Medicine and Health Sciences Commons^™

Electrical Stimulation Modulates High Γ Activity And Human Memory Performance., Michal T. Kucewicz, Brent M. Berry, Vaclav Kremen, Laura R. Miller, Fatemeh Khadjevand, Youssef Ezzyat, Joel M. Stein, Paul Wanda, Michael R. Sperling, Richard Gorniak, Md, Kathryn A. Davis, Barbara C. Jobst, Robert E. Gross, Bradley Lega, S Matt Stead, Daniel S. Rizzuto, Michael J. Kahana, Gregory A, Worrell

Department of Neurology Faculty Papers

Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus (HP), parahippocampal region (PH) neocortex, prefrontal cortex (PF), and lateral temporal cortex (TC). Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We …

Collagenous Matrix Supported By A 3d-Printed Scaffold For Osteogenic Differentiation Of Dental Pulp Cells, Farahnaz Fahimipour, Erfan Dashtimoghadam, Morteza Rasoulianboroujeni, Mostafa Yazdimamaghani, Kimia Khoshroo, Mohammadreza Tahriri, Amir Yadegari, Jose Gonzalez, Daryoosh Vashaee, Douglas C. Lobner, Tahereh S. Jafarzadeh Kashi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Objective

A systematic characterization of hybrid scaffolds, fabricated based on combinatorial additive manufacturing technique and freeze-drying method, is presented as a new platform for osteoblastic differentiation of dental pulp cells (DPCs).

Methods

The scaffolds were consisted of a collagenous matrix embedded in a 3D-printed beta-tricalcium phosphate (β-TCP) as the mineral phase. The developed construct design was intended to achieve mechanical robustness owing to 3D-printed β-TCP scaffold, and biologically active 3D cell culture matrix pertaining to the Collagen extracellular matrix. The β-TCP precursor formulations were investigated for their flow-ability at various temperatures, which optimized for fabrication of 3D printed scaffolds with …

Premature Ventricular Contraction-Induced Polymorphic Ventricular Tachycardia After Leadless Pacemaker Implantation: A Unique Adverse Effect Of Leadless Pacing., Anish K Amin, Sreedhar R Billakanty, Nagesh Chopra, Eugene Y Fu, Allan J Nichols, James M Kleman, Gregory A Kidwell

Heart and Vascular Articles

No abstract provided.

Faculty Perspectives Of Student-Faculty Collaborative Course Design, Lauren H. Mead

Teaching and Learning in Communication Sciences & Disorders

This qualitative research study explored speech-language pathology (SLP) faculty perspectives of collaborative course design (CCD). For the purposes of this study, the term “faculty” includes all those who teach at the university level. Student-faculty CCD offers benefits to course instructors and students; however, research regarding this topic is lacking in the field of SLP. Interviews with faculty members in SLP programs explored faculty perspectives regarding the incorporation of student input into course design as well as anticipated benefits and challenges involved. The results of this study identified several factors related to faculty reluctance to use CCD, including reluctance to share …

Aphasia Simulation: A Perspective From The Student And Standardized Patient, Suzanne Moineau, Deb Bennett, Alison Scheer-Cohen

Teaching and Learning in Communication Sciences & Disorders

The aim of the current study was to examine student ability, student and standardized patient perceptions of competency, and student perceptions of effectiveness of simulation methodology for conducting language screenings on individuals with aphasia. Graduate students enrolled in a mandatory course on acquired language disorders (n = 36) completed a variety of simulated learning experiences using videos, high-fidelity manikins, and standardized patients, in preparing them for clinical practice with persons with aphasia. 5-point Likert scales and open-ended survey questions relating to student and standardized patients’ perceptions were administered. Results demonstrated a strong positive perception that simulation promotes student understanding of …

Pedagogical Education Practices In Communication Sciences And Disorders Phd Programs: A Pilot Study, Laura Smith-Olinde, Stanley K. Ellis

Teaching and Learning in Communication Sciences & Disorders

The purpose of this study was two-fold: (1) to ascertain how research doctoral programs in Communication Sciences and Disorders (CSD) characterize their own efforts to educate research doctoral students about teaching at the college/university level; and (2) whether and how programs introduce the “scholarship of teaching and learning” (SoTL) to PhD students. PhD program directors (N=69) were emailed a survey for descriptions of university teaching instruction and SoTL activities, with a 27.5% return rate (n=19). Quantitative and qualitative analyses were used. Identified themes included, “course or seminar”, “experiential” and “required”. One hundred per cent of respondents offer teaching experiences and …

Assessing And Teaching Critical Thinking In Communication Science And Disorders, Richard J. Morris, Mary M. Gorham-Rowan, Jade H. Robinson Ph.D., Kendra Scholz

Teaching and Learning in Communication Sciences & Disorders

Critical thinking is considered to be an important aspect in the training of communication science and disorders students. This paper provides information on the definition, assessment, and teaching of critical thinking. Important critical thinking skills and dispositions include challenging assumptions underlying statements, recognizing the effect of context on perceptions, understandings, and interpretations of the world, developing alternative explanations for observed data they observe, and exhibiting reflective skepticism. Increasing these skills and dispositions help a student develop into a skilled clinician. Assessing students’ clinical thinking skills can be done with tests of general skills, but these often lack validity and reliability. …

Clinical Decision-Making In Speech-Language Pathology Graduate Students: Quantitative Findings, Carol C. Dudding, Danika L. Pfeiffer

Teaching and Learning in Communication Sciences & Disorders

Clinicians’ decision-making skills are the foundation for the development and implementation of evidence-based practice to provide high quality clinical care. It is proposed that these skills are a result of hands-on clinical experiences (Crebbin, Beasley, & Watters, 2013). Yet some researchers contend that the development of clinical decision-making skills requires direct instruction in critical thinking (Abrami et al., 2011; Finn, 2011). The aim of this study was to explore if and when clinical decision-making processes of speech-language pathology (SLP) students change during graduate study. Web-based case simulations were used to elicit and measure clinical decision-making in eight graduate students at …

Impact And Perceived Benefits Of A Problem-Based Learning Workshop For Continuing Education In Speech-Language Pathology: A Pilot Study, Megan S. Overby, Heather L. Rusiewicz

Teaching and Learning in Communication Sciences & Disorders

Even though speech-language pathologists (SLPs) must participate in continuing education programs, little is known about the effectiveness of these learning opportunities. This preliminary study provides empirical assessment of the impact of a problem-based learning (PBL) CE activity on SLPs as perceived by themselves and their Instructors. Twenty-five experienced SLPs participated in an intensive multi-day, PBL workshop on childhood apraxia of speech. Significant differences in the SLPs’ self-perceived clinical efficacy between T1 and T2, as well as T2 and T3. At T3, Instructors rated the clinical efficacy of the SLPs as “very good” to “excellent.” Qualitatively, SLPs reported increased confidence, critical …

Motivators For Alzheimer's Disease Clinical Trial Participation, Shoshana H. Bardach, Sarah D. Holmes, Gregory A. Jicha

Graduate Center for Gerontology Faculty Publications

Background

Alzheimer’s disease (AD) research progress is impeded due to participant recruitment challenges. This study seeks to better understand, from the perspective of individuals engaged in clinical trials (CTs), research motivations.

Methods

Participants, or their caregivers, from AD treatment and prevention CTs were surveyed about research motivators.

Results

The 87 respondents had a mean age of 72.2, were predominantly Caucasian, 55.2% were male, and 56.3% had cognitive impairment. An overwhelming majority rated the potential to help themselves or a loved one and the potential to help others in the future as important motivators. Relatively few respondents were motivated by free …

Adoptable Interventions, Human Health, And Food Safety Considerations For Reducing Sodium Content Of Processed Food Products, Abimbola Allison, Aliyar Fouladkhah

Agricultural and Environmental Sciences Faculty Research

Although vital for maintaining health when consumed in moderation, various epidemiological studies in recent years have shown a strong association between excess dietary sodium with an array of health complications. These associations are robust and clinically significant for development of hypertension and prehypertension, two of the leading causes of preventable mortality worldwide, in adults with a high-sodium diet. Data from developed nations and transition economies show worldwide sodium intake of higher than recommended amounts in various nations. While natural foods typically contain a moderate amount of sodium, manufactured food products are the main contributor to dietary sodium intake, up to …

The Santa Clara, 2018-02-01, Santa Clara University

The Santa Clara

No abstract provided.

One Jefferson News February 2018, Performance Excellence

One Jefferson News

Over the past year, we have continued our One Jefferson journey and achieved a number of integration successes for the organization. In the attached, new issue of One Jefferson News, we celebrate strides being made by collaborative teams working on evolving the Physician Enterprise, Access, Supply Chain, and System Integration initiatives.

This issue includes:

• Changing the Way We Drive Enhanced Performance
• Collaborative Teams Accelerating Outcomes

Practical Pearl: Hypertension - February 2018, Yvonne Paris Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

Predicting Cyp3a-Mediated Midazolam Metabolism In Critically Ill Neonates, Infants, Children And Adults With Inflammation And Organ Failure., Janneke M Brussee, Nienke J Vet, Elke H J Krekels, Abraham J Valkenburg, Evelyne Jacqz-Aigrain, Joop M A Van Gerven, Eleonora L Swart, Johannes N Van Den Anker, Dick Tibboel, Matthijs De Hoog, Saskia N De Wildt, Catherijne A J Knibbe

Pediatrics Faculty Publications

No abstract provided.

The Impact Of Body-Weight Supported Locomotor Training In A Toddler With Gmfcs Level V Cerebral Palsy: A Case Study, Megan Flores, Carolyn Da Silva

Physical Therapy Collection

BACKGROUND AND PURPOSE: Children with cerebral palsy (CP) in Gross Motor Function Classification System (GMFCS) level V present with decreased gross motor function and trunk control that impacts their functional activities and participation in family activities. Research indicates body-weight supported locomotor training (BWSLT) may improve motor control for children with neuromotor disabilities. The toddler years present a window of opportunity for developmental changes. The purpose of this case study was to explore the impact of a 6-week BWSLT intervention on postural control, gross motor function, and quality of life in a young child with cerebral palsy in GMFCS level …

We Are Global Health: A Rejuvenating Perspective, Evan M. Pucillo, Edward C. O'Bryan

Physical Therapy Collection

No abstract provided.

Disability And Physical Therapy Services In Rural Nicaragua: A Pilot Study, Evan M. Pucillo, Edward C. O'Bryan

Physical Therapy Collection

The World Health Organization (WHO) estimates that 15% of the world’s population is living with disability, a large majority of which can be found in developing nations. Previous studies in Nicaragua have investigated the perceptions of disability among caregivers and noted limited access to rehabilitative services. However, the general knowledge and perceptions of physical therapy services in Nicaragua remains unclear. As a result, this pilot study sought to explore the local knowledge and perceptions of disability and physical therapy services and to characterize the sample from a remote area of northwestern Nicaragua. Participants were recruited using convenience sampling during multidisciplinary …

Blood Flow Restriction Training For Chronic Quadriceps Weakness And Atrophy: A Case Report, Tobi Baldwin, Fred Baldwin

Physical Therapy Collection

Background and purpose

The high load and intensity of traditional strength training may not always be appropriate or beneficial for certain patient populations such as the elderly or those with orthopedic injuries. In these cases blood flow restriction training with light resistance has been shown to be effective method of increasing strength and hypertrophy. However, what if traditional strength training is tolerated but not effective for an individual? The purpose of this case report is to describe the use of blood flow restriction training in a recreationally active male who was fully functional but continued with chronic unilateral quadriceps weakness …

Effect Of Stable And Unstable Surfaces On The Serratus Anterior Muscle Activation In A Kinetic-Chain Exercise Among Healthy Adults, Navpreet Kaur, Kunal Bhanot, Germaine Ferreira

Physical Therapy Collection

PURPOSE/HYPOTHESIS: The stabilizing action of the serratus anterior (SA) muscle is vital in maintaining proper scapulothoracic rhythm.^1,2 Poor activation of SA muscle could lead to many shoulder dysfunctions.^1,3 This warrants for exercises that are best to activate the SA muscle. Kinetic-chain recruitment during exercises has demonstrated increased SA activation due to the myofascial connections between various segments of the body.^4–6 Variation of surfaces during an exercise has been shown to alter the muscle recruitment patterns.^7–9 The primary purpose of this study was to determine if the unstable surface can influence SA muscle activity during the kinetic …

Feasibility And Preliminary Outcomes Of A Standardized Exercise Program In Adults With Down Syndrome: A Pilot Study, Megan Flores, Kristen Barta, Martha Sneary, Germaine Ferreira, Elizabeth Ardolino

Physical Therapy Collection

Purpose/ Hypothesis: Youth with Down Syndrome (DS) have limited participation in physical activity. When compared to their typically developing peers, adults with DS display decreased functional mobility and strength. Exercise has shown to improve the physical fitness, overall health, and quality of life in people with DS. The Lee Silverman Voice Treatment (LSVT® BIG) is an effective treatment approach designed for patients with Parkinson’s disease. The core components of LSVT® BIG include large amplitude movements, sensory calibration, high intensity, and maximum effort while performing the daily exercises. Due to hypotonicity associated with DS, these individuals typically display kyphotic posture, shortened …

Global Health And Disability: A Review And Call To Action For All Rehabilitation Professions, Evan M. Pucillo, Matthew B. Huish, Quinn Tate, Edward C. O'Bryan, Ty T. Dickerson

Physical Therapy Collection

The World Health Organization estimates 15% of the world’s population is living with disability and anticipates an increase as the population ages. Disability is a growing healthcare concern and presents a tremendous burden to all nations. The world will soon need to provide health and rehabilitative care for an enormous number of persons with disability. The purpose of this article is to provide a brief narrative review pertaining to global health and rehabilitation, and to motivate the rehabilitation professions in taking immediate action through further investment in global health initiatives to manage both the current and projected burden of disability. …

Community-Deliverable Exercise And Depression In Adults With Arthritis: Confirmatory Evidence Of A Meta-Analysis Using The Ivhet Model, George A. Kelley, Kristi S. Kelley

Clinical and Translational Science Institute

Objective—Using the traditional random-effects model, a recently reported standardized effect size (g) reduction of −0.42 (95% CI, −0.58 to −0.27) was observed as a result of communitydeliverable exercise in adults with arthritis and other rheumatic diseases (AORD). However, a recently proposed alternative model (IVhet) has been shown to have superior coverage probability to the random-effects model. The purpose of this brief report was to compare these previous random-effects results with the IVhet model. Methods—Based on a previous meta-analysis of 35 g’s representing 2,449 participants, results were pooled using the IVhet model. Influence analysis, number needed-to-treat (NNT), percentile improvement, and gross …

Supplements, Nutrition, And Alternative Therapies For The Treatment Of Traumatic Brain Injury, Brandon P. Lucke-Wold, Aric F. Logsdon, Linda Nguyen, Ahmed Eltanahay, Ryan C. Turner, Patrick Bonasso, Chelsea Knotts, Adam Moeck, Joseph C. Maroon, Julian E. Bailes, Charles L. Rosen

Clinical and Translational Science Institute

Studies using traditional treatment strategies for mild traumatic brain injury (TBI) have produced limited clinical success. Interest in treatment for mild TBI is at an all time high due to its association with the development of chronic traumatic encephalopathy and other neurodegenerative diseases, yet therapeutic options remain limited. Traditional pharmaceutical interventions have failed to transition to the clinic for the treatment of mild TBI. As such, many pre-clinical studies are now implementing non-pharmaceutical therapies for TBI. These studies have demonstrated promise, particularly those that modulate secondary injury cascades activated after injury. Because no TBI therapy has been discovered for mild …

Colon Cancer Worry In Appalachia, Omar F. Attarabeen, Usha Sambamoorthi, Kevin T. Larkin, Kimberly M. Kelly

Clinical and Translational Science Institute

Appalachia has a higher incidence of and mortality from colon cancer (CC) than other regions of the United States; thus, it is important to know the potential impact of elevated risk on cancer worry. Guided by the Self-regulation model, we investigated the association of demographic, cultural (e.g., fatalism, religious commitment), and psychological factors (e.g., perceived risk, general mood) with CC worry among a sample of Appalachian women. A mixed method design was utilized. Appalachian women completed surveys in the quantitative section (n = 134) and semi-structured interviews in the qualitative section (n = 24). Logistic regression was employed to calculate …

Synthesis And Structure-Activity Relationships Of Carbohydrazides And 1,3,4-Oxadiazole Derivatives Bearing An Imidazolidine Moiety Against The Yellow Fever And Dengue Vector, Aedes Aegypti, Fatih Tok, Bedia Kocyigit-Kaymakcioglu, Nurhayat Tabanca, Alden S. Estep, Aaron D. Gross, Werner J. Geldenhuys, James J. Becnel, Jeffrey R. Bloomquist

Clinical and Translational Science Institute

BACKGROUND—1,3,4-Oxadiazole and imidazolidine rings are important heterocyclic compounds exhibiting a variety of biological activities. In this study, novel compounds with oxadiazole and imidazolidine rings were synthesized from 3-(methylsulfonyl)-2- oxoimidazolidine-1-carbonyl chloride and screened for insecticidal activities. The proposed structures of the 17 synthesized compounds were confirmed using elemental analysis, infrared (IR), proton nuclear magnetic resonance (1H-NMR), and mass spectroscopy. RESULTS—None of the compounds showed larvicidal activity at the tested concentrations against first-instar Aedes aegypti larvae. However, nine compounds exhibited promising adulticidal activity, with mortality rates of ≥80% at 5 μg per mosquito. Further dose–response bioassays were undertaken to determine median lethal …

Robot Training With Vector Fields Based On Stroke Survivors' Individual Movement Statistics, Zachary A. Wright, Emily Lazzaro, Kelly O. Thielbar, James L. Patton, Felix C. Huang

Clinical and Translational Science Institute

The wide variation in upper extremity motor impairments among stroke survivors necessitates more intelligent methods of customized therapy. However, current strategies for characterizing individual motor impairments are limited by the use of traditional clinical assessments (e.g. Fugl-Meyer) and simple engineering metrics (e.g. goal-directed performance). Our overall approach is to statistically identify the range of volitional movement capabilities, and then apply a robot-applied force vector field intervention that encourages under-expressed movements. We investigated whether explorative training with such customized force fields would improve stroke survivors’ (n = 11) movement patterns in comparison to a control group that trained without forces (n …

Predictors Of Transitioning To Incident Chronic Opioid Therapy Among Working-Age Adults In The United States, J. Douglas Thornton, Nilanjana Dwibedi, Virginia Scott, Charles D. Ponte, Douglas Ziedonis, Nethra Sambamoorthi, Usha Sambamoorthi

Clinical and Translational Science Institute

BACKGROUND: Opioids have been prescribed and used for chronic noncancer pain at prolific rates in the United States during the past 2 decades. Patients who transition to incident chronic opioid therapy are at increased risk for significant negative health consequences, including cardiovascular risk, endocrine disorders, opioid use disorder, and death. OBJECTIVE: To identify the leading predictors associated with transitioning to incident chronic opioid therapy among working-age adults without cancer. METHODS: This retrospective observational cohort study is based on medical and pharmacy claims of a nationally representative sample of adults enrolled in commercial health insurance plans. Standard parametric (logistic regressions) and …

Changes Of Lumbar Posture And Tissue Loading During Static Trunk Bending, Faisal Alessa, Xiaopeng Ning

Clinical and Translational Science Institute

Static trunk bending is an occupational risk factor for lower back pain (LBP). When assessing relative short duration trunk bending tasks, existing studies mostly assumed unchanged spine biomechanical responses during task performance. The purpose of the current study was to assess the biomechanical changes of lumbar spine during the performance of relatively short duration, sustained trunk bending tasks. Fifteen participants performed 40-s static trunk bending tasks in two different trunk angles (30° or 60°) with two different hand load levels (0 or 6.8 kg). Results of the current study revealed significantly increased lumbar flexion and lumbar passive moment during the …

Regulator Of G Protein Signaling-12 Modulates The Dopamine Transporter In Ventral Striatum And Locomotor Responses To Psychostimulants, Joshua D. Gross, Shane W. Kaski, Adam B. Schroer, Kimberley A. Wix, David P. Siderovski, Vincent Setola

Clinical and Translational Science Institute

Regulators of G protein signaling are proteins that accelerate the termination of effector stimulation after G protein-coupled receptor activation. Many regulators of G protein signaling proteins are highly expressed in the brain and therefore considered potential drug discovery targets for central nervous system pathologies; for example, here we show that RGS12 is highly expressed in microdissected mouse ventral striatum. Given a role for the ventral striatum in psychostimulant-induced locomotor activity, we tested whether Rgs12 genetic ablation affected behavioral responses to amphetamine and cocaine. RGS12 loss significantly decreased hyperlocomotion to lower doses of both amphetamine and cocaine; however, other outcomes of …