Medicine and Health Sciences Commons^™

Collaborating Against Catecholamines: Using Interprofessional Simulation To Prepare For A Potential Cardiac Emergency In Pregnancy., Julia Gogle Msn, Rnc-Ob, Tonya Kemp Rn, Rnc-Ob

Patient Care Services / Nursing

No abstract provided.

Contributions Of Mean And Shape Of Blood Pressure Distribution To Worldwide Trends And Variations In Raised Blood Pressure: A Pooled Analysis Of 1018 Population-Based Measurement Studies With 88.6 Million Participants, Majid Ezzati, Bin Zhou, James Bentham, Mariachiara Di Cesare, Honor Bixby, Goodarz Danaei, Kaveh Hajifathalian, Cristina Taddei, Rodrigo M. Carrillo-Larco, Shirin Djalalinia, Shahab Khatibzadeh, Charles Lugero, Niloofar Peykari, Wan Zhu Zhang, James Bennett, Ver Bilano, Gretchen A. Stevens, Melanie J. Cowan, Leanne M. Riley, Zhengming Chen, Ian R. Hambleton, Rod T. Jackson, Andre Pascal Kengne, Young Ho Khang, Avula Laxmaiah, Jing Liu, Reza Malekzadeh, Hannelore K. Neuhauser, Maroje Sorić, Gregor Starc

All Works

© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic …

Misplaced Central Venous Catheter In Carotid Artery During Emergency Surgery For The Total Correction Of Tetralogy Of Fallot Of An Adolescent Boy, Shabbir Ahmed, Faisal Junejo, Fazal Wahab Khan

Department of Anaesthesia

Ultrasound-guided central venous cannulation is now considered as the standard of care, and this has largely replaced blind central venous cannulation using anatomical landmarks. We are reporting a case of inadvertent placement of central venous catheter in the right common carotid artery with the use of ultrasound guidance during emergency surgery for the total correction of Tetralogy of Fallot (ToF). This patient luckily had a favourable outcome despite this inadvertent catheter placement which was not recognised even after completion of surgery .The patient also received drug infusions of inotropes and vasopressors through this malplaced central line into the aorta. The …

Pre-Anaesthetic Assessment Of Intracranial Pressure Using Optic Nerve Sheath Diameter In Patients Scheduled For Elective Tumour Craniotomy, Faraz Shafiq, Muhammad Asghar Ali, Fauzia Khan

Department of Anaesthesia

Background: The objective of study was to determine the pre-anaesthetic status of intracranial pressure (ICP), using ultrasonographic measurement of optic nerve sheath diameter (ONSD) inpatient scheduled for elective tumour craniotomy. The secondary objective was to compare the diagnostic accuracy of ONSD guided rise in ICP with clinical and radiographic parameters. This is prospective observational study, conducted at single neurosurgical theatre of The Aga Khan University over a period of one year.
Methods: After getting ethical approval and informed consent patient fulfilling inclusion criteria and planned for elective tumour craniotomy were enrolled in study. The clinical and radiographic signs predicting the …

Therapist Behaviors That Predict The Therapeutic Alliance In Couple Therapy, Bryan C. Kubricht

Theses and Dissertations

Couple therapy is successful in treating relationship distress. However, couple therapy does not benefit everyone. Consequently, it is important to study factors that predict therapeutic success. One such factor is what predicts the development of the therapeutic alliance in couple therapy. The purpose of this study was to code therapist behaviors, therapist warmth, empathy, presence, validation, collaboration, and technique factors (systemically-based techniques and session structure), in the first session of couple therapy to examine their ability to predict two aspects of the therapeutic alliance, between- and within-alliance, after the session for males and females. The hypotheses were tested utilizing multiple …

Articulatory Kinematic Differences During Adaptation To A Bite Block, Madison Ann Mchaley

Theses and Dissertations

The current study examined the effects of bite blocks on articulatory kinematics when producing /r/ within a phrase. Participants consisted of 20 young adults (10 males, 10 females) with no speech, language or hearing disorders. Participants produced the carrier phrase, I say __ with the nonsense words /əri/ (high front vowel), /əræ/ (low front vowel), /əru/ (high back vowel), /ərɑ/ (low back vowel). A Northern Digital Instruments Wave electromagnetic articulograph measured the articulatory movements while the speaker produced the stimuli in two conditions (Pre bite block and post bite block). Bilateral bite blocks were made using Express dental putty, which …

The Effects Of Social Communication Intervention On Emotion Inferencing In Children With Developmental Language Disorder, Capri Annissa Seaberg

Theses and Dissertations

Children with Developmental Language Disorder (DLD) often face problems in areas of social communication including negotiating with peers, entering ongoing interactions, and engaging in conflict resolution. A potential cause of these social communication difficulties is the decreased ability to make emotional inferences. This thesis investigates the effects of a social communication intervention on the ability of school-aged children with DLD to make inferences about emotions. Five children with DLD between the ages of 6;10 and 12;4 participated in a social communication intervention that highlighted principles of emotion understanding (recognizing emotions in facial expressions, inferring emotions with contextual information, and discussing …

"Understanding Lgbtq+ Intimate Partner Violence & Challenges In, Dr. Juanita Yates

Dissertations

This research project is a focus on Intimate Partner Violence (IPV) within LGBTQ+

community and the challenges associated with seeking family support. IPV is defined as a violent

or aggressive behavior within the home, typically involving the violent abuse of an intimate spouse

or partner. However, IPV can happen on the street, in one’s home or even in a public place. Those

exposed to IPV can be children, men and women. IPV is a prevalent issue in our society (Bright

2008). According to Ristock (2005), violence in LGBTQ+ relationships may be referred to as

partner violence, relationship violence, or LGBTQ+ …

Oil Palm Frond Supplementation Can Change Fatty Acid Composition Of Rumen Fluid, Muscle Tissue And Blood Cholesterol Level In Crossbred Male Sheep, Yong Meng Goh, Mohamed Ali Rajion, Saeid Jafari, Mahdi Ebrahimi

The Thai Journal of Veterinary Medicine

Diet composition is the major factor influencing the fatty acid composition of products derived from ruminants. Thirty 7-month-old, Barbados Black Belly × Malin crossbred male sheep were used for the trial to determine the effects of dietary supplementation of oil palm (Eleis guineensis) frond (OPF) on the fatty acid profiles of rumen fluid, muscle tissue and blood lipid parameters. Treatment diets were control diet (CON group, n=10), 25% OPF pellet in diet (% w/w) (HAF group, n=10) and 50% OPF pellet in diet (OPF group, n=10). After 100 days of feeding, eight sheep from each group were slaughtered for sampling …

Suture Attachment Sites On Stifle Joint Of Small And Large Dog Breeds For Cranial Cruciate Ligament Rupture Repair, Chaiyakorn Thitiyanaporn

The Thai Journal of Veterinary Medicine

Cranial cruciate ligament rupture is one of the most common problems in dogs. Previous studies have arrived at no absolute conclusion regarding suture attachment sites using the extracapsular technique to repair cranial cruciate ligaments in dogs. Therefore, the objective of this study was to identify and compare suture attachment sites on the femur and tibia between small and large dog breeds at different stifle angles. Twenty-seven cadaveric hind limbs of small dogs and 16 cadaveric limbs of large dogs were collected, and lateral photographs were taken at different stifle angles (including 40, 60, 80, 100, 120, 140, and 160 degrees). …

Accuracy Of Blood Beta-Hydroxybutyrate And Plasma Acetoacetate For Diagnosis Of Canine Diabetic Ketoacidosis, Anyapat Satitpornniwat, Narumol Kanokbodeevanit, Navaporn Issariyakulkarn, Wannapaun Buasai, Kris Angkanaporn, Sukullaya Ritthikulprasert

The Thai Journal of Veterinary Medicine

Diabetic ketoacidosis (DKA) is a life-threatening complication in diabetic dogs. It is caused by an increase in production and accumulation of ketone bodies in the blood, which results in metabolic acidosis. The objective of this study was to compare the diagnostic accuracy between the measurement of blood beta-hydroxybutyrate (β-OHB) concentration using a point-of-care sensor and plasma acetoacetate (AcAc) level using a urine strip test for the diagnosis of canine DKA. A total of 60 dogs were enrolled into each group: DKA (n=16), diabetic ketosis (DK) (n=5), and control (n=39). The following parameters including blood β-OHB, plasma AcAc, blood glucose, urinary …

Immune System Overdrive: A Case Study Of An Obstetric Patient With Hemophagocytic Lymphohistiocytosis., Jaime Kupillas Msn, Rn, Laurie Griesel Rn, Rnc-Ob

Patient Care Services / Nursing

No abstract provided.

Pip2 Modulation Of Afterhyperpolarizations In Magnocellular Supraoptic Neurons, Matthew Karl Kirchner

Theses and Dissertations (ETD)

Magnocellular neurosecretory cells (MNCs) are large oxytocin (OT)- and vasopressin (VP)-releasing neurons that secrete these hormones into the circulatory system in response to physiological stimuli. These cells exhibit unique phasic and burst firing patterns to release these peptides into the circulatory system where they primarily control milk ejection and parturition (OT) as well as salt-water balance and vasoconstriction (VP). This firing is underlain by intrinsic ionic mechanisms that shape the duration and frequency of these bursts. One of these mechanisms is the Ca2+-dependent afterhyperpolarization (AHP), which activates during bursts and causes spike frequency adaptation. This afterhyperpolarization has three distinct conductances: …

Reframing Medical Education, Herbert L Fred, Jed D Gonzalo

The Texas Heart Institute Journal

No abstract provided.

A Systematic Review Of The Effects Of Handwriting Interventions On Adults With Parkinson’S Disease, J. Buchanan, W. Rybak, V. Stange, J. Wing, V. Yeh, L. Carvell

Student Papers, Posters & Projects

Occupational therapists working with this population have incorporated a variety of methods into their interventions in an attempt to facilitate greater ease and legibility in handwriting. These interventions include finemotor hand exercise programs, practice-based programs, and visual and auditory cueing (Bryant, Rintala, Lai, DeBakey & Protas, 2010). Improvement in handwriting skills can increase quality of life and independence, as well as decrease frustration, for those with PD (Collett et al., 2017). A systematic review of available research was completed in order to assess the efficacy of these interventions for both short and long-term outcomes. Eleven studies were identified as relevant …

Catheter Ablation Of Ventricular Tachycardia, Nilesh Mathuria

The Texas Heart Institute Journal

No abstract provided.

Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Cardiovascular Disease In Us Military Centers, John E Thomas, Seungho Kang, Charles J Wyatt, Forest S Kim, A David Mangelsdorff, Fred K Weigel

The Texas Heart Institute Journal

Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic reactions. In addition, G6PD is a key determinant of vascular function, and its deficiency can lead to impaired nitric oxide production and greater vascular oxidant stress—precursors to atherosclerosis and cardiovascular disease. Using military medical records, we performed a retrospective, cross-sectional study to investigate whether deficient G6PD levels are associated with a higher prevalence of cardiovascular disease than are normal levels, and, if so, …

Obstructive Sleep Apnea In Heart Failure: Review Of Prevalence, Treatment With Continuous Positive Airway Pressure, And Prognosis, Himad K Khattak, Faisal Hayat, Salpy V Pamboukian, Harvey S Hahn, Brian P Schwartz, Phyllis K Stein

The Texas Heart Institute Journal

Obstructive sleep apnea is a sleep-related breathing disorder that has a major impact on cardiovascular function. It has been associated with hypertension, coronary artery disease, cardiac arrhythmias, sudden cardiac death, and heart failure. This review focuses on the relationship between obstructive sleep apnea and heart failure with either reduced or preserved ejection fraction. We discuss the pathophysiology of obstructive sleep apnea, as well as its prevalence, treatment outcomes with continuous positive airway pressure, and prognosis in these 2 distinct types of heart failure. We also identify areas in which further work is needed to improve our understanding of this association …

New Insights Into Predictors Of Cardiac Implantable Electronic Device Infection, Hossein Sadeghi, Abolfath Alizadehdiz, Amirfarjam Fazelifar, Zahra Emkanjoo, Majid Haghjoo

The Texas Heart Institute Journal

Infection is an important complication of cardiac implantable electronic device procedures. To further study the factors associated with infection, we retrospectively reviewed the records of 3,205 consecutive patients who had undergone de novo or revision cardiac electronic device implantation at our institution from March 2011 through March 2015. We recorded all infections and specified whether they were related to the characteristics of the patient, device, or procedure. To identify predictors of infection, we performed multivariate analysis.

Device infections were identified in 85 patients (2.7%), at a mean follow-up time of 27 ± 11 months. The main predictors of device infection …

J Mich Dent Assoc Jun 2018

The Journal of the Michigan Dental Association

Archival issues of the Journal of the Michigan Dental Association may include reports on the activities of the association and its members, clinical articles, information on legal and ethical practice considerations, and perspectives of interest to MDA members and those in the oral health profession.

Why Illegal Delegation Of Duties Is Unethical, Michael G. Maihofer Dds

The Journal of the Michigan Dental Association

Regular column featuring ethical guidance and consideration for practicing dentists.

Hybrid Model - Statistical Features And Deep Neural Network For Brain Tumor Classification In Mri Images, Mustafa Rashid Ismael

Dissertations

A brain tumor is the most common disease that affects the central nervous system (CNS), the brain, and spinal cord. It can be diagnosed using the safest and most reliable imaging modality, the Magnetic Resonance Imaging (MRI), by radiologists who may use the assistance of computer-aided diagnosis (CAD) tools. Automated diagnosis is sought because it is essential to overcome the drawbacks of the manual diagnosis, such as time and the stress of viewing MRI images for long hours, and the human error potential. Image analysis and machine learning algorithms are tools that can be used to build an intelligent CAD …

The Na/K-Atpase Oxidant Amplification Loop Regulates Aging, Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, Jiang Liu, Nader G. Abraham, Joseph I. Shapiro

NYMC Faculty Publications

As aging involves oxidant injury, we examined the role of the recently described Na/K-ATPase oxidant amplification loop (NKAL). First, C57Bl6 old mice were given a western diet to stimulate oxidant injury or pNaKtide to antagonize the NKAL. The western diet accelerated functional and morphological evidence for aging whereas pNaKtide attenuated these changes. Next, human dermal fibroblasts (HDFs) were exposed to different types of oxidant stress in vitro each of which increased expression of senescence markers, cell-injury, and apoptosis as well as stimulated the NKAL. Further stimulation of the NKAL with ouabain augmented cellular senescence whereas treatment with pNaKtide attenuated it. …

Nipple Sparing Mastectomy Techniques: A Literature Review And An Inframammary Technique, Andrew Y. Ashikari, Pond R. Kelemen, Bahar Tastan, C. Andrew Salzberg, Roy H. Ashikari

NYMC Faculty Publications

Nipple sparing mastectomy (NSM) has quickly become an accepted technique for patients with selected cancers and for risk reducing surgery. Much of its surgical acceptance over the last decade has been based on the low risk of nipple areolar complex (NAC) occurrence in breast cancer patients. Improved patient satisfaction due to improved cosmetic outcomes with reconstruction have also driven its popularity. We reviewed current English journals to determine the NSM techniques which achieve the lowest complications, best outcomes, and best patient satisfaction. We researched studies showing reductions in complications with improved surgical techniques and patient selection which have been implicated …

Glaucomatous Optic Neuropathy Associated With Nocturnal Dip In Blood Pressure: Findings From The Maracaibo Aging Study, Jesus D. Melgarejo, Joseph H. Lee, Michele Petitto, Juan B. Yepez, Felipe A. Murati, Zhezhen Jin, Carlos A. Chavez, Rosa V. Pirela, Gustavo E. Calmon, Matthew P. Johnson, Gladys E. Maestre

School of Medicine Publications

Purpose—To determine which nocturnal blood pressure (BP) parameters (low levels or extreme dipper status) are associated with an increased risk of glaucomatous damage in Hispanics.

Design—Observational cross-sectional study.

Participants—A subset (n=93) of the participants from the Maracaibo Aging Study (MAS) who met the study eligibility criteria were included. These participants — who were at least 40 years of age — had measurements for optical tomography coherence, visual field tests, 24-hour BP, office BP, and intraocular pressureHg.

Methods—Univariate and multivariate logistic regression analyses under the generalized estimating equations (GEE) framework were used to examine the relationships between …

Clinical Significance Of Muc13 In Pancreatic Ductal Adenocarcinoma, Sheema Khan, Nadeem Zafar, Shabia S. Khan, Saini Setua, Stephen Behrman, Zachary E. Stiles, Murali M. Yallapu, Prabhakar Pradhan, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

Background—Poor prognosis of pancreatic cancer (PanCa) is associated with lack of an effective early diagnostic biomarker. This study elucidates significance of MUC13, as a diagnostic/prognostic marker of PanCa.

Methods—MUC13 was assessed in tissues using our in-house generated anti-MUC13 mouse monoclonal antibody and analyzed for clinical correlation by immunohistochemistry, immunoblotting, RT-PCR, computational and submicron scale mass-density fluctuation analyses, ROC and Kaplan Meir curve analyses.

Results—MUC13 expression was detected in 100% pancreatic intraepithelial neoplasia (PanIN) lesions (Mean composite score: MCS=5.8; AUC >0.8, P<0.0001), 94.6% of pancreatic ductal adenocarcinoma (PDAC) samples (MCS=9.7, P<0.0001) as compared to low expression in tumor adjacent tissues (MCS=4, P<0.001) along with faint or no expression in normal pancreatic tissues (MCS=0.8; AUC >0.8; P<0.0001). Nuclear MUC13 expression positively correlated with nodal metastasis (P<0.05), invasion of cancer to peripheral tissues (P<0.5) and poor patient survival (P<0.05; prognostic AUC=0.9). Submicron scale mass density and artificial intelligence based algorithm analyses also elucidated association of MUC13 with greater morphological disorder (P<0.001) and nuclear MUC13 as strong predictor for cancer aggressiveness and poor patient survival.

Conclusion—This study provides significant information regarding MUC13 expression/ subcellular localization in PanCa samples …

Variability Of Extracorporeal Cardiopulmonary Resuscitation Utilization For Refractory Adult Out-Of-Hospital Cardiac Arrest: An International Survey Study., Patrick J. Coppler, Benjamin S. Abella, Clifton W. Callaway, Minjung Kathy Chae, Seung Pill Choi, Jonathan Elmer, Won Young Kim, Young-Min Kim, Michael Kurz, Joo Suk Oh, Joshua C. Reynolds, Jon C. Rittenberger, Kelly N. Sawyer, Chun Song Youn, Byung Kook Lee, David F. Gaieski

Department of Emergency Medicine Faculty Papers

Objective: A growing interest in extracorporeal cardiopulmonary resuscitation (ECPR) as a rescue strategy for refractory adult out-of-hospital cardiac arrest (OHCA) currently exists. This study aims to determine current standards of care and practice variation for ECPR patients in the USA and Korea.

Methods: In December 2015, we surveyed centers from the Korean Hypothermia Network (KORHN) Investigators and the US National Post-Arrest Research Consortium (NPARC) on current targeted temperature management and ECPR practices. This project analyzes the subsection of questions addressing ECPR practices. We summarized survey.

Results: Overall, 9 KORHN and 4 NPARC centers reported having ECPR programs and had complete …

Investigating The Impact Of Seasonal Variations On The Dynamics Of Chikungunya, Md Rafiul Islam

Biology and Medicine Through Mathematics Conference

No abstract provided.

Spatial Modeling Of In-Vivo Viral Infection With Interferon Response, Gary M. Lavigne Jr

Biology and Medicine Through Mathematics Conference

No abstract provided.

Nonlinearities In Prey Growth, Size-Dependent Predation Risk, And Functional Responses: Understanding The Effects Of Multiple Predators On A Shared Prey Using Agent-Based Models, Russell Dixon, Jeremy Wojdak

Biology and Medicine Through Mathematics Conference

No abstract provided.