Medicine and Health Sciences Commons^™

Sun Prevention Fun (Spf): A Multicomponent Sun Prevention Program For Children In Kindergarten And First Grade, Sarah Gouker

Evidence-Based Practice Project Reports

Skin cancer is an important topic in the United States due to the recent increase in cost and mortality. The purpose of this evidence-based practice (EBP) project was to determine if the early implementation of a multicomponent sun prevention program positively impacted kindergarten and first grade students’ knowledge and behavioral intentions to practice safe sun techniques after a one week period. Kotter’s Model of Change and the ACE Star model were utilized to guide this EBP project. An exhaustive review of the literature yielded 12 articles which were used to develop best practices for education on sun safety. The quality …

Microrna Expression And Disease Correlation In A Hispanic Lupus Cohort, Thandiwe Jere

Theses & Dissertations

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with varying clinical presentation and severity in different ethnicities/races. Micro-RNAs (miRNAs) modulate the immune system, and there is a growing interest in their role in SLE pathogenesis and disease presentation. Studies on miRNAs expression in SLE have been done in Caucasians and Asians but no comprehensive profiling has been done in Hispanics. This cross-sectional study of a Hispanic cohort of SLE patients (n =185) and healthy controls (HC) (n =185) from the Dominican Republic determined the expression of 10 selected miRNAs and their correlation to inflammatory markers and auto-antibody production in …

The Beta-Catenin/Muc1.Ct Interaction In Pancreatic Cancer, Edwin Wiest

Theses & Dissertations

MUC1 is overexpressed in over 90% of pancreatic cancer cases, and its interaction with beta-catenin promotes progression of the disease. Various in vitro and in vivo methods show that beta-catenin and MUC1 interact by way of the cytoplasmic tail of MUC1 (MUC1.CT). This interaction occurs in the membrane of pancreatic cancer cells but is found to a smaller extent in the nucleus as well. Biophysical methods suggest that MUC1 interacts with beta-catenin through a sequence of amino acids in the tail of MUC1 that sit very near the transmembrane domain of MUC1. In pancreatic ductal adenocarcinoma cells, it appears that …

Enhanced Recovery After Orthopedic Surgery In Total Hips And Knees, Christine Rigg

Doctor of Nursing Practice Projects

The prevalence of total knee and hip replacement surgery is increasing related to a combination of factors including osteoarthritis, age, and obesity (Christelis et al., 2015). The increased demand for joint replacement, current cost, and length of stay (LOS) place an increasing burden on clinical and financial resources. Enhanced recovery after surgery (ERAS) protocols have facilitated improved outcomes, such as increased patient satisfaction, decreased LOS, and associated costs (Bernard & Foss, 2014; Husted, Holm, & Jacobsen, 2008). Development and subsequent anesthesia group education were the beginning steps toward orthopedic protocol implementation in this project. This practice project had two goals: …

A Retrospective Analysis Of An Opiate Education And Naloxone Distribution Program, Ashley M. Tyler

Doctor of Nursing Practice Projects

Abstract

Trends indicate that misuse of opiates has increased nationally, frequently resulting in death. Substance use treatment clinics are now distributing naloxone (Narcan) to clients and laypeople as an antidote for opiate-related overdose. Offering Opiate Education and Naloxone Distribution (OEND) programs at treatment facilities increase the naloxone education opportunities available to those most closely affected by overdose.

Methods: The evaluation of naloxone distribution at a Midwestern substance use disorder clinic involved a retrospective analysis via chart audit of data regarding the delivery and administration of naloxone. The project focused on 48 individuals in the initial treatment phase for opiate use …

Developing An Online Wellness Curriculum For Nurse Anesthesia Students, Gina Calvanese, Jamie Rynearson

Doctor of Nursing Practice Projects

Student Registered Nurse Anesthetists (SRNAs) begin graduate school as confident critical care nurses, unaware of the impact that constant, daily stress will have on their lives. Wildgust (1986) presented the earliest known research and concluded stress negatively impacted the physiologic wellbeing of SRNAs. It has been reported that students in anesthesia programs experiencing high levels of stress and burnout are more likely to make critical errors when caring for their patients (de Oliveira, 2013). The goal of this doctoral project was to promote wellness and stress management among students enrolled in Southern Illinois University Edwardsville’s Nurse Anesthesia program by proposing …

Promoting Antibiotic Stewardship For Uti Management In Long Term Care Residents Through Standardized Clinical Practice Guidelines., Juliana M. Enoakpa

Doctor of Nursing Practice Projects

Urinary tract infections (UTIs) are the most diagnosed infections requiring antibiotics in long-term care (LTC) facilities. The rising prevalence of antimicrobial resistance (AMR) threatens treatment of infections that were once responsive to antibiotic therapy. The inappropriate use of antibiotics in this Midwestern LTC facility provided the impetus for implementing a standardized clinical practice guideline (CPG) for diagnosing UTIs among the LTC residents. A data collection tool was developed for the audit that identified the specific assessment criteria for UTI management and eligibility criteria for antibiotics. Physicians and NPs at the LTC facility were administered a questionnaire prior to implementation of …

Standardized Patient Handoff Tool, Matthew Marten

Doctor of Nursing Practice Projects

Patient handoffs are defined as the transmission of information and accountability between teams and individuals. These handoffs can be periods of increased risk for the patient and increased errors among anesthesia providers and PACU nurses (Segall et al., 2012). The Joint Commission recommends healthcare providers improve patient handoff as a national goal (Robins & Dai, 2015). The purpose of this nursing doctoral project was to determine if using a standardized patient handoff tool could improve communication and satisfaction between anesthesiologists, CRNAs, and PACU nurses. A review of the current literature supported the need for a standardized patient handoff tool for …

Occurrence Of Pathogenic Vibrio Cholerae Serogroups O1 And O139 In Some Estuaries Of Tanzania, David Temba, Lucy Namkinga, Sabrina Moyo, Thomas J. Lyimo, Charles V. Lugomela

Tanzania Journal of Science

In this study, the occurrence of culturable Vibrio cholerae serogroup O1 and O139 in three selected Tanzanian Estuaries, Mzinga, Pangani and Ruvu were explored. A total of 480 water and plankton samples were collected along salinity gradients (fresh, brackish and marine waters). Samples were enriched in Alkaline Peptone Water (APW) and subsequently cultured on Thiosulfate Citrate Bile-Salt Sucrose (TCBS) agar. Resulting isolates were serially identified by oxidase test, API-20E test and monoclonal antibodies for V. cholerae serogroup O1 and O139. A total of 670 presumptive V. cholerae isolates were obtained from 416 samples (86.7%), where 137 (20.4%) were oxidase test …

The Impact Of Rural-Urban Residency On Colorectal Cancer Screening, Stage At Diagnosis And Treatment In The Privately Insured Population, Mesnad Alyabsi

Theses & Dissertations

Colorectal Cancer (CRC) is the third most common and leading cause of cancer death in the United States. Although CRC screening can prevent and detect CRC at an early stage, about 35% of Americans are not screened. Despite the recent increase in screening, people with lower SES and those who live in rural areas have lowest screening. In rural areas, a common obstacle for screening is the long trips for health services which is associated with advanced CRC.

Moreover, surgery is a substantial part of CRC treatment since stages I-III and some metastatic CRC (mCRC) patients are treated with surgery. …

Data On The Risk Perceptions Of Beach Water Safety In Coastal Georgia, Jeffery A. Jones, Asli Aslan, Rakhi Trivedi, Maria I. Olivas, Mikayla Hoffmann

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

These data reflect the perceptions of beach water quality drawn from a convenience sample of 238 visitors to Georgia (USA) beaches collected in June–July 2017 and are related to the research article entitled “Water quality and the perception of risk: a study of Georgia, USA, beachgoers” (Jones et al., 2018) [1]. Data were collected both via an online survey distributed through Facebook and through in-person questionnaires collected directly on the beaches.

Overpriced And Under Regulated: A Crackdown On Pharmaceutical Monopolization And Malfeasance, Taryn Dewey

Missouri S&T’s Peer to Peer

As the price of medication skyrockets in 2017, investigating large pharmaceutical companies’ behavior is on the forefront of lowering the cost of medicine. With the help of Supreme Court rulings and patent layering, these companies have been able to take advantage of Food and Drug Administration regulations regarding market exclusivity and in turn are able to control drug costs and manufacturing. This control has caused a series of price gouges and has led to people not being able to afford the medication they require. Using government records, lawsuits, investigative reports, scholarly journals, and proxy statements, this study evaluated the current …

Athletic Turf As A Risk To Public Health, Darius Mann

Missouri S&T’s Peer to Peer

In recent years, synthetic turf playing surfaces have been rapidly replacing natural grass fields across the country. This includes middle school and high school sports fields and parks, meaning children and adolescents are the primary age groups being exposed to any potential adverse effects of these surfaces. With any technology that affects children, it is critical that the risks that the technology potentially poses to them be thoroughly explored and understood. A college soccer coach by the name of Amy Griffin brought the safety concerns over these turf fields to the minds of the American public when she noticed an …

2018 May Parkview Signature Care Thought Leader Forum, Jeanne Wickens, Sue Ehinger Phd, Jolynn Suko

Presentations and Events

No abstract provided.

Ua61/16 White Coat Ceremony Program, Wku Physical Therapy

WKU Administration Documents

White coat ceremony program for WKU Physical Therapy class of 2018.

Interlace: Designing An Inclusionary Architecture For Alzheimer's Sufferers, Alexander Fashinasi

Bachelor of Architecture Theses - 5th Year

This thesis intends to address the increasing challenges the Alzheimer’s disease poses for our growing American population. The research begins by looking at the brain as a combination of components which make up the individual. Following this, the research compiles information on the Alzheimer’s disease and its symptoms, followed by an analysis of the built environments effects on the condition.

Through analysis of precedent cases and the combined Alzheimer’s research, I chose to propose an experimental community in which those with Alzheimer’s can live a life with greater autonomy while simultaneously slowing the progression of the disease. I place this …

An Analysis Of Socio-Economic Consequences Of Cancer In Nepal, Soumi Roy Chowdhury

Economics ETDs

This dissertation investigates the socio-economic burden of cancer patients using a primary survey in Nepal. Given the low uptake rate of cancer screening facilities in developing countries, my study covers three important issues: the need of information dissemination on cancer prevention among asymptomatic individuals, the emotional stress of cancer patients in relation to a control group of patients, and the severity of economic burden due to premature cancer related deaths measured at the national and individual levels. In developing countries with low level of information and awareness, it is difficult to communicate the importance of cancer preventative measures to the …

Abcg5 And Abcg8: More Than A Defense Against Xenosterols, Shailendra B. Patel, Gregory A. Graf, Ryan E. Temel

Pharmaceutical Sciences Faculty Publications

The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body. Two proteins, ABCG5 and ABCG8, encoded by the sitosterolemia locus, work as obligate dimers to pump sterols out of hepatocytes and enterocytes. ABCG5/ABCG8 are key in regulating whole-body sterol trafficking, by eliminating sterols via the biliary tree as well as the intestinal tract. Importantly, these transporters keep xenosterols from accumulating in the body. The sitosterolemia locus has been genetically associated with lipid levels and downstream atherosclerotic disease, as well as …

Modeling And Analyzing An Optogenetic System For Photoactivatable Protein Dissociation, Anvin Thomas, James Schaff

Honors Scholar Theses

Computational modeling of cell-cell interactions can grant clues and can answer questions about an experiment, especially for observations about binding interactions and kinetics. This approach was used to investigate an interaction between a light-oxygen-voltage (LOV) domain and an engineered protein called Zdark (Zdk). The LOV domain is membrane-bound while Zdk is cytosolic. The LOV domain and Zdk bind strongly in dark (K_d 26.2 nM), and weakly upon exposure to blue light (K_d > 4 μM). Total internal reflection fluorescence (TIRF) images are acquired of Zdk, the fluorescent species bound to a mCherry tag, and the loss of fluorescence is …

05-08-2018 Revised Hsc Committee Meeting Agenda, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Intermittent Fetal Heart Rate Monitoring Using A Fetoscope Or Hand Held Doppler In Rural Tanzania: A Randomized Controlled Trial, Paschal Francis Mdoe, Hege L. Ersdal, Estomih R. Mduma, Jeffrey M. Perlman, Robert Moshiro, Peter T. Wangwe, Hussein Kidanto

Obstetrics and Gynaecology, East Africa

Background: Neonatal mortality is a global challenge, with an estimated 1.3 million intrapartum stillbirths in 2015. The majority of these were found in low resource settings with limited options to intrapartum fetal heart monitoring devices. This trial compared frequency of abnormal fetal heart rate (FHR) detection and adverse perinatal outcomes (i.e. fresh stillbirths, 24-h neonatal deaths, admission to neonatal care unit) among women intermittently assessed by Doppler or fetoscope in a rural low-resource setting.

Methods: This was an open-label randomized controlled trial conducted at Haydom Lutheran Hospital from March 2013 through August 2015. Inclusion criteria were; women in labor, …

Facilitating The Everyday Steward: Impact Of Mandatory Antimicrobial Indication/Duration And A 48 Hour Time Out, Ann L. Wirtz, Alaina N. Burns, Brian R. Lee, Tammy Frank, Laura Fitzmaurice, Richard Ogden, Brian O'Neal, Jennifer Goldman

Posters

Introduction: Required indication, duration, and a 48-hour antimicrobial timeout are an integral part of antimicrobial stewardship standards; however, limited data are available to demonstrate an effect on antimicrobial utilization and antimicrobial stewardship practice. Therefore, we evaluated the impact of mandatory declared indication/duration along with a pharmacy-driven 48-hour timeout on antimicrobial utilization and antimicrobial stewardship interventions.

Methods: We performed a retrospective evaluation of ASP interventions and antimicrobial use following implementation of mandatory antimicrobial indication/duration at the point of computerized physician order entry (CPOE). A pharmacist-driven 48-hour antimicrobial timeout was introduced on the same date. This study was conducted at Children’s Mercy …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Examines Muscle-Strengthening and Aerobic Activities and Mortality in Cancer Survivors

A New Perspective On The Outcomes Of Children With Cleft Lip And Palate: Application Of The Icf-Cy, Brenda Louw

ETSU Faculty Works

Learner Outcomes:

• Acknowledge the application value of the ICF to individuals with CLP.
• Integrate the ICF framework into the assessment of individuals with CLP.
• Formulate intervention goals that go beyond speech production skills to include functional communication outcomes in a variety of life situations.
• Include improvement and changes in communication participation in everyday functioning in assessment and progress reports.

Tipqc Breastfeeding Collaborative: Lessons Learned, Karen E. Schetzina, Julie Ware, Anna Morad

ETSU Faculty Works

No abstract provided.

Transition Of Care For The Young Adult With Cleft Palate: Stuck Between Goodbye To The Pediatric Team And Hello To Adult-Centered Care, Linda Vallino, Brenda Louw

ETSU Faculty Works

Participants will be able to:

• Describe the characteristics and needs of young adults with CLP.
• Discuss the model of transition of care for the young adult with CLP.
• Extrapolate strategies that teams could use to improve the care of young adults with CLP.

Ophthalmic Manifestations Of Heimler Syndrome Due To Pex6 Mutations., Nutsuchar Wangtiraumnuay, Waleed Abed Alnabi, Mai Tsukikawa, Avrey Thau, Jenina Capasso, Reuven Sharony, Chris F. Inglehearn, Alex V. Levin

Wills Eye Hospital Papers

BACKGROUND/AIMS: Pigmentary retinal dystrophy and macular dystrophy have been previously reported in Heimler syndrome due to mutations in PEX1. Here we reported the ocular manifestations in Heimler syndrome due to mutations in PEX6.

MATERIALS AND METHODS: Medical records were reviewed to identify patient demographics, ophthalmic and systemic findings, and results of diagnostic testing including whole genome sequencing.

RESULTS: Patient 1 is 12-year-old boy with a novel mutation c.275T>G (p.Val92Gly) and known mutation c.1802G>A (p.Arg601Gln) in PEX6. Patient 2 is a 7-year-old girl with the same known c.1802G>A (p.Arg601Gln) mutation and another novel missense mutation c.296G>T (p.Arg99Leu). …

Diabetes Education, Audra Trump

Doctor of Nursing Practice Projects

Background: Diabetes Self-Management Education (DSME) has been shown to improve diabetes management. However, a Midwest academic clinic does not offer formal diabetes education. The health department offers formal diabetes education classes twice a year. However, the classes are not flexible, long, and offered infrequently. Objective: The purpose of this project is to improve access to and standardize DSME for patients newly diagnosed with type II diabetes. Methods: The project design includes a one group pre-test/post-test convenience sample of adult patients who are newly diagnosed with type II diabetes in an academic outpatient setting. Results: At the time of diagnosis, the …

Local Anesthetic Systemic Toxicity Management: An Assessment Of Simulation-Based Staff Education, Kevin L. Kanallakan

Doctor of Nursing Practice Projects

When local anesthetics are administered at toxic doses or when certain local anesthetics are directly injected into the patient’s circulation, excessive plasma concentrations of the drug will produce a systemic cascade of events known as local anesthetic systemic toxicity (LAST). LAST is a rare, potentially life-threatening complication, which affects both the central nervous and cardiovascular systems. Anesthesia providers and perioperative healthcare professionals must remain current on best practice LAST management in order to reduce morbidity and mortality.

This quality improvement project utilized high fidelity simulation paired with LAST education to improve stakeholder knowledge and management of a LAST scenario. With …

Assessment Of The Validity Of Patient-Stated Allergies: De-Labeling And Education, Tawny Thomas, Angelina Leitschuh

Doctor of Nursing Practice Projects

The initial direction of the project was to develop and implement a research-based protocol to de-label hospitalized patients with a patient-stated penicillin allergy who were not truly allergic (Phase I). The project was abruptly halted due to the lack of data to justify the need, lack of sufficient communication among stakeholders, questions regarding financial cost of implementation, and strong concerns regarding educational needs of nursing staff. After developing the initial protocol, the project team was redirected to provide evidence-based allergy assessment education to the nursing staff to foster reliable and accurate patient interviews and documentation of the results (Phase II). …