Medicine and Health Sciences Commons^™

Dimerization Of The Voltage-Sensing Phosphatase Controls Its Voltage-Sensing And Catalytic Activity., Vamseedhar Rayaprolu, Perrine Royal, Karen Stengel, Guillaume Sandoz, Susy C Kohout

Cooper Medical School of Rowan University Departmental Research

Multimerization is a key characteristic of most voltage-sensing proteins. The main exception was thought to be the Ciona intestinalis voltage-sensing phosphatase (Ci-VSP). In this study, we show that multimerization is also critical for Ci-VSP function. Using coimmunoprecipitation and single-molecule pull-down, we find that Ci-VSP stoichiometry is flexible. It exists as both monomers and dimers, with dimers favored at higher concentrations. We show strong dimerization via the voltage-sensing domain (VSD) and weak dimerization via the phosphatase domain. Using voltage-clamp fluorometry, we also find that VSDs cooperate to lower the voltage dependence of activation, thus favoring the activation of Ci-VSP. Finally, using …

Ada News - 05/07/2018, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

A Comical Look At Occupational Therapy, Karen Mccarthy, Kira Kuwada

Collected Faculty Scholarship

n 2015, I attended the Association of Occupational Therapists of Ireland Conference and was inspired by the keynote address given by Sue Baptiste, MHSc, OT(C). Baptiste explored how she viewed the profession of occupational therapy as moving away from its roots in occupation and becoming more reductionistic in its practice. The profession of occupational therapy has seen many paradigm shifts—from a paradigm of occupation, to a mechanistic paradigm, and then toward a contemporary paradigm, which embraces (1) emphasizing the importance of occupation to health and well-being, (2) recognizing occupational problems and/or challenges as the focus of occupational therapy, and (3) …

What's Happening: May 7, 2018, Maine Medical Center

What's Happening

No abstract provided.

International Scope Of Emergency Ultrasound: Barriers In Applying Ultrasound To Guide Central Line Placement By Providers In Nairobi, Kenya, Fareen Zaver, Keith Boniface, Benjamin Wachira, Grace Wanjiku, Hamid Shokoohi

Emergency Medicine, East Africa

Background: While ultrasound (US) use for internal jugular central venous catheter (CVC) placement is standard of care in North America, most developing countries have not adopted this practice. Previous surveys of North American physicians have identified lack of training and equipment availability as the most important barriers to the use of US.

Objective: We sought to identify perceived barriers to the use of US to guide CVC insertion in a resource-constrained environment.

Methods: Prior to an US-guided CVC placement training course conducted at the Aga Khan University Hospital in Nairobi, Kenya, physicians were asked to complete a survey to determine …

Capecitabine And Temozolomide In Neuroendocrine Tumor Of Unknown Primary, Aman Chauhan, Zainab Farooqui, Leaundra Murray, Heidi L. Weiss, Zin W. Myint, Arun Kumar A. Raajasekar, B. Mark Evers, Susanne M. Arnold, Lowell B. Anthony

Internal Medicine Faculty Publications

Incidence of low grade well-differentiated neuroendocrine tumors (NET) is on the rise. The North American Neuroendocrine Tumor Society estimates that the United States has more than 150,000 gastroenteropancreatic NET patients. About 10% of metastatic NETs can be unknown primary, and due to their rarity, dedicated treatment algorithms and regimens are not defined. Combination of capecitabine and temozolomide (CAPTEM) is one of the systemic treatments used in gastroenteropancreatic NETs. We explored clinical activity of CAPTEM in NET of unknown primary. Methods. Retrospective review of NET of unknown primary managed at the University of Kentucky over the past five years (2012–2016). …

The Influence Of Therapist-Patient Religious/Spiritual Congruence On Satisfaction With Therapy: A Review Of Research, Tammy E. Henderson

Theses and Dissertations

The goal of this review was to examine the relationship between mental health and religion and/or spirituality. Specifically, it was believed that religion and spiritual congruence had a positive influence on satisfaction with therapy. Indeed, the literature reviewed suggests that therapists should be more open to addressing a patient's religious and/or spiritual beliefs as it could lead to more attuned therapeutic sessions. The importance of congruence between patient and therapist is a factor that can impact the therapeutic alliance, based on the literature, this concept appears to hold true for those that are or are not religiously and/or spiritually inclined.

When Disaster Strikes: A Training Intervention To Improve Nurses' Confidence And Preparedness For The Surge, Nichole M. Weber

Evidence-Based Practice Project Reports

There has been an exponential rise in mass casualty incidents (MCI) internationally. These human induced and naturally occurring events have affected over 4.6 billion people, and are not discriminatory to region or community (World Health Organization, 2011). Governing bodies require training and education, but nurses continue to report suboptimal competence and self-reported readiness, and a need for standardized, evidence-based training remains. The purpose if this evidence-based practice project is to authenticate current research supporting implementation of competency-based education, to improve nurses’ self- perceived preparedness and confidence in their ability to respond to MCI. The project results can be utilized for …

Barriers To Pregnancy Spacing In Women Living With Hiv: A Series Of Informational Interviews, Rachel K. Scott, Piyapa Praditpan, Patricia Tanjutco, Elizabeth Laidlaw, Regina Zopf, Manon M. Schladen

The Qualitative Report

For reproductive-age women living with HIV, birth spacing allows for optimization of maternal health and viral suppression to prevent mother-to-child transmission of HIV. We conducted semi-structured informational interviews to explore use of contraception for birth spacing. Interviews were transcribed and analyzed. Audio files were reviewed to capture non-explicit data. We interviewed 18 multiparous HIV positive women. All described experiences with at least one contraceptive method. Six themes emerged: Burden of contraception, Failure of birth control, Impact of youth and lack of life experience, Community beliefs about birth control, Lack of partner cooperation, and Altruism. Women viewed birth spacing favorably. Young …

Medical School Watercooler Newsletter - May 6, 2018, Lindsey Lyle

Watercooler Newsletter

This is the May 6, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Medical School Graduates Participate in Honors Convocation Ceremony
• USA Health joins NIH All of Us Research Program to advance precision medicine
• Dr. Chip Hartin Raising Funds for Leukemia &Lymphoma Society’s Man of the Year Competition
• COM Alumni to Reunite at Annual Alumni Weekend
• USA Medical Students Present Research at MASA Annual Meeting

Perfusion Imaging In Autoimmune Encephalitis, Deepak Vallabhaneni, Muhammad Atif Naveed, Rajiv Mangla, Awss Zidan, Rashi I. Mehta

Clinical and Translational Science Institute

Encephalitis is characterized by inflammation of brain tissue and has various infectious and noninfectious causes. CSF analysis and MRI usually reveal inflammatory changes although sometimes brain imaging may be normal. Autoimmune encephalitis is caused by antibodies against neuronal synaptic receptors, surface proteins, or intracellular proteins. In this case report, we present a 65-year-old female who presented with a fall and altered mental status. Workup for infectious etiologies was negative and MRI of the brain displayed focal restricted diffusion with corresponding T2-FLAIR hyperintensity involving gray matter structures, making the diagnosis unclear. CT perfusion of the brain demonstrated increased cerebral blood volume …

The Use Of Regional Anesthesia With A Paravertebral Nerve Block And Its Effects On Breast Cancer Recurrence And Metastasis, Jessica M. Hall

Nursing Capstones

No abstract provided.

Adult Naloxone Administration Protocol, Samuel S. Adhikari

Doctor of Nursing Practice Projects

Abstract

A tertiary care facility in central Illinois noted an increase in inpatient opioid-related adverse events, including acute opioid withdrawal syndrome due to a higher than a necessary dose of naloxone. The patient required intubation with a prolonged intensive care unit stay. A naloxone administration protocol encouraging cautious titration of naloxone could potentially decrease, if not entirely avoid similar events. When a patient exhibits opioid overdose symptoms, airway management, hemodynamic support, and due appreciation of the elimination half-life of naloxone become vital in preventing potentially tragic outcomes. This quality improvement project was non-experimental and involved the design and introduction of …

Kaempferol Induces G2/M Cell Cycle Arrest Via Checkpoint Kinase 2 And Promotes Apoptosis Via Death Receptors In Human Ovarian Carcinoma A2780/Cp70 Cells, Ying Gao, Junfeng Yin, Gary O. Rankin, Yi Charlie Chen

Clinical and Translational Science Institute

Kaempferol is a widely distributed dietary flavonoid. Epidemiological studies have demonstrated kaempferol consumption lowers the risk of ovarian cancer. Our previous research proved that kaempferol suppresses human ovarian cancer cells by inhibiting tumor angiogenesis. However, the effects of kaempferol on the cell cycle and extrinsic apoptosis of ovarian cancer cells have not yet been studied. In the present study, we demonstrated that kaempferol induced G2/M cell cycle arrest via the Chk2/Cdc25C/Cdc2 pathway and Chk2/p21/Cdc2 pathway in human ovarian cancer A2780/CP70 cells. Chk2 was not responsible for kaempferol-induced apoptosis and up-regulation of p53. Kaempferol stimulated extrinsic apoptosis via death receptors/FADD/Caspase-8 pathway. …

Mobile Hiv Units In South Africa: A Systematic Review, Meaghan Doherty

Senior Honors Projects, 2010-2019

Abstract

Objective: To examine existing literature on mobile HIV testing units to determine if they have the potential to increase access to testing, treatment, and HIV education to decrease rates of HIV in South Africa.

Participants: Ten research articles evaluating the HIV intervention method of mobile HIV units in South Africa, including outcome measures.

Analysis: Systematic search of 87 articles from 2000 to 2018 and review of the 10 articles that met inclusion criteria.

Results: Several studies (n=5) showed that mobile testing units are effective at attracting hard to reach populations, such as men and young adults. Studies (n=3) also …

An Investigation Of Personality Traits As Predictors For Mobile Phone Dependency, Elijah Phillips

Senior Honors Projects, 2010-2019

This study sought to determine if certain personality traits are correlates of mobile phone dependency, motivations for purchasing a mobile phone, and reasons for commonly using a cell phone. The impact of mobile phones on human day-to-day living and the interplay between cellular devices and human behavior have been topics of ongoing research. Through these investigatory efforts, numerous potential harms of mobile phone overuse and abuse have recently become increasingly apparent, but very little research has generated conclusive results about the interaction between human persona and mobile dependency. This was a cross-sectional study of a quasi-randomized sample of undergraduate students …

The Correlation Between Quality Of Care And Type Of Room In Long-Term Care Facilities In The Shenandoah Valley Of The Commonwealth Of Virginia, Hannah Twomey

Senior Honors Projects, 2010-2019

The purpose of this study was to examine if there was a present correlation the quality of care a resident in a long-term care facility received and the type of room they resided in. The researcher conducted a quantitative, cross-sectional research study of direct care healthcare providers (n=77) in four long-term care facilities in the Shenandoah Valley of Virginia through the documentation of a paper survey. The survey questions were adapted from Nursing Home Survey on Patient Safety Culture and participants responded according to their personal habits regarding the quality of care they gave residents and feelings about their place …

Development Of A Survey To Examine The Association Between Relationship Status And Human Papillomavirus Vaccination Behavior, Ansley Waters

Senior Honors Projects, 2010-2019

Literature: HPV is the most prevalent STI in the United States. Although a vaccine to prevent HPV infection exists, only 49.5% of females were up-to-date on the recommended vaccination HPV vaccination series in 2016. Though recommended for younger individuals, there is a catch-up period for females ages 18-26, which shows consistent under-participation. One potential risk factor for non-vaccination may be relationship status. Unlike other sexual health issues where monogamous, long-term relationships serve as a protective factor, such relationships may negatively impact HPV infection risk perception. Building from previous qualitative research, this study examined the quantitative association between relationship status and …

Impact Of A Hand Hygiene Curriculum And Group Handwashing Station At Two Primary Schools In East Africa, Stephanie Pasewaldt

Senior Honors Projects, 2010-2019

Handwashing drastically reduces the transmission of deadly, preventable diseases. Schools, even those with limited resources, have the power to promote handwashing through simple, effective interventions. This study evaluated the impact of a school-based handwashing program consisting of two interventions: a hand-hygiene curriculum and group handwashing station. Mixed quantitative and qualitative pre/post intervention surveys were administered to students at one primary school in Kenya (n=38) and at one primary school in Uganda (n=57). Identical procedures were followed at each school. Paired t-tests for pre/post-surveys demonstrated an increase in students’ knowledge (p

Effects Of Mental Health Campaigns, Susan Schott

Senior Honors Projects, 2010-2019

This project examines the effects of a mental health campaign on college students. This is important to research because universities and colleges alike need to understand the effects that campaigns about mental health on campus can have on students. I researched this by conducting an online experimental study on a sample of 511 students at a university in the Mid-Atlantic region. Qualtrics randomly assigned the participants into two groups, where one group viewed an experimental campaign and the other a control ad. The participants were measured using a post- test questionnaire which tested their self-perceptions of anxiety and level of …

The State Of The Translational Chaperone Icd-1 During Apoptosis In Caenorhabditis Elegans, Kyle Cicalese

Senior Honors Projects, 2010-2019

The unfolded protein response (UPR) is a signal transduction cascade that mitigates low levels of misfolded protein stress in the endoplasmic reticulum (ER) in an effort to save the affected cell, while prolonged and/or acute ER stress leads to UPR-initiated apoptosis (programmed cell death). One putative step driving apoptosis is the cleavage of chaperones, proteins tasked to help misfolded proteins refold, by caspases, proteases essential to the execution of apoptosis. We are studying the nascent polypeptide-associated complex (NAC), a heterodimeric chaperone complex essential for viability, to determine if its beta subunit is cleaved by caspases during apoptosis to prevent the …

Characterization Of Isolates And Whole Samples From Turkeys Infected With Bordetellosis, Alexandra Lovrinic

Senior Honors Projects, 2010-2019

Bordetellosis is a disease in turkeys attributed to the Gram-negative bacterium, Bordetella avium. The closely related species, B. hinzii, is known to colonize in turkeys as well but was not thought to cause disease. However, over the past few years, B. hinzii has been isolated from turkeys diagnosed with bordetellosis. The presumed identification of isolates obtained from Butterball farms in different locations was conducted through standard identification tests, including hemagglutination, PCR of B. avium specific genes, 16s rDNA PCR, carbohydrate utilization tests, and complete genome sequencing of a few strains. Out of ~100 isolates tested, 14 yielded contradictory …

The Efficacy Of The Teach-Back Method Of Education On Readmission Rates In Heart Failure Patients Within 30 Days Of Discharge, Catherine Lynch

Senior Honors Projects, 2010-2019

Background: The teach-back method is a method of education that is being used with heart failure patients in order to improve their quality of education and lower readmission rates. This literature review is aimed at synthesizing studies conducted to determine the efficacy of the teach-back method with this specific patient population.

Methods: Electronic searches of CINAHL and PubMed were performed through James Madison University libraries. Articles selected for inclusion were evaluated for study design, relevance, and sample size.

Results: Three studies met eligibility criteria, these studies showed statistically significant evidence that the teach-back method did reduce readmission rates in heart …

Addressing Disparities Among The Homeless Population With Type Ii Diabetes Through The Use Of Educational Programs, Allison Moses

Senior Honors Projects, 2010-2019

Background: The homeless population is exposed to many difficulties and barriers while attempting to manage Type II Diabetes Mellitus (DMII), which involves complex medication regimens and dietary and exercise modifications. The aim of this literature review is to increase awareness among healthcare professionals, to improve their understanding and ability to educate the homeless population, to help reduce health disparities and promote chronic disease management.

Methods: Access to two electronic search engines, CINAHL and PubMed, was obtained through James Madison University’s Library Database. The Ratings System for Level of Evidence was used to determine articles for inclusion based on reliability, sample …

Validity And Reliability Of The Ymca Submaximal Cycle Test Using An Electrically Braked Ergometer, Justin Kidd

Senior Honors Projects, 2010-2019

Purpose: To test the effect of using an electrically braked ergometer on the validity and reliability of the YMCA submaximal cycle test.

Methods: 22 male and 13 female subjects ages 19 to 31 completed one maximal treadmill test and four submaximal cycle tests to measure and estimate VO_2max, respectively. The maximal tests involved recording heart rate and VO₂ during graded exercise until volitional fatigue; an actual max was verified when two out of the following criteria: respiratory Exchange Ratio > 1.1, VO₂ plateau (< 150 ml/min increase in VO₂ during final stage), and achievement of 90% age-predicted HR max (or completed …

The Effect Of A Stage Of Change Tailored Intervention On Physical Activity And Psychological States Of Older Adults, Emilee Blosser

Senior Honors Projects, 2010-2019

Abstract

The Effect of a Stage of Change Tailored Intervention on Physical Activity and Psychological States of Older Adults

Introduction: As life expectancy increases in the United States, activity promotion programs aim to help older adults continue to remain happy, healthy, and productive. Programs that facilitate exercise and lifestyle changes can offset regular age-related declines and improve participation in regular fitness programs. Developing more active lifestyles can help the elderly maintain independence in their everyday activities.

Purpose: The goal of this study was to determine the effectiveness of a physical activity intervention tailored to participants’ stage of change on attitudes …

Nature's Effect On Mental Health, Hannah Thomas

Senior Honors Projects, 2010-2019

The United States has an overwhelming number of people suffering from mental illness, especially anxiety and depression. These disorders can be debilitating in many areas of the person’s life. Not even half of those diagnosed with these conditions are treated effectively and costs are expected to rise significantly in the coming years. One population that is often overlooked that suffers from these conditions is health professionals themselves. Physicians and nurses have high rates of depression and anxiety due to the stress from their occupation. In order for more patients and providers to be treated and for the health care system …

A Step Towards Differentiating Language Difference From Disorder, Sarah Scribano

Senior Honors Projects, 2010-2019

English learners (ELs) composed 10% of the American school-age population in the 2014 – 2015 school year. However, only a small percentage of speech language pathologists (SLPs) report feeling well qualified to address the cultural and linguistic needs of ELs. This can be attributed to a number of factors, including inadequate clinical markers, a shortage of developmental data for ELs, and a lack of cultural consideration in standardized assessments. Due to these barriers, SLPs struggle to differentiate between language differences and language disorders and are at risk for over-identifying or under-identifying language impairment (LI) in ELs. Research suggests that a …

Behavioral Audiometry Testing In Drosophila Melanogaster, Amanda Cascio

Senior Honors Projects, 2010-2019

The genetic make up of Drosophila melanogaster aligns closely enough to humans for them to function as models for the study of hearing loss and disorders (Albert & Göpfert, 2015; Duyk et al., 1997). The purpose of this project was to design a computer automated program capable of quickly assessing the hearing of flies based on their suppression of courtship behaviors in the presence of an audible stimulus. We were unable to document the male courtship song due to low frequency noise present in our sound attenuating booth. We continued the experiment using a spectrum of fly noise unassociated with …

Augmented Reality For At-Home Speech Intervention, Emily Vayo

Senior Honors Projects, 2010-2019

Augmented Reality (AR) is a technology that allows users to view graphics, videos, or other applications in their environment in real time using mobile devices, such as a smartphone or tablet. It provides an interactive way to combine technology and learning. Although AR has potential applications in the field of Communication Sciences and Disorders, few studies have investigated its reliability in speech intervention. This project explores whether parents are receptive to implementing AR technology into speech intervention and addresses one way to make intervention more engaging. The project looked at parental attitudes toward AR in integrating speech intervention goals at …