Medicine and Health Sciences Commons^™

Wide Complex Tachycardia In An Elderly Woman Due To Ebstein's Anomaly With Two Accessory Pathways, V. Radulescu, J. Donnelly, J. Willner, S. Beldner, A. Patel, S. G. Saba

Journal Articles

No abstract provided.

A Novel Diagnostic Approach To A Mass On A Device Lead, D. Chang, J. Gabriels, S. Laighold, A. K. Williamson, H. Ismail, L. M. Epstein

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No abstract provided.

Excellent Response To Nivolumab And Ipilimumab In Metastatic Gastroesophageal Junction Squamous Carcinoma., N. Sadagopan, C. Devoe

Journal Articles

Unresectable gastroesophageal junction (GEJ) cancers have a poor prognosis and limited treatment options. We report the case of a patient with a Siewert class III gastroesophageal junction squamous carcinoma with metastatic spread into the liver who had an exceptional response to a combination therapy of nivolumab and ipilimumab despite being programmed death-ligand 1 (PD-L1) negative, microsatellite stable (MSS), and having a low tumor mutational burden. He initially experienced disease progression on the chemotherapy regimens modified DCF and FOLFIRI resulting in limited functional status, esophageal stent placement, and feeding tube placement. After about 6 months on nivolumab and ipilimumab, he had …

Shorter Disease Duration Is Associated With Higher Rates Of Response To Vedolizumab In Patients With Crohn's Disease But Not Ulcerative Colitis., D. M. Faleck, A. Winters, S. Chablaney, P. Shashi, J. Meserve, A. Weiss, V. Kesar, K. Sultan, A. Swaminath, R. Ungaro, +24 Additional Authors

Journal Articles

BACKGROUND & AIMS: Patients with Crohn's disease (CD), but not ulcerative colitis (UC), of shorter duration have higher rates of response to tumor necrosis factor (TNF) antagonists than patients with longer disease duration. Little is known about the association between disease duration and response to other biologic agents. We aimed to evaluate response of patients with CD or UC to vedolizumab, stratified by disease duration.

METHODS: We analyzed data from a retrospective, multicenter, consortium of patients with CD (n = 650) or UC (n = 437) treated with vedolizumab from May 2014 through December 2016. Using time to event analyses, …

Metabolic And Microstructural Alterations In The Sle Brain Correlate With Cognitive Impairment, M. Mackay, A. Vo, C. C. Tang, W. Anderson, N. J. Ploran, C. Aranow, P. Watson, B. T. Volpe, B. Diamond, D. Eidelberg, +5 Additional Authors

Journal Articles

No abstract provided.

Forebrain Cholinergic Signaling Regulates Innate Immune Responses And Inflammation, K. R. Lehner, H. A. Silverman, M. E. Adorissio, A. Roy, A. Al-Onaizi, S. S. Chavan, Y. Al-Abed, C. N. Metz, K. J. Tracey, V. A. Paviov, +6 Additional Authors

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No abstract provided.

Influence Of Genetic Copy Number Variants Of The Human Glut3 Glucose Transporter Gene Slc2a3 On Protein Expression, Glycolysis And Rheumatoid Arthritis Risk: A Genetic Replication Study, K. R. Simpfendorfer, W. Li, A. Shih, H. Wen, N. P. Kothari, A. Einsidler, A. Wuster, J. Hunkapiller, T. W. Behrens, P. K. Gregersen, +5 Additional Authors

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No abstract provided.

Patterns Of Ana(+) B Cells For Sle Patient Stratification, J. Suurmond, Y. Atisha-Fregoso, A. N. Barlev, S. A. Calderon, C. Mackay, Z. Aranow, B. Diamond

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No abstract provided.

Tissue-Specific Metabolic Profiles After Prolonged Cardiac Arrest Reveal Brain Metabolome Dysfunction Predominantly After Resuscitation, J. Choi, M. Shoaib, T. Yin, G. Nayyar, Shinozaki, G. F. Stevens, L. B. Becker, J. Kim

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No abstract provided.

Challenges And Inconsistencies In Using Lysophosphatidic Acid As A Biomarker For Ovarian Cancer, T. Yagi, M. Shoaib, C. E. Kuschner, M. Nishikimi, B. Becker, Z. T. Lee, J. Kim

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No abstract provided.

Assessment Of Pain Symptoms And Quality Of Life Using The International Spinal Cord Injury Data Sets In Persons With Chronic Spinal Cord Injury, K. Gibbs, A. Beaufort, A. Stein, T. M. Leung, N. Sison, Z. Bloom

Journal Articles

Introduction: Traumatic spinal cord injury (SCI) triggers complex changes that can negatively impact health and quality of life. The International SCI Data Sets were developed to enable more comparable data collection on the complex sequelae of SCI across studies. This should facilitate progress in mechanistic understanding and improving treatments of SCI. Study design: Prospective observational pilot study. Objectives: To collect data on pain symptoms and quality of life (QoL) in adults living with chronic SCI. Setting: Academic medical center, New York, USA. Methods: The International SCI Basic Pain and Qol Data Sets were used to collect data from participants with …

Aquaporin-4 Water Channel In The Brain And Its Implication For Health And Disease., S. Mader, L. Brimberg

Journal Articles

Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyelitis optica spectrum disorder (NMOSD). Emerging data suggest that AQP4 may also be implicated in the glymphatic system and may be involved in the clearance of beta-amyloid in Alzheimer's disease (AD). In this review, we will describe the role of AQP4 in the adult and developing brain as well as its implication …

Human B-1 Cells And B-1 Cell Antibodies Change With Advancing Age, N. Rodriguez-Zhurbenko, T. D. Quach, T. J. Hopkins, T. L. Rothstein, Z. M. Hernandez

Journal Articles

© 2019 Rodriguez-Zhurbenko, Quach, Hopkins, Rothstein and Hernandez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Age-related deficits in the immune system have been associated with an increased incidence of infections, autoimmune diseases, and cancer. Human B cell populations change quantitatively …

Large-Scale Validation Of The Paddling Pool Task In The Clockmaze For Studying Hippocampus-Based Spatial Cognition In Mice, R. Sankowski, T. S. Huerta, R. Kalra, T. J. Klein, J. Strohl, A. Al-Abed, S. Robbiati, P. T. Huerta

Journal Articles

No abstract provided.

Editorial: Recent Advances In Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, And Mild Encephalitis, K. Bechter, D. Brown, S. Najjar

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No abstract provided.

Consensus Statement From The International Consensus Meeting On The Role Of Decompressive Craniectomy In The Management Of Traumatic Brain Injury: Consensus Statement, P. J. Hutchinson, A. G. Kolias, T. Tajsic, A. Adeleye, A. T. Aklilu, T. Apriawan, A. H. Bajamal, E. J. Barthelemy, J. S. Ullman, F. Servadei, +41 Additional Authors

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No abstract provided.

Noninvasive Sub-Organ Ultrasound Stimulation For Targeted Neuromodulation, V. Cotero, Y. Fan, T. Tsaava, A. M. Kressel, I. Hancu, T. R. Coleman, S. Zanos, K. J. Tracey, S. S. Chavan, C. Puleo, +10 Additional Authors

Journal Articles

© 2019, The Author(s). Tools for noninvasively modulating neural signaling in peripheral organs will advance the study of nerves and their effect on homeostasis and disease. Herein, we demonstrate a noninvasive method to modulate specific signaling pathways within organs using ultrasound (U/S). U/S is first applied to spleen to modulate the cholinergic anti-inflammatory pathway (CAP), and US stimulation is shown to reduce cytokine response to endotoxin to the same levels as implant-based vagus nerve stimulation (VNS). Next, hepatic U/S stimulation is shown to modulate pathways that regulate blood glucose and is as effective as VNS in suppressing the hyperglycemic effect …

Inhibition Of Hmgb1/Rage-Mediated Endocytosis By Hmgb1 Antagonist Box A, Anti-Hmgb1 Antibodies, And Cholinergic Agonists Suppresses Inflammation, H. Yang, H. Liu, Q. Zeng, G. H. Imperato, M. E. Addorisio, M. He, K. F. Cheng, Y. Al-Abed, S. S. Chavan, K. J. Tracey, +3 Additional Authors

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No abstract provided.

Towards Reconstructing Intelligible Speech From The Human Auditory Cortex, H. Akbari, B. Khalighinejad, J. L. Herrero, A. D. Mehta, N. Mesgarani

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No abstract provided.

Using A Problem/Case-Based Learning Program To Increase First And Second Year Medical Students’ Discussions Of Health Care Cost Topics, S. B. Ginzburg, J. Schwartz, S. Deutsch, D. E. Elkowitz, R. Lucito, J. E. Hirsch

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No abstract provided.

A Quality Improvement Assessment Of The Delivery Of Mental Health Services Among Wtc Responders Treated In The Community, M. Bellehsen, J. Moline, R. Rasul, K. Bevilacqua, S. Schneider, J. Kornrich, R. M. Schwartz

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No abstract provided.

Increased Incidence Of Thyroid Cancer Among World Trade Center First Responders: A Descriptive Epidemiological Assessment, S. Tuminello, M. A. Van Gerwen, E. Genden, M. Crane, W. Lieberman-Cribbin, E. Taioli

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size (p = 0.4), and were diagnosed at a similar age (p = …

Change In Quality Of Life After A Cancer Diagnosis Among A Nationally Representative Cohort Of Older Adults In The Us, R. M. Schwartz, K. A. Ornstein, B. Liu, N. Alpert, K. G. Bevilacqua, E. Taioli

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No abstract provided.

Central Serous Chorioretinopathy: Towards An Evidence-Based Treatment Guideline, T. J. Van Rijssen, E. H. Van Dijk, S. Yzer, K. Ohno-Matsui, J. E. Keunen, R. O. Schlingemann, S. Sivaprasad, G. Querques, L. A. Yannuzzi, C. J. F. Boon, +10 Additional Authors

Journal Articles

© 2019 The Authors Central serous chorioretinopathy (CSC) is a common cause of central vision loss, primarily affecting men 20–60 years of age. To date, no consensus has been reached regarding the classification of CSC, and a wide variety of interventions have been proposed, reflecting the controversy associated with treating this disease. The recent publication of appropriately powered randomised controlled trials such as the PLACE trial, as well as large retrospective, non-randomised treatment studies regarding the treatment of CSC suggest the feasibility of a more evidence-based approach when considering treatment options. The aim of this review is to provide a …

How Well Does The Standardized Video Interview Score Correlate With Traditional Interview Performance?, A. S. Chung, K. H. Shah, M. Bond, B. Ardolic, A. Husain, I. Li, L. Cygan, W. Caputo, J. Shoenberger, M. Weizberg, +2 Additional Authors

Journal Articles

© 2019 Chung et al. Introduction: In 2017, all medical students applying for residency in emergency medicine (EM) were required to participate in the Standardized Video Interview (SVI). The SVI is a video-recorded, unidirectional interview consisting of six questions designed to assess interpersonal and communication skills and professionalism. It is unclear whether this simulated interview is an accurate representation of an applicant’s competencies that are often evaluated during the in-person interview. Objective: The goal of this study was to determine whether the SVI score correlates with a traditional in-person interview score. Methods: Six geographically and demographically diverse EM residency programs …

Volumetric Laser Endomicroscopy And Its Application To Barrett's Esophagus: Results From A 1,000 Patient Registry., M. S. Smith, B. Cash, V. Konda, A. J. Trindade, S. Gordon, S. Demeester, V. Joshi, C. Lee, D. V. Sejpal, K. Chang, +38 Additional Authors

Journal Articles

Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett's esophagus (BE) management. All procedures utilized the NvisionVLE Imaging System (NinePoint Medical, Bedford, MA) which was used by investigators to identify the tissue types present, along with focal areas of concern. Following the VLE procedure, …

Phase Ii Randomised Discontinuation Trial Of Brivanib In Patients With Advanced Solid Tumours, R. L. Jones, M. J. Ratain, P. J. O'Dwyer, L. L. Siu, J. Jassem, J. Medioni, M. Dejonge, C. Rudin, R. Maki, G. Schwartz, +20 Additional Authors

Journal Articles

© 2019 The Author(s) Background: Brivanib is a selective inhibitor of vascular endothelial growth factor and fibroblast growth factor (FGF) signalling. We performed a phase II randomised discontinuation trial of brivanib in 7 tumour types (soft-tissue sarcomas [STS], ovarian cancer, breast cancer, pancreatic cancer, non-small-cell lung cancer [NSCLC], gastric/esophageal cancer and transitional cell carcinoma [TCC]). Patients and methods: During a 12-week open-label lead-in period, patients received brivanib 800 mg daily and were evaluated for FGF2 status by immunohistochemistry. Patients with stable disease at week 12 were randomised to brivanib or placebo. A study steering committee evaluated week 12 response to …

An Interim Report Of The Scleroderma Clinical Trials Consortium Working Groups, M. Baron, B. Kahaleh, E. J. Bernstein, L. Chung, P. J. Clements, C. Denton, R. T. Domsic, N. Ferdowsi, S. Narain, A. Vacca, +12 Additional Authors

Journal Articles

© The Author(s) 2018. The Scleroderma Clinical Trials Consortium represents many of the clinical researchers in the world who are interested in improving the efficiency of clinical trials in systemic sclerosis. The Scleroderma Clinical Trials Consortium has established 11 working groups to develop and validate better ways of measuring and recording multiple aspects of this heterogeneous disease. These include groups working on arthritis, disease damage, disease activity, cardiac disease, juvenile systemic sclerosis, the gastrointestinal tract, vascular component, calcinosis, scleroderma renal crisis, interstitial lung disease, and skin measurement. Members of the Scleroderma Clinical Trials Consortium may join any one or more …

Lumen Apposing Metal Stents Are Superior To Plastic Stents In Pancreatic Walled-Off Necrosis: A Large International Multicenter Study., Y. Chen, J. Yang, S. Friedland, I. Holmes, R. Law, A. Hosmer, D. V. Sejpal, S. Inamdar, A. J. Trindade, M. A. Khashab, +30 Additional Authors

Journal Articles

Background and study aims  The use of lumen apposing metal stents (LAMS) during EUS-guided transmural drainage (EUS-TD) of pancreatic walled-off necrosis (WON) has gained popularity. Data supporting their use in WON over plastic stents (PS), however, remain scarce. The aim of this study was to compare the clinical efficacy of LAMS (Axios, Boston Scientific) with PS in WON. Patients and methods  This was a multicenter, retrospective study involving 14 centers. Consecutive patients who underwent EUS-TD of WON (2012 - 2016) were included. The primary end point was clinical success defined as WON size ≤ 3 cm within a 6-month period …

Disruption Of Apol1-Mir193a Axis Induces Disorganization Of Podocyte Actin Cytoskeleton, V. Kumar, N. Paliwal, K. Ayasolla, H. Vashistha, A. Jha, N. Chandel, S. Chowdhary, M. A. Saleem, A. Malhotra, P. C. Singhal, +2 Additional Authors

Journal Articles

No abstract provided.