Medicine and Health Sciences Commons^™

Save The Pharmacy Piggy Bank: Managing Mega High-Cost Drugs, Richard K. Ogden Jr., Jerame Hill, Sam Abdelghany

Pharmacy Presentations

No abstract provided.

Save The Pharmacy Piggy Bank: Managing Mega High-Cost Drugs, Richard K. Ogden Jr., Jerame Hill, Sam Abdelghany

Pharmacy Posters

No abstract provided.

Social Determinants Of Health And What Mothers Say They Need And Want After Release From Jail., Elisabeth Stelson, Marjie Mogul, Holly Harner, Jeane Ann Grisso, Rosemary Frasso Phd, Msc, Cph

College of Population Health Faculty Papers

Identifying the biopsychosocial needs of mothers who have been released from jail is critical to understanding the best ways to support their health and stability after release. In May through August 2014, we interviewed 15 mothers who had been released from an urban jail about their reentry experiences, and we analyzed transcripts for themes. Eight domains of community reentry emerged through analysis: behavioral health services, education, employment, housing, material resources, medical care, relationships with children, and social support. Participants defined barriers to successful reentry, which paralleled the social determinants of health, and shared suggestions that could be used to mitigate …

Updated Efficacy Of First Or Second-Line Pembrolizumab Plus In Metastatic Triple Negative Breast Cancer And Correlations With Baseline Lymphocyte And Naïve Cd4+ T-Cell Count, David Page, Joanna Pucilowska, Laura Bennetts, I Kim, Katherine Sanchez, Maritza Martel, Alison Conlin, Nikki Moxon, Staci Mellinger, Anupama Acheson, K Kemmer, Z Mitri, J Vuky, J Ahn, C Abaya, T Manigault, R Basho, Walter Urba, Hl Mcarthur

Books, Presentations, Posters, Etc.

Background: In mTNBC, anti-PD-1/L1 monotherapy is most effective when administered early in the course of disease, with recent trials demonstrating overall response rates (ORR) of 23-26% in the first-line setting and 5-6% in later lines. This may reflect iatrogenic lymphopenia from preceding cytotoxic chemotherapy. Furthermore, curative-intent chemotherapy is associated with prolonged suppression of naïve CD4+ cells, a T-cell subset that may play a critical role in the generation of de novo anti-tumor immune responses. We present the final clinical results of a pilot study evaluating the safety and efficacy of combining pembrolizumab plus standard-of-care capecitabine in the first/second-line mTNBC …

A Comparison Of Maternal And Newborn Health Services Costs In Sindh Pakistan, Asif Raza Khowaja, Craig Mitton, Rahat Qureshi, Stirling Bryan, Laura A. Magee, Peter Von Dadelszen, Zulfiqar A. Bhutta

Department of Paediatrics and Child Health

Pakistani women suffer the highest rate of maternal mortality in South Asia. A lack of comprehensive knowledge about maternal and newborn health (MNH) services costs impedes policy decisions to maximize the benefit from existing, as well as emerging, MNH interventions in Pakistan. We compared MNH service costs at different levels of care. A cross-sectional survey was conducted during January to March 2016 as part of a large economic evaluation in Sindh, Pakistan. Health providers and facilities were selected from a sampling frame, inclusive of public and private sectors. This study utilized a broad perspective (i.e. costs to the health system …

The Utilization Of Venous-Venous Extracorporeal Membrane Oxygenation Membrane For The Management Of Status Asthmaticus, Kenneth Miller Msrt, Med, Rrt-Accs, Faarc,, Jennifer Strow Do, Alison N. Bedekovich Msn, Rn

Patient Care Services / Nursing

No abstract provided.

Dextromethorphan/Quinidine (Nuedexta) Treatment Implications For Impulsivity And Aggression In A Patient With Antisocial Personality Disorder And Major Depression: Case Study, Jacqueline M. Grinnell

Nursing Capstones

No abstract provided.

Coordinating Care And Managing Transitions For Individuals With Complex Care Needs Using The Cctm Rn Model, Sheila Haas, Phd, Rn, Faan, Beth Swan, Phd, Crnp, Faan, Traci Haynes, Msn, Rn, Cen, Ccctm

College of Nursing Posters

Objectives

• Discuss demand for care transition management for individuals with complex care needs across the care continuum
• Describe development of the Care Coordination and Transition Management (CCTM) dimensions and competencies
• Discuss challenges, future directions, and outcomes of the CCTM RN Model in managing care transitions for individuals with complex care needs

The Influence Of Predisposing, Enabling And Reinforcing Factors On The Solid Waste Management System. A Case Study On Kampala And Nairobi., Bethel Mwenze

Honors Theses

This study is a literature review on available research on the solid waste management issues that are overwhelming the cities of Kampala and Nairobi. The populations of these cities are growing as these cities attempt to fast track development in their cities. With this, means a multitude of issues that are too overwhelming for the current infrastructure. If these issues are not properly dealt with environmental and health problems are sure to ensue This study distributes these issues on the individuals, workers and policy makers in reference to their responsibilities. So, one can understand the predisposing factors such as knowledge …

Acromial Insufficiency Fractures In Reverse Total Shoulder Arthroplasty: A Biomechanical Study, Alicia Kerrigan

Electronic Thesis and Dissertation Repository

Reverse total shoulder arthroplasty (RTSA) is increasingly utilized in the aging population, with a growing list of surgical indications including rotator cuff tear arthropathy, proximal humerus fractures, and revision arthroplasty. Acromial insufficiency fractures following RTSA are poorly understood, difficult to diagnose, and associated with inferior clinical outcomes. There is limited knowledge in the literature regarding the etiology of post-operative acromial fractures. The purpose of this study is to evaluate the role of implant parameters on acromial strain following RTSA.

Using a cadaveric model, a custom designed modular RTSA system was implanted that allowed for evaluation of modifiable parameters including glenoid …

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Investigating The Use Of M-Health For Learning And Clinical Training By Medical Students In Ghana, Abdul M. Sulley

Electronic Thesis and Dissertation Repository

There is a challenge with healthcare access in most developing countries. With the high rate of mobile technology penetration in these countries, there is a strong belief that mobile technology can help address this and other health system and education challenges. This study investigated how clinical year medical students in Ghana used m-health and with what outcomes. This was a mixed-methods study to assess what technologies students used, what the impact of use was, what enablers and barriers they encountered, what factors explained m-health adoption and what the attitudes of students, staff and faculty members were towards m-health use. The …

Investigating The Practical And Clinical Effectiveness Of Applying Current Steering To Deep Brain Stimulation For Parkinsonian Gait Therapy, Daphne Hui

Electronic Thesis and Dissertation Repository

Multiple neural network integration, influence of bradykinesia and rigidity, and bias of upper limb symptom improvement during deep brain stimulation implementation may attribute to the variable responsiveness of Parkinsonian gait therapy. Current steering (CS) addresses variability through fractionating current to fine-tune the stimulation field shape. It was hypothesized that CS would exhibit greater gait improvements and lower the total electrical energy delivered (TEED), which reduces power consumption and battery drainage. Divisions of 70/30 and 50/50 and single-contact stimulation modelled CS and conventions, respectively. Overall ambulation improved with TEED reduction; further, bilateral CS improved step time and length but left CS …

Exploring Social Cohesion Among Syrian Refugees In Canada: A Secondary Analysis, Sara Calvert

Electronic Thesis and Dissertation Repository

BACKGROUND: As a result of the ongoing crisis in Syria, more than 11 million people have been displaced or killed over the past seven years (Mercy Corps, 2018). Despite efforts by the Canadian government to increase refugee uptake and promote social cohesion, refugees may still face negative resettlement experiences (Galabuzi, 2006; McCoy, Kirova, & Knight, 2016). Exploring how Syrian refugees have experienced social cohesion within their first year in Canada may help to address resettlement needs.

METHODS: This study was a secondary analysis on data collected from the Housing Education for Syrian Refugees and their Landlords study, which evaluated the …

Investigating The Role Of Endogenous Atf4 Upregulation On Neuronal Glutathione Level, Fatemeh Mirshafiei

Electronic Thesis and Dissertation Repository

ATF4 is a transcription factor that is activated in response to integrated stress response (ISR). In neurons specifically, ATF4 has been suggested to act as a pro-apoptotic transcription factor. The expression of ATF4, as well as its downstream gene targets have been implicated in both in vivo and in vitro models of Alzheimer’s and Parkinson’s Disease. However, the mechanism by which ATF4 promotes cell death remains unclear. It was previously shown that overexpression of ATF4 in primary cortical neurons caused a reduction in glutathione levels, resulting in oxidative stress-induced cell death. The aim of this project was to investigate whether …

Applications Of Ct Perfusion-Based Triaging And Prognostication In Acute Ischemic Stroke, Eric A. Wright

Electronic Thesis and Dissertation Repository

CT Perfusion (CTP) is a minimally invasive imaging technique that aids acute ischemic stroke (AIS) triage and prognostication by determining tissue viability based on hemodynamic parameters. The goals of this research are to determine: 1) CTP thresholds for estimation of infarct and penumbra volume, 2) how CTP scan duration impacts infarct and penumbra volume estimates, and 3) reliability of CTP for predicting functional outcomes following intra-arterial therapy (IAT).

Chapter 2 introduced an experimental study for determining ischemia-time dependent thresholds for brain infarction using multimodal imaging in a porcine stroke model that is easier to implement than previous large animal stroke …

Canvass: A Crowd-Sourced, Natural-Product Screening Library For Exploring Biological Space, Sara E. Kearney, Gergely ZahoráNszky-KőHalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Robert B. Grossman

Chemistry Faculty Publications

Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Characterization of the library in terms of physicochemical properties, structural diversity, and similarity to compounds in publicly available libraries indicates that the Canvass library contains many structural elements in common with approved drugs. The …

Executive Summary: A Comprehensive Report On Marijuana: Focus On The Paso Del Norte Region, Gabriel Frietze, Nora Hernandez, José O. Rivera

Departmental Papers (Pharmacy)

No abstract provided.

A Comprehensive Report On Marijuana: Focus On The Paso Del Norte Region, Gabriel Frietze, Nora Hernandez, José O. Rivera

Departmental Papers (Pharmacy)

The present executive summary highlights topics discussed within a comprehensive and extensive report on marijuana. This condensed summary discusses the chemical compounds within marijuana, the various methods of consuming marijuana, the therapeutic effects and health consequences associated with marijuana use, and repercussions that have emerged as a result of the legalization of marijuana in many states within the United States. Additionally, the impact of marijuana in communities within the Paso del Norte Region are discussed.

Read more: Executive Summary

Dose–Response Functions And Methodological Insights For Sensory Tests With Astringent Stimuli, Jonathan Kershaw, Cordelia Running

Public and Allied Health Faculty Publications

Sensations such as bitterness and astringency can limit the acceptance of many purportedly healthy foods. The purpose of this study was to investigate dose–response relationships of various astringent and bitter stimuli in a beverage, and to simultaneously gain additional methodological insight for the effects of wording, repeated tasting, and beverage matrix on these sensations. Untrained participants were presented with samples of a “flavored beverage” or water containing various concentrations of four stimuli (alum, malic acid, tannic acid, and quinine) and were asked to rate intensities of tastes (bitterness, sourness, and sweetness) and astringency subqualities (roughing, drying, and constricting or puckering) …

Establishing Trust In Hiv/Hcv Research Among People Who Inject Drugs (Pwid): Insights From Empirical Research, Roberto Abadie, Shira Goldenberg, Melissa Welch-Lazoritz, Celia B. Fisher

Department of Sociology: Faculty Publications

Background — The establishment of trust between researchers and participants is critical to advance HIV and HCV prevention particularly among people who inject drugs (PWID) and other marginalized populations, yet empirical research on how to establish and maintain trust in the course of community health research is lacking. This paper documents ideas about trust between research participants and researchers amongst a sub-sample of PWID who were enrolled in a large, multi-year community health study of social networks and HIV/HCV risk that was recently conducted in rural Puerto Rico.

Methods — Qualitative research was nested within a multi-year Social Network and …

Physical Properties And Solubility Studies Of Nifedipine-Peg 1450/Hpmcas-Hf Solid Dispersions, Rahul V. Haware, Bhavani Prasad Vinjamuri, Monika Gavireddi, Vivek S. Dave, Deepak Gupta, Mahavir B. Chougule, William C. Stagner

Pharmacy Faculty/Staff Publications

Low-order high-energy nifedipine (NIF) solid dispersions (SDs) were generated by melt solvent amorphization with polyethylene glycol (PEG) 1450 and hypromellose acetate succinate (HPMCAS-HF) to increase NIF solubility while achieving acceptable physical stability. HPMCAS-HF was used as a crystallization inhibitor. Individual formulation components, their physical mixtures (PMs), and SDs were characterized by differential scanning calorimetry, powder X-ray diffraction, and Fourier transform infrared spectroscopy (FTIR). NIF solubility and percent crystallinity (PC) were determined at the initial time and after 5 days stored at 25 °C and 60% RH. FTIR indicated that hydrogen bonding was involved with the amorphization process. FTIR showed that …

Targeting The Brd4/Foxo3a/Cdk6 Axis Sensitizes Akt Inhibition In Luminal Breast Cancer, Jingyi Liu, Weijie Guo, Zhibing Duan, Lei Zeng, Yadi Wu, Yule Chen, Fang Tai, Yifan Wang, Yiwei Lin, Qiang Zhang, Yanling He, Jiong Deng, Rachel L. Stewart, Chi Wang, Pengnian Charles Lin, Saghi Ghaffari, B. Mark Evers, Suling Liu, Ming-Ming Zhou, Binhua P. Zhou, Jian Shi

Molecular and Cellular Biochemistry Faculty Publications

BRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer progression. However, it remains unclear whether BRD4-mediated gene transcription is required for tumor cells to develop drug resistance. Our data show that prolonged treatment of luminal breast cancer cells with AKT inhibitors induces FOXO3a dephosphorylation, nuclear translocation, and disrupts its association with SirT6, eventually leading to FOXO3a acetylation as well as BRD4 recognition. Acetylated FOXO3a recognizes the BD2 domain of BRD4, recruits the BRD4/RNAPII complex to the CDK6 gene promoter, and induces its transcription. Pharmacological inhibition of either BRD4/FOXO3a association or …

Innocent Heart Murmur., Arpan R. Doshi

Manuscripts, Articles, Book Chapters and Other Papers

Heart murmur is the most common reason for a referral to a pediatric cardiologist. Virtually all children have a heart murmur during their childhood. Less than 1% of murmurs are pathological in children. Innocent/functional heart murmur is the most common type of heart murmur. There are multiple theories proposed to identify etiology of innocent heart murmur with varying consensus, but everybody agrees that innocent heart murmur does not carry any morbidity or mortality risk. Even today, heart murmur is associated with high physician uncertainty and parental anxiety. Extensive cardiac evaluation for such a benign finding is also associated with high …

Assessment Of Pharmacist Competency During Cardiopulmonary Arrest Code Participation In A Community Hospital, Lissette Bauza, Yarelys Garcia, Ada Jalice

All Publications

No abstract provided.

Drowning Prevention: Define And Then Gather Evidence Or Gather Evidence To Define?, Nina J. Nyitrai, Suzi Edwards, Nicholas O'Dwyer

International Journal of Aquatic Research and Education

According to the World Health Organization, drowning fatalities are a neglected public health issue ranked as the third most frequent cause of unintentional death by injury. Data used to record drowning incidents are acknowledged as inaccurate. Recommendations on drowning prevention based on these data are currently not informed by accurate, detailed and reliable evidence. Two modifications to current practice are proposed: 1) an Aquatic Incident Report needs to be developed as an extension of the current workplace incident report to prompt for information commonly not included in current drowning reports; and 2) National Water Safety Plans should be modified to …