Medicine and Health Sciences Commons^™

Repetition-To-Repetition Differences Using Cluster And Accentuated Eccentric Loading In The Back Squat, John P. Wagle, Christopher B. Taber, Kevin M. Carroll, Aaron J. Cunanan, Matt L. Sams, Alexander Wetmore, Garett E. Bingham, Brad H. Deweese, Kimitake Sato, Charles A. Stuart, Michael H. Stone

ETSU Faculty Works

The current investigation was an examination of the repetition-to-repetition magnitudes and changes in kinetic and kinematic characteristics of the back squat using accentuated eccentric loading (AEL) and cluster sets. Trained male subjects (age = 26.1 ± 4.1 years, height = 183.5 ± 4.3 cm, body mass = 92.5 ± 10.5 kg, back squat to body mass ratio = 1.8 ± 0.3) completed four load condition sessions, each consisting of three sets of five repetitions of either traditionally loaded straight sets (TL), traditionally loaded cluster sets (TLC), AEL cluster sets (AEC), and AEL straight sets where only the initial repetition had …

Repetition-To-Repetition Differences Using Cluster And Accentuated Eccentric Loading In The Back Squat, John P. Wagle, Christopher B. Taber, Aaron J. Cunanan, Matt L. Sams, Alexander Wetmore, Garett E. Bingham, Brad H. Deweese, Kimitake Sato, Charles A. Stuart, Michael H. Stone

Exercise Science Faculty Publications

The current investigation was an examination of the repetition-to-repetition magnitudes and changes in kinetic and kinematic characteristics of the back squat using accentuated eccentric loading (AEL) and cluster sets. Trained male subjects (age = 26.1 ± 4.1 years, height = 183.5 ± 4.3 cm, body mass = 92.5 ± 10.5 kg, back squat to body mass ratio = 1.8 ± 0.3) completed four load condition sessions, each consisting of three sets of five repetitions of either traditionally loaded straight sets (TL), traditionally loaded cluster sets (TLC), AEL cluster sets (AEC), and AEL straight sets where only the initial repetition had …

Volitional Down-Regulation Of The Primary Auditory Cortex Via Directed Attention Mediated By Real-Time Fmri Neurofeedback, Matthew Sherwood, Jason G. Parker, Emily E. Diller, Subhashini Ganapathy, Kevin B. Bennett, Jeremy T. Nelson

Neuroscience, Cell Biology & Physiology Faculty Publications

The present work assessed the efficacy of training volitional down-regulation of the primary auditory cortex (A1) based on real-time functional magnetic resonance imaging neurofeedback (fMRI-NFT). A1 has been shown to be hyperactive in chronic tinnitus patients, and has been implicated as a potential source for the tinnitus percept. 27 healthy volunteers with normal hearing underwent 5 fMRI-NFT sessions: 18 received real neurofeedback and 9 sham neurofeedback. Each session was composed of a simple auditory fMRI followed by 2 runs of A1 fMRI-NFT. The auditory fMRI alternated periods of no auditory with periods of white noise stimulation at 90 dB. A1 …

Développement D’Une Approche Par Séquençage De Nouvelle Génération Pour L’Étude De La Diversité Fongique Des Bioaérosols, Hamza Mbareche, Marc Veillette, Marie-Ève Dubuis, Laetitia Bonifait, Guillaume J. Bilodeau, Caroline Duchaine

Rapports de recherche scientifique

L’exposition aux bioaérosols de différents milieux de travail n’est pas étrangère au développement de maladies respiratoires; les moisissures y tiendraient d’ailleurs un rôle important. De par les activités qui y sont menées, certains milieux de travail génèrent de grandes quantités d’aérosols (incluant des moisissures), qui proviennent de la matière présente dans l’environnement. Des facteurs, tels que l’humidité relative et le type de ventilation du bâtiment peuvent accentuer l’effet de l’exposition aux moisissures dans les environnements touchés. La présence de moisissures dans l’air a d’abord été confirmée par l’emploi de méthodes d’analyse par culture. Ces méthodes dites classiques induisent un …

Enzyme Replacement Therapies: What Is The Best Option?, Azam Safary, Mostafa Akbarzadeh Khiavi, Rahimeh Mousavi, Jaleh Barar, Mohammad Rafi

Department of Neurology Faculty Papers

Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the infused enzyme and development of resistance to enzymes persist. These issues may limit the desired therapeutic outcomes of a majority of the lysosomal storage diseases (LSDs). Furthermore, the biodistribution of the recombinant enzymes into the target cells within the central nervous system (CNS), bone, cartilage, cornea, and heart still remain unresolved. All these shortcomings necessitate the development of more effective diagnosis and treatment modalities against LSDs. …

In Harriet’S Tragic Death, The Vulnerability Caused By Huntington's Disease – But Also The Story Of A Beautiful Soul, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Case Report Of An Enlarged Suboccipital Nerve With Cutaneous Branch., Sasha Lake, Joe Iwanaga, Rod J Oskouian, Marios Loukas, R Shane Tubbs

Articles, Abstracts, and Reports

Variations of the suboccipital nerve are infrequently reported. This nerve derived from the C1 spinal nerve is usually a small branch that primarily innervates the short suboccipital muscles. During the routine dissection of the occipital region in an adult cadaver, a vastly enlarged left-sided suboccipital nerve was identified. The nerve innervated the short suboccipital muscles and overlying semispinalis capitis in normal fashion. However, it continued cranially to end in the overlying skin of the occiput. Although not normally thought to have a cutaneous branch, recalcitrant occipital neuralgia might be due to such a variant branch. Future studies are necessary to …

Identifying The 5’End Of The Camta1 Genes In Zebrafish, Morgan Fronk

Undergraduate Honors Theses

Congenital heart diseases (CHDs) are a significant cause of infant death and are frequently caused by mutations in transcription factors. Camta1 (calmodulin binding transcription activator 1) is a transcription factor that has been proposed as a modulator in embryonic heart development and a possible cause of CHDs. The only other known member of its family in vertebrates is involved in activating a hypertrophy gene program in adult heart failure. Unlike camta2, camta1 is expressed in the embryonic heart during heart looping. However, few studies have been done on camta1. In zebrafish, there are two camta1 ohnologs (homologs created through …

Cysteine Modifiers Suggest An Allosteric Inhibitory Site On The Cal Pdz Domain, Yu Zhao, Patrick R. Cushing, David C. Smithson, Maria Pellegrini, Alexandre A. Pletnev, Sahar Al-Ayyoubi, Andrew V. Grassetti, Scott A. Gerber, R. Kiplin Guy, Dean R. Madden

Pharmaceutical Sciences Faculty Publications

Protein–protein interactions have become attractive targets for both experimental and therapeutic interventions. The PSD-95/Dlg1/ZO-1 (PDZ) domain is found in a large family of eukaryotic scaffold proteins that plays important roles in intracellular trafficking and localization of many target proteins. Here, we seek inhibitors of the PDZ protein that facilitates post-endocytic degradation of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR): the CFTR-associated ligand (CAL). We develop and validate biochemical screens and identify methyl-3,4-dephostatin (MD) and its analog ethyl-3,4-dephostatin (ED) as CAL PDZ inhibitors. Depending on conditions, MD can bind either covalently or non-covalently. Crystallographic and NMR data confirm that MD …

Artificial Gravity As A Countermeasure To The Cardiovascular Deconditioning Of Spaceflight: Gender Perspectives, Joyce M. Evans, Charles F. Knapp, Nandu Goswami

Biomedical Engineering Faculty Publications

Space flight-induced physiological deconditioning resulting from decreased gravitational input, decreased plasma volume, and disruption of regulatory mechanisms is a significant problem in returning astronauts as well as in normal aging. Here we review effects of a promising countermeasure on cardiovascular systems of healthy men and women undergoing Earth-based models of space-flight. This countermeasure is produced by a centrifuge and called artificial gravity (AG). Numerous studies have determined that AG improves orthostatic tolerance (as assessed by various protocols) of healthy ambulatory men, of men deconditioned by bed rest or by immersion (both wet and dry) and, in one case, following spaceflight. …

What's So Bad About Hooking Up? : Factors Predictive Of More Positive Perceptions Following A Hookup, Jade A. M. Spaulding

Theses and Dissertations

The purpose of the study was to examine factors predictive of a more positive perceptions following a hookup. The participants included 188 students from Illinois State University. Participants completed a demographics questionnaire, the Hookup Scale, the Rosenberg Self-Esteem Scale, the Sexual Self-Esteem Inventory, religiosity questions, attitudes toward hooking up questionnaire, emotional reactions to hooking up questionnaire, and the Social Academic, Romantic, and Sexual Hooking Up Reactions Scale. The current study found that participants who reported high global self-esteem, high sexual self-esteem, and positive attitudes toward hooking up reported less regret, more positive reactions, and fewer negative reactions following a hookup.

Automated Real-Time Collection Of Pathogen-Specific Diagnostic Data: Syndromic Infectious Disease Epidemiology, Lindsay Meyers, Christine C. Ginocchio, Aimie N. Faucett, Frederick S. Nolte, Per H. Gesteland, Amy Leber, Diane Janowiak, Virginia Donovan, Jennifer Dien Bard, Silvia Spitzer, Kathleen A. Stellrecht, Hossein Salimnia, Rangaraj Selvarangan, Stefan Juretschko, Judy A. Daly, Jeremy C. Wallentine, Kristy Lindsey, Franklin Moore, Sharon L. Reed, Maria Aguero-Rosenfeld, Paul D. Fey, Gregory A. Storch, Steve J. Melnick, Christine C. Robinson, Jennifer F. Meredith, Camille V. Cook, Robert K. Nelson, Jay D. Jones, Samuel V. Scarpino, Benjamin M. Althouse, Kirk M. Ririe, Bradley A. Malin, Mark A. Poritz

Manuscripts, Articles, Book Chapters and Other Papers

© Lindsay Meyers, Christine C Ginocchio, Aimie N Faucett, Frederick S Nolte, Per H Gesteland, Amy Leber, Diane Janowiak,.

Background: Health care and public health professionals rely on accurate, real-time monitoring of infectious diseases for outbreak preparedness and response. Early detection of outbreaks is improved by systems that are comprehensive and specific with respect to the pathogen but are rapid in reporting the data. It has proven difficult to implement these requirements on a large scale while maintaining patient privacy.

Objective: The aim of this study was to demonstrate the automated export, aggregation, and analysis of infectious disease diagnostic test …

Emergent Chest Wall Reconstruction For An Incarcerated Pulmonary Hernia, Allison G. Mcnickle Md, Timonthy Dickhudt Md, Jorge A. Vega Md, Paul J. Chestovich, Douglas R. Fraser

School of Medicine Faculty Research

No abstract provided.

Mooney Face Stimuli For Visual Perception Research, Caspar M. Schwiedrzik, Lucia Melloni, Aaron Schurger

Psychology Faculty Articles and Research

In 1957, Craig Mooney published a set of human face stimuli to study perceptual closure: the formation of a coherent percept on the basis of minimal visual information. Images of this type, now known as "Mooney faces", are widely used in cognitive psychology and neuroscience because they offer a means of inducing variable perception with constant visuospatial characteristics (they are often not perceived as faces if viewed upside down). Mooney's original set of 40 stimuli has been employed in several studies. However, it is often necessary to use a much larger stimulus set. We created a new set of over …

The Chloroplast Division Protein Arc6 Acts To Inhibit Disassembly Of Gdp-Bound Ftsz2, Min Woo Sung, Rahamthulla Shaik, Allan D. Terbush, Katherine W. Osteryoung, Stanislav Vitha, Andreas Holzenburg

School of Medicine Publications

Chloroplasts host photosynthesis and fulfill other metabolic functions that are essential to plant life. They have to divide by binary fission to maintain their numbers throughout cycles of cell division. Chloroplast division is achieved by a complex ring-shaped division machinery located on both the inner (stromal) and the outer (cytosolic) side of the chloroplast envelope. The inner division ring (termed the Z ring) is formed by the assembly of tubulin-like FtsZ1 and FtsZ2 proteins. ARC6 is a key chloroplast division protein that interacts with the Z ring. ARC6 spans the inner envelope membrane, is known to stabilize or maintain the …

Dietary Flavonoids And The Prevalence And 15-Y Incidence Of Age-Related Macular Degeneration, Bamini Gopinath, Gerald Liew, Annette Kifley, Victoria M. Flood, Nichole Joachim, Joshua Lewis, Jonathan M. Hodgson, Paul Mitchell

Research outputs 2014 to 2021

Background: The majority of research performed to date has examined the effects of commonly known antioxidants such as vitamins C, E, and A and carotenoids on age-related macular degeneration (AMD) risk and progression. To date, there is limited research on promising phytochemicals with antioxidant and anti-inflammatory properties, including flavonoids.

Objective: In this exploratory study, we aimed to assess the independent associations between dietary intake of total flavonoids and common flavonoid classes with the prevalence and 15-y incidence of AMD.

Design: In this population-based cohort study, 2856 adults aged ≥49 y at baseline and 2037 followed up 15 …

Evaluating A Metric To Predict The Academic And Clinical Success Of Master’S Students In Speech-Language Pathology, Joshua Troche, Jacqueline Towson

Teaching and Learning in Communication Sciences & Disorders

Speech-Language Pathology is one of the fastest growing professions in the United States. As such graduate programs have become inundated with applications to their programs in Speech-Language Pathology. Admissions committees often use GPA scores and GRE scores to determine the merit of an undergraduate student for acceptance into their graduate programs. This study examines a metric created to predict the success of graduate students in their academic and clinical work. It was determined that a metric that equally weighs GRE and GPA scores was not particularly predictive of graduate school success. Presented in this work is a new metric that …

Speech-Language Pathology Student Participation In Verbal Reflective Practice Groups: Perceptions Of Development, Value And Group Condition Differences., Gina D. Tillard, Kate Cook, Daniel Gerhard, Lydia Keast, Megan Mcauliffe

Teaching and Learning in Communication Sciences & Disorders

The aim of this study was to determine whether significant differences in perceptions of reflective practice were present across two groups of students engaged in standard practice and experimental group conditions. Twenty-seven undergraduate speech-language pathology students participated in the study. A two-condition, non-randomised, pre-test post-test design was employed with two groups (a standard practice condition and an experimental practice condition, utilizing structured activities and prompts). Participants took part in weekly reflective practice groups over a six week period, in which discussion centered on students’ clinical experiences. Pre and post intervention, the students completed a questionnaire designed to examine perceptions of …

Language, Literacy, And Multiliteracies: Preparing Graduate Students To Provide Language Intervention In The 21st Century, Wanda M. V. Kent

Teaching and Learning in Communication Sciences & Disorders

The concept of multiliteracies and its application in educational settings are described with a specific focus on the potential benefits and challenges in use of this approach with children with a language-based learning disability (LLD). The role of traditional literacy skills within a multiliteracies perspective is examined and the literacy skills required by children when using new modes of communication such as texting are discussed. Finally, the implications for educating prospective speech-language pathologists to provide service in a broader literacy landscape are examined.

Impact Of Virtual Simulation And Coaching On The Interpersonal Collaborative Communication Skills Of Speech-Language Pathology Students: A Pilot Study, Jacqueline A. Towson Ph.D., Ccc-Slp, Matthew S. Taylor Ph.D., Jennifer Tucker Pt, Dpt, Pcs, Claire Paul Ph.D., Bcba, Patrick Pabian Pt, Dpt, Scs, Ocs, Richard I. Zraick Ph.D., Ccc-Slp

Teaching and Learning in Communication Sciences & Disorders

Communication between clinicians, teachers, and family members is a critical skill when addressing and providing for the individual needs of patients. However, graduate students in speech-language pathology (SLP) programs often have limited opportunities to practice these skills prior to or during externship placements. The purpose of this study was to explore the use of virtual-reality based rehearsal with coaching on the interpersonal collaborative communication skills of SLP graduate students when delivering information regarding a singular patient to different stakeholders. Three graduate students completing their third semester in a SLP program participated in the study. Each participant was provided a clinical …

Predicting Graduate School Success In A Speech-Language Pathology Program, Larry Boles

Teaching and Learning in Communication Sciences & Disorders

Graduate programs in speech-language pathology continue to experience high volumes of applicants seeking admission. There appear to be as many configurations of admission criteria as there are graduate programs. Yet, what evidence do we have for these criteria making a difference in graduate student outcome? Graduate Record Examination (GRE) scores, undergraduate grade point average (GPA), prerequisite GPA, letters of recommendation, and letters of intent are valued differently by programs. These variables were investigated for their value in predicting successful graduate school outcome in a program of speech-language pathology. Three measures proved predictive: the verbal portion of the GRE, the quantitative …

A Novel Hplc Method For Determination Of Phenytoin In Human Plasma, Jesse Flores, Sheril Alexander, Mariana Babayeva

Touro College of Pharmacy (New York) Publications and Research

Aim: Aim of this research was to develop and validate a simple, efficient and reproducible high performance liquid chromatography method to measure phenytoin concentrations in human plasma

Study Design: Linearity, selectivity, sensitivity, accuracy and precision of the analytical methods were validated according to ICH guidelines.

Methodology: The method employed a Phenomenex C18 column kept at 25ºC. The mobile phase consisted of a 0.05 M potassium dihydrogen phosphate buffer solution (pH 2.8) and methanol in a ratio of 60:40, respectively. The flow rate of the mobile phase was 0.7 mL/min. Phenytoin was detected at a wavelength of 250 …

Superior Cerebellar Arteries Originating From The Posterior Cerebral Arteries But Normal Course Of The Oculomotor Nerves., Dominic Dalip, Joe Iwanaga, Marios Loukas, Rod J Oskouian, R Shane Tubbs

Articles, Abstracts, and Reports

The posterior cerebral artery (PCA) is a branch of the terminal part of the basilar artery and perfuses the temporal lobes, midbrain, thalamus, and the posterior inferior portion of the parietal lobes. It is divided into P1-P4 segments. Variations in the P1 segment of the PCA are important to neurosurgeons when performing surgery, for example, on basilar tip aneurysms. We report bilateral superior cerebellar artery (SCA) arising from the P1 segment of the PCA. Such a configuration appears to be uncommon but should be kept in mind by neurosurgeons, neurointerventionalists, and neuroradiologists.

The Effect Of Abnormal Vitamin D Levels In Athletes., Jakub Sikora-Klak, Steven J Narvy, Justin Yang, Eric Makhni, F Daniel Kharrazi, Nima Mehran

Articles, Abstracts, and Reports

Vitamin D is a lipophilic prohormone integral to musculoskeletal, autoimmune, oncologic, cardiovascular, and mental health. Of particular importance to the orthopedic surgeon is the role of vitamin D in the regulation of bone mass, muscle strength, and physical performance. Although vitamin D-related skeletal pathologies are rare in industrialized nations, emerging research in the field has shown that most American adults have inadequate levels of vitamin D. Even among athletes, there is a high prevalence of vitamin D deficiency, which may place competitors at risk of stress fractures, illness, and delayed muscle recovery. Adequately identifying vitamin D-deficient individuals in need of …

Similarities And Difference In The Neural Processing Of Speech And Song In Religious Music, Brett Pielstick

Undergraduate Honors Theses

An fMRI study was performed to see the differences in the neurological processing between spoken and sung language in religious music. Students at Brigham Young University, who are members of the Church of Jesus Christ of Latter-day Saints, were exposed to alternating blocks of spoken and sung lyrics of religious and non-religious songs. There was no significant activation when contrasting speech and song, but there was significant activation in the right middle temporal gyrus and the posterior cingulate gyrus when listening to spoken and sung religious lyrics, suggesting an emotional reaction to religious stimuli. Contrasting spoken stimuli for both religious …

Why The Uk Needs A Separate Justice System For People With Mental Illness, Karen A. Snedker

Sociology Faculty Articles and Research

"Severe mental illness is on the rise in the UK, and an increasing number of people with mental illness are behind bars and supported by inadequate mental health services. This is a situation that could be improved by the introduction of courts specifically geared for hearing cases involving defendants with mental health issues."

A Cross-Sectional Study Of The Use And Effectiveness Of The Individual Development Plan Among Doctoral Students, Nathan L. Vanderford, Teresa M. Evans, L. Todd Weiss, Lindsay Bira, Jazmin Beltran-Gastelum

Toxicology and Cancer Biology Faculty Publications

Background: The Individual Development Plan (IDP) was introduced as a tool to aid in career planning for doctoral trainees. Despite the National Institutes of Health and academic institutions creating policies that mandate the use of IDPs, little information exists regarding the use and effectiveness of the career planning tool.
Methods: We conducted a multi-institutional, online survey to measure IDP use and effectiveness. The survey was distributed to potential respondents via social media and direct email. IDP survey questions were formatted using a five-point Likert scale (strongly agree, agree, neutral, disagree and strongly disagree). For data analysis purposes, responses were grouped …

High-Density Lipoprotein Inhibits Serum Amyloid A-Mediated Reactive Oxygen Species Generation And Nlrp3 Inflammasome Activation, Preetha Shridas, Maria C. De Beer, Nancy R. Webb

Internal Medicine Faculty Publications

Serum amyloid A (SAA) is a high-density apolipoprotein whose plasma levels can increase more than 1000-fold during a severe acute-phase inflammatory response and are more modestly elevated in chronic inflammation. SAA is thought to play important roles in innate immunity, but its biological activities have not been completely delineated. We previously reported that SAA deficiency protects mice from developing abdominal aortic aneurysms (AAAs) induced by chronic angiotensin II (AngII) infusion. Here, we report that SAA is required for AngII-induced increases in interleukin-1β (IL-1β), a potent proinflammatory cytokine that is tightly controlled by the Nod-like receptor protein 3 (NLRP3) inflammasome and …

Differential Well-Being In Response To Incivility And Surface Acting Among Nurses As A Function Of Race, Lauren Sarah Park

Dissertations and Theses

Demand for healthcare services is rising dramatically as the proportion of older adults in the United States increases, and the success of these healthcare organizations depends on cooperation among patients, doctors, and nurses. These interpersonal interactions come with costs associated with managing one's emotions in ways that are in line with completing job tasks effectively, especially as past research has demonstrated that nurses are likely to experience and respond to incivility, and nurses of minority backgrounds even moreso. This study examines the effect of experiencing incivility on engaging in surface acting, or simulating emotions that are not actually felt; how …

Transcriptomics Of Learning, Pablo Iturralde

Theses

Learning is a basic and important component of behavior yet we have very little empirical information about the interaction between mechanisms of learning and evolution. In our work, we are testing hypotheses about the neurogenetic mechanisms through which animal learning abilities evolve. We are able to test this directly by using experimentally evolved populations of flies, which differ in learning ability. These populations were previously evolved within the lab by creating worlds with different patterns of change following theoretically predicted effects on which enhanced learning will evolve. How has evolution acted to modulate genes and gene expression in the brain …