Medicine and Health Sciences Commons^™

Comparison Of Pharmacologic Treatments For Postmenopausal Osteoporosis, Kaitlyn Wirtz

Physician Assistant Scholarly Project Posters

The prevalence of osteoporosis in the United States in adults > 50 years of age is “more than 10 million people overall and 33 million have low bone mineral density (BMD) at the hip” (DynaMed Plus, 2018).

 To combat postmenopausal osteoporosis, two treatment options include bisphosphonates and the anti-receptor activator of nuclear factor kappa β ligand (RANKL) agent (denosumab).

 The purpose of this scholarly project is to determine if there is a statistical significance regarding safety, efficacy, and preference between bisphosphonates and denosumab.

 Three databases were searched: PubMed, CINAHL, and Cochrane Database of Systematic Reviews. Topics researched included: …

Athletic Identity, Need Satisfaction, And Burnout In Collegiate Athletes, Rachel Brooke Daniels

Online Theses and Dissertations

PURPOSE: The relationship between need satisfaction and burnout has been well defined in literature, but studies of the relationship between athletic identity and burnout have produced varying results. The purpose of this study is to examine the factors that may contribute to burnout in athletes by determining the direction and strength of a relationship between burnout, athletic identity, and need satisfaction.

METHODS: In this study, an online survey was distributed to a population of NCAA Division I varsity and club student-athletes. The survey consisted of demographic questions, the Athletic Identity Measurement Scale (AIMS), the Basic Need Satisfaction in Sport Scale …

The Treatment Of Shoulder Dysfunction By The Correction Of Shouler Girdle Muscle Imbalances: A Case Study, Zachary Peterson

Physical Therapy Scholarly Projects

Background and Purpose: Shoulder dysfunction is a broad expression that encompasses the shoulder girdle not being able to perform fluently, without pain, or within normal ranges of motion. Current literature elaborates on potential causes of dysfunction such as: osteoarthritis, impingement syndrome, and cervical myelopathy. From a clinical standpoint, it is crucial to differentiate between possible diagnoses to ensure the proper treatment is utilized.

Case Description: The patient was a 66‐year‐old female who was referred with the initial diagnosis of shoulder osteoarthritis. She presented with headache pain that was debilitating and followed a pattern consistent with muscle guarding, limited L shoulder …

Santa Clara Magazine, Volume 61 Number 1, Winter 2019, Santa Clara University

Santa Clara Magazine

14 - IN THE BEGINNING An interview with Santa Clara University President Kevin O’Brien, S.J. on what's next and noticing what we swim in. Matt Morgan

22 - ADAM, EVE, AND THE APPLE If making—and appreciating—art makes us human, what happens when we get help making a masterpiece from something unhuman? Lauren Loftus.

28 - BEDROCK When faced with tough decisions, Santa Clara values stand as good guides, says Leon Panetta ’60, J.D. ’63. Leslie Griffy.

Ovalbumin-Sensitized Mice Have Altered Airway Inflammation To Agriculture Organic Dust, Kristi J. Warren, John D. Dickinson, Amy J. Nelson, Todd A. Wyatt, Debra J. Romberger, Jill A. Poole

Journal Articles: Environmental, Agricultural & Occupational Health

Agriculture exposures are associated with reducing the risk of allergy and asthma in early life; yet, repeated exposures later in life are associated with chronic bronchitis and obstructive pulmonary diseases. The objective of this study was to investigate the airway inflammatory response to organic dust extract (ODE) in mice with established ovalbumin (OVA)-induced experimental asthma. C57BL/6 mice were either OVA sensitized/aerosol-exposed or saline (Sal) sensitized/aerosol-challenged. Both groups were then subsequently challenged once with intranasal saline or swine confinement ODE to obtain 4 treatment groups of Sal-Sal, Sal-ODE, OVA-Sal, and OVA-ODE. Airway hyper-responsiveness (AHR) to methacholine, bronchiolar lavage fluid, lung tissues, …

Characterizing The Development Of Episodic Memory And Assessing The Reliability Of Fmri Measures, Lingfei Tang

Wayne State University Dissertations

The ability to remember past events is critical for everyday life and showed robust improvement over development from childhood to adulthood. With advances in noninvasive neuroimaging methods such as functional MRI in recent years, research efforts have been focused on identifying neural correlates underpinning developmental gains in memory performance. In my dissertation work, using a widely-validated subsequent memory paradigm, I aim to characterize functional MRI correlates of memory development. Specifically, I focused my investigation on identifying age differences in the functional patterns of two brain regions critical for memory, the prefrontal cortex and the hippocampus. Focusing on the prefrontal cortex …

Introduction: Notes From The Bedside, Sheila P. Davis

Journal of Health Ethics

No abstract provided.

Living With Productive Discomfort: Ethical Reflections On Critical Care Medicine, Peter A. Depergola Ii

Journal of Health Ethics

In this essay, the author considers the theme of deaths and resurrections in light of uncertain outcomes, and captures the pressure on ethicists to always know “the right thing to do.”

The Bionic Brain: Pragmatic Neuroethics And The Moral Plausibility Of Cognitive Enhancement, Peter A. Depergola Ii

Journal of Health Ethics

The seemingly infinite possibilities of contemporary neuroscience span from the augmentation of memory, executive function, appetite, libido, sleep, and mood, to the maturation and development of emotional health and personality. These prospects hint at the capacity to alter neurocognitive conceptions of reality. They also mark the unavoidable inculcation of nuanced individual responses, perhaps radical, to these “tailor- made” perceptions. Hence, there exists certain neuroethical, and even more generally, existential risks within this fascinating and expeditious enterprise. The primary question in the context of present-day neurotechnology is not what can be done, but what should be. To that end, this paper …

Consequences Of Pathogen Lists: Why Some Diseases May Continue To Plague Us, David Brett-Major, Trina Racine, Gary P. Kobinger

Journal Articles: Epidemiology

The current strategy used by many funding agencies for determining how money is spent on research to help prevent infectious disease outbreaks is based on pathogen-specific priority lists. Listing disease threats provides focus for business and research planning conducive to specific goals of developing a drug, or a vaccine, or other particular product. But, this singular type of focus has consequences. This perspective explores the consequences of lists, and describes how parallel programming independent of disease lists that address what we need to do to prevent and mitigate emerging disease risks may provide benefits out of reach of a singular …

Low Albumin And Mortality, Judith L. Dedeker

DNP Research Projects

Sepsis is a major epidemic worldwide and is a large unmet medical need in this country. Annual costs for the treatment of sepsis are over $3.4 billion dollars, and over 1.7 million people die each year from sepsis. Effective treatment of sepsis has two major obstacles: failure to recognize the early stages of sepsis and misjudging the severity of the disease. Identifying patients who are at higher risk for mortality and morbidity related to sepsis would be beneficial in keeping the numbers of deaths down, as well as decreasing the overall cost to the hospitals, as well as to the …

An Assessment Of Attitudes And Perceptions Of College Students Toward A Suicide Program On A College Campus: A Descriptive Study, Rachel Tolliver

DNP Research Projects

OBJECTIVE: A baseline assessment examines the status of attitudes and perceptions about the suicide prevention program of a small, private, southeastern, Christian university. Gaps in the literature include the lack of baseline evaluations at universities before evidenced-based practice (EBP) interventions.

PARTICIPANTS: A purposive sample of sixty-nine sophomores classified as first-year students for the 2016-2017 school year. The study sample lived on campus both semesters of the 2016-2017 school year.

METHODS: Participants completed the retired Suicide Prevention Exposure, Awareness and Knowledge Survey (SPEAKS) – SV (Student Version) by the Substance Abuse & Mental Health Services Administration (SAMHSA) for the Garrett …

Effect Of Abo Blood Group On Asymptomatic, Uncomplicated And Placental Plasmodium Falciparum Infection: Systematic Review And Meta-Analysis, Abraham Degarege, Merhawi T. Gebrezgi, Consuelo M. Beck-Sague, Mats Wahlgren, Luiz Carlos De Mattos, Purnima Madhivanan

Journal Articles: Epidemiology

BACKGROUND: Malaria clinical outcomes vary by erythrocyte characteristics, including ABO blood group, but the effect of ABO blood group on asymptomatic, uncomplicated and placental Plasmodium falciparum (P. falciparum) infection remains unclear. We explored effects of ABO blood group on asymptomatic, uncomplicated and placental falciparum infection in the published literature.

METHODS: A systematic review and meta-analysis was performed using the preferred reporting items for systematic reviews and meta-analyses guidelines. Articles in Pubmed, Embase, Web of Science, CINAHL and Cochrane Library published before February 04, 2017 were searched without restriction. Studies were included if they reported P. falciparum infection incidence or prevalence, …

The Impact Of Travel Time On Colorectal Cancer Stage At Diagnosis In A Privately Insured Population, Mesnad Alyabsi, Mary Charlton, Jane L. Meza, K. M. Monirul Islam, Amr Soliman, Shinobu Watanabe-Galloway

Journal Articles: Epidemiology

BACKGROUND: Rural residents are less likely to receive screening for colorectal cancer (CRC) than urban residents. However, the mechanisms underlying this disparity, especially among people aged 50-64 years old with private health insurance, are not well understood. We examined the impact of travel time on stage at CRC diagnosis.

METHODS: This retrospective cohort study used data from the Blue Cross and Blue Shield of Nebraska. Members of this private insurance company aged 50-64 years, diagnosed with CRC during the period 2012-2016, and continuously enrolled in the insurance plan for at least 6 months prior to CRC diagnosis, were selected for …

Vaccination Coverage And Awareness Of Hepatitis B Virus Among Healthcare Students At A University In Cyprus, Zoe Roupa, Maria Noula, Evi A. Farazi, Antonis Stylianides, Christos Papaneophytou

Journal Articles: Epidemiology

Introduction: The risk for healthcare students to get infected by transmitting infectious viruses, including hepatitis B virus (HBV), in a hospital setting is extremely high through exposure to blood and/or body secretions.

Aim: The aim of this work was to evaluate both the vaccination history of healthcare students at a University in Cyprus and their serologic immunity against HBV. In addition, we assessed their knowledge and behaviors towards the transmission and prevention of hepatitis B (HB).

Results: Total amount of 168 students participated in this study and more than 50% of them provided complete documentation of vaccination history against HBV. …

Awareness Of Human Papilloma Virus And Cervical Cancer Prevention Among Cypriot Female Healthcare Workers, Andria Christodoulou, Jirayr Ajzajian, Dejun Su, Hongmei Wang, Zoe Roupa, Evi A. Farazi

Journal Articles: Epidemiology

Background: Cervical cancer incidence varies around the world with the highest rates in Eastern Africa and the lowest rates in Western Asia. In Cyprus, a small Mediterranean island, cervical cancer incidence was 6.4 per 100,000 in 2013. HPV is an established risk factor for cervical cancer with HPV-16 and HPV-18 being the most common carcinogenic strains. Cervical cancer is preventable through primary (HPV vaccination) and secondary (Pap and HPV tests) prevention. These prevention methods should be promoted, however, in order to design a cancer prevention programme and the awareness and characteristics of populations should be investigated so that prevention programmes …

Project-Based Learning, Paulchris Okpala

Q2S Enhancing Pedagogy

Reflection Statement regarding Project-based learning.

The adoption of the project-based learning (PBL) that was held in 2018 Winter Institute requires me to use new instructional strategies that allow me to take up the role of a guide or facilitator in the learning process. Without adequate support, the adoption of PBL-based instructional strategies and the subsequent transition from direct-instructional approaches to strategies that require me to carry out coaching and modeling can be challenging. Changing from the direct-instructional approaches to the PBL-based instructional strategies requires thorough preparation, guidance, and evidence-based approaches. Thus, in 2018 Winter Institute, I learned better ways of …

Draft: Department Of Nursing Master Of Science In Nursing Eportfolio Policy, Cheryl Brandt

Q2S Enhancing Pedagogy

The purpose of the Department of Nursing Master of Science in Nursing program portfolio requirement was unclear. To clarify the portfolio purpose and process, and to update from a paper to an electronic portfolio format, a detailed ePortfolio policy was drafted in the course of the Teaching Resource Center 2019 Summer ePortfolio Institute. Reflection prompts and a scoring rubric were to be finalized after approval of the policy. The policy was submitted to the Department of Nursing Graduate Affairs Committee for review and approval. Ironically, the discussion of the policy among Graduate Affairs Committee members culminated in a decision to …

Acue Course In Effective Teaching Practices: The Impact On Student Learning, Danuta Wojnar

Q2S Enhancing Pedagogy

Association of College and University Educators (ACUE) Course in Effective Teaching Practices, consisting of a total of 25 modules, provides an opportunity to learn how to design courses, engage learners, and establish a productive learning environment in both online and face-to-face teaching format. Upon completion of each module, course participants reflect on potential benefits of the proposed solutions and interventions.

Keywords: Q2S, ACUE, college education, course design, learning environment

Public Health And Personal Choice: The Ethics Of Vaccine Mandates And Parental Refusal In The United States, Rebecca Horan, Jonelle Depetro

2019 Awards for Excellence in Student Research and Creative Activity – Documents

In January 2019 The World Health Organization (WHO) released its list Ten threats to global health in 2019. For the first time ever, vaccine hesitancy, “the reluctance or refusal to vaccinate despite the availability of vaccine services” is officially on the list.1 Although great progress has been made in reducing or eradicating various diseases such as polio, measles, and whooping cough (pertussis), the number of parents refusing vaccination for their children is growing rapidly in what is now often referred to as the “anti-vaccination movement” ( or “anti-vax movement”). This is causing a threat to public health as …

The Relationship Between Participation In Community-Level Service-Learning And Career Plans To Practice In Underserved Areas Among 4th-Year Medical Students, Felicia Bolden Mobley

Graduate Research Theses & Dissertations

Service-learning is a form of experiential learning that allows students to combine knowledge acquired in the classroom with community-level experiences. In medical education, service-learning provides medical students the opportunity to apply clinical knowledge to health-related experiences within communities in an effort to prepare them to address the health needs of communities after they graduate. Research shows that without service-learning opportunities, some medical students may lack a level of compassion and empathy that is necessary to treat medically underserved patients.

A secondary data analysis was conducted using 4th-year medical students’ survey responses on the Association of American Medical Colleges Graduation Questionnaire …

U.S. Adult Perceptions Of The Harmfulness Of Tobacco Products: Descriptive T Findings From The 2013–14 Baseline Wave 1 Of The Path Study, Geoffrey T. Fong, Tara Elton-Marshall, Pete Driezen, Annette R. Kaufman, K. Michael Cummings, Kelvin Choi, Jonathan Kwan, Amber Koblitz, Andrew Hyland, Maansi Bansal-Travers, Charles Carusi, Mary E. Thompson

United States Food and Drug Administration: Publications

Introduction: This study is the first nationally representative survey of U.S. adults (18+) to examine perceptions of the relative harms of eight non-cigarette tobacco products.

Methods: Data are from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study Adult Questionnaire, a nationally representative study of 32,320 adults in the United States conducted from September 2013 to December 2014.

Results: 40.7% of adults believed that electronic cigarettes were less harmful than cigarettes, and 17.8% of adults believed that hookah was less harmful than cigarettes. Those less knowledgeable about the health risks of smoking were more likely to believe …

Down-Regulation Of Circular Rnaitch And Circhipk3 In Gastric Cancer Tissues, Sara Ghasemi, Modjtaba Emadi-Baygi, Parvaneh Nikpour

Turkish Journal of Medical Sciences

Background/aim: Gastric cancer (GC) is one of the major causes of cancer mortality worldwide. As a novel type of endogenous noncoding RNAs, circular RNAs (circRNAs) are formed by a covalent link between 5' and 3' ends. They are very stable and abundant in eukaryotes. As there were no reported studies on the expression profiles of circular RNA ITCH (cir-ITCH) and circHIPK3 in GC, in the current study, we aimed to delineate the expression profiles and clinicopathological relevance of these two circRNAs in GC tissues compared to their paired adjacent noncancerous tissues.Materials and methods: Quantitative real-time polymerase chain reaction was performed …

Speech Language Pathology Graduate Handbook - 2018-2019, Department Of Audiology And Speech-Language Pathology, East Tennessee State University

Speech-Language Pathology Handbooks

No abstract provided.

The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine, Alexandra Thomas

Yale Medicine Thesis Digital Library

Major depressive disorder is a common and debilitating illness for which there is a notable lack of efficient, effective treatment. While currently available pharmacotherapies typically take eight weeks to take effect and fail to do so at all for about a third of patients, the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown a much more favorable effectiveness profile, including improvements in symptoms within hours of administration, even for many patients who do not respond to typical antidepressants. Ketamine, as a modulator of glutamate signaling in the brain, has a distinct mechanism of action from the serotonin and norepinephrine modulators that …

Identifying Quantitative Enhancement-Based Imaging Biomarkers In Patients With Colorectal Cancer Liver Metastases Undergoing Loco-Regional Tumor Therapy, Mansur Abdul Ghani

Yale Medicine Thesis Digital Library

The purpose of this study was to test and compare the ability of radiologic measurements of lesion diameter, volume, and enhancement on baseline magnetic resonance (MR) images to be predictors of overall survival (OS) and markers of treatment response in patients with liver-dominant colorectal cancer metastases undergoing loco-regional tumor therapies.

This retrospective study included 88 patients with colorectal cancer (CRC) liver metastases, treated with transarterial chemoembolization (TACE) or Y90 transarterial radioembolization (TARE) between 2001 and 2014. All patients received contrast-enhanced MRI prior to therapy. Semi-automated whole liver and tumor segmentations of three dominant lesions were performed on baseline MRI to …

The Genetics Of Vein Of Galen Malformation And Assessment Of Candidate Genes In Xenopus Tropicalis, Jonathan Read Gaillard

Yale Medicine Thesis Digital Library

The Vein of Galen Malformation (VOGM) is a specific subtype of arteriovenous malformation (AVM) that becomes evident in weeks 6-11 of embryonic development. VOGM comprise less than 1% of all vascular malformations, yet represent 30% of all pediatric intracranial vascular malformations. Depending on their specific characteristics, i.e. its feeding vessels, it can present clinically as devastating congestive heart failure in neonates, hydrocephalus in children, or seizures and headaches in young adults. Advances in treatment provide improved survival, primarily through endovascular surgery. The genetic and molecular etiology of VOGM remains relatively unknown, with the only associated genes being in the context …

Outcomes Of Human Papillomavirus-Associated Head And Neck Cancers, Hong Li

Yale Medicine Thesis Digital Library

Head and neck cancers are the 6th most common solid cancer in the world. Human papillomavirus (HPV) infections are now accepted to be a previously unrecognized causative agent for head and neck squamous cell carcinomas (HNSCCs). However, research surrounding HPV’s effect at non-oropharynx sub-site is limited. There is also mixed literature over the prognostic effect of patient sex and age on overall survival in HNSCCs. We sought to utilize the National Cancer Database from 2004-2013 to evaluate the outcomes of the aforementioned objectives. Univariate and multivariate survival analyses were conducted with chi-square tests, Kaplan-Meier estimates, log-rank tests, and Cox proportional …

Home Visits In Internal Medicine Graduate Medical Education, Amitte Rosenfeld

Yale Medicine Thesis Digital Library

Home-based care training is largely absent from internal medicine (IM) graduate medical education, and home-based care program evaluation largely focuses on resident attitudes and satisfaction, rather than impact on practice or the patient experience. In the 2015-16 academic year, the Yale Primary Care Internal Medicine residency program (YPC) incorporated required home visits for all PGY-1s and PGY-2s. These visits are intended to build unique clinical skillsets, enhance education about the role of psychosocial determinants of health, and potentially impact resident wellbeing. A qualitative method was used to evaluate this program with the goal of characterizing the impact of one-time home …

Exploring The Effectiveness Of A Computer-Delivered Alcohol Intervention In First-Generation College Students, Pamela Helen Taylor

Graduate Research Theses & Dissertations

First-generation (first-gen) students encounter not only the typical anxieties and

aggravations of attending college but also face stressors from social and cultural transitions.

Social adjustment, including college alcohol use, directly affects the success of a first-gen

student. Due to an increased reliance on computer-delivered alcohol interventions (CDIs) and

the growth in the number of first-gen college students, a need has emerged to investigate

alcohol use and web-based interventions among this population. Exploring the effectiveness of

CDIs and first-gen experiences will increase knowledge and improve current practice on

college campuses.

Methods

Phase 1: A systematic review using the reach, effectiveness, adoption, …