Medicine and Health Sciences Commons^™

Recruitment Via Social Media: Advantages And Potential Biases, C. Benedict, A. L. Hahn, M. A. Diefenbach, J. S. Ford

Journal Articles

© The Author(s) 2019. Background: Adolescent and young adult (AYA) cancer survivors are under-represented in research. Social media is increasingly used for recruitment given its ability to reach large audiences. Differences in participant characteristics and potential biases due to recruitment source are not well understood. Purpose: This study aimed to: (a) compare recruitment strategies (hospital-based v. social media) in enrollment metrics, and (b) among enrolled participants, evaluate group differences in patient characteristics and patient reported outcomes (PROs). Methods: Preliminary data from a cancer and fertility study with female AYAs were evaluated. Hospital-based recruitment used electronic medical records (EMR) to identify …

Ileal Adenocarcinoma With Liver Metastasis In Patient With Crohn's Disease: A 9-Year Survival., J. P. Kothadia, D. H. Nagaraju, S. Katz, H. Bruckner, S. H. Itzkowitz, M. Schwartz

Journal Articles

Small bowel adenocarcinoma is a rare but well-known complication of Crohn's disease. The diagnosis of small bowel adenocarcinoma remains difficult since its presentation is highly variable and mimics active or obstructive Crohn's disease. The diagnosis is often delayed and typically detected only at surgery in an advanced stage with a poor prognosis. We report a case of metastatic ileal adenocarcinoma in a patient with Crohn's disease with prolonged survival. Our case describes serial promising treatment options of these advanced malignancies and raises a possible role for checkpoint immunotherapy.

Behavioral Economics Implementation: Regret Lottery Improves Mhealth Patient Study Adherence., S. A. Husain, K. Diaz, J. E. Schwartz, F. E. Parsons, M. M. Burg, K. W. Davidson, I. M. Kronish

Journal Articles

Background: Nonadherence to study protocols reduces the generalizability, validity, and statistical power of longitudinal studies.

Purpose: To determine whether an automated electronically-delivered regret lottery would improve adherence to an intensive mHealth self-monitoring protocol as part of a longitudinal observational study.

Methods: We enrolled 77 adults into a 52-week study requiring five daily ecologic momentary assessments (EMA) of stress and daily accelerometer use. We performed a pre/post single-arm study to evaluate the efficacy of a lottery intervention in improving adherence to this protocol. Midway through the study, participants were invited to enter a weekly regret lottery ($50 prize, expected value

Results: …

Randomised Prospective Trial To Assess The Clinical Utility Of Multianalyte Assay Panel With Complement Activation Products For The Diagnosis Of Sle., D. J. Wallace, R. V. Alexander, T. O'Malley, A. Khosroshahi, M. Hojjati, K. Loupasakis, J. Alper, Y. Sherrer, S. Narain, T. Dervieux, +6 Additional Authors

Journal Articles

Objective: We compared the physician-assessed diagnostic likelihood of SLE resulting from standard diagnosis laboratory testing (SDLT) to that resulting from multianalyte assay panel (MAP) with cell-bound complement activation products (MAP/CB-CAPs), which reports a two-tiered index test result having 80% sensitivity and 86% specificity for SLE.

Methods: Patients (n=145) with a history of positive antinuclear antibody status were evaluated clinically by rheumatologists and randomised to SDLT arm (tests ordered at the discretion of the rheumatologists) or to MAP/CB-CAPs testing arm. The primary endpoint was based on the change in the physician likelihood of SLE on a five-point Likert scale collected before …

Defining Inflammatory Cell States In Rheumatoid Arthritis Joint Synovial Tissues By Integrating Single-Cell Transcriptomics And Mass Cytometry, F. Zhang, K. Wei, K. Slowikowski, C. Y. Fonseka, A. Rao, Kelly, S. M. Goodman, D. Tabechian, P. K. Gregersen, S. Raychaudhuri, +55 Additional Authors

Journal Articles

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibroblasts from 51 samples of synovial tissue from patients with RA or osteoarthritis (OA). Utilizing an integrated strategy based on canonical correlation analysis of 5,265 scRNA-seq profiles, we identified 18 unique cell populations. Combining mass cytometry and transcriptomics revealed cell states expanded in RA synovia: THY1(CD90) + HLA-DRA hi sublining fibroblasts, IL1B + …

Erratum: Distinct Hla Associations With Rheumatoid Arthritis Subsets Defined By Serological Subphenotype (The American Journal Of Human Genetics (2019) 105(3) (616–624), (S0002929719303052), (10.1016/J.Ajhg.2019.08.002)), C. Terao, B. Brynedal, Z. Chen, X. Jiang, Westerlind, Hansson, P. J. Jakobsson, K. Lundberg, P. K. Gregersen, S. Raychaudhuri, +10 Additional Authors

Journal Articles

© 2019 The Author(s) (The American Journal of Human Genetics 105, 616–624; September 5, 2019) In the originally published version of this article, the first author, Chikashi Tereo, had footnotes indicating affiliations with the first seven institutions. The correct affiliations are the first six plus footnote 17, indicating equal contribution. This error has been corrected here and online, and the authors and copyeditor express their regret for the mistake.

Fc Receptor-Like 2 (Fcrl2) Is A Novel Marker Of Low-Risk Cll And Refines Prognostication Based On Ighv Mutation Status, L. K. Shea, K. Honjo, D. T. Redden, E. Tabengwa, Li, J. Li, M. Shakhmatov, N. Chiorazzi, R. S. Davis

Journal Articles

No abstract provided.

Clinically Significant Gains In Skillful Grasp Coordination By An Individual With Tetraplegia Using An Implanted Brain-Computer Interface With Forearm Transcutaneous Muscle Stimulation, M. Bockbrader, N. Annetta, D. Friedenberg, M. Schwemmer, Skomrock, Colachis, M. Zhang, C. Bouton, A. Rezai, W. J. Mysiw, +1 Additional Author

Journal Articles

© 2019 American Congress of Rehabilitation Medicine Objective: To demonstrate naturalistic motor control speed, coordinated grasp, and carryover from trained to novel objects by an individual with tetraplegia using a brain-computer interface (BCI)-controlled neuroprosthetic. Design: Phase I trial for an intracortical BCI integrated with forearm functional electrical stimulation (FES). Data reported span postimplant days 137 to 1478. Setting: Tertiary care outpatient rehabilitation center. Participant: A 27-year-old man with C5 class A (on the American Spinal Injury Association Impairment Scale) traumatic spinal cord injury Interventions: After array implantation in his left (dominant) motor cortex, the participant trained with BCI-FES to control …

Rnai Transfection Optimized In Primary Naïve B Cells For The Targeted Analysis Of Human Plasma Cell Differentiation, T. Shih, S. De, B. J. Barnes

Journal Articles

Upon antigen recognition, naïve B cells undergo rapid proliferation followed by differentiation to specialized antibody secreting cells (ASCs), called plasma cells. Increased circulating plasma cells are reported in patients with B cell-associated malignancies, chronic graft-vs.-host disease, and autoimmune disorders. Our aim was to optimize an RNAi-based method that efficiently and reproducibly knocks-down genes of interest in human primary peripheral B cells for the targeted analysis of ASC differentiation. The unique contributions of transcriptional diversity in species-specific regulatory networks and the mechanisms of gene function need to be approached directly in human B cells with tools to hone our basic inferences …

The Bin1 Rs744373 Snp Is Associated With Increased Tau-Pet Levels And Impaired Memory, N. Franzmeier, A. Rubinski, J. Neitzel, M. Ewers, W. Weiner, Aisen, R. Petersen, C. R. Jack, P. Davies, B. Ances, +90 Additional Authors

Journal Articles

© 2019, The Author(s). The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer’s disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown. Here we find in 89 older individuals without dementia, that BIN1 rs744373 risk-allele carriers show higher AV1451 tau-PET across brain regions corresponding to Braak stages II–VI. In contrast, the BIN1 rs744373 SNP was not associated …

Altered Dynamics Of Visual Contextual Interactions In Parkinson's Disease., M. I. Vanegas, A. Blangero, J. E. Galvin, A. Di Rocco, A. Quartarone, M. F. Ghilardi, S. P. Kelly

Journal Articles

Over the last decades, psychophysical and electrophysiological studies in patients and animal models of Parkinson's disease (PD), have consistently revealed a number of visual abnormalities. In particular, specific alterations of contrast sensitivity curves, electroretinogram (ERG), and visual-evoked potentials (VEP), have been attributed to dopaminergic retinal depletion. However, fundamental mechanisms of cortical visual processing, such as normalization or "gain control" computations, have not yet been examined in PD patients. Here, we measured electrophysiological indices of gain control in both space (surround suppression) and time (sensory adaptation) in PD patients based on steady-state VEP (ssVEP). Compared with controls, patients exhibited a significantly …

Ieeg-Bids, Extending The Brain Imaging Data Structure Specification To Human Intracranial Electrophysiology, C. Holdgraf, S. Appelhoff, S. Bickel, K. Bouchard, S. D'Ambrosio, O. David, O. Devinsky, B. Dichter, A. Flinker, D. Hermes, +29 Additional Authors

Journal Articles

No abstract provided.

Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments, M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors

Journal Articles

No abstract provided.

Deep Brain Stimulation: Current Challenges And Future Directions, A. M. Lozano, N. Lipsman, H. Bergman, P. Brown, S. Chabardes, J. W. Chang, K. Matthews, C. C. Mcintyre, M. Schulder, J. K. Krauss, +3 Additional Authors

Journal Articles

No abstract provided.

An Effective Method For Acute Vagus Nerve Stimulation In Experimental Inflammation, A. S. Caravaca, A. L. Gallina, L. Tarnawski, K. J. Tracey, V. A. Pavlov, Y. A. Levine, P. S. Olofsson

Journal Articles

© 2019 Caravaca, Gallina, Tarnawski, Tracey, Pavlov, Levine and Olofsson. Neural reflexes regulate inflammation and electrical activation of the vagus nerve reduces inflammation in models of inflammatory disease. These discoveries have generated an increasing interest in targeted neurostimulation as treatment for chronic inflammatory diseases. Data from the first clinical trials that use vagus nerve stimulation (VNS) in treatment of rheumatoid arthritis and Crohn’s disease suggest that there is a therapeutic potential of electrical VNS in diseases characterized by excessive inflammation. Accordingly, there is an interest to further explore the molecular mechanisms and therapeutic potential of electrical VNS in a range …

Spectrotemporal Modulation Provides A Unifying Framework For Auditory Cortical Asymmetries, A. Flinker, W. K. Doyle, A. D. Mehta, O. Devinsky, D. Poeppel

Journal Articles

No abstract provided.

Physician Assistant Fort Meyers, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Occupational Therapy Fort Lauderdale 2019, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

A Website Designed To Equip Occupational Therapists With Information And Strategies For Holistically Addressing Sexual Activity With The Geriatric Population, Amber Fernandez, Ashleigh Mora

Occupational Therapy Capstones

As individuals age, they are likely to experience occupational deprivation. Occupational deprivation occurs in many forms. Many older adults experience occupational deprivation relating to the activity of daily living, sexual activity. Older adults experience many age-related changes, which impacts their ability to engage in sexual activity. Health care professionals have a responsibility to ensure older adults are able to engage in safe sexual practices. Yet, healthcare professionals, including occupational therapists, are not addressing this need with their clients in a routine manner. A literature review was conducted in order to gain a comprehensive understanding of all the barriers older adults …

The Perception Of School Food-Service Professionals On The Implementation Of The Healthy, Hunger-Free Kids Act Of 2010: A Mixed-Methods Study, Zainab Rida, Elisha Hall, Saima Hasnin, Jessie Coffey, Dipti Dev

Department of Child, Youth, and Family Studies: Faculty Publications

Objective: To: (i) understand the nutrition attitudes, self-efficacy, knowledge and practices of school food-service personnel (SFP) in Nebraska and (ii) identify potential barriers that schools face in offering healthy school meals that meet the US Department of Agriculture (USDA) nutrition standards.

Design: Convergent parallel mixed-methods study.

Setting: Kindergarten–12th grade schools in Nebraska, USA.

Participants: SFP (260 survey participants; fifteen focus group participants) working at schools that participate in the USDA National School Lunch Program.

Results: Mixed-methods themes identified include: (i) ‘Mixed attitudes towards healthy meals’, which captured a variety of conflicting positive and negative attitudes depending on the situation; (ii) …

Ada News Convention Daily - 2019 Day 2, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Ada News Convention Daily - 2019 Day 3, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Ada Constitution & Bylaws (2019), American Dental Association

Constitution & Bylaws

The ADA Commons Constitution & Bylaws archival collection comprises printed issues of the American Dental Association's Constitution and Bylaws. The collection also includes the ADA Charter and the ADA Code of Ethics issued 1924-1946.

Combined Multi-Segmental Surgical-Orthodontic Treatment In Skeletal Class Iii With Facial Asymmetry And Gummy Smile: Two-Year Stability, Rouh-Hwai Wang, Hui-Ling Chen

Taiwanese Journal of Orthodontics

This is a case of skeletal class III malocclusion with facial asymmetry, gummy smile, and maxillary canting, treated with bimaxillary surgery and orthodontic treatment. The two-jaw surgery was performed including a 3-pieces LeFort I segmental osteotomy, anterior segment impaction with clockwise rotation, and bilateral sagittal split osteotomies with genioplasty. Through the 2-year-4-month treatment procedure, the skeletal and occlusal relationship turned to be normal with esthetically pleasing smile and profile. Furthermore, in the two-year follow-up, we found the treatment results were quite stable no matter in skeletal or dental aspects.

Market Claims And Efficacy Information In Direct‐To‐Consumer Prescription Drug Print Advertisements, Kathryn J. Aikin Phd, Kevin R. Betts Phd, Aysha Keisler Phd, Kathryn Schaefer Ziemer Phd

United States Food and Drug Administration: Publications

This study examined the impact of “New” and “#1 Prescribed” market claims and quantitative efficacy information on perceptions of a hypothetical prescription drug in a direct‐to‐consumer (DTC) print advertisement. We examined two market claims (New and #1 Prescribed), two efficacy levels (higher and lower), and a control condition without this information. Participants with diabetes were randomized to review one ad version and asked their perceptions of the ad's message, the drug's benefits, side effects and risks, doctors' opinions about the drug, and behavioral intention to use the drug, as well as recall and recognition of drug benefits and risks. Results …

Youth Perception Of Harm And Addictiveness Of Tobacco Products: Findings From The Population Assessment Of Tobacco And Health Study (Wave 1), David R. Strong, Karen Messer, Martha White, Yuyan Shi, Madison Noble, David B. Portnoy, Alexander Persoskie, Annette R. Kaufman, Kelvin Choi, Charles Carusi, Maansi Bansal-Travers, Andrew Hyland, John Pierce

United States Food and Drug Administration: Publications

Purpose: We provide a US national assessment of youth perceptions of the harm and addictiveness of six separate tobacco products, identifying a continuum of perceived harm associated with a range of products in relation to patterns of current use, former use, and susceptibility to use tobacco products.

Methods: We evaluated youth respondents (N=13,651) ages 12–17 from Wave 1 (2013–2014) of the Population Assessment of Tobacco and Health (PATH) Study. Analyses (2015–2016) focused on refining mea- sures of perceived harm for each product and delineating youth characteristics (demographic, tobacco use status) associated with beliefs about the harmfulness and addictiveness of tobacco …

Associations Of Risk Factors Of E-Cigarette And Cigarette Use And Susceptibility To Use Among Baseline Path Study Youth Participants (2013–2014), Michael D. Sawdey, Hannah R. Day, Blair Coleman, Lisa D. Gardner, Sarah E. Johnson, Jean Limpert, Hoda T. Hammad, Macieji L. Goniewicz, David B. Abrams, Cassandra A. Stanton, Jennifer L. Pearson, Annette R. Kaufman, Heather L. Kimmel, Cristine D. Delnevo, Wilson M. Compton, Maansi Bansal-Travers, Raymond S. Niaura, Andrew Hyland, Bridget K. Ambrose

United States Food and Drug Administration: Publications

Introduction: Improved understanding of the distribution of traditional risk factors of cigarette smoking among youth who have ever used or are susceptible to e-cigarettes and cigarettes will inform future longitudinal studies examining transitions in use.

Methods: Multiple logistic regression analysis was conducted using data from youth (ages 12–17 years) who had ever heard of e-cigarettes at baseline of the PATH Study (n = 12,460) to compare the distribution of risk factors for cigarette smoking among seven mutually exclusive groups based on ever cigarette/e-cigarette use and sus- ceptibility status.

Results: Compared to committed never users, youth susceptible to e-cigarettes, cigarettes, or …

Selection And Consumption Of Lunches By National School Lunch Program T Participants, Janet G. Peckham, Jaclyn D. Kropp, Thomas A. Mroz, Vivian Haley-Zitlin, Ellen M. Granberg

United States Food and Drug Administration: Publications

The Healthy, Hunger-Free Kids Act of 2010 requires schools participating in the National School Lunch Program (NSLP) to offer a variety of healthy food options each day. Using digital photography data collected from two suburban elementary schools in the spring of 2013, we examine NSLP participant's selection and consumption of all five NSLP lunch components ((1) milk, (2) vegetable, (3) fruit, (4) meat/meat alternate (MA), and (5) grain). We use logit regressions to analyze the selection of the various lunch components by race/ethnicity, gender, grade, and household income level. In addition, ordinary least squares regressions are used to analyze the …

Examining The Role Of Menthol Cigarettes In Progression To Established T Smoking Among Youth, James Nonnemaker, Shari P. Feirman, Anna Macmonegle, Bridget K. Ambrose, Kia J. Jackson, Megan J. Schroeder, Alexandria A. Smith, William Ridgeway, Olga Rass

United States Food and Drug Administration: Publications

Background: Menthol, a flavoring compound added to cigarettes, makes cigarettes more appealing to youth and inexperienced smokers and increases cigarettes' abuse liability. However, limited studies are available on menthol's role in smoking progression.

Methods: To assess the association between menthol in cigarettes and progression to established smoking, we used five waves of data from the Evaluation of Public Education Campaign on Teen Tobacco Cohort Study, a nationally representative longitudinal survey of U.S. youth conducted as part of “The Real Cost” evaluation. We used discrete time survival analysis to model the occurrence of two event outcomes—progression to established, current smoking and …

Comparison Of Emla And Diclofenac On Reduction Of Pain And Phlebitis Caused By Peripheral Iv Catheter: A Randomized-Controlled Trial Study, Faezeh Babaieasl, Hossein Y. Yarandi, Seyedehtanaz Saeidzadeh, Motahareh Kheradmand

Nursing Faculty Research Publications

Peripheral venous catheters (PVC) are often used to provide hydration, medications, and blood products when the length of therapy is expected to be less that one week. Pain and phlebitis are frequent complications of PVC. Diclofenac and EMLA have been used to minimize these adverse effects, however, conflicting results have been reported regarding which has better outcomes. This double-blind, randomized controlled trial was conducted to compare the efficacy of EMLA and Diclofenac (TDP) in attenuating PVC pain and phlebitis. The inpatient setting was chosen because of the higher frequency of PVC insertions, allowing for a sufficient sample size. One hundred …