What Are Typical Outcomes Associated With Physical Therapy For Foot & Ankle Patients?, Judith F. Baumhauer, Christopher Neville, Kostantinos Vasalos, Chad Condidorio, Kathleen Fear, Jeff Houck

Faculty Publications - College of Physical Therapy

Introduction/Purpose: It is unclear whether patients attending physical therapy, post-op or for conservative care, achieve clinically important differences (CID) on the patient reported outcome information system (PROMIS) scales. Key PROMIS outcomes physical function (PF) and pain interference (PI) match well with treatments provided in physical therapy. Physical therapy may also influence depression (Dep). Documentation of PROMIS outcomes associated with physical therapy are useful to help set patient expectations. The purpose of this analysis was to document expected PROMIS PF, PI, and Dep outcomes after physical therapy for foot and ankle diagnoses by 1) reporting average improvement and 2) examining whether …

Smoking Cessation Treatments Varenicline (Chantix®️), Nrts, And Nicotine Dependence, Marley Vea Devoss

Biology: Student Scholarship & Creative Works

Varenicline was approved in 2006 by the FDA as an effective smoking cessation drug. Varenicline was designed to bind with α4β2 nicotinic acetylcholine receptors (nAChR) to work as both an agonist and antagonist. Other drugs like nicotine replacement therapies (NRTs) have also contributed to the decreasing rate of active smokers in the United States. The mechanisms of varenicline and its role in addiction are reviewed in this paper. With NRTs and recent trends in electronic smoking devices, nicotine dependence is still a cause for concern due to studies connecting nicotine with cell proliferation and heart disease.

Research Day Abstracts 2018-2019

Student Research

No abstract provided.

Integrative Molecular Pathological Epidemiology Of Congenital And Infant Acute Leukemia, Heather Elizabeth Williams

Health Sciences Program Student Theses, Dissertations and Capstones

Congenital and infant acute leukemia remain one of the most puzzling clinical issues in pediatric hematology-oncology. There is a paucity of studies focused on these rare, aggressive, acute leukemias; specifically, there is little study on the differences in disease in the youngest of infants less than 1 year of age unlike the numerous studies of the disease in older children. The United States National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) cancer population registry program has been integral for a plethora of clinical population and pathology research studies for numerous diseases in the last 40 years and has an …

E-Cigarettes: Perceived Harm Among Youth In The United States, Sherbert Samuels

Health Sciences Program Student Theses, Dissertations and Capstones

Studies have shown e-cigarette use surged among youth, but there is limited literature about how youth perceived the harm of these products. In this dissertation study, perceived harm of e-cigarettes and e-cigarette use over time among youth in the United States was explored. The dissertation study also included assessment of associations between perceived harm and susceptibility to e-cigarette use. A subset of data from Wave 1 and Wave 2 of the Population Assessment of Tobacco and Health (PATH) study, a national longitudinal study, was utilized. The PATH study used a questionnaire to capture self-reported data from non-institutionalized participants. Data from …

Constituents Of Talisia Nervosa With Potential Utility Against Metabolic Syndrome, Yelkaira Vásquez, Jianping Zhao, Shabana I. Khana, Mahabir P. Gupta, Ikhlas A. Khana

Faculty and Student Publications

© 2019, The Author(s). As coral cover has declined on Caribbean reefs, space has become occupied by other benthic taxa, including sponges, which may affect the recruitment of new corals, thereby affecting the ability of reefs to recover to coral-dominated states. Sponges may inhibit coral recruitment by pre-empting potential recruitment space, overgrowing recruits, or through allelopathy. This study examined coral recruitment across six coral reef sites surrounding St. Thomas, US Virgin Islands, and the impact of one species of sponge and the sponge community as a whole on coral recruitment. To test the effect of a single species of sponge …

Schinus Molle: Anatomy Of Leaves And Stems, Chemical Composition And Insecticidal Activities Of Volatile Oil Against Bed Bug (Cimex Lectularius), Camila D. Machado, Vijayasankar Raman, Junaid U. Rehman, Beatriz H.L.N.S. Maia, Emanuelle K. Meneghetti, Valter P. Almeida, Rosi Z. Silva, Paulo V. Farago, Ikhlas A. Khan, Jane M. Budel

Faculty and Student Publications

© 2019 by the authors The investigation of the constituents that were isolated from Turnera diffusa (damiana) for their inhibitory activities against recombinant human monoamine oxidases (MAO-A and MAO-B) in vitro identified acacetin 7-methyl ether as a potent selective inhibitor of MAO-B (IC50 = 198 nM). Acacetin 7-methyl ether (also known as 5-hydroxy-40, 7-dimethoxyflavone) is a naturally occurring flavone that is present in many plants and vegetables. Acacetin 7-methyl ether was four-fold less potent as an inhibitor of MAO-B when compared to acacetin (IC50 = 50 nM). However, acacetin 7-methyl ether was >500-fold selective against MAO-B over MAO-A as compared …

Cultural Competency Training In Primary Care: A Pilot Project For Improving Culturally Competent Care, Diane F. Riff

Doctor of Nursing Practice Projects

As America grows increasingly diverse, there is a recognized need for increased cultural competence in Nurse Practitioners (NPs) and other healthcare workers. Research has shown that when health care providers are not attentive to providing culturally competent care, there is a subsequent negative impact on the quality, safety and cost of patient care. Cultural

competency is a recognized and popular approach to improving the provision of health

care to racial/ethnic minority groups in the community with the aim of reducing health disparities in racial/ethnic minorities. The project sought to improve NPs’ and other health care workers’ abilities to provide culturally …

Utilizing Simulation For Family Member Caregivers Of Nicu Infants: A Pilot Project, Brenda M. Seegmiller

Doctor of Nursing Practice Projects

According to the World Health Organization (WHO), there are approximately 15 million babies born prematurely every year. Family members of premature infants in the Neonatal Intensive Care Units (NICU) are overwhelmed and lack confidence with basic skills to care for their newborn. Simulation is an education modality used for adult learners that utilizes a hands-on method for education and allows application of knowledge and skill development in a safe environment. Although clinicians are frequently trained utilizing simulation, there is limited information on its use among family members and caregivers. The purpose of this DNP Project was to explore use of …

Colorectal Cancer Educational Program In A Community Senior Center, Cathy A. Catlett Dr.

Doctor of Nursing Practice Projects

Colorectal cancer (CRC) is a preventable cancer but prevention can only occur through screening. Screenings are recommended for those 50 to 75 years of age, however rates remain low with 25.6 percent having never been screened and 7.1 percent not up-to-date. The U.S. Preventive Services Task Force (USPSTF) recommends strategies such as education to increase screening rates. Education may be used to inform and motivate individuals to be screened. Research supports the use of educational activities in a community setting to increase CRC knowledge and increase CRC screening rates. A group educational program using the Centers for Disease Control’s (CDC) …

Method Development For Structural Assessment Of Nanolipoprotein Particles With And Without Cross-Linked Lipids, Emma J. Mullen, Wei He, Sean Gilmore, Matthias Frank, Matthew Coleman, Megan Shelby

STAR Program Research Presentations

Membrane proteins make up approximately 30% of the cellular proteome and account for over 60% of pharmaceutical targets.1 Determining the structures of this class of proteins is critical to our understanding of disease states and will advance rational drug design. But membrane proteins have limited solubility, rarely form large crystals that diffract well, and often misfold outside of a bilayer, hindering crystallographic studies.1 Nanolipoprotein particles (NLPs) have arisen as a platform to readily solubilize membrane proteins while mimicking a native lipid environment. NLPs consist of a discoidal phospholipid bilayer encircled by an apolipoprotein belt. In an effort to optimize and …

Progressive Hypoxia-On-A-Chip: An In Vitro Oxygen Gradient Model For Capturing The Effects Of Hypoxia On Primary Hepatocytes In Health And Disease, Young Bok Abraham Kang, Jinsu Eo, Beyza Bulutoglu, Martin L. Yarmush, O. Berk Usta

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

Oxygen is vital to the function of all tissues including the liver and lack of oxygen, that is, hypoxia can result in both acute and chronic injuries to the liver in vivo and ex vivo. Furthermore, a permanent oxygen gradient is naturally present along the liver sinusoid, which plays a role in the metabolic zonation and the pathophysiology of liver diseases. Accordingly, here, we introduce an in vitro microfluidic platform capable of actively creating a series of oxygen concentrations on a single continuous microtissue, ranging from normoxia to severe hypoxia. This range approximately captures both the physiologically relevant oxygen gradient …

Interrater Reliability Of The Pediatric Neuromuscular Recovery Scale In Children With Spina Bifida, Elizabeth Ardolino, Megan Flores, Germaine Ferreira, Susan Jeantete, Kathleen Manella

Physical Therapy Collection

Purpose: There is a paucity of outcome measures to assess the quality of functional mobility in children with spina bifida¹. The Pediatric Neuromuscular Recovery Scale (Peds NRS) is a valid and reliable outcome measure that was developed to assess the motor capacity of children with spinal cord injury^2-6. The purpose of this study was to examine the interrater reliability of the Pediatric Neuromuscular Recovery Scale (Peds NRS) to classify motor capacity in children with myelomeningocele (MMC) form of spina bifida.

Subjects: Twenty-one children with MMC (1.4- 10 years of age; mean age of 5.3 …

Integrating Interprofessional Education With Simulation Experiences Within Ot And Pt Curricula: A Look At The Backwards Design Process, Nicole Rodriguez, Norman C. Belleza, Maureen Johnson

Physical Therapy Collection

Interprofessional education has become a significant focus across healthcare disciplines noting the benefits that can be achieved through improving patient outcomes, increasing awareness for potential referral to other providers, and fostering collaboration.

The integration of simulation into established OT and PT curriculum was a less daunting task by using the backward design process. Continued growth and the addition of Speech Therapy, Nursing, and Physician’s Assistant programs will further necessitate use of backward design to integrate meaningful multidisciplinary activities for students.

The Role Of Risk Tolerance In Publics’ Health Risk Perception And Responses, Hyoyeun Jun, Yen-I Lee

International Crisis and Risk Communication Conference

To better understand how uncertainty influences publics’ risk perception and responses, this study introduced risk tolerance as a new concept to public relations literature and then investigated how publics react to health risks with different temporal distances: climate change and foodborne illness. Through an online survey, this study found out that uncertainty, induced by risk temporal distance, leads to varied risk tolerance, which subsequently influences where and how people seek and share risk information.

Understanding Flu Vaccination Acceptance Among U.S. Adults: The Health Belief Model And Media Sources, Tong Xie, Connor Grady, Michael Cacciatore, Glen Nowak

International Crisis and Risk Communication Conference

Based on previous studies about the Health Belief Model (HBM) and the reinforcing relationship between media selectivity or preference and individual’s behavior, this study used a national representative adult sample to assess flu vaccination as the result of an appraisal of relevant health beliefs, trust towards the authoritative entities (e.g. CDC & FDA) and vaccine-related media information, in addition to one’s existing behavior pattern. Results showed that not-vaccinated individuals differ significantly in their vaccine-related health believes and the trust towards the authoritative information sources. This group acquired less recommendation from health care providers and more negative sentiments about flu vaccine …

Perceptions Of Risk Of Health Disparities Amid Previously Identified Political Corruption And Ageism In Slovakia, Marta N. Lukacovic, Deborah D. Sellnow-Richmond, Monika Durechova

International Crisis and Risk Communication Conference

This study examines the role of traditional versus new media’s impact on citizens’ perceptions of risk within elder care. We analyzed survey data from 112 Slovak citizens regarding their social network activity and perceptions of corruption, ageism, and health disparities in the Slovak elder care system. Previous research (Lukacovic, Sellnow-Richmond, & Durechova, under contract) identified three prominent sociopolitical issues present in the Slovak medical system among Slovak UGC discourse regarding Slovak healthcare inequity: corruption, threats to dignity, and discrimination. Here, we examined the extent to which social media users perceive the prevalence and subsequent risk of experiencing health disparities within …

Emergency Physicians' Perception Of Barriers And Facilitators For Adopting An Opioid Prescribing Guideline In Ohio: A Qualitative Interview Study, Jonathan Penm, Neil J. Mackinnon, Chloe Connelly, Rebecca Mashni, Michael S. Lyons, Edmond A. Hooker, Erin L. Winstanley, Steve Carlton-Ford, Erica Tolle, Jill Boone, Kathleen Koechlin, Jolene Defiore-Hyrmer

Clinical and Translational Science Institute

Background Ohio has the fifth highest rate of prescription opioid overdose deaths in the United States. One strategy implemented to address this concern is a state-wide opioid prescribing guideline in the emergency department (ED). Objective Our aim was to explore emergency physicians’ perceptions on barriers and strategies for the Ohio ED opioid prescribing guideline. Methods Semi-structured interviews with emergency physicians in Ohio were conducted from October to December 2016. Emergency physicians were recruited through the American College of Emergency Physicians Ohio State Chapter. The interview guide explored issues related to the implementation of the guidelines. Interview data were transcribed and …

Impact Of Rural Versus Urban Geographic Location On Length Of Stay After Carotid Endarterectomy, Samantha D. Minc, Ranjita Misra, Sari D. Holmes, Yue Ren, Luke Marone

Faculty & Staff Scholarship

Abstract

Background: Reducing the incidence of extended length of stay (ELOS) after carotid endarterectomy (CEA), defined as LOS > I day, is an important quality improvement focus of the Vascular Quality Initiative (VQI). Rural patients with geographic barriers pose a particular challenge for discharge and may have higher incidences of ELOS as a result. The purpose of this study was to examine the impact of patients’ home geographic location on ELOS after CEA.

Methods: The VQI national database for CEA comprised the sample for analyses (N = 66,900). Rural-Urban Commuting Area (RUCA) codes, a validated system used to classify the nation’s …

Bariatric Surgery Outcomes In Appalachia Influenced By Surgery Type, Diabetes, And Depression, Makenzie L. Barr, Lawrence E. Tabone, Stephanie J. Cox, Cassie Brode, Nova Szoka, I. Mark Olfert, Laura Davisson, Melissa D. Olfert

Faculty & Staff Scholarship

Background

Most effective treatment for morbid obesity and its comorbidities is bariatric surgery. However, research is limited on weight loss and associated outcomes among patients in Appalachia. The objective of this study was to examine demographic and comorbidity influence on surgical outcomes of this population including age, sex, race, state of residence, education, marital status, body mass index (BMI kg/m2), excess body weight (EBW), percent excess weight loss (%EWL), blood pressure, diagnosed depression, diagnosed type 2 diabetes (T2D), Beck Depression Inventory-II (BDI-II), and laboratory values (i.e., hemoglobin A1c).

Methods

A retrospective electronic medical record (EMR) data extraction was performed on …

Differences Between Occupational And Non-Occupational-Related Motor Vehicle Collisions In West Virginia: A Cross-Sectional And Spatial Analysis, Toni Marie Rudisill

Faculty & Staff Scholarship

Background

Motor vehicle collisions comprise the majority of occupational-related fatalities in the United States and West Virginia has one of the highest occupational-related fatality rates in the nation. The purpose of this study was to compare work and non-work-related collisions, crash locations, and the characteristics of in-state and out-of-state drivers ≥18 years of age who were fatally injured in work-related collisions in West Virginia.

Methodology

Data were from the 2000–2017 Fatality Analysis Reporting System. Work and non-work-related crashes and characteristics in-state vs. out-of-state drivers were compared using binary and multivariable logistic regression analyses. Crash locations were compared via spatial analyses …

Eustachian Tube Foreign Body With Endoscopic-Assisted Surgical Removal, Phillip R. Purnell, Adam Bender Heine, Habib Zalzal, Abdul R. Tarabishy, Adam Casis

Faculty & Staff Scholarship

Abstract

Objectives. Foreign bodies of the external and middle ear are not uncommon; however, foreign bodies in the eustachian tube are rare. Here we describe the presentation, imaging, and endoscopic-assisted surgical management of a case of eustachian tube foreign body. Methods. A 34-year-old male was seen for evaluation of foreign body of the left eustachian tube while working with metal at a machine shop. Imaging and surgical management are highlighted and review of available literature regarding foreign bodies of the eustachian tube is presented. Results. A CT scan revealed a foreign body present approximately 1 cm into …

Traumatic Bladder Ruptures: A Ten-Year Review At A Level 1 Trauma Center, John Barnard, Tyler Overholt, Ali Hajiran, Chad Crigger, Morris Jessop, Jennifer Knight, Chad Morley

Faculty & Staff Scholarship

Abstract

Bladder rupture occurs in only 1.6% of blunt abdominopelvic trauma cases. Although rare, bladder rupture can result in significant morbidity if undiagnosed or inappropriately managed. AUA Urotrauma Guidelines suggest that urethral catheter drainage is a standard of care for both extraperitoneal and intraperitoneal bladder rupture regardless of the need for surgical repair. However, no specific guidance is given regarding the length of catheterization. The present study seeks to summarize contemporary management of bladder trauma at our tertiary care center, assess the impact of length of catheterization on bladder injuries and complications, and develop a protocol for management of bladder …

Melatonin Prevents Osteoarthritis-Induced Cartilage Degradation Via Targeting Microrna-140, Yijian Zhang, Jun Lin, Xinfeng Zhou, Xi Chen, Angela Carley Chen, Bin Pi, Guoquing Pan, Ming Pei, Huilin Yang, Tao Liu, Fan He

Faculty & Staff Scholarship

Abstract

Osteoarthritis (OA) is characterized by the progressive destruction of articular cartilage, which is involved in the imbalance between extracellular matrix (ECM) synthesis and degradation. MicroRNA-140-5p (miR-140) is specifically expressed in cartilage and plays an important role in OA-induced matrix degradation. The aim of this study was to investigate (1) whether intra-articular injection of melatonin could ameliorate surgically induced OA in mice and (2) whether melatonin could regulate matrix-degrading enzymes at the posttranscriptional level by targeting miR-140. In an in vitro OA environment induced by interleukin-1 beta (IL-1β), melatonin treatment improved cell proliferation of human chondrocytes, promoted the …

Effect Of A Motivational Interviewing–Based Intervention On Initiation Of Mental Health Treatment And Mental Health After An Emergency Department Visit Among Suicidal Adolescents, Jacqueline Grupp-Phelan, Jack Stevens, Stephanie Boyd, Daniel M. Cohen, Robert T. Ammerman, Stacey Liddy-Hicks, Kendra Heck, Steven C. Marcus, Lara Stone, John V. Campo, Jefferey A. Bridge

Faculty & Staff Scholarship

Abstract

IMPORTANCE Emergency department (ED) visits present opportunities to identify and refer suicidal youth for outpatient mental health care, although this practice is not routine.

OBJECTIVE To examine whether a motivational interviewing–based intervention increases linkage of adolescents to outpatient mental health services and reduces depression symptoms and suicidal ideation in adolescents seeking emergency care for non–mental health–related concerns who screen positive for suicide risk.

DESIGN, SETTING, AND PARTICIPANTS In this randomized clinical trial, adolescents aged 12 to 17 years who screened positive on the Ask Suicide Screening Questions (ASQ) during a nonpsychiatric ED visit at 2 academic pediatric EDs in …

Cecal Perforation In The Setting Of Campylobacter Jejuni Infection, Seema Jain, Weston Betrner, Dane Olevian, Dhiraj Yadav

Faculty & Staff Scholarship

Campylobacter infection is the leading cause of bacterial gastroenteritis worldwide, yet life-threatening complications are extremely rare. We present a 32-year-old previously healthy man who presented with dysentery from Campylobacter jejuni, which was complicated by cecal perforation and secondary bacterial peritonitis.

Acute Levodopa Dosing Around-The-Clock Ameliorates Rem Sleep Without Atonia In Hemiparkinsonian Rats, Vishakh Iyer, Quynh Vo, Anthony Mell, Siven Chinniah, Ashley Zenerovitz, Kala Venkiteswaran, Allen R. Kunselman, Jidong Fang, Thyagarajan Subramanian

Faculty & Staff Scholarship

• Article
• Open Access
• Published: 29 November 2019

Acute levodopa dosing around-the-clock ameliorates REM sleep without atonia in hemiparkinsonian rats

• Vishakh Iyer,
• Quynh Vo,
• Anthony Mell,
• Siven Chinniah,
• Ashley Zenerovitz,
• Kala Venkiteswaran,
• Allen R. Kunselman,
• Jidong Fang &
• Thyagarajan Subramanian

npj Parkinson's Disease volume 5, Article number: 27 (2019) Cite this article

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Abstract

Rapid-eye-movement (REM) sleep without atonia (RSWA), a marker of REM sleep behavior disorder (RBD), is frequently comorbid with Parkinson’s disease (PD). Although rodent models are commonly used for studying PD, the neurobiological and behavioral correlates of …

Investigation Of The Cofiring Process Of Raw Or Torrefied Bamboo And Masson Pine By Using A Cone Calorimeter, Hongzhong Xiang, Jianfei Yang, Zixing Feng, Wanhe Hu, Fang Liang, Liangmeng Ni, Qi Gao, Zhijia Liu

Faculty & Staff Scholarship

Cofiring characteristics of raw or torrefied bamboo and masson pine blends with different blend ratios were investigated by cone calorimetry, and its ash performance from cofiring was also determined by a YX-HRD testing instrument, X-ray fluorescence, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Results showed that bamboo and masson pine had the different physicochemical properties. Torrefaction improved fuel performances, resulting in a more stable cofiring process. It also decreased the heat release rate, total heat release, and total suspended particulates of fuels, especially CO2 and CO release. Masson pine ash mainly included CaO, SiO2, Fe2O3, K2O, and Al2O3. …

Impact Of Fibronectin Knockout On Proliferation And Differentiation Of Human Infrapatellar Fat Pad-Derived Stem Cells, Yiming Wang, Yawen Fu, Zuoqin Yan, Xiao-Bing Zhang, Ming Pei

Faculty & Staff Scholarship

Fibronectin plays an essential role in tissue development and regeneration. However, the effects of fibronectin knockout (FN1-KO) on stem cells’ proliferation and differentiation remain unknown. In this study, CRISPR/Cas9 generated FN1-KO in human infrapatellar fat pad-derived stem cells (IPFSCs) was evaluated for proliferation ability including cell cycle and surface markers as well as stemness gene expression and for differentiation capacity including chondrogenic and adipogenic differentiation. High passage IPFSCs were also evaluated for proliferation and differentiation capacity after expansion on decellularized ECM (dECM) deposited by FN1-KO cells. Successful FN1-KO in IPFSCs was confirmed by Sanger sequencing and Inference of CRISPR Edits …

Improving Exposure For Transoral Oropharyngeal Surgery With The Floor Of Mouth Window: A Cadaveric Feasibility Study, Jefferson Chung, Adam Bender-Heine, H. Wayne Lambert

Faculty & Staff Scholarship

Background: Transoral robotic and laser surgery is rising in popularity due to the increasing incidence of Human Papilloma Virus (HPV) related oropharyngeal cancer. However, adequate exposure of the tongue base remains a major hurdle in many cases. This study introduces a novel surgical technique called the Floor of Mouth Window, which can be used to improve tongue base exposure at the time of transoral surgery. Methods: This is a preclinical anatomic cadaver study. Seven fresh cadavers were used for this study. Exposure of the tongue base was compared between conventional mouth gags – the Feyh-Kastenbauer and McIvor – and our …