Medicine and Health Sciences | Open Access Articles

Choosing Core Outcomes For Use In Clinical Trials In Ophthalmology: Perspectives From Three Ophthalmology Outcomes Working Groups, I. J. Saldanha, J. T. Le, S. D. Solomon, M. X. Repka, E. K. Akpek, T. Li, N. Afshari, A. Ambrus, H. Perry, A. Wenick, +29 Additional Authors

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Safety And Efficacy Of Amniotic Cytokine Extract In The Treatment Of Dry Eye Disease., E. Yeu, D. F. Goldberg, F. S. Mah, K. A. Beckman, J. I. Luchs, J. D. Solomon, D. E. White, P. K. Gupta

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No abstract provided.

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Nonemergent Percutaneous Coronary Intervention On An Unprotected Left Main Coronary Artery Supported With Impella® Heart Pump In Patients Ineligible For Surgical Revascularization, P. M. Meraj, S. Dixon, J. Moses, K. Ibrahim, A. Schäfer, I. Akin, J. Hill, T. Schreiber, W. W. O'Neill

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© 2019 Perwaiz M. Meraj et al. Objectives. We sought to assess if ineligibility to coronary artery bypass grafting (CABG) constitutes a risk factor in patients who underwent a nonemergent unprotected left main coronary artery (ULMCA) percutaneous coronary intervention (PCI) with prophylactic Impella® heart pump support. Background. ULMCA PCI in patients not deemed eligible for CABG is associated with significantly worse outcomes compared to ULMCA PCI in eligible patients. Methods. Patients from the cVAD Registry and the PROTECT II trial who underwent a nonemergent ULMCA PCI were identified. We compared in-hospital mortality and major adverse cardiac and cerebrovascular event (MACCE) …

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Myocardial Fibrosis And Arrhythmogenesis In Elite Athletes, S. A. Ahmad, N. Khalid, E. Shlofmitz, L. Chhabra

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No abstract provided.

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The Role Of Novel Oral Anticoagulants And Antiplatelet Therapy After Percutaneous Coronary Intervention: Individualizing Therapy To Optimize Outcomes, E. Shlofmitz, R. Shlofmitz, M. S. Lee

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No abstract provided.

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Effect Of Negative Pressure Wound Therapy On Wound Complications Post-Pancreatectomy, M. P. Kuncewitch, A. U. Blackham, C. J. Clark, R. M. Dodson, G. B. Russell, E. A. Levine, P. Shen

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No abstract provided.

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Use Of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide For Chronic Wound Treatment, A. R. Oropallo

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© 2019 Lippincott Williams and Wilkins.All right reserved. Background: Chronic wounds represent a significant financial burden to the healthcare system and a quality-of-life burden to patients. Many chronic wounds have elevated bioburden in the form of biofilm, which has been associated with delayed wound healing. This study examined the use of a native type I collagen matrix with the antimicrobial polyhexamethylene biguanide (PCMP) in the management of bioburden and treatment of chronic, nonhealing wounds over 12 weeks. Methods: A prospective case series of PCMP enrolled adults ≥18 years old with a nonhealing wound. At week 0, the wound was prepared …

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Longitudinal Low Density Lipoprotein Cholesterol Goal Achievement And Cardiovascular Outcomes Among Adult Patients With Familial Hypercholesterolemia: The Cascade Fh Registry, P. B. Duell, S. S. Gidding, R. L. Andersen, T. Knickelbine, L. Anderson, E. Gianos, P. Shrader, I. Kindt, E. C. O'Brien, J. W. Knowles, +17 Additional Authors

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© 2019 [The Author/The Authors] Background and aims: There are limited data from the US on outcomes of patients in specialty care for familial hypercholesterolemia (FH). Methods: CASCADE FH Registry data were analyzed to assess longitudinal changes in medication usage, in low density lipoprotein cholesterol (LDL-C) levels, and the rate of major adverse cardiovascular events (MACE (myocardial infarction, coronary revascularization, stroke or transient ischemic attack) in adults with FH followed in US specialty clinics. Results: The cohort consisted of 1900 individuals (61% women, 87% Caucasian), with mean age of 56 ± 15 years, 37% prevalence of ASCVD at enrollment, mean …

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Periarticular Injection And Continuous Femoral Nerve Block Versus Continuous Femoral Nerve Block Alone On Postoperative Opioid Consumption And Pain Control Following Total Knee Arthroplasty: Randomized Controlled Trial, D. Dimaculangan, J. F. Chen, R. B. Borzio, J. J. Jauregui, V. J. Rasquinha, A. V. Maheshwari

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© 2017 Continuous femoral nerve block (CFNB) has been used to prevent the breakthrough pain after total knee arthroplasty (TKA). Multimodal drug injection (PMDI) has also been shown to decrease opioid consumption and pain. We investigated whether the use of PMDI further improves analgesic and rehabilitation outcomes when used in conjunction with CFNB. This is a prospective randomized controlled study of 44 patients undergoing primary TKA. The treatment group (n = 23) received a PMDI of combined ropivacaine, epinephrine, ketorolac and morphine, and the controlled group (n = 21) received saline at wound closure. Total opioid consumption, pain scores, knee …

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Optimum Anatomic Socket Position And Sizing For The Direct Anterior Approach: Impingement And Instability, N. Mercer, E. Hawkins, L. Menken, A. Deshmukh, P. Rathod, J. A. Rodriguez

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© 2019 A comprehensive strategy is important for ensuring reproducible and safe acetabular component sizing and positioning. Presented here is our approach for anatomic acetabular component positioning in direct anterior total hip arthroplasty. This strategy has evolved with our understanding of the ramifications of socket sizing and positioning on instability and impingement. Data collected by a single surgeon (J.A.R.) between 2009 and 2011 influenced our current paradigm. We compare the sizing and positioning parameters of the anterior and posterior approach, thus demonstrating how the 2 are different. By highlighting these differences, we hope to provide a clear, defined approach to …

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Rhyme Awareness In Children With Normal Hearing And Children With Cochlear Implants: An Exploratory Study., L. Jing, K. Vermeire, A. Mangino, C. Reuterskiöld

Journal Articles

Phonological awareness is a critical component of phonological processing that predicts children's literacy outcomes. Phonological awareness skills enable children to think about the sound structure of words and facilitates decoding and the analysis of words during spelling. Past research has shown that children's vocabulary knowledge and working memory capacity are associated with their phonological awareness skills. Linguistic characteristics of words, such as phonological neighborhood density and orthography congruency have also been found to influence children's performance in phonological awareness tasks. Literacy is a difficult area for deaf and hard of hearing children, who have poor phonological awareness skills. Although cochlear …

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Comparison Of The Panther Fusion And Bd Max Gbs Assays For Detection Of Group B Streptococcus In Prenatal Screening Specimens., G. J. Berry, F. Zhang, R. Manji, S. Juretschko

Journal Articles

Streptococcus agalactiae, or Group B Streptococcus (GBS) is the cause of early and late-onset GBS disease in neonates and can present as septicemia, meningitis, and pneumonia. Our objective was to compare the performance of two FDA-approved nucleic acid amplification tests (NAATs), the Panther Fusion and BD MAX™ systems, for detection of group B Streptococcus (GBS) in vaginal-rectal screening specimens. A total of 510 vaginal-rectal prepartum specimens were tested simultaneously in both NAATs following broth enrichment. Assay agreement was calculated using the kappa statistics. Overall agreement between assays was 99.0% (505/510; 95% CI: 0.951 to 0.997; kappa = 0.974). Discordant results …

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Primary Follicular Lymphoma Of The Bladder Mimicking Inflammatory Condition: Case Report And Review Of The Literature, N. Haghi, X. Zhang, J. Kreshover

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© 2019 The Authors Primary lymphoma of the bladder is rare and may present with nonspecific symptoms and infection. Primary follicular lymphoma of the bladder is extremely rare with only a dozen reported cases. We present one case clinically mimicking an inflammatory process. A 79 year-old woman presents with recurrent urinary tract infections, urinary incontinence and frequency. Cystoscopic examination demonstrated a raised but flat lesion, suspicious for inflammatory lesion. Biopsy revealed a diagnosis of follicular lymphoma, grade 1–2. The presentation of primary follicular lymphoma of the bladder may be nonspecific, therefore it is important to consider this diagnosis in patients …

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Familial Inheritance Of The 3q29 Microdeletion Syndrome: Case Report And Review, W. A. Khan, N. Cohen, S. A. Scott, E. M. Pereira

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Performance Evaluation Of The Luminex Aries® C. Difficile Assay In Comparison To Two Other Molecular Assays Within A Multi-Hospital Health Care Center., S. Juretschko, R. Manji, R. Khare, S. Das, S. Dunbar

Journal Articles

Clostridioides difficile infections (CDI) remain a serious issue in the U.S. Both fast and accurate diagnosis of CDI is paramount to achieve immediate infection control initiation, triaging and isolation, as well as appropriate antibiotic treatment. However, both, over- and under-diagnosis can lead to adverse patient outcomes, such as unnecessary administration of antibiotics or unwanted spread of spores in any hospital setting, respectively. In this prospective study, we evaluated the FDA-cleared ARIES® C. difficile Assay and compared its performance and workflow characteristics to the BD MAX Cdiff and Xpert C.difficile/Epi assays. Out of 302 samples tested, 55 (18.2%) samples were positive, …

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Quantitative Human Immunodeficiency Virus (Hiv)-1 Antibodies Correlate With Plasma Hiv-1 Rna And Cell-Associated Dna Levels In Children On Antiretroviral Therapy, M. Mcmanus, J. Henderson, A. Gautam, R. Brody, E. R. Weiss, D. Persaud, E. Mick, K. Luzuriaga, V. Bonagura, I. Febo, +22 Additional Authors

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Ulcerative Colitis Mucosal Transcriptomes Reveal Mitochondriopathy And Personalized Mechanisms Underlying Disease Severity And Treatment Response, Y. Haberman, R. Karns, P. J. Dexheimer, M. Schirmer, J. Somekh, I. Jurickova, T. Braun, E. Novak, J. Markowitz, L. A. Denson, +32 Additional Authors

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© 2019, The Author(s). Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408 participants. We observe a marked suppression of mitochondrial genes and function across cohorts in active UC, and that increasing disease severity is notable for enrichment of adenoma/adenocarcinoma and innate immune genes. A subset of severity genes improves prediction of corticosteroid-induced remission in the discovery …

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Homozygous Nlrp1 Gain-Of-Function Mutation In Siblings With A Syndromic Form Of Recurrent Respiratory Papillomatosis, S. B. Drutman, F. Haerynck, F. L. Zhong, D. Hum, N. J. Hernandez, S. Belkaya, F. Rapaport, S. J. De Jong, V. R. Bonagura, J. Laurent-Casanova, +13 Additional Authors

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© 2019 National Academy of Sciences. All rights reserved. Juvenile-onset recurrent respiratory papillomatosis (JRRP) is a rare and debilitating childhood disease that presents with recurrent growth of papillomas in the upper airway. Two common human papillomaviruses (HPVs), HPV-6 and -11, are implicated in most cases, but it is still not understood why only a small proportion of children develop JRRP following exposure to these common viruses. We report 2 siblings with a syndromic form of JRRP associated with mild dermatologic abnormalities. Whole-exome sequencing of the patients revealed a private homozygous mutation in NLRP1, encoding Nucleotide-Binding Domain Leucine-Rich Repeat Family Pyrin …

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Advisory Committee On Immunization Practices Recommended Immunization Schedule For Children And Adolescents Aged 18 Years Or Younger - United States, 2019, C. L. Robinson, H. Bernstein, J. R. Romero, P. Szilagyi

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No abstract provided.

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Interrogating The Genetic Determinants Of Tourette's Syndrome And Other Tic Disorders Through Genome-Wide Association Studies, D. Yu, J. H. Sul, F. Tsetsos, M. S. Nawaz, A. Y. Huang, I. Zelaya, C. Illmann, C. L. Budman, C. Budman, M. Woods, +119 Additional Authors

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No abstract provided.

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Gene Expression Imputation Across Multiple Brain Regions Provides Insights Into Schizophrenia Risk, L. M. Huckins, A. Dobbyn, D. M. Ruderfer, G. Hoffman, W. Wang, A. F. Pardinas, V. M. Rajagopal, T. D. Als, A. K. Malhotra, P. F. Sullivan, +343 Additional Authors

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No abstract provided.

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Clinical Relevance Of Paliperidone Palmitate 3-Monthly In Treating Schizophrenia, M. Mathews, S. Gopal, I. Nuamah, L. Hargarter, A. J. Savitz, E. Kim, W. Tan, B. Soares, C. U. Correll

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No abstract provided.

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The Early Psychosis Screener For Internet (Epsi)-Sr: Predicting 12 Month Psychotic Conversion Using Machine Learning, B. B. Brodey, R. R. Girgis, O. V. Favorov, C. E. Bearden, S. W. Woods, J. Addington, D. O. Perkins, E. F. Walker, B. A. Cornblatt, K. S. Cadenhead, +3 Additional Authors

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Long-Term Effectiveness Of Oral Second-Generation Antipsychotics In Patients With Schizophrenia And Related Disorders: A Systematic Review And Meta-Analysis Of Direct Head-To-Head Comparisons, T. Kishimoto, K. Hagi, M. Nitta, J. M. Kane, C. U. Correll

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No abstract provided.

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Incoming Interns Perceived Preparedness For Core Entrustable Professional Activities, R. E. Pearlman, M. A. Pawelczak, J. B. Bird, A. C. Yacht, G. A. Farina

Journal Articles

© 2019, International Association of Medical Science Educators. Introduction: The AAMC described 13 core entrustable professional activities (EPAs) for which every graduating medical student should perform proficiently on day 1 of residency. We studied how prepared starting interns felt in the core EPAs. Methods: Interns from a diverse health system were surveyed on how well medical school prepared them in the 13 core EPAs. Data were collected on type of medical school, participation in an acting/sub-internship (AI/SI), knowledge of EPAs, and participation in an EPA experience. Results: We collected 224 surveys out of 384 (58%) interns. 61.2% attended allopathic, 14.6% …

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Recent Advances In Personalizing Cardiac Arrest Resuscitation, C. E. Kuschner, L. B. Becker

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© 2019 Kuschner CE and Becker LB. Cardiac arrest remains a significant cause of death and disability throughout the world. However, as our understanding of cardiac arrest and resuscitation physiology has developed, new technologies are fundamentally altering our potential to improve survival and neurologic sequela. Some advances are relatively simple, requiring only alterations in current basic life support measures or integration with pre-hospital organization, whereas others, such as extra-corporeal membrane oxygenation, require significant time and resource investments. When combined with consistent rescuer and patient-physiologic monitoring, these innovations allow an unprecedented capacity to personalize cardiac arrest resuscitation to patient-specific pathophysiology. However, …

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Sexual Dimorphism Of Gut Microbiota Dictates Therapeutics Efficacy Of Radiation Injuries, M. Cui, H. Xiao, Y. Li, S. Zhang, J. Dong, B. Wang, C. Zhu, M. Jiang, H. Wang, S. Fan, +2 Additional Authors

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© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Accidental or iatrogenic ionizing radiation exposure precipitates acute and chronic radiation injuries. The traditional paradigm of mitigating radiotherapy-associated adverse side effects has ignored the gender-specific dimorphism of patients' divergent responses. Here, the effects of sexual dimorphism on curative efficiencies of therapeutic agents is examined in murine models of irradiation injury. Oral gavage of simvastatin ameliorates radiation-induced hematopoietic injury and gastrointestinal tract dysfunction in male mice, but adversely deteriorates these radiation syndromes in female animals. In a sharp contrast, feeding animals with high-fat diet (HFD) elicites explicitly contrary …

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Physician Agreement On The Diagnosis Of Sepsis In The Intensive Care Unit: Estimation Of Concordance And Analysis Of Underlying Factors In A Multicenter Cohort, B. K. Lopansri, R. R. Miller, J. P. Burke, M. Levy, S. Opal, M. Narasimhan, A. Tsegaye, S. Hahn, P. Mayo, R. B. Brandon, +19 Additional Authors

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© 2019 The Author(s). Background: Differentiating sepsis from the systemic inflammatory response syndrome (SIRS) in critical care patients is challenging, especially before serious organ damage is evident, and with variable clinical presentations of patients and variable training and experience of attending physicians. Our objective was to describe and quantify physician agreement in diagnosing SIRS or sepsis in critical care patients as a function of available clinical information, infection site, and hospital setting. Methods: We conducted a post hoc analysis of previously collected data from a prospective, observational trial (N = 249 subjects) in intensive care units at seven US hospitals, …

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Related Peripheral Blood Stem Cell Donors Experience More Severe Symptoms And Less Complete Recovery At One Year Compared To Unrelated Donors, M. A. Pulsipher, B. R. Logan, D. M. Kiefer, P. Chitphakdithai, M. L. Riches, D. Rizzo, P. Anderlini, R. Bayer, I. Sahdev, B. E. Shaw, +51 Additional Authors

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Probabilistic Modeling Of Personalized Drug Combinations From Integrated Chemical Screen And Molecular Data In Sarcoma, N. E. Berlow, R. Rikhi, M. Geltzeiler, J. Abraham, M. N. Svalina, L. E. Davis, E. Wise, M. Mancini, R. G. Maki, C. Keller, +19 Additional Authors

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Full-Text Articles in Medicine and Health Sciences

Choosing Core Outcomes For Use In Clinical Trials In Ophthalmology: Perspectives From Three Ophthalmology Outcomes Working Groups, I. J. Saldanha, J. T. Le, S. D. Solomon, M. X. Repka, E. K. Akpek, T. Li, N. Afshari, A. Ambrus, H. Perry, A. Wenick, +29 Additional Authors

Journal Articles

Safety And Efficacy Of Amniotic Cytokine Extract In The Treatment Of Dry Eye Disease., E. Yeu, D. F. Goldberg, F. S. Mah, K. A. Beckman, J. I. Luchs, J. D. Solomon, D. E. White, P. K. Gupta

Journal Articles

Nonemergent Percutaneous Coronary Intervention On An Unprotected Left Main Coronary Artery Supported With Impella® Heart Pump In Patients Ineligible For Surgical Revascularization, P. M. Meraj, S. Dixon, J. Moses, K. Ibrahim, A. Schäfer, I. Akin, J. Hill, T. Schreiber, W. W. O'Neill

Journal Articles

Myocardial Fibrosis And Arrhythmogenesis In Elite Athletes, S. A. Ahmad, N. Khalid, E. Shlofmitz, L. Chhabra

Journal Articles

The Role Of Novel Oral Anticoagulants And Antiplatelet Therapy After Percutaneous Coronary Intervention: Individualizing Therapy To Optimize Outcomes, E. Shlofmitz, R. Shlofmitz, M. S. Lee

Journal Articles

Effect Of Negative Pressure Wound Therapy On Wound Complications Post-Pancreatectomy, M. P. Kuncewitch, A. U. Blackham, C. J. Clark, R. M. Dodson, G. B. Russell, E. A. Levine, P. Shen

Journal Articles

Use Of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide For Chronic Wound Treatment, A. R. Oropallo

Journal Articles

Journal Articles

Journal Articles

Optimum Anatomic Socket Position And Sizing For The Direct Anterior Approach: Impingement And Instability, N. Mercer, E. Hawkins, L. Menken, A. Deshmukh, P. Rathod, J. A. Rodriguez

Journal Articles

Rhyme Awareness In Children With Normal Hearing And Children With Cochlear Implants: An Exploratory Study., L. Jing, K. Vermeire, A. Mangino, C. Reuterskiöld

Journal Articles

Comparison Of The Panther Fusion And Bd Max Gbs Assays For Detection Of Group B Streptococcus In Prenatal Screening Specimens., G. J. Berry, F. Zhang, R. Manji, S. Juretschko

Journal Articles

Primary Follicular Lymphoma Of The Bladder Mimicking Inflammatory Condition: Case Report And Review Of The Literature, N. Haghi, X. Zhang, J. Kreshover

Journal Articles

Familial Inheritance Of The 3q29 Microdeletion Syndrome: Case Report And Review, W. A. Khan, N. Cohen, S. A. Scott, E. M. Pereira

Journal Articles

Performance Evaluation Of The Luminex Aries® C. Difficile Assay In Comparison To Two Other Molecular Assays Within A Multi-Hospital Health Care Center., S. Juretschko, R. Manji, R. Khare, S. Das, S. Dunbar

Journal Articles

Journal Articles

Ulcerative Colitis Mucosal Transcriptomes Reveal Mitochondriopathy And Personalized Mechanisms Underlying Disease Severity And Treatment Response, Y. Haberman, R. Karns, P. J. Dexheimer, M. Schirmer, J. Somekh, I. Jurickova, T. Braun, E. Novak, J. Markowitz, L. A. Denson, +32 Additional Authors

Journal Articles

Homozygous Nlrp1 Gain-Of-Function Mutation In Siblings With A Syndromic Form Of Recurrent Respiratory Papillomatosis, S. B. Drutman, F. Haerynck, F. L. Zhong, D. Hum, N. J. Hernandez, S. Belkaya, F. Rapaport, S. J. De Jong, V. R. Bonagura, J. Laurent-Casanova, +13 Additional Authors

Journal Articles

Advisory Committee On Immunization Practices Recommended Immunization Schedule For Children And Adolescents Aged 18 Years Or Younger - United States, 2019, C. L. Robinson, H. Bernstein, J. R. Romero, P. Szilagyi

Journal Articles

Interrogating The Genetic Determinants Of Tourette's Syndrome And Other Tic Disorders Through Genome-Wide Association Studies, D. Yu, J. H. Sul, F. Tsetsos, M. S. Nawaz, A. Y. Huang, I. Zelaya, C. Illmann, C. L. Budman, C. Budman, M. Woods, +119 Additional Authors

Journal Articles

Gene Expression Imputation Across Multiple Brain Regions Provides Insights Into Schizophrenia Risk, L. M. Huckins, A. Dobbyn, D. M. Ruderfer, G. Hoffman, W. Wang, A. F. Pardinas, V. M. Rajagopal, T. D. Als, A. K. Malhotra, P. F. Sullivan, +343 Additional Authors

Journal Articles

Clinical Relevance Of Paliperidone Palmitate 3-Monthly In Treating Schizophrenia, M. Mathews, S. Gopal, I. Nuamah, L. Hargarter, A. J. Savitz, E. Kim, W. Tan, B. Soares, C. U. Correll

Journal Articles

The Early Psychosis Screener For Internet (Epsi)-Sr: Predicting 12 Month Psychotic Conversion Using Machine Learning, B. B. Brodey, R. R. Girgis, O. V. Favorov, C. E. Bearden, S. W. Woods, J. Addington, D. O. Perkins, E. F. Walker, B. A. Cornblatt, K. S. Cadenhead, +3 Additional Authors

Journal Articles

Long-Term Effectiveness Of Oral Second-Generation Antipsychotics In Patients With Schizophrenia And Related Disorders: A Systematic Review And Meta-Analysis Of Direct Head-To-Head Comparisons, T. Kishimoto, K. Hagi, M. Nitta, J. M. Kane, C. U. Correll

Journal Articles

Incoming Interns Perceived Preparedness For Core Entrustable Professional Activities, R. E. Pearlman, M. A. Pawelczak, J. B. Bird, A. C. Yacht, G. A. Farina

Journal Articles

Recent Advances In Personalizing Cardiac Arrest Resuscitation, C. E. Kuschner, L. B. Becker

Journal Articles

Sexual Dimorphism Of Gut Microbiota Dictates Therapeutics Efficacy Of Radiation Injuries, M. Cui, H. Xiao, Y. Li, S. Zhang, J. Dong, B. Wang, C. Zhu, M. Jiang, H. Wang, S. Fan, +2 Additional Authors

Journal Articles

Journal Articles

Related Peripheral Blood Stem Cell Donors Experience More Severe Symptoms And Less Complete Recovery At One Year Compared To Unrelated Donors, M. A. Pulsipher, B. R. Logan, D. M. Kiefer, P. Chitphakdithai, M. L. Riches, D. Rizzo, P. Anderlini, R. Bayer, I. Sahdev, B. E. Shaw, +51 Additional Authors

Journal Articles

Probabilistic Modeling Of Personalized Drug Combinations From Integrated Chemical Screen And Molecular Data In Sarcoma, N. E. Berlow, R. Rikhi, M. Geltzeiler, J. Abraham, M. N. Svalina, L. E. Davis, E. Wise, M. Mancini, R. G. Maki, C. Keller, +19 Additional Authors

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