Medicine and Health Sciences Commons^™

Emerging Cellular Therapies For Glioblastoma Multiforme., Paul J Choi, R Shane Tubbs, Rod J Oskouian

Articles, Abstracts, and Reports

Glioblastoma multiforme (GBM) is the most common type of malignant primary brain cancer in adults. It is composed of highly malignant cells that display metastatic and angiogenic characteristics, making it resistant to current first-line chemotherapy with temozolomide, an alkylating agent. Despite many years of research, GBM remains poorly responsive to multiple available therapies, giving GBM patients, who receive the conventional combination of chemoradiotherapies and surgical resection, a dismal prognosis. There is growing evidence that the conventional systemic chemotherapeutic agents for GBM are ineffective in improving the disease progression. We aim to explore the emerging cellular therapies which may play a …

Foster Youth Transition To Adulthood: Effects Of Housing Stability And Social Support On Mental Health, Elizabeth Gray Kaiser

DNP Projects

Foster care adolescents have a more difficult time transitioning to adulthood, compared to non-foster care peers, due to the maltreatment and uprooting they often experience prior to entering the foster care system. Although foster care protects children from harmful environments, literature supports that multiple placement changes and lack of stable family and social support contributes to higher likelihood of housing instability, such as homelessness, and mental health problems, including stress, anxiety, and depression, in adulthood. Independent living programs, such as YVLifeSet, facilitate more successful transitions to adulthood by offering support in the form of mentors, life-skills training, and counseling. These …

Promo Flyer (Pdf), Lsu Health Sciences Center - New Orleans

Usher Syndrome in Louisiana

3rd Symposium - Usher Syndrome in Louisiana was held Saturday, March 10 at the Cecil J. Picard Center for Child Development & Lifelong Learning University of Louisiana, Lafayette. It included ongoing discussions on the diagnosis and treatment of Usher Syndrome, and the progress of research to develop therapies for vision loss for those with Usher Syndrome.

Flavonoids From Chinese Bayberry Leaves Induced Apoptosis And G1 Cell Cycle Arrest Via Erk Pathway In Ovarian Cancer Cells, Yu Zhang, Shiguo Chen, Chaoyang Wei, Gary O. Rankin, Xingqian Ye, Yi Charlie Chen

Clinical and Translational Science Institute

Ovarian cancer is one of the leading causes of death related to the female reproductive system in western countries. Adverse side effects and resistance to platinum based chemotherapy have become the major obstacles for ovarian cancer treatment. Natural products have gained great attention in cancer treatment in recent years. Chinese bayberry leaves flavonoids (BLF) containing rich content of myricitrin (myricetin 3-O-rhamnoside) and a part of quercetrin (quercetin 3-rhamnoside) inhibited the growth of an ovarian cancer cell line A2780/CP70. Such inhibitory effects might be due to the induction of apoptosis and G1 cell cycle arrest. BLF treatment increased the expression of …

Design And Implementation Of A Ferrocement Improved Cookstove In Rural Panama, Josh Donegan

USF Tampa Graduate Theses and Dissertations

Household air pollution contributes to the premature death of more than 4 million people annually. Improved cookstoves are one technological intervention that can potentially reduce exposure to household air pollution. However, improved cookstove implementation programs need to consider measures to increase sustainability and promote long-term adoption. The objectives of this research were 1) to develop and implement a new ferrocement cookstove for Peña Blanca, a rural indigenous community in the Ngäbe-Bugle region of Panama, 2) to evaluate its potential sustainability in comparison to the most common cooking technologies observed in the community, 3) to prepare a construction manual for the …

Correlation Of Solid Dosage Porosity And Tensile Strength With Acoustically Extracted Mechanical Properties, Xiaochi Xu, Connor Mack, Zachary J. Cleland, Chaitanya Krishna Prasad Vallabh, Vivek S. Dave, Centin Cetinkaya

Doctoral External Publications

Currently, the compressed tablet and its oral administration is the most popular drug delivery modality in medicine. The accurate porosity and tensile strength characterization of a tablet design is vital for predicting its performance such as disintegration, dissolution, and drug-release efficiency upon administration as well as ensuring its mechanical integrity. In current work, a non-destructive contact ultrasonic approach and an associated testing procedure are presented and employed to quantify and relate the acoustically extracted mechanical properties of pharmaceutical compacts to direct porosity and tensile strength measurements. Based on a comprehensive set of experimental data, it is demonstrated how strongly the …

Berduka Pada Perempuan Hiv Positif, Rizka Ristriyani, Imami Nur Rachmawati, Yati Afiyanti

Jurnal Keperawatan Indonesia

The Grieving Process of The HIV-Positive Women. HIV as a chronic disease can change the quality of life of sufferers. This study aimed to identify the intensity of grief response in HIV-positive women. The study was a survey which applied a consecutive sampling to involve 235 HIV positive women. The women were at a Community Health Center in Jakarta, Indonesia. The result showed that a mean value of denial was 2.25 (SD 0.75) in the range of 2.18 to 2.38; a mean value of resistance was 1.67 (SD 0.89) in the range of 1.84–2.07; the middle value of sorrow was …

Use Of Excel Spreadsheet Calculators In Handling Data Generated From Uv- Spectrometer, Mercy Okezue, Kari Clase, Steve Byrn

BIRS Symposium

To ease the complexities of handling data generated from different analytical procedures, validated excel spreadsheet containing relevant formulas are developed to ensure the process of data handling will consistently produce the expected results. This paper introduces the use of Excel spreadsheets in handling data generated from using a UV-Spectrometer in determination of analyte concentration in various dosage forms

Acute Loss Of Iron-Sulfur Clusters Results In Metabolic Reprogramming And Generation Of Lipid Droplets In Mammalian Cells, Daniel R. Crooks, Nunziata Maio, Andrew N. Lane, Michal Jarnik, Richard M. Higashi, Ronald G. Haller, Ye Yang, Teresa Whei-Mei Fan, W. Marston Linehan, Tracey A. Rouault

Center for Environmental and Systems Biochemistry Faculty Publications

Iron–sulfur (Fe-S) clusters are ancient cofactors in cells and participate in diverse biochemical functions, including electron transfer and enzymatic catalysis. Although cell lines derived from individuals carrying mutations in the Fe-S cluster biogenesis pathway or siRNA-mediated knockdown of the Fe-S assembly components provide excellent models for investigating Fe-S cluster formation in mammalian cells, these experimental strategies focus on the consequences of prolonged impairment of Fe-S assembly. Here, we constructed and expressed dominant–negative variants of the primary Fe-S biogenesis scaffold protein iron–sulfur cluster assembly enzyme 2 (ISCU2) in human HEK293 cells. This approach enabled us to study the early metabolic reprogramming …

Clinical Feasibility Of Umbilical Cord Tissue-Derived Mesenchymal Stem Cells In The Treatment Of Multiple Sclerosis., Neil H Riordan, Isabela Morales, Giselle Fernández, Nicole Allen, Neal E Fearnot, Michael E Leckrone, Dedra Jones Markovich, Darla Mansfield, Dorita Avila, Amit N Patel, Santosh Kesari, Jorge Paz Rodriguez

Articles, Abstracts, and Reports

BACKGROUND: Multiple sclerosis (MS) is a progressively debilitating neurological condition in which the immune system abnormally erodes the myelin sheath insulating the nerves. Mesenchymal stem cells (MSC) have been used in the last decade to safely treat certain immune and inflammatory conditions.

METHODS: A safety and feasibility study was completed on the use of umbilical cord MSC (UCMSC) as a treatment for MS. In this 1-year study, consenting subjects received seven intravenous infusions of 20 × 10

RESULTS: Twenty subjects were enrolled in this study. No serious adverse events were reported. Of the mild AEs denoted as possibly related to …

Goldstein Sees A Bright Future For Organizational Psychology, Aldemaro Romero Jr.

Publications and Research

“I was always interested in people. I think I could have been a clinical psychologist who talks to people about their problems and tries to help them. But at some point, I shifted toward understanding people’s backgrounds and issues, so I ended up in industrial organizational psychology. I always had a bent towards working with people, trying to understand and help them.”

That’s the way Dr. Harold Goldstein explains how he became the psychologist he is today. A native of Columbus, Ohio, Goldstein got his bachelor’s degree in psychology from the University of Michigan in Ann Arbor, his master’s and …

Instituting Process Control Mechanisms In A Quality Control Analytical Chemistry Laboratory, Mercy Okezue, Kari Lynn Clase, Stephen Byrn

BIRS Symposium

Statistical Process Control by means of using control charts was a means of monitoring performance of analytical equipment. Quality control checks on test items using these equipment generated data used for plotting X-bar charts. The charts generated had warning and control limits which helped monitor system performance

To Push Or Not To Push? Use Of Iv Dextrose Vs. Oral Dex4 For Treatment Of Hypoglycemia., Lauren Amiano Bsn Rn, Mia Martinez Bsn Rn, Emma Morasco Bsn Rn, Lauren Wolfe Bsn Rn

Patient Care Services / Nursing

No abstract provided.

Improving Nurse Confidence In Using The Cam Tool To Identify Delirium., Christina Aquino Bsn, Rn, Nancy Peacock Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Does The Use Of A Wireless Monitor Decrease The Time From Admission To Complete Dilation?, Lauren Bozilesky Bsn, Rn, Jennifer Cleffi Bsn, Rn, Stacey Soto Bsn, Rn, Christy Trexler Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Improving Thermoregulation In Infants By Delaying The First Bath., Chelsea Avron Bsn, Rn, Courtney Krahling Bsn, Rn, Gina Toomey Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Improving Nurse Perception Of Recognition On The Spot., Margaret Mitchell Bsn, Rn, Jaslyn Silva Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Genetic And Molecular Mechanisms Underlying Symbiotic Specificity In Legume-Rhizobium Interactions, Qi Wang, Jinge Liu, Hongyan Zhu

Plant and Soil Sciences Faculty Publications

Legumes are able to form a symbiotic relationship with nitrogen-fixing soil bacteria called rhizobia. The result of this symbiosis is to form nodules on the plant root, within which the bacteria can convert atmospheric nitrogen into ammonia that can be used by the plant. Establishment of a successful symbiosis requires the two symbiotic partners to be compatible with each other throughout the process of symbiotic development. However, incompatibility frequently occurs, such that a bacterial strain is unable to nodulate a particular host plant or forms nodules that are incapable of fixing nitrogen. Genetic and molecular mechanisms that regulate symbiotic specificity …

Timely Insulin Coverage For Point Of Care Glucose Testing., Joy Paniczko Bsn, Rn, Cynthia Pena Bsn, Rn, Alyssa Politi Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Promoting A Family Centered Nicu Using Empathy Training For Rns., Bethany Leonard Bsn, Rn, Amel Moussa Bsn, Rn, Katie Scully Bsn, Rn, Amanda Strohl Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

The Impact Of Junk Food Marketing Regulations On Food Sales: An Ecological Study, Y Kovic, Jonathan K. Noel, J A. Ungemack, J A. Burleson

Health & Wellness Department Faculty Publications and Research

No abstract provided.

Bat Detective—Deep Learning Tools For Bat Acoustic Signal Detection, Oisin Mac Aodha, Rory Gibb, Kate E. Barlow, Michael Firman, Robin Freeman, Briana Harder, Libby Kinsey, Gary R. Mead, Stuart E. Newson, Ivan Pandourski, Stuart Parsons, Jon Russ, Abigel Szodoray-Paradi, Elena Tilova, Mark Girolami, Gabriel Brostow, Kate E. Jones

Bioacoustics Collection

Passive acoustic sensing has emerged as a powerful tool for quantifying anthropogenic impacts on biodiversity, especially for echolocating bat species. To better assess bat population trends there is a critical need for accurate, reliable, and open source tools that allow the detection and classification of bat calls in large collections of audio recordings. The majority of existing tools are commercial or have focused on the species classification task, neglecting the important problem of first localizing echolocation calls in audio which is particularly problematic in noisy recordings. We developed a convolutional neural network based open-source pipeline for detecting ultrasonic, full-spectrum, search-phase …

Aberrant Glyrs-Hdac6 Interaction Linked To Axonal Transport Deficits In Charcot-Marie-Tooth Neuropathy., Zhongying Mo, Xiaobei Zhao, Huaqing Liu, Qinghua Hu, Xu-Qiao Chen, Jessica Pham, Na Wei, Ze Liu, Jiadong Zhou, Robert W. Burgess, Samuel L Pfaff, C Thomas Caskey, Chengbiao Wu, Ge Bai, Xiang-Lei Yang

Faculty Research 2018

Dominant mutations in glycyl-tRNA synthetase (GlyRS) cause a subtype of Charcot-Marie-Tooth neuropathy (CMT2D). Although previous studies have shown that GlyRS mutants aberrantly interact with Nrp1, giving insight into the disease's specific effects on motor neurons, these cannot explain length-dependent axonal degeneration. Here, we report that GlyRS mutants interact aberrantly with HDAC6 and stimulate its deacetylase activity on α-tubulin. A decrease in α-tubulin acetylation and deficits in axonal transport are observed in mice peripheral nerves prior to disease onset. An HDAC6 inhibitor used to restore α-tubulin acetylation rescues axonal transport deficits and improves motor functions of CMT2D mice. These results link …

Using Safety Checklists Outside Of The Operating Room, Annabelle Gerhardt

Doctor of Nursing Practice Scholarly Projects

Abstract

The use of a Time Out checklist for patient safety in non-operating room procedural areas is equally important for positive patient outcomes as in the operating room (OR). In this busy southwestern United States hospital, the procedural teams in the non-operating room areas were reported to not be fully engaged during the performance of the Time Out pre-procedural pause prior to gastroenterological (GI) procedures. This study was conducted to improve compliance with the scripted Time Out checklist and promote full engagement of the GI procedural team during the Time Out thus reducing risks of wrong site surgery. Literature has …

Factors Associated With Late Diagnosis Of Congenital Heart Disease In Kenya, Mercy Chebet Ng’Eno-Owino

Master of Medicine in Paediatrics and Child Health

Introduction: Congenital heart disease (CHD) is the most common congenital anomaly (one-third of all congenital anomalies) with a global birth prevalence of 8/1,000 live births. About 30-50% of all CHD can be categorized as those that will result in death or long-term disability if surgery or catheter-based intervention is not done within one year (major CHD) or four weeks (critical CHD). Early diagnosis of CHD with subsequent prompt surgical/catheter-based interventions has been associated with better outcomes. In this study, late diagnosis of CHD is defined as cases of CHD diagnosed after the first year of life. Knowledge on presentations of …

Premenstrual Syndrome: Existence, Knowledge, And Attitude Among Female University Students In Karachi, Aleena Mohib, Amara Zafar, Areeba Najam, Hafsa Tanveer, Rehana Rehman

Department of Biological & Biomedical Sciences

Objective: The aim of this study was to investigate the existence, knowledge, and the attitude of female students towards premenstrual syndrome (PMS).
Methods: This cross-sectional study was conducted in three universities in Karachi, Pakistan. A total of 448 female students participated in the study. The clinical criterion of American College of Obstetricians and Gynecologists (ACOG) for PMS was used to assess the prevalence of PMS in the participants. The questionnaire was set in four parts, one each to assess the knowledge, the attitude, and practices regarding PMS and one to assess the gap between self-perceived PMS and actual PMS. Data …

Partnership Between Islam And Palliative Care At Swedish Health Services, Hodo Mohamud, Renee Rassilyer-Bomers, Samantha Bohn, Greg Malone, Hilaire Thompson (Faculty Capstone Project Committee Chair), Eeeseung Byun (Committee Member), Margaret Heitkemper (Committee Member)

Articles, Abstracts, and Reports

The spiritual practice of Islam is considered one of the three major monotheistic religions. Islam is the second largest religion in the world with 1.6 billion followers; about 3.5 million of those live in the U.S.1 The number of Muslims in the U.S. is projected to double by 2030.1 Additionally, the number of adults age 65 and older in the U.S. is projected to double from 46 million today to over 98 million by 2060.2 As the U.S. population ages, many healthcare workers are often too overwhelmed to handle the varying and intricate social, economic, familial, spiritual, and cultural needs …

Continuous Training And Certification In Neonatal Resuscitation In Remote Areas Using A Multi-Platform Information And Communication Technology Intervention, Compared To Standard Training: A Randomized Cluster Trial Study Protocol, Carlos Alberto Delgado, Enrique M. Gómez Pomar, Pablo Velásquez, Víctor Sánchez, Roberto Shimabuku, Luis Huicho, Rcpneoperu Study Group

Pediatrics Faculty Publications

Background: About 10% of all newborns may have difficulty breathing and require support by trained personnel. In Peru, 90% of deliveries occur in health facilities. However, there is not a national neonatal resuscitation and certification program for the public health sector. In addition, the Andes and the Amazon regions concentrate large rural remote areas, which further limit the implementation of training programs and the accomplishment of continuous certification. Neonatal resuscitation training through the use of Information, Communication and Technology (ICT) tools, running on computers, tablets or mobile phones, may overcome such limitations. This strategy allows online and offline access …

Α-Catenin-Dependent Cytoskeletal Tension Controls Yap Activity In The Heart., Alexia Vite, Caimei Zhang, Roslyn Yi, Sabrina Emms, Glenn L. Radice

Center for Translational Medicine Faculty Papers

Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. At the same time, the N-cadherin/catenin cell adhesion complex accumulates at the cell termini, creating a specialized type of cell-cell contact called the intercalated disc (ICD). To investigate the relationship between ICD maturation and proliferation, αE-catenin (Ctnna1) and αT-catenin (Ctnna3) genes were deleted to generate cardiac-specific α-catenin double knockout (DKO) mice. DKO mice exhibited aberrant N-cadherin expression, mislocalized actomyosin activity and increased cardiomyocyte proliferation that was dependent on Yap activity. To assess effects on tension, cardiomyocytes were cultured on deformable polyacrylamide hydrogels of varying stiffness. When …

Profiles Of Mirna Isoforms And Trna Fragments In Prostate Cancer., Rogan G. Magee, Aristeidis G. Telonis, Phillipe Loher, Eric R Londin, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

MicroRNA (miRNA) isoforms ("isomiRs") and tRNA-derived fragments ("tRFs") are powerful regulatory non-coding RNAs (ncRNAs). In human tissues, both types of molecules are abundant, with expression patterns that depend on a person's race, sex and population origin. Here, we present our analyses of the Prostate Cancer (PRAD) datasets of The Cancer Genome Atlas (TCGA) from the standpoint of isomiRs and tRFs. This study represents the first simultaneous examination of isomiRs and tRFs in a large cohort of PRAD patients. We find that isomiRs and tRFs have extensive correlations with messenger RNAs (mRNAs). These correlations are disrupted in PRAD, which suggests disruptions …