg, Rachel Grubb

Oral History Posters

Objective: The objective of the overall study was to gain insight into Dr. Lela Llorens’s life experiences and leadership throughout her time of work in the profession of occupational therapy.

Method: This was a qualitative study done using a life history approach. The participant was selected from a list compiled through purposive sampling by the project directors. Data was gathered through a two-hour, semi-structured interview with Dr. Llorens via Zoom, and through her curriculum vitae. The two-hour interview was audio-recorded and transcribed verbatim. Member checking was not used for the triangulation of the data. The data collapsed into …

Evolution Of Occupational Therapy Practice: Life History Of Ivelisse Lazzarini, Otd, Ashley Timm, Aspen Pitcher

Oral History Posters

This life history is one of 30 life history interviews which are part of a larger project,Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) at the National Level and Beyond. The purpose of study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond. It is anticipated that the life history process will be a powerful way to gather …

A Case Report: Treatment Of Facioscapulohumeral Muscular Dystrophy, Jeremy Korthuis

Physical Therapy Scholarly Projects

Purpose: The purpose of the case study was to explain a treatment program involving low/moderate intensity strength training and stretching for a patient with facioscapulohumeral muscular dystrophy (FSHD).

Background: FSHD is the third most common type of muscular dystrophy. This pathology results from a mutation in chromosome 4 and results in progressive weakening of facial, scapular, and hip musculature. Research behind effective strengthening programs is often inconclusive and varies in results.

Case Description: The patient was a 34-year-old female, who was diagnosed with FSHD 3 years prior to our first visit. She had complaints of left shoulder pain (2-3/10), shoulder …

Outpatient Pt Management Of Patient With Bilateral Knee Pain S/P Stem Cell Cartilage Replacement Therapy Of Both Knees, Justin Hett

Physical Therapy Scholarly Projects

Background and Purpose: This article describes the 6-week outpatient physical therapy management of a 65-year-old male who c/o bilateral knee pain s/p stem cell cartilage replacement therapy. The patient presented with decreased ROM in both knees R>L, difficulty ambulating moderate distances, knee pain, and decreased LE strength bilaterally. The purpose of this article is to describe the treatments used for this patient and the results from these treatments.

Description: The treatment of this patient involved range of motion, strengthening, patient education, and stretching.

Outcomes: Following PT intervention, the patient had increased ROM in both knees L>R, normal strength, …

Standard And Cognitive Four Square Step Test (Fsst), Renee Hoffman, Hannah Bucholz

Physical Therapy Scholarly Projects

Background/Purpose: The Four Square Step Test (FSST) measures dynamic standing balance and agility and was developed to identify older adults at risk for falls. It has a cognitive component for remembering the stepping sequence but has never been tested with an additional cognitive task. The purpose of this study was to collect normative data for the FSST and Cognitive FSST in community dwelling adults for various age groups.

Materials/Methods: Eighty-seven community-dwelling adults (55 females, 32 males) between the age 21 and 86 (48.22 years) were included in the study. Participants completed a fall risk checklist and a cognitive screen prior …

Outpatient Physical Therapy Management Of A Patient Diagnosed With Myotonic Muscular Dystrophy Type 2, Ashley Jobe

Physical Therapy Scholarly Projects

Background and Purpose. This article describes the 3-week outpatient Physical Therapy management of a 63-year-old female with a diagnosis of Myotonic Muscular Dystrophy (MMD) Type 2. MMD is an inherited disorder, which progressively impacts muscular, respiratory, cardiac, nervous, and endocrine systems. MMD Type 2 is characterized by muscle weakness, muscle pain, and myotonia. The patient in this case study presented to physical therapy with upper and lower extremity weakness and balance impairment. The purpose of this article is to describe the initial physical therapy evaluation process for a patient with MMD, as well as the interventions used for this patient …

Pelvic Examinations For Ovarian Cancer Screening In Asymptomatic Adult Women, Riann Collar

Physician Assistant Scholarly Project Posters

There is discrepancy amongst organizations and the medical community whether bimanual pelvic examinations should be performed in asymptomatic women for routine screening. The purpose of this literature review was to determine whether bimanual pelvic examinations are beneficial for screening for ovarian cancer in comparison to no screening. In addition, research was conducted to see if healthcare providers’ professional beliefs align with the evidence and national recommendations, to determine women’s thoughts and beliefs regarding pelvic examinations, and identify other screening methods if bimanual pelvic exams are determined to be an invalid screening tool. Throughout reviewing peer reviewed articles and high-quality evidence, …

Benefits Of Hpv Vaccination In Adolescent Males, Budd Theriot

Physician Assistant Scholarly Project Posters

HPV is the most common sexually transmitted infection in the United States, affecting approximately 75-80% of young adults at some point in their lives, and it is also known to be directly related to several forms of cancer including cervical, vaginal, penile, anal, oral, and oropharyngeal cancer. Vaccination against several high-risk strains of HPV first became available in the U.S. in June of 2006 and has been proven to be effective in creating antibodies against several strains of high-risk HPV, potentially decreasing and preventing more than 30,000 new cases of HPV related cancers each year. Despite this fact, HPV vaccination …

Comparison Of Hemodialysis And Peritoneal Dialysis Outcomes In The Older Adult Patient, Dane Rasmussen

Physician Assistant Scholarly Project Posters

The objective of this research and systematic literature review was to determine the dialysis modality of choice for elderly patients with end-stage renal disease. This literature review compared the outcomes of hemodialysis and peritoneal dialysis, which was judged by morbidity, mortality, and quality of life.

• PubMed, Embase, and DynaMedwere searched using a specific set of keywords and mesh headings. Results of the searches were then filtered to include human-only studies, patients over 65 years old, and published within the last ten years. There were 12 studies that met inclusion criteria and were selected.

• The studies suggested that there …

Parenteral Ascorbic Acid For Treatment Of Sepsis, Lindsey Hiatt

Physician Assistant Scholarly Project Posters

Sepsis kills nearly 1 million people each year in the United States and sepsis-related hospitalizations cost approximately $24 billion annually (Paoli, Reynolds, Sinha, Gitlin, & Crouser, 2018). Current treatment guidelines are limited to targeted antibiotics and hemodynamic support. While antibiotics are the definitive treatment to eradicate the infectious pathogen, there are currently no standard-of-care treatments that consistently and successfully attenuate the damage sustained to the body by its own inflammatory response to infection. Many different treatments have been trialed and failed to show improved outcomes. Vitamin C, or ascorbic acid, has long been associated with supporting immune function, and has …

The Use Of Dhea In The Treatment Of Depression, Bryan Tipton

Physician Assistant Scholarly Project Posters

No abstract provided.

Outcomes In Treatment Of Major Depressive Disorder: Pharmacogenomic Testing Vs. Treatment As Usual, Zachary Horoshak

Physician Assistant Scholarly Project Posters

• The goal of this scholarly project was to evaluate the efficacy of pharmacogenomic testing (PGx) versus treatment as usual (TAU) in the treatment of major depressive disorder (MDD). According to Huang & Lin (2015), MDD is characterized by multiple signs and symptoms consisting of mood, vegetative, cognitive, and even psychotic behaviors that may cause substantial impairment in the functioning and quality of life in an affected individual. This literature review consisted of articles found in PubMed, Cochrane, and PsychINFO which were extensively reviewed. Articles prior to 2008 were excluded due to the ever-changing landscape of PGx testing. In this …

Use Of Beta-Antagonists Or Hmg-Coa Reductase Inhibitors For Cardioprotection During Chemotherapy In Oncology Patients, Nicole Streich

Physician Assistant Scholarly Project Posters

Over the years, oncologists are better able to fight cancer and have increased cancer survival, but we are also finding that these lifesaving therapies can affect the heart and other parts of the body in a negative way. Chemotherapy is excellent at destroying cancer cells, but it also causes collateral damage to other healthy cells. There are certain chemotherapeutic agents that are known to cause cardiotoxicity. Currently we are monitoring the heart function of the patients who are receiving these cardiotoxic drugs prior to starting the chemotherapy as well as during and after treatment. However, there are currently no recommendations …

Glucagon-Like Peptide-1s Compared To Sulfonylureas In The Treatment Of Adults Diagnosed With Type Ii Diabetes Mellitus In Primary Care, Tracy Kirchner

Physician Assistant Scholarly Project Posters

Type II diabetes mellitus (T2DM) is a prevalent disease in our country. Bullard et al. (2018) report approximately 21 million adults have T2DM in the United States. “The total estimated cost of diagnosed diabetes in 2017 is $327 billion, including $237 billion in direct medical costs and $90 billion in reduced productivity” (Yang et al., 2018). Treatment of T2DM is individualized to each patient based on their co-morbidities, fiscal responsibility, and route of administration options. Sulfonylureas and Glucagon-like Peptide-1s (GLP-1) are two classes of antidiabetic drugs that are available for use as second line treatment options after metformin. This review …

Obesity: Modern Medicine Vs. Lifestyle, Jenny Christianson

Physician Assistant Scholarly Project Posters

• Obesity is a rising epidemic, and is one of the most common, costly and preventable health problems the world is experiencing today (Center for Disease Control and Prevention, [CDC], 2017).

• From this, it is important to establish an effective treatment plan that can be implemented across the nation for maximum patient benefit.

• Lifestyle changes such as diet and exercise are important to any health care plan and are equally necessary to reduce health risks. However, in certain patients, lifestyle changes are not enough due to the maladaptive biologic process in their brain. Thus, additional treatment options need …

Evolution Of Occupational Therapy Practice: Life History Of Kathlyn L. Reed, Ph.D., Otr, Faota, Mlis, Tristen Smith, Audrya Tarango

Oral History Posters

This life history is one of 30 life history interviews which are part of a larger project, Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) at the National Level and Beyond. The purpose of the study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond. It is anticipated that the life history process will be a powerful way …