Medicine and Health Sciences Commons^™

Jefferson Digital Commons Quarterly Report: October-December 2017, Kelsey Duinkerken Msi, Dan Kipnis Msi, James Copeland Libt

Jefferson Digital Commons Reports

This quarterly report includes:

• Assorted assets added to the JDC in the last quarter
• Grand Rounds Recordings
• College Within a College (CWIC) Posters
• Program of Industrial Design Capstones
• What people are saying about the JDC

Erk-Mediated Phosphorylation Regulates Sox10 Sumoylation And Targets Expression In Mutant Braf Melanoma., Shujun Han, Yibo Ren, Wangxiao He, Huadong Liu, Zhe Zhi, Xinliang Zhu, Tielin Yang, Yu Rong, Bohan Ma, Timothy J. Purwin, Zhenlin Ouyang, Caixia Li, Xun Wang, Xueqiang Wang, Huizi Yang, Yan Zheng, Andrew E. Aplin, Jiankang Liu, Yongping Shao

Department of Cancer Biology Faculty Papers

In human mutant BRAF melanoma cells, the stemness transcription factor FOXD3 is rapidly induced by inhibition of ERK1/2 signaling and mediates adaptive resistance to RAF inhibitors. However, the mechanism underlying ERK signaling control of FOXD3 expression remains unknown. Here we show that SOX10 is both necessary and sufficient for RAF inhibitor-induced expression of FOXD3 in mutant BRAF melanoma cells. SOX10 activates the transcription of FOXD3 by binding to a regulatory element in FOXD3 promoter. Phosphorylation of SOX10 by ERK inhibits its transcription activity toward multiple target genes by interfering with the sumoylation of SOX10 at K55, which is essential for …

Differential Impact Of Rb Status On E2f1 Reprogramming In Human Cancer., Christopher Mcnair, Kexin Xu, Amy C. Mandigo, Matteo Benelli, Benjamin E. Leiby, Daniel Rodrigues, Johan Lindberg, Henrik Gronberg, Mateus Crespo, Bram De Laere, Luc Dirix, Tapio Visakorpi, Fugen Li, Felix Y. Feng, Johann De Bono, Francesca Demichelis, Mark A. Rubin, Myles Brown, Karen E. Knudsen

Department of Cancer Biology Faculty Papers

The tumor suppressor protein retinoblastoma (RB) is mechanistically linked to suppression of transcription factor E2F1-mediated cell cycle regulation. For multiple tumor types, loss of RB function is associated with poor clinical outcome. RB action is abrogated either by direct depletion or through inactivation of RB function; however, the basis for this selectivity is unknown. Here, analysis of tumor samples and cell-free DNA from patients with advanced prostate cancer showed that direct RB loss was the preferred pathway of disruption in human disease. While RB loss was associated with lethal disease, RB-deficient tumors had no proliferative advantage and exhibited downstream effects …

The Emerging International Taxation Problems, James G. Yang, Victor N.A. Metallo

Department of Accounting and Finance Faculty Scholarship and Creative Works

The problems of tax evasion and tax avoidance are as old as taxes themselves. Between 2015 and 2016 alone, many U.S. multinational corporations were involved in tax disputes with the European Commission. From a historical perspective, these disputes are unprecedented as they have resulted in tremendous amount of tax penalties. The most notable case was Apple for €13 billion of unpaid tax. This article discusses what tax strategies these corporations used that caused such disputes. It specifically investigates seven corporations: Apple Inc., McDonald’s, Starbucks, Fiat, Amazon, Google, and Ikea, and elaborates on the following tax strategies: high royalties, intercompany transfer …

Algorithm Development For Intrafraction Radiotherapy Beam Edge Verification From Cherenkov Imaging., Clare Snyder, Brian W. Pogue, Michael Jermyn, Irwin Tendler

Dartmouth Scholarship

Imaging of Cherenkov light emission from patient tissue during fractionated radiotherapy has been shown to be a possible way to visualize beam delivery in real time. If this tool is advanced as a delivery verification methodology, then a sequence of image processing steps must be established to maximize accurate recovery of beam edges. This was analyzed and developed here, focusing on the noise characteristics and representative images from both phantoms and patients undergoing whole breast radiotherapy. The processing included temporally integrating video data into a single, composite summary image at each control point. Each image stack was also median filtered …

Improving Outcomes In Adults With Diabetes Through An Interprofessional Collaborative Practice Program, Jean Nagelkerk, Margaret E. Thompson, Michael Bouthillier, Amy Tompkins, Lawrence J. Baer, Jeff Trytko, Andrew Booth, Adam Stevens, Kayleah Groeneveld

Open Access Publishing Support Funded Articles

In 2014, the Midwest Interprofessional Practice, Education and Research Center partnered with a Federally Qualified Health Center (FQHC) to implement an interprofessional collaborative practice (IPCP) education program to improve the health of adult patients with diabetes and to improve practice efficiency. This partnership included integrating an interprofessional team of students with the practice team. Twenty-five students and 20 staff engaged in the IPCP program, which included completion of educational modules on IPCP and implementation of daily huddles, focus patient visits, phone calls, team-based case presentations, medication reconciliation, and student-led group diabetes education classes. This study used a sequential mixed methods …

Surprised By Benefit In Pediatric Palliative Care Research, Meaghann S. Weaver, Cynthia J. Bell, Jessica L. Diver, Shana Jacobs, Maureen E. Lyon, Kim Mooney-Doyle, Amy Rose Newman, Julia Slutsman, Pamela S. Hinds

College of Nursing Faculty Research and Publications

No abstract provided.

Antagonistic Actions Of Juvenile Hormone And 20-Hydroxyecdysone Within The Ring Gland Determine Developmental Transitions In Drosophila, Suning Liu, Kang Li, Yue Gao, Xi Liu, Weiting Chen, Wei Ge, Qili Feng, Subba Reddy Palli, Sheng Li

Entomology Faculty Publications

In both vertebrates and insects, developmental transition from the juvenile stage to adulthood is regulated by steroid hormones. In insects, the steroid hormone, 20-hydroxyecdysone (20E), elicits metamorphosis, thus promoting this transition, while the sesquiterpenoid juvenile hormone (JH) antagonizes 20E signaling to prevent precocious metamorphosis during the larval stages. However, not much is known about the mechanisms involved in cross-talk between these two hormones. In this study, we discovered that in the ring gland (RG) of Drosophila larvae, JH and 20E control each other’s biosynthesis. JH induces expression of a Krüppel-like transcription factor gene Kr-h1 in the prothoracic gland (PG), a …

Factors Associated With Low Birthweight In Term Pregnancies: A Matched Case–Control Study From Rural Pakistan, Atif Habib, Camille R. Greenow, Shabina Arif, Sajid Bashir Soofi, Abid Hussain, Qamar Junejo, A Hussain, Fariha Shaheen, Kirsten I. Black

Department of Obstetrics & Gynaecology

Low birthweight (LBW) remains a significant public health problem in Pakistan and further understanding of factors associated with LBW is required. We conducted a hospital-based matched case control study to identify risk factors associated with LBW in a rural district of Pakistan. We found that illiteracy (AOR: 2.68; 95% CI: 1.59 - 4.38), nulliparity (AOR: 1.82; 95% CI: 1.26-2.44), having a previous miscarriage/abortion (AOR: 1.22; 95% CI: 1.06-2.35), having < 2 antenatal care (ANC) visits during last pregnancy (AOR: 2.43; 95% CI: 1.34-2.88), seeking ANC in third trimester (AOR: 3.62; 95% CI : 2.14-5.03), non-use of iron folic acid during last pregnancy (AOR: 2.72; 95% CI: 1.75-3.17), having hypertension during last pregnancy (AOR: 1.42; 95% CI: 1.13-2.20), being anemic (AOR: 2.67; 95% CI: 1.65-5.24) and having postpartum weight of <45 kg (AOR: 3.30; 95% CI : 1.97-4.52) were significantly associated with an increased odds of having a LBW baby. Our study identifies modifiable risk factors requiring immediate commitment from the health authorities.

Patients And Animal Models Of Cngβ1-Deficient Retinitis Pigmentosa Support Gene Augmentation Approach., Simon M Petersen-Jones, Laurence M. Occelli, Paige A. Winkler, Winston Lee, Janet R Sparrow, Mai Tsukikawa, Sanford L. Boye, Vince Chiodo, Jenina E. Capasso, Elvir Becirovic, Christian Schön, Mathias W. Seeliger, Alex V. Levin, Stylianos Michalakis, William W. Hauswirth, Stephen H. Tsang

Wills Eye Hospital Papers

Retinitis pigmentosa (RP) is a major cause of blindness that affects 1.5 million people worldwide. Mutations in cyclic nucleotide-gated channel β 1 (CNGB1) cause approximately 4% of autosomal recessive RP. Gene augmentation therapy shows promise for treating inherited retinal degenerations; however, relevant animal models and biomarkers of progression in patients with RP are needed to assess therapeutic outcomes. Here, we evaluated RP patients with CNGB1 mutations for potential biomarkers of progression and compared human phenotypes with those of mouse and dog models of the disease. Additionally, we used gene augmentation therapy in a CNGβ1-deficient dog model to evaluate potential translation …

Randomized Trial To Reduce Air Particle Levels In Homes Of Smokers And Children, Suzanne C. Hughes, John Belletierre, Benjamin Nguyen, Sandy Liles, Neil E. Klepeis, Penelope J.E. Quintana, Vincent Berardi, Saori Obayashi, Savannah Bradley, C. Richard Hofstetter, Melbourne F. Hovell

Psychology Faculty Articles and Research

Introduction

Exposure to fine particulate matter in the home from sources such as smoking, cooking, and cleaning may put residents, especially children, at risk for detrimental health effects. A randomized clinical trial was conducted from 2011 to 2016 to determine whether real-time feedback in the home plus brief coaching of parents or guardians could reduce fine particle levels in homes with smokers and children.

Design

A randomized trial with two groups—intervention and control.

Setting/participants

A total of 298 participants from predominantly low-income households with an adult smoker and a child aged <14 years. Participants were recruited during 2012–2015 from multiple sources in San Diego, mainly Women, Infants and Children Program sites.

Intervention

The multicomponent intervention consisted of continuous lights and …

Week Of January 2, 2018, New York Medical College

InTouch

• Empire State Development Awards BioInc@NYMC More Than One Million Dollars
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Development Of An Objective Assessment Tool For Total Laparoscopic Hysterectomy: A Delphi Method Among Experts And Evaluation On A Virtual Reality Simulator., Sophie Knight, Rajesh Aggarwal, Md, Phd, Frcs, Facs, Aubert Agostini, Anderson Loundou, Stéphane Berdah, Patrice Crochet

Department of Surgery Faculty Papers

INTRODUCTION: Total Laparoscopic hysterectomy (LH) requires an advanced level of operative skills and training. The aim of this study was to develop an objective scale specific for the assessment of technical skills for LH (H-OSATS) and to demonstrate feasibility of use and validity in a virtual reality setting.

MATERIAL AND METHODS: The scale was developed using a hierarchical task analysis and a panel of international experts. A Delphi method obtained consensus among experts on relevant steps that should be included into the H-OSATS scale for assessment of operative performances. Feasibility of use and validity of the scale were evaluated by …

The Art And Science Of Occupation As Therapy, Jennifer Fortuna

The Open Journal of Occupational Therapy

Ashley Woo Lee, an occupational therapy student based in Loma Linda, CA, provided the cover art for the Winter 2018 issue of The Open Journal of Occupational Therapy (OJOT) (Figure 1). The piece, titled “Tree of Life,” is a 11” x 14” drawing made from mixed media. As a child living in Korea, Ashley enjoyed drawing as a favorite pastime. After her family relocated to the United States, art became Ashley’s primary means for self-expression. When a career in art was not an option, the field of occupational therapy satisfied Ashley’s artistic and scientific interests. In a recent interview, Ashley …

Factors Associated With Academic Performance Among Second-Year Undergraduate Occupational Therapy Students, Tore Bonsaksen, Brian J. Ellingham, Tove Carstensen

The Open Journal of Occupational Therapy

Background: Research into occupational therapy education and its outcomes for students is growing. More research is needed to determine the factors of importance for occupational therapy students’ academic outcomes. This study aimed to investigate factors associated with academic performance among second-year undergraduate occupational therapy students in Norway.

Methods: Occupational therapy students (n = 111) from two education programs completed questionnaires asking for sociodemographic, work-related, and education-related information. Hierarchical linear regression analysis was used to examine factors independently associated with the students’ academic performance.

Results: A higher age was associated with better average academic performance among the students, whereas having …

Co-Constructing Simulations With Learners: Roles, Responsibilities, And Impact, Diane E. Mackenzie, Kathleen E. Collins, Mylene J. Guimond, Abby C. Hunter, Kassia J. Jurcina, Johanna L. Mcdonald, Nikki L. Richards, Stephanie. H. Sinclair, Kelsey Y. Taylor

The Open Journal of Occupational Therapy

Co-constructed simulations were designed and piloted with senior occupational therapy master’s students in a neurorehabilitation practice module. The instructor served as the guide for the students through all phases of the case creation, simulation development, delivery, and debrief. The instructor facilitation promoted self-regulated learning (SRL) of knowledge and skill development through independent discovery and peer learning. This paper provides an evidence-informed co-construction simulation design with outlined stages, roles, and responsibilities for the instructor and learner. Thematic qualitative analysis of student feedback highlighted enhanced insight and SRL as a result of multiple role preparation, observation and interaction with peers, close interaction …

Pennsylvania Occupational Therapy Fieldwork Educator Practices And Preferences In Clinical Education, Kaitlyn Ryan, Melanie Beck, Lee Ungaretta, Magdalena Rooney, Elaina Dalomba, Leamor Kahanov

The Open Journal of Occupational Therapy

The shortage of clinical education fieldwork sites coupled with a concern over the quality of the required fieldwork experience poses an unintended outcome for the recent changes in the health care system and an increasing number of occupational therapy students. While the Accreditation Council for Occupational Therapy Education (ACOTE) issues standards for fieldwork education, the quality of the experience is known to vary. The present study employed a mixed methods concurrent nested design with a quantitative online survey alongside qualitative individual semi-structured online interviews to examine the practices and preferences of fieldwork educators in Pennsylvania ACOTE accredited programs. From the …

Balancing Efficacy And Effectiveness With Philosophy, History, And Theory-Building In Occupational Therapy Education Research, Barbara Hooper, Jyothi Gupta, Andrea Bilics, Steven D. Taff

The Open Journal of Occupational Therapy

The preferred focus for education research in occupational therapy increasingly rests on studies that investigate efficacy and effectiveness in the teaching-learning context. While important, the almost exclusive promotion of outcomes-focused studies can come at the expense of other forms of inquiry, including philosophy, history, and theory-building. To fully inform education and enhance practice, outcomes-focused research needs the conceptual foundation provided by philosophical, historical, and theory-building studies. In this paper, the authors suggest that the research enterprise in occupational therapy education is in its infancy and, therefore, quite susceptible to shortcuts that head straight to outcomes. To address this issue, the …

Use Of Religious Observance As A Meaningful Occupation In Occupational Therapy, Kelly Thompson, Bryan M. Gee, Sara Hartje

The Open Journal of Occupational Therapy

Background: Research shows that religious and spiritual beliefs influence a person’s health and quality of life. Studies have found that religious people are healthier and require less access to health services, and that clients want to have their religious and spiritual needs addressed as a part of their plan of care.

Method: This study used a descriptive survey design to explore the attitudes and behaviors of occupational therapists concerning religious observance in clinical practice. The survey yielded 181 responses from a random sampling from members of the American Occupational Therapy Association.

Results: The study found that while …

Occupational Therapy Employers’ Perceptions Of Professionalism, Vicki C. Mason, Kathleen Mathieson

The Open Journal of Occupational Therapy

Background: The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) patient satisfaction survey, the Hospital Readmissions Reduction Program, and the Bundled Payments for Care Improvement Initiative in the Affordable Care Act (ACA) are affecting expectations of professionalism in health care. These initiatives and shifts in expectations are especially concerning for occupational therapists whose services historically have not been well understood.

Method: Eighteen supervisory and managerial occupational therapy practitioners were interviewed regarding perceptions of professionalism in occupational therapy employees. The semi-structured interview guide explored professionalism in occupational therapists’ interactions with patients and co-workers and in an employer’s organization. …

Expressive Art To Facilitate The Development Of The Occupational Profile: A Scoping Review, Verna G. Eschenfelder, Christina M. Gavalas, Taylor M. Pendergast, Colleen A. Gorman

The Open Journal of Occupational Therapy

Background. The American Occupational Therapy Association and the American Medical Association have changed CPT codes to require a completed occupational profile at every evaluation and re-evaluation session for reimbursement as of January 1, 2017. A revitalization of art in occupational therapy has led to a recent increase in the evidence supporting the use of expressive art in practice. The benefits of expressive art can directly enhance the occupational profile required by these changing reimbursement requirements.

Methods. A scoping review method was applied in the current study. Out of 347 initial articles, 12 met the inclusion criteria and were analyzed through …

A Bibliometric Analysis Of Peer-Reviewed Journal Publications By British Occupational Therapy Authors, Ted Brown, Yuh-Shan Ho, Sharon A. Gutman

The Open Journal of Occupational Therapy

Background: A bibliometric analysis was completed of the peer-reviewed literature from 1991 to 2015 written by British occupational therapy authors that was indexed in the Science Citation Index-Expanded (SCI-Expanded) or Social Sciences Citation Index (SSCI) databases.

Methods: “Occupational therapy” and “occupational therapist” were used as keywords to search journal articles’ publication title, abstract, author details, keywords, and KeyWords Plus. One of the authors had to be identified as a qualified occupational therapist with a British affiliation.

Results: From 1991 to 2015, 680 journal articles were published by British occupational therapy authors. The top three journals in which authors published …

Discovering Perspectives On Health And Well-Being From Parents And Teachers Of Preschool- Aged Children, Divya Sood, Delawnia Comer-Hagans, Dirk Anderson, Diana Basmajian, Ashley Bohlen, Michelle Grome, Irada Imanova, Kimberly Martin

The Open Journal of Occupational Therapy

Background: This study explores the concept of health and well-being as perceived by teachers and parents of preschool-aged children in the specific context of a child day care facility. The study also identifies the barriers parents and teachers encounter and the supports they require in promoting the health and well-being of preschool-aged children.

Method: A qualitative phenomenological research design combined with a projective technique of Photovoice was used for data collection. A total of eight participants, four teachers and four parents of preschool-aged children from a child day care facility, participated in the study.

Results: Several themes were identified related …

Feasibility Exploration Of Electrodermal Response To Food In Children With Asd Compared To Typically Developing Children, Michelle A. Suarez

The Open Journal of Occupational Therapy

Background: Children with Autism Spectrum Disorder (ASD) frequently have food selectivity that causes additional health and quality of life stressors for the child and the family. The causes of food selectivity are currently unknown but may be linked, at least in part, to sensory processing problems.

Method: The purpose of this study was to test the feasibility of using electrodermal activity (EDA) measurement in response to food to gain insight into the physiological processes associated with eating for children with ASD compared to typically developing children. In addition, differences in food acceptance and the relationship between food acceptance …

A Retrospective Pre-Post Treatment Study Of Occupational Therapy Intervention For Children With Sensory Processing Challenges, Sarah A. Schoen, Lucy Jane Miller, Joanne Flanagan

The Open Journal of Occupational Therapy

Background: This study investigated the impact of an intensive, short-term program that incorporates the principles of sensory integration and relationship-based therapies with extensive parent collaboration. The goals were to identify measures sensitive to change and explore the relation between sensory modulation characteristics and change in behavior after intervention.

Method: A retrospective chart review examined routine clinical data pre-post intervention from 179 children identified with sensory processing challenges without comorbid autism. Change in measures of adaptive behavior, emotional functioning, sensory-related behaviors, and motor functioning were evaluated. Relations between sensory modulation and behavior were explored.

Results: Improvements were noted …

Selection Of Post-Acute Care For Stroke Patients, Kathryn M. Gulfo, Glen Gillen, Lauri Bishop, Clare C. Bassile, Randy B. Kolodny, Joel Stein

The Open Journal of Occupational Therapy

Background: Significant variation exists in post-acute care for stroke survivors. This study examines referral practices of occupational and physical therapists for patients after acute stroke.

Method: Occupational therapists (OTs) and physical therapists (PTs) were surveyed either electronically or in person at a national conference. The respondents selected the most appropriate referral for each of five case vignettes. The referral choices included Inpatient Rehabilitation Facility (IRF), Skilled Nursing Facility (SNF), Long-Term Acute Care Hospital (LTACH), home with home services, or home with outpatient services. Demographic data included practice location, setting, and duration. The respondents were also asked to rate …

Occupational Adaptation As A Construct: A Scoping Review Of Literature, Lenin Grajo, Angela Boisselle, Elaina Dalomba

The Open Journal of Occupational Therapy

Background: This study integrates research on practice applications of the construct of occupational adaptation with occupational therapy and occupational science literature.

Method: Using Arksey and O’Malley’s 5-step Scoping Study Framework (2005), we conducted a scoping review of 74 articles from five online databases and literature hand-searching and performed quantitative and thematic analyses.

Results: The Occupational Adaptation model (Schkade & Schultz, 1992; n = 74) and the Model of Human Occupation (Kielhofner, 2008; n = 37) were the most frequently cited literature influences. Occupational adaptation has been defined as a process (n = 49), an outcome (n = …

State Of The Journal: Past, Present, And Future, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

Building A Soccer Dynasty, Carter Bedsole, Gary Buckley

Student Scholarship - College of Business

The soccer world operates as a free market. Buying, selling, and trading of players is vital to the success of a club. A successful soccer club brings a great deal of revenue and growth to a local economy. Therefore, clubs ought to be prudent when signing players. In this paper, we use ordinary least squares regressions on Major League Soccer player data from 2015-2018 to determine the effect strikers and goalkeepers have on team success. In other words, what is the marginal impact of a good striker relative to a bad one? A good goalkeeper relative to a mediocre one? …

Stay In School, Kids, Caleb Reynolds, Julia Wenndt

Student Scholarship - College of Business

This paper presents an analysis of the effects of football wins percentage on universities’ retention rates. Using an OLS model we determine the causal relationship between football wins percentages, other independent variables, and universities’ retention rates. Throughout the paper we will define all relevant independent variables and present an overview of the data gathered in order to formulate our results. A theoretical framework will be presented followed by a thorough analysis of the OLS estimation results.