Medicine and Health Sciences Commons^™

One-Compound-Two-Pharmacophores: Design, Synthesis And Antimalarial Activities Of Chloroquinoline-Cassiarin, Thobias M. Kalenga, Monica M. Ndoile, Quintino A. Mgani

Tanzania Journal of Science

This paper describes the design and synthesis of a potential antimalarial compound, chloroquinoline-cassiarin (6) using 4,7-dichloroquinoline and the natural product barakol (1) extracted from the leaves of Cassia siamea as starting materials. In this paper a one compound-two-pharmacophores concept is introduced in which coupling of two known pharmacophores into one has been described. The concept is not only useful to organic synthesis but also to drug development researches. The synthesized compound 6 exhibited potent in vitro antimalarial activity at IC50 = 0.51 µM, and low toxicity where at 20 µM, 80% viability of HeLa cells was observed.

Trefoil Factor 1 (Tff1) Expression In E3 And Ewd8 Breast Cancer Cell Lines, Jazmyn Mosqueda-Banuelos, Nicholas A. Pullen

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

The ability to identify and treat cancer early can drastically improve patient survival outcomes. While much effort is placed on anti-cancer therapeutics, a developing area of interest is the identification of cancer biomarkers for the early detection of different types of cancer. Trefoil factors (TFFs) are a family of proteins whose known functions suggest that they may be major contributors to cancer; however, these proteins are understudied in a disease state like cancer. In this work, we identify expression of TFF1 among varying cancer types. We then investigate the correlation between varying levels of TFF1 expression and the aggressiveness of …

Nonketotic Hyperglycemia Induced Occipital Lobe Seizures: A Case Report, Samantha Richardson, Sona K. Shah

Marshall Journal of Medicine

Typically, nonketotic hyperglycemia induces partial motor seizures. We present a rare case of nonketotic hyperglycemia induced occipital lobe seizures and discuss the impact of hemoglobin A1c on seizure activity, typical imaging results, and use of anti epileptic drugs in management.

Rural Medical Student Opinions About Rural Practice: Does Choice Of College Make A Difference?, William J. Crump, Craig H. Ziegler, R. Steve Fricker

Marshall Journal of Medicine

Purpose

While many programs assume medical students who attended rural colleges are more likely to practice in smaller towns later, there are few studies to support this assumption. This study examines aspects of medical students’ opinions about rural living and rural practice based on where they attended college.

Method

Students with rural upbringing were identified and administered a previously published rural health opinion survey. The opinion survey was administered across three academic years, from 2015 to 2017, and included a total of three scales and nine subscales for analysis. Factor analysis was used to identify the nine subscales.

Results

Respondents …

Gastritis Induced St Segment Elevation On Electrocardiogram, Obadah Aqtash, Ahmed Amro, Ala Gabi, Amal Sobeih, Dr. Mehiar El-Hamdani, Ellen A. Thompson

Marshall Journal of Medicine

ST segment elevation on an electrocardiogram (EKG) is an alarming finding that warrants an urgent coronary angiogram. Early diagnosis and intervention is extremely important in the setting of Acute Coronary Syndrome (ACS) to prevent irreversible myocardium damage and reduce the mortality rate. However, it is very important to know that not all ST- Elevations (STE) on EKG are due to myocardial infraction. Etiologies can be divided into cardiac and non-cardiac causes. Cardiac causes can include coronary aneurysm and acute pericarditis while non-cardiac causes can include acute cholecystitis and pulmonary embolism. In this paper, we are presenting a unique case of …

Improving Postoperative Pain Control After Cesarean Delivery With Enhanced Recovery In Patients On Buprenorphine Therapy, Kevin D. White, Shirin Azadi, Nadim Bou Zgheib, Brenda L. Mitchell

Marshall Journal of Medicine

Abstract:

Introduction:

Prescription drug abuse presents a significant challenge to the management of post operative pain.Pain control amongst the opioid addicted patient can be especially challenging. We aimed to improve pain control after caesarian delivery with enhanced recovery in patients who are on buprenorphine medication-assisted therapy for the treatment of opioid addiction.

Materials and Methods:

We conducted a pilot study by implementing a protocol using liposomal bupivacaine injected at the time of cesarean delivery. Patients were then given 500mg acetaminophen every 4 hours, 800mg ibuprofen every 8 hours and 0.3mg IV buprenorphine every 6 hours as needed. The patients’ maintenance …

Knowledge And Risk Factors For Stroke Among Undergraduates In Southwestern Nigeria, Wasiu Olalekan Adebimpe

Marshall Journal of Medicine

The burden of non-communicable diseases due to stroke is increasing. Despite this, community based studies that could stimulate stroke primordial prevention among the population at risk are sparse. This study assessed community knowledge and risk factors to stroke among University undergraduates in Osogbo, southwestern Nigeria. A descriptive cross sectional study was conducted among 420 male undergraduates selected through multi-stage sampling method. Research instruments were self-administered semi structured questionnaire. Data was analyzed using the SPSS software version 17.0. Four hundred and seven (96.9%) have heard about stroke. Good mean knowledge score of causes, symptoms, warning signs and risk factors of stroke …

The State Of Neonatal Abstinence Syndrome In West Virginia, Sean Loudin

Marshall Journal of Medicine

No abstract provided.

Robotic-Assisted Laparoscopic Surgery In Pediatric Urology: Capacity Building And Reflecting On Five Years’ Experience In West Virginia, Chad B. Crigger, Osama Al-Omar

Marshall Journal of Medicine

Robotic surgery was born at the turn of the millennium as it was first approved by the US food and Drug Administration in 2000 with the introduction of the da Vinci (Intuitive Surgical, Inc., Mountain View, Ca) robotic surgical platform. However, its adoption by pediatric urologists did not occur until 2002, and even then it was used by only a select handful of surgeons. While the use of robotics in pediatric urology has grown steadily worldwide, its implementation in treating pediatric urology patients in West Virginia has been much slower. Reasons for this are twofold: historically, the lack of pediatric …

Siloed To Solutions: Creating A Culture Of Collaboration, Darshana T. Shah

Marshall Journal of Medicine

No abstract provided.

Application Of Jean Watson's Theory Of Transpersonal Caring In Nurses Practicing In A Pain Center, Patricia Malone Hubert

Seton Hall University DNP Final Projects

The aim of this project was to determine if an educational intervention utilizing Jean Watson’s Theory of Human Caring influences nurses’ level of awareness and practice of loving kindness to self and others. Watson’s paradigm of transpersonal caring is presented as a means to provide the compassionate care needed by patients with chronic pain, who are vulnerable to the comorbidities of depression and anxiety and often have poor outcomes. This quality improvement project was implemented with five Registered Nurses working in a pain center. A two-pronged intervention was structured to begin developing a Caritas Consciousness in Session 1 by focusing …

Pathophysiology Of Infective Endocarditis (Ie) Associated With Intravenous Drug Use, Kaleigh Cline

Nursing Student Class Projects (Formerly MSN)

Intravenous drug use (IVDU) is an activity that has the potential of devastating outcomes and affects individuals all over the world. One potential outcome a patient using IV drugs may experience is infective endocarditis (IE). This poster details the significance of IE, its underlying pathophysiology, significance of pathophysiology, signs and symptoms, and nursing implications.

Advocacy Projects In Interprofessional Education: Update On The Jefferson Health Mentors Program, Nethra S. Ankam, Md, Anne Mitchell, Phd, Anp-Bc, Sarah Dallas, Ba, Sarah Libros, Ba, Tracey Vause Earland, Phd, Otr/L, Lauren Collins, Md, Elena Umland, Pharmd

JCIPE Posters

Background

Patient advocacy, essential to optimal team-based care, is included in the accreditation standards for many professions. Advocacy is an ideal vehicle for interprofessional education. Implemented since 2007, the Jefferson Health Mentors Program (HMP) is a required longitudinal program for first and second-year students from:

• Couple and Family Therapy
• Human Genetics and Genetic Counseling
• Medical Laboratory Science
• Medicine
• Nursing
• Occupational Therapy
• Pharmacy
• Physical Therapy
• Physician Assistant Studies

Distribution-Based Measures Of Tumor Heterogeneity Are Sensitive To Mutation Calling And Lack Strong Clinical Predictive Power., Javad Noorbakhsh, Hyunsoo Kim, Sandeep Namburi, Jeffrey H Chuang

Faculty Research 2018

Mutant allele frequency distributions in cancer samples have been used to estimate intratumoral heterogeneity and its implications for patient survival. However, mutation calls are sensitive to the calling algorithm. It remains unknown whether the relationship of heterogeneity and clinical outcome is robust to these variations. To resolve this question, we studied the robustness of allele frequency distributions to the mutation callers MuTect, SomaticSniper, and VarScan in 4722 cancer samples from The Cancer Genome Atlas. We observed discrepancies among the results, particularly a pronounced difference between allele frequency distributions called by VarScan and SomaticSniper. Survival analysis showed little robust predictive power …

What's Happening: July 30, 2018, Maine Medical Center

What's Happening

No abstract provided.

The Incisive Canal: A Comprehensive Review., Sasha Lake, Joe Iwanaga, Shogo Kikuta, Rod J Oskouian, Marios Loukas, R Shane Tubbs

Articles, Abstracts, and Reports

The incisive canal, also known as the nasopalatine canal, is an interosseous conduit through the anterior maxilla connecting the oral and nasal cavities. Within this canal lies the nasopalatine nerve and the vascular anastomosis between the greater palatine and sphenopalatine arteries. The embryology of the canal has led to interesting theories explaining its function. Efforts have been made to describe the morphometrics of the incisive canal by radiologic evaluation across sex and ethnicities. This paper aims to review the current literature on the embryology, anatomy, and clinical relevance of the incisive canal.

Demographic, Clinical, And Behavioral Determinants Of 7-Year Weight Change Trajectories In Roux-En-Y Gastric Bypass Patients., Michelle R. Lent, Yirui Hu, Peter N Benotti, Anthony T Petrick, G Craig Wood, Christopher D Still, H Lester Kirchner

PCOM Scholarly Works

BACKGROUND: Weight change trajectories after weight-loss surgery may vary significantly.

OBJECTIVES: This study evaluated the weight trajectories of Roux-en-Y gastric bypass (RYGB) patients and identified the distinct clinical, behavioral, and demographic features of patients by trajectory.

SETTING: Data from 2918 RYGB patients from a comprehensive medical center between January 2004 and November 2016 were included.

METHODS: This retrospective, observational study used data for RYGB patients up to year 7 postsurgery. Group-based trajectory models were fitted for percentage weight change. Variables evaluated by trajectory included age, sex, diagnoses, medications, smoking, presurgical body mass index, preoperative weight loss, and early postoperative weight …

An Analysis On The Policy Implementation Of Antibacterial Resistance Control At The Hospital, Nani Indriana, Wiku Bakti B. Adisasmito

Journal of Indonesian Health Policy and Administration

In order to control Antibacterial Resistance at the hospital in Indonesia, the Government of Indonesia established an Antibiotics Resistance Control Committee and issued a Regulation from the Ministry of Health, regulation no 8/2015 on an antibiotics resistance control program at the hospital. This is an investigation on the Antibacterial Resistance Control Program (ARCP) at the Hospital, which compares its implementation at a government hospital and a private hospital, Persahabatan Central General Hospital (CGH) and Bogor Indonesian Red Cross Hospital (BIRCH). This was a descriptive study with a qualitative analysis obtained through indepth interviews and documentary research. We discovered that the …

An Analysis Of The Healthcare Center System As A Gatekeeper In 2018, Septiana Maharanti, Puput I Oktamiant

Journal of Indonesian Health Policy and Administration

In managed care, primary healthcarecare facilities acts as the gatekeepers, and its success is judged from the number of visits. In the year 2016, the Healthcare Centers in Tangerang was unable to meet the targets set by BPJS healthcare, ideally the visit rate should reach >150‰ and the referral ratio <10%. However, the visit rate only reachd 41‰ and the referral ratio was 29%. In addition, most healthcare centers the nonspecialised referral ratio was above 5%. The purpose of this research is to analyze the healthcare service system as the gatekeepers in managed care. This research is a descriptive analytical study with a qualitative approach. The data was collected through in-depth interviews, examination of documents and observations. Research conducted at healthcare centers and clinics Pedurenan Pabuaran Tumpeng from May-June 2018. From this research we discovered that the low contact lrate was caused be the low first contact levels, continuity, and comprehensiveness. The registering process was also complicated. We also discovered that the lack of human resources also influences the low contact rate.

An Analysis Of The Health Centers Readiness For Accreditation In Brebes District In 2018, Deny Ardi Lourina, Dumilah Ayuningtyas

Journal of Indonesian Health Policy and Administration

The accreditation of health centers is an endeavor by the Ministry of Health to improve the quality and performance of health centers regulated by Permenkes No. 4/2015. Of the 38 health centers in Brebes, only 10 has been accredited. We wish to discover how prepared are the health centers to be accredited based on the resources available and pre-accreditation survey. Data was obtained through in-depth interviews and documentary research. Results indicated that there was sufficient funds, facilities and equipment for the accreditation. However, the assessment scores for human resources sufficiency and documentary completeness was low.

Designed Environment For Healthy Aging, Attila Lawrence

Architecture Faculty Research

A growing number of aging adults want to remain in multi generational communities rather than relocating to retirement communities, or having to resort to an institutional setting. To productively function in an environment where all generations interact and live well together, however, one’s ability to manage diminishing cognitive and physical conditions precipitated by the aging process is a major factor that bears on everyone’s quality of life. Because the designed environment frequently plays a significant role in the occurrence of neurodegenerative disorders that involve biological changes, it is self-evident that design strategies intended to support the management of these symptoms …

Tranexamic Acid Utilization In Cesarean Section Patients, Justin Heinz

Nursing Capstones

No abstract provided.

Multiracial Patient Experiences With Racial Microaggressions In Health Care Settings, Cyndy R. Snyder, Prince Z. Wang, Anjali R. Truitt

Journal of Patient-Centered Research and Reviews

Purpose: Illuminating patients’ experiences of microaggressions in health care settings can help practitioners develop care that is more culturally responsive. While much of the literature on health care disparities focuses on minority groups generally, we sought to identify and to describe the ways in which racial microaggressions manifest for multiracial individuals and families specifically.

Methods: Using a combination of interviews and focus groups, we conducted 15 interviews and 3 focus groups. Eligible participants self-identified as more than one race and/or they self-identified as part of an interracial family, and they and/or someone they considered to be part of their family …

Improving Health And Well-Being: Connecting Research And Practice. The 24th Annual Conference Of The Health Care Systems Research Network, Karen L. Margolis, Nico Pronk, Jane E. Duncan, Sarah M. Greene

Journal of Patient-Centered Research and Reviews

The 24th annual conference of the Health Care Systems Research Network (HCSRN, formerly the HMO Research Network), held April 11–13, 2018, in Minneapolis, Minnesota, attracted 357 attendees. The HCSRN is a consortium of 18 community-based research organizations embedded in or affiliated with large health care delivery systems. Its annual research conference, held since 1994, is a unique venue that brings diverse stakeholders (eg, research teams, clinicians, patients, funders) together to explore a range of health research topics and scientific findings, with a unifying goal of connecting applied research to real-world care delivery for the betterment of individual and community health. …

Design, Development And Construct Validation Of The Children’S Dietary Inflammatory Index, Samira Khan, Micheal D. Wirth, Andrew Ortaglia, Christian R. Alvarado, Nitin Shivappa, Thomas Hurley, James R. Hébert

Faculty Publications

Objective: To design and validate a literature-derived, population-based Children’s Dietary Inflammatory Index (C-DII)TM. Design: The C-DII was developed based on a review of literature through 2010. Dietary data obtained from children in 16 different countries were used to create a reference database for computing C-DII scores based on consumption of macronutrients, vitamins, minerals, and whole foods. Construct validation was performed using quantile regression to assess the association between C-reactive protein (CRP) concentrations and C-DII scores. Data Sources: All data used for construct validation were obtained from children between six and 14 years of age (n = 3300) who participated in …

Racial Disparity Among Women Diagnosed With Invasive Breast Cancer In A Large Integrated Health System, Maharaj Singh, Santhi D. Konduri, George C. Bobustuc, Amin B. Kassam, Richard A. Rovin

Journal of Patient-Centered Research and Reviews

Purpose: Reasons for the well-described disparity in outcomes between African American (AA) and non-Hispanic white (NHW) women with invasive breast cancer are unclear, making it difficult to identify solutions. This study examined the effects of demographics, biomarkers, tumor characteristics, cancer stage, morphology, and treatment variables on overall and cancer-free survival in these patient populations.

Methods: We retrospectively reviewed data for 6231 patients diagnosed with invasive breast cancer throughout an integrated health system from January 2006 through March 2015. Included for analysis were 5023 NHW and 413 AA women. All category and continuous variables in the study were described in the …

Role Of Echocardiography In The Intensive Care Unit: Overview Of The Most Common Clinical Scenarios, Luca Longobardo, Concetta Zito, Scipione Carerj, Giuseppe Caracciolo, Bijoy K. Khandheria

Journal of Patient-Centered Research and Reviews

The intensive care unit (ICU) is among the more important settings in which echocardiography plays a pivotal role. The ease of use, speed of execution, and completeness of information on heart anatomy and function that echocardiography is able to provide makes this tool the perfect diagnostic technique in patients for whom exhaustive information must be quickly obtained by physicians who sometimes lack specific skills in cardiovascular imaging. However, the clinical entities encountered by ICU clinicians are often difficult to distinguish and patient symptoms may not be obvious. This brief review describes three common clinical scenarios that benefit from echocardiography in …

Women’S Pregnancy Life History And Alzheimer’S Risk: Can Immunoregulation Explain The Link?, Molly Fox, Carlo Berzuini, Leslie A. Knapp, Laura M. Glynn

Psychology Faculty Articles and Research

Background:

Pregnancy is associated with improvement in immunoregulation that persists into the geriatric phase. Impaired immunoregulation is implicated in Alzheimer’s disease (AD) pathogenesis. Hence, we investigate the relationship between pregnancy and AD. Methods:

Cross-sectional cohort of British women (N = 95). Cox proportional hazards modeling assessed the putative effects of cumulative months pregnant on AD risk and the mutually adjusted effects of counts of first and third trimesters on AD risk. Results:

Cumulative number of months pregnant, was associated with lower AD risk (β = −1.90, exp(β) = 0.15, P = .02). Cumulative number of first trimesters …

Influence Of Built Environment And Social Capital On Mental Health Of Residents Of Assisted Living Communities In Louisville, Ky., Sarah E. Walsh, A. Scott Lajoie

Faculty and Staff Scholarship

Objectives: Prior research has shown social capital and built environment quality are associated with overall health status and the incidence of mental illness. This study explores the relationship between social capital, built environment, and quality of life specifically for assisted living residents, currently a gap in the literature. Method: A total of 76 assisted living residents were interviewed for the study using researcher-administered questionnaires. In addition, site audits were conducted to quantitatively evaluate the built environment surrounding 12 assisted living communities in the Louisville Metro region. Results: There was a moderate, positive correlation between social capital and mental health, r …

Mobile Health Technology Knowledge And Practices Among Patients Of Safety-Net Health Systems In Washington State And Washington, Dc, Sharon S. Laing, Muhammad Alsayid, Carlota Ocampo, Stacey Baugh

Journal of Patient-Centered Research and Reviews

Purpose: Mobile health technology (mHealth) can reduce health disparities, but research on the health behaviors of low-income patients is needed. This study evaluates mHealth knowledge and practices of low-resource safety-net patients.

Methods: We administered a 47-item questionnaire to 164 low-income patients accessing services at community health centers in the state of Washington and Washington, DC. Predictor variables included demographic factors: age, race, ethnicity, income. Outcome variables were smartphone knowledge (smartphones as a wellness tool), medical app knowledge (availability of medical-based apps), smartphone practices (ever used smartphones for wellness), health apps practices (ever used health-based apps), and medical apps practices (ever …