Medicine and Health Sciences Commons^™

Investigation Of The Relationship Between Ischemic Stroke And Endothelial Nitric Oxide Synthase Gene Polymorphisms [G894t, Intron 4 Vntr And T786c], Süleyman Ömer Anliaçik, Osman Serhat Tokgöz, Ayşegül Zamani̇, Mahmut Selman Yildirim, Mehmet Si̇nan İyi̇soy

Turkish Journal of Medical Sciences

Background/aim: We aimed to investigate the associations between endothelial nitric oxide synthase(eNOS) gene polymorphisms [G894T (rs1799983)], intron 4 (27-bpTR) variable number tandem repeat (VNTR) and T786C (rs2070744), and ischemic stroke in the Anatolian population.Materials and methods: This case-control study included 112 patients with "stroke of undetermined etiology" and 160 controls. Real-time polymerase chain reaction (RT-PCR) analysis was used to analyze these polymorphisms. Between-group frequencies of alleles and genotypes were compared using binary logistic regression analysis.Results: No significant difference was observed between the two groups in terms of the genotype and allele distributions of the eNOS G894T (rs1799983) polymorphism (P > 0.05). …

The Tailoring Of National Guidelines For Upper Extremity Post-Stroke Rehabilitation: A Concept In Use., Salem F. Alatawi

Internet Journal of Allied Health Sciences and Practice

Background: In Saudi Arabia, national evidence-based clinical guidelines (NCG) were created based for healthcare interventions. However, clinicians appear to be slow to incorporate the evidence into practice. As a result, there exists a time-gap between the gathering and presentation of evidence for best practice and the use of that evidence by clinicians. It becomes, therefore, imperative to investigate the gap between the research evidence and clinical practice. The knowledge to action (KTA) framework is available to facilitate the implementation of research evidence. This framework incorporates the theory of tailoring, a concept that is intended to create a fit between …

Improving Early Mobilization In Acute Stroke Patients Through Best Practice Education, Angela Christine Middleton

Walden Dissertations and Doctoral Studies

Nonadherence to best practice guidelines in early mobilization in acute stroke increases the time from admission to mobilization and may increase residual long-term stroke effects. Early mobilization following an acute stroke is known to decrease long-term and secondary disability. The purpose of this project was to decrease the time from admission to mobilization in the acute stroke patient population by improving knowledge of best-practice guidelines in early mobility using an educational intervention for advanced practice nurse practitioners, physicians, and registered nurses. The practice-focused question for this project asked whether a staff educational program based on best-practice guidelines would decrease the …

Promoting Tia Awareness: Decreasing Stroke Mortality In Vermont, Nicole Becher

Family Medicine Clerkship Student Projects

The death rate from stroke in Washington County, VT was nearly twice that of the state in 2015. Risk of death from stroke can be decreased by timely intervention, however many patients are unaware as to signs and symptoms of stroke, and when to seek medical attention. A brochure was developed and distributed, aiming to shorten the time between experiencing TIA symptoms and point of contact with medical professionals.

Paired Associative Stimulation As A Tool To Assess Plasticity Enhancers In Chronic Stroke, Joshua Silverstein, Mar Cortes, Katherine Z. Tsagaris, Alejandra Climent, Linda M. Gerber, Clara Oromendia, Pasquale Fonzetti, Rajiv R. Ratan, Tomoko Kitago, Marco Iacoboni, Allan Wu, Bruce Dobkin, Dylan J. Edwards

Research outputs 2014 to 2021

Background and Purpose: The potential for adaptive plasticity in the post-stroke brain is difficult to estimate, as is the demonstration of central nervous system (CNS) target engagement of drugs that show promise in facilitating stroke recovery. We set out to determine if paired associative stimulation (PAS) can be used (a) as an assay of CNS plasticity in patients with chronic stroke, and (b) to demonstrate CNS engagement by memantine, a drug which has potential plasticity-modulating effects for use in motor recovery following stroke.

Methods: We examined the effect of PAS in fourteen participants with chronic hemiparetic stroke at five time-points …

Ky Stroke Encounter Quality Improvement Project: An Evaluation Of The Differential Administration Of Tpa In Acute Ischemic Stroke, Payton Malone

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

No abstract available

The Impact Of Depression On Treatment Outcomes For Patients With Aphasia Who Participate In An Intensive Comprehensive Aphasia Program (Icap), Harley B. Kincheloe

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Abstract

Background: Aphasia is a multi-modal impairment resulting from left-hemisphere stroke. Aphasia is often accompanied by post-stroke depression. Acquiring aphasia and depression is seen to hinder quality of life and rehabilitative outcomes. Traditional stroke therapy often does not monitor or treat psychological difficulties such as depression. Such psychological difficulties hinder progress in recovery and may need to be addressed in therapy to ensure the best possible outcomes.

Aims: In response to the lack of psychological support for persons with aphasia, this literature review aims to explore the impact of depression on functional outcomes. Furthermore, this literature review will explore how …

Evidence-Based Music Therapy Treatment To Elevate Mood During Acute Stroke Care, Jessica L. Rushing

Theses and Dissertations--Rehabilitation Sciences

Stroke is the fifth leading cause of death in the U.S. with approximately 795,000 Americans experiencing a stroke each year. In addition to common difficulties with communication and physical impairments following stroke, psychosocial impacts warrant assessment and treatment. Experiencing a stroke can lead to depression, mood disorders, and difficulties with emotion regulation. It is well documented that post-stroke depression (PSD) affects a third of stroke survivors. Higher levels of depression and depressive symptoms are associated with a less efficient use of rehabilitation services, poor functional outcomes, greater odds of hospital readmission, negative impacts on social participation, and increased mortality. The …

Regeneration Enhances Metastasis: A Novel Role For Neurovascular Signaling In Promoting Melanoma Brain Metastasis., Roshini Prakash, Sivan Izraely, Nikita S Thareja, Rex H Lee, Maya Rappaport, Riki Kawaguchi, Orit Sagi-Assif, Shlomit Ben-Menachem, Tsipi Meshel, Michal Machnicki, Shuichi Ohe, Dave S B Hoon, Giovanni Coppola, Isaac P Witz, S Thomas Carmichael

Articles, Abstracts, and Reports

Neural repair after stroke involves initiation of a cellular proliferative program in the form of angiogenesis, neurogenesis, and molecular growth signals in the surrounding tissue elements. This cellular environment constitutes a niche in which regeneration of new blood vessels and new neurons leads to partial tissue repair after stroke. Cancer metastasis has similar proliferative cellular events in the brain and other organs. Do cancer and CNS tissue repair share similar cellular processes? In this study, we identify a novel role of the regenerative neurovascular niche induced by stroke in promoting brain melanoma metastasis through enhancing cellular interactions with surrounding niche …

Treatment Fidelity In The Very Early Rehabilitation In Speech (Verse) Randomised Controlled Trial: An Exploration Of Treatment For Aphasia, Emily Louise Brogan

Theses: Doctorates and Masters

Background

Aphasia is a neurological condition that affects the expression and/or comprehension of language and can have considerable impact on a person’s quality of life. Treatment for aphasia from speech language pathologists is effective. However, more information is needed on the nature of effective intervention including consideration for what therapy is provided, when it is commenced and how it is delivered. Treatment fidelity is concerned with ensuring research treatment protocols are implemented as they were intended, which assists in uncovering the specifics of how and why treatments work. When treatment fidelity is investigated thoroughly, researchers and research consumers can be …

Cerebro-Vascular Accident, Mehak Gera, Rajendra Prasad, Suresh Babu, Manthappa M

Digital Journal of Clinical Medicine

No abstract provided.

The Effects Of Early Neurodevelopmental Bobath Approach And Mobilization On Quadriceps Muscle Thickness In Stroke Patients, Arzu Güçlü Gündüz, Gökhan Yazici, Çağla Özkul, Hami̇t Küçük, Hale Zeynep Batur Çağlayan, Bi̇jen Nazliel

Turkish Journal of Medical Sciences

Background/aim: Following stroke, damage to the central nervous system and adaptive changes in muscle tissue are factors responsible for the loss of muscle strength. Even though it is suggested that early physiotherapy and mobilization prevent structural adaptive changes in muscle tissue, studies regarding this issue are insufficient. The aim of this study is to investigate the effects of early physiotherapy and mobilization on quadriceps muscle thickness (QMT) in stroke patients.Materials and methods: Twelve stroke patients who were admitted to the neurology intensive care unit and 13 healthy controls were included in the study. QMT was examined at admission and discharge …