Medicine and Health Sciences Commons^™

Graft-Versus-Host Disease In Recipients Of Male Unrelated Donor Compared With Parous Female Sibling Donor Transplants, Anita J. Kumar, Soyoung Kim, Michael T. Hemmer, Mukta Arora, Stephen R. Spellman, Mitchell S. Cairo, Alison W. Loren

NYMC Faculty Publications

Optimal donor selection is critical for successful allogeneic hematopoietic cell transplantation (HCT). Donor sex and parity are well-established risk factors for graft-versus-host disease (GVHD), with male donors typically associated with lower rates of GVHD. Well-matched unrelated donors (URDs) have also been associated with increased risks of GVHD as compared with matched sibling donors. These observations raise the question of whether male URDs would lead to more (or less) favorable transplant outcomes as compared with parous female sibling donors. We used the Center for International Blood and Marrow Transplant Research registry to complete a retrospective cohort study in adults with acute …

Identification Of A Metabolic Disposal Route For The Oncometabolite S-(2-Succino)Cysteine In Bacillus Subtilis, Thomas D. Niehaus, Jacob Folz, Donald R. Mccarty, Arthur Cooper, David Moraga Amador, Oliver Fiehn, Andrew D. Hanson

NYMC Faculty Publications

Cellular thiols such as cysteine spontaneously and readily react with the respiratory intermediate fumarate, resulting in the formation of stable S-(2-succino)-adducts. Fumarate-mediated succination of thiols increases in certain tumors and in response to glucotoxicity associated with diabetes. Therefore, S-(2-succino)-adducts such as S-(2-succino)cysteine (2SC) are considered oncometabolites and biomarkers for human disease. No disposal routes for S-(2-succino)-compounds have been reported prior to this study. Here, we show that Bacillus subtilis metabolizes 2SC to cysteine using a pathway encoded by the yxe operon. The first step is N-acetylation of 2SC followed by an oxygenation that we propose results in the release of …

Creation And Initial Validation Of The International Dysphagia Diet Standardisation Initiative Functional Diet Scale, Catriona M. Steele, Ashwini M. Namasivayam-Macdonald, Brittany T. Guida, Julie A. Cichero, Janice Duivestein, Ben Hanson, Peter Lam, Luis F. Riquelme

NYMC Faculty Publications

OBJECTIVE: To assess consensual validity, interrater reliability, and criterion validity of the International Dysphagia Diet Standardisation Initiative Functional Diet Scale, a new functional outcome scale intended to capture the severity of oropharyngeal dysphagia, as represented by the degree of diet texture restriction recommended for the patient. DESIGN: Participants assigned International Dysphagia Diet Standardisation Initiative Functional Diet Scale scores to 16 clinical cases. Consensual validity was measured against reference scores determined by an author reference panel. Interrater reliability was measured overall and across quartile subsets of the dataset. Criterion validity was evaluated versus Functional Oral Intake Scale (FOIS) scores assigned by …

Effectiveness Of Integrative Restoration (Irest) Yoga Nidra On Mindfulness, Sleep, And Pain In Health Care Workers, Eva Livingston, Katreena Collette Merrill

Faculty Publications

This article examines the effectiveness of Integrative Restoration (iRest) Yoga Nidra meditation on mindfulness, sleep, and pain in health care workers. As health care workers provide emotional support to patients, it is not uncommon for workers to experience both physical and mental exhaustion. One holistic approach to support employees is mindfulness training. iRest Yoga Nidra is a complementary and integrative health therapy that increases mindfulness. A pre-/postinterveniton descriptive survey design was used. Before and after experiencing iRest meditation, participants completed a 51-item questionnaire consisting of demographics plus 3 validated instruments: the Five-Facet Mindfulness Questionnaire (FFMQ), the Epworth Sleepiness Scale (ESS), …

Predicting And Preventing Common Volleyball Injuries With Functional Tests, Madison Marshall

Honors Theses

The purpose of this thesis is to provide a compilation of screening tests best suited for predicting and preventing volleyball’s most common injuries. Research displays a gap in knowledge pertaining to volleyball-specific injury prevention tests. A literary analysis was completed for information regarding; correct volleyball techniques, incorrect techniques that are commonly observed, common injuries resulting from faulty technique, and tests best designed to prevent these injuries. It was found that knees and ankles were the two joints most often injured. These injuries mainly occurred during the landing phase of the jumping-landing sequence. Therefore, ankle and knee injury rates were higher …

Comparison Of Psychological States Of Runners Within Urban And Rural Environments, Christian Demastus

Honors Theses

With the research on persons health and well being increasing within the past years, new questions have emerged on if certain environments can also benefit along with exercise. This study looked at the different psychological states of endurance runners as they run in urban environments and transition into rural settings. The results of this study showed significant differences between urban and rural environments. Also showed increased focus going downhill in nature and greater inward attention while moving uphill in nature. With the findings from this study, it explains why runners choose to run or train where they do.

Caesarean Section Rate Amongst Obstetricians At A Tertiary-Care Hospital Of Karachi, Iffat Ahmed, Dureshahwar Kanwar, Munazza Akhtar, Azra Amerjee

Department of Obstetrics & Gynaecology

Objective: To analyze the Caesarean Section (CS) rate among different groups of consultants dealing with Nulliparous Term Singleton pregnancy with Vertex (NTSV) presentation delivering at a tertiary care hospital of Karachi over four months.
Methods: This is a secondary analysis of a retrospective data that analyzed factors affecting the CS-rate of NTSV patients. Patients with CS (n=106) were taken as cases and vaginal deliveries (n=106) as controls. This was an unmatched retrospective case-control study.
Results: Mean age of patients was 26.6(SD: 4.2) years. Mean gestational-age was 38.6(SD: 1.0) weeks. Likelihood of CS was slightly less in patients who were attended …

Tissue Engineered Micro And Macrovasculature Utilizing Stromal Vascular Fraction., Joseph Samir Zakhari

Electronic Theses and Dissertations

This dissertation describes the use of stromal vascular fraction to tissue engineer 3D microvasculature and macrovasculature. Stromal vascular fraction is an easily isolatable cell source from adipose tissue depots. It has demonstrated remarkable potential both in vitro and in vivo for forming microcirculation capable of perfusion upon implantation. SVF is clinically utilized as a therapeutic cell source for anti-inflammation for osteoarthritis and is being studied for ischemic tissue application to stimulate revascularization. The work described herein is divided within four chapters. Chapter I provides an introductory overview and lists the aims and hypothesis for the dissertation. Chapter II describes experiments …

Optimizing High-Speed Exercise Performance : Effect Of Load., Ling Bai

Electronic Theses and Dissertations

The purpose of this study was to identify an optimal load for the knee extension exercise done with Impulse (Newnan, GA). Forty-one women and twenty-nine men made six laboratory visits, including two familiarization sessions of the knee extension exercise and four real workout sessions which entailed four 30-second exercise sets, separated by 120-second rests, against four different loads (0Kg, 3.41Kg, 5.68Kg, 7.95Kg). A Latin Squares design was used to counterbalance the sequence of the sets. Average force (AF), peak force (PF), total work (TW), Impulse value, and the number of knee extension repetitions were each analyzed with a 2 (gender) …

An Assessment Of The Disaster Preparedness Knowledge Of Emergency Medical Services Providers In Hajj Of 2016., Ahmed Meaiwedh Al-Otaibi

Electronic Theses and Dissertations

Objectives: 1) Assess knowledge regarding disaster preparedness for mass gathering among SRC-EMS providers during the Hajj 2016 2) Explore the relationship between the demographic variables and knowledge about disaster preparedness among SRC-EMS providers during the Hajj 2016 3) Explore the sources of knowledge for SRC-EMS providers about disaster preparedness. Method: The data collection for this study was a cross-sectional survey using an online Qualtrics survey. It was convenience sample of 1650 respondents. For the analyses descriptive statistics was used, one-way ANOVA and Bonferroni correction for multiple comparisons tests, multiple regression analyses, and Pearson’s product coefficients. Results: The main findings in …

Effect Of Porcelain Thickness And Translucency On The Final Shade Of Ips E.Max Cad Overlaying A Dark Substrate., Peter F. Alena

Electronic Theses and Dissertations

IPS e.max is a very esthetic lithium disilicate used in dental ceramics. Unfortunately, it can unintentionally change color after cementation with resin cements. The purpose of this study is to better understand how combining thickness and translucency affects the post-cementation shade of IPS e.max CAD overlaying a dark substrate, thereby enabling clinicians to choose more appropriate techniques and materials. IPS e.max CADs (A1 shade) had either a low translucency (LT) or high translucency (HT), and cut with 0.3mm, 0.5mm, and 1.0mm thicknesses. Each sample overlaid a resin cement and dark substrate, a spectrophotometer helped derive the color difference (ΔE*ab), and …

Neuropsychiatric Aspects Of Near-Death Experience, Jerod Buchta, Mir Saleem

Biology Faculty Articles

Throughout human history, there have been numerous reports of a baffling process when individuals have come to the brink of death. This process, referred to as near death experiences (NDEs), cause an individual to experience events that even the most advanced science can still not answer. This review serves as a reference for the factors, phenomenology, and measurement techniques for near death experiences as well as summarizing these experiences in certain conditions, such as cardiac arrest and admission of anesthetics. Discussed are the theories, effects, analyses of specific processes involved pertaining to experiences of those who walked along the edge …

Periodontitis In Patients With Type 2 Diabetes Mellitus, Simran Agarwal, Deepthi Gangaram, Mir Saleem

Biology Faculty Articles

Periodontitis is a chronic, inflammatory disease that is characterized by swollen gums, degradation of jaw structure, and potentially tooth loss. Like Periodontitis, Type 2 Diabetes Mellitus is also highly prevalent and largely multifactorial. Type 2 Diabetes is a condition in which higher than normal blood glucose levels cannot be properly maintained as the body’s normal mechanism of maintaining proper blood glucose levels, the release of insulin from pancreatic islet β-cells, becomes ineffective. The purpose of this literature review is to explore the relationship between the incidences of Periodontitis and Type 2 Diabetes. The risk that Type 2 Diabetes poses for …

Hepatitis C In Injection Drug Users: A Study Of A Detoxification Program In Maine, Meghan Rousselle

Muskie School Capstones and Dissertations

The opiate epidemic has had an impact on the lives of millions of people in this county. As we explore ways to address this issue, it is important to consider the long-term consequences that the epidemic will have. One long-term consequence is the spread of the hepatitis C virus (or HCV). Approximately 3.2 million people in the United States are chronically infected with this virus. Without consideration about ways to treat this virus and prevent its transmission, there will be large numbers of people who will die from complications of HCV in the future. These losses will contribute to the …

Designing Synthetic Environments To Control Valvular Interstital Cells In Vitro, Kent E. Coombs

Biomedical Sciences ETDs

Aortic valve disease (AVD) is a large contributor to health costs in the United States affecting 2.8% of the population greater than 75 years old. With a growing elderly population due to medical advances, AVD will continue to rise in prevalence over time. Current treatments for AVD are insufficient due to a lack of preventative therapies and the bioprosthetic valves used for surgical replacement have major limitations. Tissue engineered heart valves (TEHVs) present an ideal solution to current AVD needs because of their biocompatibility, capability to integrate with the host’s tissue, and ability to utilize the natural repair mechanisms of …

Structure Based Drug Design Of High Affinity Kras Inhibitors, Michael Mccarthy

Dissertations and Theses (Open Access)

RAS, one of the most well characterized membrane-associated small GTPases, is a notorious oncogene with >15% of all tumors harboring RAS mutations. When RAS is mutated it becomes constitutively active sending cell growth, survival and proliferation into overdrive, which subsequently leads to cancer. Although, RAS has been aggressively targeted with drug design efforts for more than 30 years an FDA approved direct inhibitor has not yet been developed. There are three isoforms of RAS in cells; HRAS, NRAS and KRAS. We focused on KRAS since it is the most frequently mutated isoform in cancer. To identify novel non-covalent small molecules …

The Role Of Merlin And Apicobasal Polarity In Endometrial Development And Homeostasis, Erin Lopez

Dissertations and Theses (Open Access)

Apicobasal polarity and cell adhesion are necessary for the proper formation and organization of epithelial tissues. Merlin couples cell polarity and adhesion through correct localization of the polarity protein Par3 and maturation of apical junctions. Merlin and Par3 are necessary for the development and homeostasis of highly regenerative tissues like the epidermis. The continual repopulation of the endometrium after each menstrual cycle requires a constant reorganization of cell polarity and adhesion. The endometrium consists of a luminal epithelium that postnatally gives rise to the distinct glandular epithelium. Endometrial glands are necessary to secrete nutrients for the pre-implantation embryo. In addition, …

Psychiatric Impact Of Tuberous Sclerosis Complex And Utilization Of Mental Health Treatment, Kate Mowrey

Dissertations and Theses (Open Access)

Tuberous sclerosis complex (TSC) is a multi-system, neurocutaneous disorder with neuropsychiatric features known as TSC-associated neuropsychiatric disorders (TAND). While 90% of individuals with TSC have some TAND features, only 20% receive treatment, leading to a 70% treatment gap. This study evaluated perception of disease severity, presence of anxiety and depression, as well as the utilization and barriers towards mental health services among adults with TSC. Disease severity had a moderate and low-moderate association with anxiety and depression, respectively. Regardless of past utilization, respondents had a positive outlook towards the use of mental health services with the major barrier being cost.

Characteristics Of Individuals Undergoing Panel Genetic Testing For Primary Brain Tumors, Sarah Azam

Dissertations and Theses (Open Access)

Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution. Our aim was to describe patient-specific characteristics and family histories across mutation-positive, negative, and variant of uncertain significance (VUS) cohorts based on cancer-panel genetic test results among patients with a PBT.

Methods. Subjects were referred for multi-gene panel testing between March 2012 and June 2016. Clinical data were ascertained from test requisition forms. The incidence of pathogenic mutations (including likely pathogenic) and VUS’s were …

Mechanisms And Targeting Of Neurodevelopmental Regulator Rest In Medulloblastoma Dissemination, Keri Callegari

Dissertations and Theses (Open Access)

Molecular subgrouping of medulloblastoma (MB) has produced four subgroups: wingless (WNT), sonic hedgehog (SHH), group 3, and group 4. While patients with WNT tumors have the best prognosis, patients with SHH tumors have a more variable prognosis concurrent with metastatic disease. This subset of SHH patients have elevated levels of the neurogenic regulator, RE1 Silencing Transcription factor (REST). To understand the role of REST in MB, we utilized a novel transgenic mouse model wherein REST expression can be conditionally elevated during postnatal development in the cells of origin of SHH MB, cerebellar granule neural progenitors (GNPs). While these mice did …

Patient Attitudes To Ward Genetic Testing For Inherited Predispositions To Hematologic Malignancies, Taylor Beecroft

Dissertations and Theses (Open Access)

Although inherited predispositions to hematologic malignancies have previously been considered extremely rare, approximately 12 causative genes have been implicated in the last decade. Since individuals diagnosed with leukemia have not historically been considered for evaluation of inherited predispositions, genetic testing is underperformed in this population. This study used focus group discussions to explore the attitudes, motivations, and barriers to genetic testing for 23 patients with leukemia. Participants generally exhibited a positive regard for the utility of genetic testing, and were primarily motivated by concern for their family and a sense of altruism toward all leukemia patients. While drawbacks and barriers …

A Cross-Training Program Does Not Alter Self-Reported Physical Activity Levels In Elementary School Children, Melody L. White, Matthew S. Renfrow, Richards S. Farley, Dana K. Fuller, Brandi M. Eveland-Sayers, Jennifer L. Caputo

ETSU Faculty Works

The purpose of the study was to examine the effects of a school-based cross-training program on body mass index (BMI), attitudes toward physical activity (ATPA), and physical activity (PA) levels of children in the 4^th and 5^th grades. Children (N = 118) were divided into control (n = 60) and experimental (n = 58) groups based on class availability. While the control group continued academic classes as usual, the experimental group participated in cross-training involving resistance training (RT), calisthenics, and stretching twice a week for 10 weeks. Pre- and post-intervention measures included height, mass, ATPA, and PA. BMI …

Increasing Awareness Of Autism Spectrum Disorders In Law Enforcement In Hispanic Communities, Annette M. Cano

Theses and Dissertations

The aim of the present study was to study autism awareness amongst law enforcement officers (LEO) and first responders (FR) serving the Rio Grande Valley (RGV). A 17-question survey was conducted to collect demographic data, knowledge, and level of training that officers and responders have when serving individuals with Autism Spectrum Disorder (ASD).

Stroke Severity Affects Timing: Time From Stroke Code Activation To Initial Imaging Is Longer In Patients With Milder Strokes., Kimberly T. Kwei, John W. Liang, Natalie Wilson, Stanley Tuhrim, Mandip Dhamoon

Department of Neurology Faculty Papers

Optimizing the time it takes to get a potential stroke patient to imaging is essential in a rapid stroke response. At our hospital, door-to-imaging time is comprised of 2 time periods: the time before a stroke is recognized, followed by the period after the stroke code is called during which the stroke team assesses and brings the patient to the computed tomography scanner. To control for delays due to triage, we isolated the time period after a potential stroke has been recognized, as few studies have examined the biases of stroke code responders. This "code-to-imaging time" (CIT) encompassed the time …

Development Of A Journaling Application To Track Progress Of Adaptation To Amplification For Adult Patients: Deardiary, Nicole C. Snider

Dissertations, Theses, and Capstone Projects

The DEar Diary application is an illustration of concept of an Apple iOS (operating system) application designed as a tool for supporting compliance and satisfaction with the use of amplification. The audiologist’s main purpose is to counsel, support and to provide rehabilitative counseling to their patients. Helping a patient succeed while using hearing devices for the first time is a complicated task which can be accomplished with the proper counseling and helpful tools in place.

The use of a journal to write down experiences and providing written support material the patient can refer to once they are out of the …

Otologic Blast Injuries, Michelle Singer

Dissertations, Theses, and Capstone Projects

The otologic system functions as a highly sensitive pressure transducer. Because of this, the ear is the most commonly affected organ in primary blast injury. Frequently encountered symptoms include hearing loss, tinnitus, and tympanic membrane perforations. The ear is repeatedly overlooked during triage and easily forgotten in subjects with multiple injuries after major catastrophic events such as explosions. This systematic review provides an overview of the most common otologic injuries observed after blast exposure in a variety of settings and populations. An analysis of 35 studies and an additional 23 reviews was performed in attempt to uncover patterns of otologic …

Factors Associated With Household Contacts' Tuberculosis Testing And Evaluation, Elvy G. Barroso

Dissertations, Theses, and Capstone Projects

Contact investigation (CI) is one of the core elements of tuberculosis (TB) control. It is intended to achieve early identification of contacts who may have been exposed to a patient with infectious active TB and contacts who may benefit from treatment for latent tuberculosis infection (LTBI). LTBI is an infection in which the Mycobacterium tuberculosis organisms cause no signs and symptoms but the infection can be reactivated and develop into full-blown active TB disease. Failure to be identified as a contact is the primary reason for disease development in more than half of TB patients, thus a complete and timely …

Audiometric Status, Self-Perception Of Hearing Disorders, And Noise Dose In Audio Post-Production Engineers, Laura M. Sinnott

Dissertations, Theses, and Capstone Projects

Numerous studies have assessed the risk of hearing injury for musicians and other sound professionals due to excessive sound exposure, however no studies have investigated whether audio post-production engineers have this same risk. This preliminary study first measured 23 participants’ hearing thresholds and prevalence of audiometric notches. Second, a questionnaire, the Questionnaire for Sound Professionals (QUSP), was designed and administered to determine whether correlations between audiometric status and self-perception of hearing loss and hearing disorders existed. Third, sound dosimetry measurements were conducted at film audio post-production studios to assess whether this population is at risk for permanent hearing loss due …

The Effects Of The Type And Timing Of Dietary Folate On Memory, Learning, And Gene Expression In Mice, Caleb Schreiner

Senior Honors Theses

Folate has been known as an important vitamin for several decades. It is vital in development and epigenetics and is especially known for its involvement in the prevention of neural tube defects in newborns. Due to this ability, a synthetic form of folate, folic acid, was mandated by the government to be reinforced into cereals and grains. This study used a mouse model to determine the effects folic acid and 5-methyltetrahydrofolate have on gene expression and behavior. Since folate is known to be important for epigenetics and neuronal development, this study examined the effects of folate by applying behavioral tests …

Antioxidant Activity Of Unpolished Riceberry Rice (Oryza Sativa) And The Inhibition Of Calcium Oxalate Crystal Growth And Aggregation, Witoon Khawsuk, Tistaya Semangoen, Parinyaporn Nuurai, Woramathi Mepan, Kiattipoom Wingworn

Chulalongkorn Medical Journal

Background : The inhibition of calcium oxalate monohydrate (COM) growth andaggregation can prevent the kidney stone formation. Black-purple rice (Oryzasativa), including Riceberry rice, contains high amount of antioxidantsubstances, such as anthocyanin, gamma - oryzanol and alpha-tocophorol.A previous study revealed that the high antioxidant content substances canprevent the formation of CaOx crystal.Objective : To prove the high antioxidant activity of unpolished Riceberry rice extractcan inhibit the growth and aggregation of CaOx crystal, especially COM.Methods : Unpolished Riceberry rice (UBR) grain was extracted by ethanol.The monomeric anthocyanin content of the extract was assessed by pHdifferential method. The total phenolic compound was determined …