Medicine and Health Sciences Commons^™

Necrotizing Infection Of The Aortic Arch: Reconstruction Utilizing Unusual Extra-Anatomic Bypass Grafts To Reroute Cerebral Blood Flow., J. M. Hemli, B. D. Patton, S. J. Scheinerman, D. R. Brinster

Journal Articles

Destructive infections of the aortic arch and great vessels are challenging to manage. We describe a novel technique for debranching the right cerebral and upper extremity arteries via composite extra-anatomic bypasses from the femoral artery, with subsequent homograft in-line reconstruction of the arch, in a patient with Staphylococcus sepsis and necrosis of the arch and great vessels.

Breadth And Depth Of Working Memory And Executive Function Compromises In Mild Cognitive Impairment And Their Relationships To Frontal Lobe Morphometry And Functional Competence, L. Garcia-Alvarez, J. J. Gomar, A. Sousa, M. P. Garcia-Portilla, T. E. Goldberg

Journal Articles

© 2019 Introduction: The extent of working memory (WM) and executive function (EF) impairment in mild cognitive impairment (MCI) is not well-characterized. Methods: We compared 48 patients with MCI, 124 noncognitively impaired elderly healthy controls, and 57 patients with Alzheimer's disease (AD) on multiple WM/EF measures, frontal lobe integrity indexes, and functioning. Results: Patients with MCI demonstrated worse performance on nearly all WM/EF tests. This profile of impairment was refined in a factor analysis that identified three primary WM/EF constructs: WM storage; speed and controlled visual search; and manipulation of information and problem solving. EF impairments were associated with reductions …

Internet Searches For Medical Symptoms Before Seeking Information On 12-Step Addiction Treatment Programs: A Web-Search Log Analysis, G. Nitzburg, I. Weber, E. Yom-Tov

Journal Articles

© 2019 George Nitzburg, Ingmar Weber, Elad Yom-Tov. Background: Brief intervention is a critical method for identifying patients with problematic substance use in primary care settings and for motivating them to consider treatment options. However, despite considerable evidence of delay discounting in patients with substance use disorders, most brief advice by physicians focuses on the long-term negative medical consequences, which may not be the best way to motivate patients to seek treatment information. Objective: Identification of the specific symptoms that most motivate individuals to seek treatment information may offer insights for further improving brief interventions. To this end, we used …

Objective User Engagement With Mental Health Apps: Systematic Search And Panel-Based Usage Analysis., A. Baumel, F. Muench, S. Edan, J. Kane

Journal Articles

BACKGROUND: Understanding patterns of real-world usage of mental health apps is key to maximizing their potential to increase public self-management of care. Although developer-led studies have published results on the use of mental health apps in real-world settings, no study yet has systematically examined usage patterns of a large sample of mental health apps relying on independently collected data.

OBJECTIVE: Our aim is to present real-world objective data on user engagement with popular mental health apps.

METHODS: A systematic engine search was conducted using Google Play to identify Android apps with 10,000 installs or more targeting anxiety, depression, or emotional …

Quality Of Life Outcomes Following Organ-Sparing Sbrt In Previously Irradiated Recurrent Head And Neck Cancer, E. Gogineni, I. Zhang, Z. Rana, M. Marrero, G. Gill, A. Sharma, A. C. Riegel, S. Teckie, M. Ghaly

Journal Articles

No abstract provided.

Assessing Cognitive Impairment In Sle: Examining Relationships Between Resting Glucose Metabolism And Anti-Nmdar Antibodies With Navigational Performance., E. Ploran, C. Tang, M. Mackay, E. Anderson, C. Aranow, C. Sartori, P. Watson, B. Volpe, B. Diamond, D. Eidelberg, +4 Additional Authors

Journal Articles

Objective: Resting Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) brain imaging and neuropsychological testing were used to investigate the usefulness of a spatial navigation task (SNT) as a performance benchmark for cognitive impairment related to anti-N-methyl D-aspartate (anti-NMDA) receptor antibodies (DNRAb) in SLE.

Methods: Neuropsychological assessments, including a desktop 3-D virtual SNT, were performed on 19 SLE participants and 9 healthy control (HC) subjects. SLE participants had stable disease activity and medication doses and no history of neuropsychiatric illness or current use of mind-altering medications. Resting FDG-PET scans were obtained on all SLE participants and compared with a historical set from …

Cold-Inducible Rna-Binding Protein Induces Neutrophil Extracellular Traps In The Lungs During Sepsis, Y. Ode, M. Aziz, H. Jin, A. Arif, J. G. Nicastro, P. Wang

Journal Articles

No abstract provided.

Extracellular Cold Inducible Rna-Binding Protein Mediates Binge Alcohol-Induced Brain Hypoactivity And Impaired Cognition In Mice, A. Jacob, Y. Ma, E. Nasiri, M. Ochani, J. Carrion, S. Peng, M. Brenner, P. T. Huerta, P. Wang

Journal Articles

No abstract provided.

Neurogenesis In Neurodegenerative Diseases: Role Of Mfg-E8, C. Cheyuo, M. Aziz, P. Wang

Journal Articles

No abstract provided.

Author Correction: Chd3 Helicase Domain Mutations Cause A Neurodevelopmental Syndrome With Macrocephaly And Impaired Speech And Language., L. S. Blok, J. Rousseau, J. Twist, S. Ehresmann, M. Takaku, H. Venselaar, L. H. Rodan, M. G. Bialer, C. Moore, M. Blyth, +90 Additional Authors

Journal Articles

© 2019, The Author(s). The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versions of the Article.

De Novo Interstitial Deletion Of 9q In A Pediatric Patient With Global Developmental Delay., D. Keselman, R. Singh, N. Cohen, Z. Fefer

Journal Articles

Cytogenomic microarray (CMA) methodologies, including array comparative genomic hybridization (aCGH) and single-nucleotide polymorphism-detecting arrays (SNP-array), are recommended as the first-tier test for the evaluation of imbalances associated with intellectual disability, autism, and multiple congenital anomalies. The authors report on a child with global developmental delay (GDD) and a de novo interstitial 7.0 Mb deletion of 9q21.33q22.31 detected by aCGH. The patient that the authors report here is noteworthy in that she presented with GDD and her interstitial deletion is not inclusive of the 9q22.32 locus that includes the PTCH1 gene, which is implicated in Gorlin syndrome, or basal cell nevus …

Persistent Cloaca And Caudal Duplication In A Monovular Twin, A Rare Case Report, N. Cohen, M. N. Ahmed, R. Goldfischer, N. Zaghloul

Journal Articles

© 2019 Introduction: A cloaca occurs when genitourinary tract and bowel converge into a common channel. We report a case of partial caudal duplication, persistent cloaca and vestigial appendage in a monovular female twin infant. Presentation of case: This is a monochorinonic-diamniotic twin born at 36 weeks with apgars of 9/9. She had a duplicated labia with two clitorises, and a partially formed accessory foot with 2 toes protruding from the right gluteal region. There was anal atresia and a punctate urethral opening in the right genitalia through which she voided spontaneously. X-ray of the accessory foot had rudimentary metatarsals …

Pleiotropic Meta-Analysis Of Cognition, Education, And Schizophrenia Differentiates Roles Of Early Neurodevelopmental And Adult Synaptic Pathways, M. Lam, W. D. Hill, J. W. Trampush, J. Yu, E. Knowles, G. Davies, E. Stahl, P. Derosse, A. K. Malhotra, T. Lencz, +58 Additional Authors

Journal Articles

No abstract provided.

Abnormal Involuntary Movement Scale In Tardive Dyskinesia: Minimal Clinically Important Difference, M. Stacy, M. Sajatovic, J. M. Kane, A. J. Cutler, G. S. Liang, C. F. O'Brien, C. U. Correll

Journal Articles

No abstract provided.

Lithium For The Maintenance Treatment Of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Discontinuation Study, R. L. Findling, N. K. Mcnamara, M. Pavuluri, J. A. Frazier, M. Rynn, R. Scheffer, V. Kafantaris, A. Robb, M. Delbello, P. Taylor-Zapata, +7 Additional Authors

Journal Articles

No abstract provided.

Propensity-Matched Analysis Of Patient-Reported Outcomes For Neoadjuvant Chemotherapy Prior To Radical Cystectomy, M. A. Feuerstein, L. Goldstein, B. Reaves, A. Sun, M. Goltzman, B. A. Morganstern, A. Shabsigh, D. F. Bajorin, J. E. Rosenberg, B. H. Bochner, +7 Additional Authors

Journal Articles

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: To evaluate patient-reported outcomes (PROs) for bladder cancer patients undergoing neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) using longitudinal data and propensity-matched scoring analyses. Methods: 155 patients with muscle-invasive bladder cancer scheduled for RC completed the European Organization for Research and Treatment of Cancer questionnaires, EORTC QLQ-C30, EORTC QLQ-BLM30, Fear of Recurrence Scale, Mental Health Inventory and Satisfaction with Life Scale within 4 weeks of surgery. A propensity-matched analysis was performed comparing pre-surgery PROs among 101 patients who completed NAC versus 54 patients who did not receive NAC. We …

Evaluation Of Safe Sleep Practices Of Cribs For Kids Class Attendees, Halimat Adeshola Olaoluwa

Master of Public Health Program Student Publications

Sudden Infant Death Syndrome (SIDS) is a major cause of infant mortality, and sleep-related causes of SIDS are a focus of many strategies to combat infant mortality because they are largely preventable. One intervention that combines the distribution of a portable crib and safe sleep education to families that indicate a financial need is the Cribs for Kids program. The purpose of this study was to assess any changes in recommended safe sleep practices by Cribs for Kids attendees before and after the receipt of a portable crib and safe sleep education. Families who met eligibility criteria were enrolled in …

Comorbidities In A Sample Of Adults With Hiv In Puerto Rico: An Exploratory Study., Carlos E. Rodríguez-Díaz, Edda I Santiago-Rodríguez, Gerardo G Jovet-Toledo, Jorge Santana-Bagur, Yemile Ron-Suarez, Juan C Orengo, Felipe Arbelaez, Homero Monsanto

Prevention and Community Health Faculty Publications

Background: Puerto Rico is among the areas with the highest estimated rates of people living with HIV in the United States. Despite the epidemiologic data available, there is limited real-world information that can help understand the comorbidities of people with HIV. In this study, we describe common comorbidities among adults with HIV attending treatment clinics in Puerto Rico.

Methods: An exploratory, retrospective, cross-sectional study was conducted at five HIV clinics in Puerto Rico. A random sample of medical records was reviewed. Descriptive statistics were used to summarize patient demographics, morbidity, and clinical characteristics. Multivariate analyses were conducted to explore comorbidities …

Pheochromocytoma And Paraganglioma, Christopher Foltz

Nursing Student Class Projects (Formerly MSN)

Pheochromocytoma and paraganglioma are rare, possibly malignant, catecholamine secreting tumors. These tumors arise from the adrenal medulla and extra-adrenal sites, with reports of 80-85% and 15-20% respectively. The expanding field of genetics is contributing valuable information in recent years in regards to pathogenesis, and identifying patients with increased risk of occurrence. If found, prompt treatment- and usually surgical resection, is advised.

Iron Deficiency Anemia, Heather Weaver

Nursing Student Class Projects (Formerly MSN)

“Iron deficiency anemia (IDA) is the most common type of nutritional disorder worldwide, occurring in both developing and developed countries and affecting as many as one-fifth of the world population” (Huether & McCance, 2018, p. 934). There are many causes including bleeding (usually intestinal or menstrual), pregnancy, malnutrition, and malabsorption. Some of the signs and symptoms include fatigue, dizziness, headaches, exertional shortness of breath, cold intolerance, and paler than normal skin tones. The American Society of Hematology (2019) reports iron is important in the production of hemoglobin and maintenance of healthy cells. The topic of IDA was chosen as a …

Acute Respiratory Distress Syndrome, Kimberly Dyer

Nursing Student Class Projects (Formerly MSN)

Acute Respiratory Distress Syndrome is a common and life-threatening condition. It is the result of a direct or indirect lung injury and requires complex treatment modalities. Pathophysiology, signs and symptoms, nursing considerations, and a case study are presented within this poster.

Pathophysiology Of Osteoarthritis, Lara Stover

Nursing Student Class Projects (Formerly MSN)

Osteoarthritis (OA) is one of the most common joint diseases worldwide, and especially in the United States. This disease can cause chronic pain and disability, and can impair a patient’s quality of life and ability to perform activities of daily living. There are many different factors that can contribute to the development, progression, and severity of OA. Chronic inflammation and the inflammatory response is the primary pathological process that contributes to the development of OA. With the number of cases of OA expected to increase in the United States, it is important that primary care providers have an understanding of …

Aortic Aneurysm, James Lower

Nursing Student Class Projects (Formerly MSN)

An aneurysm is a bulging or outpouching of the vessel wall which can progress to a dissection or a tear in the vessel wall. There are two types of classification for aortic aneurysms based on the Standford classification: type A involving the ascending aorta, and type B involving the descending aorta. Major risk factors for aortic aneurysms are hypertension, smoking, and male gender. Aortic aneurysms can be asymptomatic or include a wide range of symptoms such as vague back pain that radiates, and shortness of breath. The overarching pathophysiology is inflammation causing a breakdown in elastin and collagen. Inflammation, oxidative …

Malignant Hyperthermia, Alexandra Mcguire

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia (MH) is a rare but life-threatening, genetic condition that can manifest when a patient is exposed to certain inhalation agents used in anesthesia as well as the depolarizing muscle relaxant succinylcholine (Rosenberg, Pollock, Schiemann, Bulger, & Stowell, 2015, p. 1). MH can develop during or after a surgical procedure and if left untreated, can cause major organ system damage and death (Seifert, Wahr, Pace, Cochrane, & Bagnola, 2014, p. 189). Creating awareness of this rare genetic condition allows for quicker interventions in reversing MH.

Cirrhosis Of The Liver, Sabina Lamichhane Wagle

Nursing Student Class Projects (Formerly MSN)

Liver cirrhosis is a chronic, end-stage liver disease. It is a term given to a condition where normal liver parenchyma is replaced by fibrotic tissues. This condition arises once hepatocytes become unable to overcome the hepatic insults via undergoing the process of mitosis. Alcohol, hepatitis B, hepatitis C, Wilson disease, hemochromatosis, aldolase B deficiency, alpha 1 antitrypsin deficiency, and autosomal recessive polycystic kidney diseases are few risk factors for liver cirrhosis. Ascites, asterixis, hepatic encephalopathy, scleral icterus, portal hypertension, and gynecomastia are a few symptoms of this condition. Liver transplant is the only definitive treatment for this condition, so symptoms …

Heart Failure With Preserved Ejection Fraction, Abigalle Ryan

Nursing Student Class Projects (Formerly MSN)

Heart failure with preserved ejection fraction (HFpEF), formerly known as diastolic heart failure, is a chronic disease that affects millions of people around the world. HFpEF has no cure and can only be managed with therapeutic treatments that optimize cardiac function and quality of life (Gazewood & Turner, 2017). The condition is precipitated by several systemic, myocardial, infiltrative, and pericardial diseases that overwhelmingly ail the aging population. There is not a set of widely accepted diagnostic criteria, and as a result, the morbidity and mortality have not improved in recent years (Tawil & Gelzinis, 2016). Because HFpEF has become more …

Osteoarthritis (Oa), Erin Steele

Nursing Student Class Projects (Formerly MSN)

Osteoarthritis (OA) is the primary cause of chronic pain, affecting approximately 27 million people in the United States. OA is a disease in the synovial joint. In humans, the knee is the largest synovial joint. Hips, hands and facet joints of the spine are other sites of the OA pain. There are several interventions and treatment options available to manage the symptoms. Studies have shown other helpful hints in hopes to prevent and slow the progress of this degenerative disease.

Tuberculosis: Early Diagnosis And Treatment, Gloria Obeng

Nursing Student Class Projects (Formerly MSN)

Although there are measures in place to control tuberculosis (TB) cases in the U.S., TB is prevalent and has high morbidity and mortality rate. This issue is due to the failure to identify and treat the disease as early as possible, especially in the latent stage. The late diagnosis of the disease causes a delay in treatment which may result in complications or even death. Understanding the pathophysiological process of TB will aid in the control of the disease. Also, TB cases have been recorded among foreign-born and immigrants who are visiting the U.S. but some of these immigrants are …

Pathophysiology Of Ovarian Cancer, Christina Eagle

Nursing Student Class Projects (Formerly MSN)

This poster project is a culmination of evidence-based practice research conducted to educate on the lethality of ovarian cancer and the importance of early detection of the vague signs and symptoms associated with this disease. Worldwide, approximately 240,000 women are diagnosed with ovarian cancer each year, and 140,200 were projected to succumb to this disease in 2016 (Kroeger, Jr. & Drapkin, 2017). This case-to-fatality ratio is nearly three times that of breast cancer, making ovarian cancer the most lethal gynecological malignancy in developed countries (Kroeger, Jr. & Drapkin, 2017). Educating women about the risk factors and the elusive signs and …

News From The Graduate School - Nursing, Otterbein Office Of Graduate Programs

Graduate School

Newsletter that provides updates from the Graduate School and the Nursing Graduate Program.