Medicine and Health Sciences Commons^™

Effective Coping Strategies To Reduce Nursing Burnout: An Integrative Literature Review, Martha Amador

Grace Peterson Nursing Research Colloquium

No abstract provided.

In Vivo Brainstem Imaging In Alzheimer’S Disease: Potential For Biomarker Development, David J. Braun, Linda J. Van Eldik

Neuroscience Faculty Publications

The dearth of effective treatments for Alzheimer’s disease (AD) is one of the largest public health issues worldwide, costing hundreds of billions of dollars per year. From a therapeutic standpoint, research efforts to date have met with strikingly little clinical success. One major issue is that trials begin after substantial pathological change has occurred, and it is increasingly clear that the most effective treatment regimens will need to be administered earlier in the disease process. In order to identify individuals within the long preclinical phase of AD who are likely to progress to dementia, improvements are required in biomarker development. …

Hcv-Associated Exosomes Promote Myeloid-Derived Suppressor Cell Expansion Via Inhibiting Mir-124 To Regulate T Follicular Cell Differentiation And Function, Ling Wang, Dechao Cao, Ling Wang, Juan Zhao, Lam Nhat Nguyen, Xindi Dang, Yingjie Ji, Xiao Y. Wu, Zheng D. Morrison, Qian Xie, Mohamed El Gazzar, Shunbin Ning, Jonathon P. Moorman, Zhi Q. Yao

ETSU Faculty Works

Virus-infected cells can regulate non-permissive bystander cells, but the precise mechanisms remain incompletely understood. Here we report that this process can be mediated by transfer of viral RNA-loaded exosomes shed from infected cells to myeloid-derived suppressor cells (MDSCs), which in turn regulate the differentiation and function of T cells during viral infection. Specifically, we demonstrated that patients with chronic hepatitis C virus (HCV) infection exhibited significant increases in T follicular regulatory (TFR) cells and decreases in T follicular helper (TFH) cells. These MDSC-mediated T-cell dysregulations resulted in an increased ratio of TFR/TFH and IL-10 production in peripheral blood. Specifically, co-culture …

Can Placental Corticotropin-Releasing Hormone Inform Timing Of Antenatal Corticosteroid Administration?, Danielle A. Swales, Leah A. Grande, Deborah A. Wing, Michelle Edelmann, Laura M. Glynn, Curt A. Sandman, Roger Smith, Maria Bowman, Elysia Poggi Davis

Psychology Faculty Articles and Research

Context

Antenatal corticosteroids commonly are administered to pregnant women at risk of delivering between 23 and 34 gestational weeks, providing crucial benefits to fetal lung maturation and reducing risk of neonatal morbidity and mortality. Corticosteroids are maximally efficacious for lung maturation when administered within 2 to 7 days of delivery. Accurately identifying the timing of preterm delivery is thus critical to ensure that antenatal corticosteroids are administered within a week of delivery and to avoid unnecessary administration to women who will deliver at term. A plausible biomarker for predicting time of delivery is placental corticotropin-releasing hormone (pCRH). Objective

The current …

Association Between Subjective Indicators Of Recovery Status And Heart Rate Variability Among Divison-1 Sprint-Swimmers, Andrew A. Flatt, Michael R. Esco, Fabio Y. Nakamura

Health Sciences & Kinesiology: Faculty Publications

Heart rate variability (HRV) is a physiological marker of training adaptation among athletes. However, HRV interpretation is challenging when assessed in isolation due to its sensitivity to various training and non-training-related factors. The purpose of this study was to determine the association between athlete-self report measures of recovery (ASRM) and HRV throughout a preparatory training period. Ultra-short natural logarithm of the root mean square of successive differences (LnRMSSD) and subjective ratings of sleep quality, fatigue, muscle soreness, stress and mood were acquired daily for 4 weeks among Division-1 sprint-swimmers (n = 17 males). ASRM were converted to z-scores …

Vaccination Recommendations For Oral Health Professionals, Susan H. Davide, Christine Macarelli, Anty Lam

Publications and Research

Dental teams should familiarize themselves with vaccination recommendations to reduce the risk of infectious diseases and better educate patients about the importance of immunizations

Integrating Standardized Whole Genome Sequence Analysis With A Global Mycobacterium Tuberculosis Antibiotic Resistance Knowledgebase, Rumina Hasan, Matthew Ezewudo, Amanda Borens, Álvaro Chiner-Oms, Paolo Miotto, Leonid Chindelevitch, Angela M. Starks, Debra Hanna, Richard Liwsk, Matteo Zignol

Department of Pathology and Laboratory Medicine

Drug-resistant tuberculosis poses a persistent public health threat. The ReSeqTB platform is a collaborative, curated knowledgebase, designed to standardize and aggregate global Mycobacterium tuberculosis complex (MTBC) variant data from whole genome sequencing (WGS) with phenotypic drug susceptibility testing (DST) and clinical data. We developed a unified analysis variant pipeline (UVP) ( https://github.com/CPTR-ReSeqTB/UVP ) to identify variants and assign lineage from MTBC sequence data. Stringent thresholds and quality control measures were incorporated in this open source tool. The pipeline was validated using a well-characterized dataset of 90 diverse MTBC isolates with conventional DST and DNA Sanger sequencing data. The UVP exhibited …

What's Happening: September 10, 2018, Maine Medical Center

What's Happening

No abstract provided.

A Severe Case Of Neutropenia Secondary To Clopidogrel, Harrynauth Persaud, William B. Chung

Publications and Research

An 83-year-old male patient presented with complaints of generalized body aches, fever, rhinorrhea, and worsening dyspnea for the past 5 days. Four weeks ago, he was started on clopidogrel after he underwent stent placement to his left leg. Current admission laboratory findings revealed a white blood cell (WBC) count of 1180, with no neutrophils corresponding to an absolute neutrophil count of zero. After an extensive negative infectious workup, clopidogrel was determined to be the offending agent. This medication was discontinued and the patient was placed on a leukocyte growth factor with significant improvement in his WBC and neutrophil counts. On …

Susceptibility Of Mental Disorders: Examining The Comorbidity Of Seasonal Affective Disorder, Nathaniel Wasden

Student Works

This literature review examines the symptoms, theorized causes, and comorbidity of seasonal affective disorder (SAD). Although causes of SAD remain unknown, researchers have observed a common pattern of vitamin D deficiency among patients with SAD. The importance of vitamin D in regulating serotonergic activity has been well documented, including the positive correlation between decreased serotonin levels and increased depressive symptoms. For more than 30 years, researchers have hypothesized that decreased serotonin activity is linked to symptoms of SAD. Furthermore, patients with other mental disorders, including depression, bipolarity, obsessive-compulsive disorder, etc. are likely to experience aggravation of symptoms during peak SAD …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Looks at Presence of Antibiotic-resistant Bacteria in Treated Wastewater Used for Irrigation

Reducing Sexual Victimization On College Campuses: The Impact Of A Collegiate-Level Human Sexual Behavior Course On Students’ Level Of Sexual Assertiveness, Ashlee D. Carter

Seton Hall University Dissertations and Theses (ETDs)

As the national conversation around the perpetration of sexual violence continues, research around sexual assault on college campuses continues to grow. By collecting both quantitative and qualitative data, this dissertation investigated the effects on students’ levels of sexual assertiveness, sexual awareness, communication skills, and sexual refusal skills as a result of taking a college-level human sexual behavior course. Through a lens of cognitive development theory and social cognitive theory, this study adds to the framework of promotion of cognitive development, which can assist in strengthening a young woman’s sexual assertiveness.

Results of this mixed methods analysis suggest that there is …

Glutathione De Novo Synthesis But Not Recycling Process Coordinates With Glutamine Catabolism To Control Redox Homeostasis And Directs Murine T Cell Differentiation, Gaojian Lian, J. N. Rashida Gnanaprakasam, Tingting Wang, Ruohan Wu, Xuyong Chen, Lingling Liu, Yuqing Shen, Mao Yang, Jun Yang, Ying Chen, Vasilis Vasiliou, Teresa A. Cassel, Douglas R. Green, Yusen Liu, Teresa W. -M. Fan, Ruoning Wang

Toxicology and Cancer Biology Faculty Publications

Upon antigen stimulation, T lymphocytes undergo dramatic changes in metabolism to fulfill the bioenergetic, biosynthetic and redox demands of proliferation and differentiation. Glutathione (GSH) plays an essential role in controlling redox balance and cell fate. While GSH can be recycled from Glutathione disulfide (GSSG), the inhibition of this recycling pathway does not impact GSH content and murine T cell fate. By contrast, the inhibition of the de novo synthesis of GSH, by deleting either the catalytic (Gclc) or the modifier (Gclm) subunit of glutamate–cysteine ligase (Gcl), dampens intracellular GSH, increases ROS, and impact T cell differentiation. Moreover, the inhibition of …

Maternal Experiences Of Intimate Partner Violence And C-Reactive Protein Levels In Young Children In Tanzania, Natalie Slopen, Jing Zhang, Samuel S. Urlacher, Gretchen De Silva, Mona Mittal

Publications and Research

Intimate partner violence (IPV) is a critical public health issue that impacts women and children across the globe.Prior studies have documented that maternal experiences of IPV are associated with adverse psychological and physical health outcomes in children; however, research on the underlying physiological pathways linking IPV to these conditions is limited. Drawing on data from the 2010 Tanzania Demographic and Health Survey, we examined the relationship between maternal report of IPV in the past 12 months and inflammation among children ages 6 months to 5 years. Our study included 503 children who were randomly selected to provide a blood sample …

Ubiquitin Receptor Rpn13 Mediates The Inhibitory Interaction Of Diphenyldihaloketones Clefma And Ef24 With The 26s Proteasome, Geeta Rao, Gregory Nkepang, Jian Xu, Hooman Yari, Hailey Houson, Chengwen Teng Pharm.D., Ph.D., Vibhudutta Awasthi

Faculty Publications

The proteasome is a validated target in drug discovery for diseases associated with unusual proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24, inhibit the peptidase activity of the 26S proteasome. The objective of this study was to investigate interaction of these compounds with the proteasome and identify a putative target within the protein components of the 26S proteasome. We employed standard fluorogenic peptide-based proteasome activity assay for trypsin-like, chymotrypsin-like, and caspase-like activities of human purified 26S proteasome in cell-free conditions. GFPu-1 and HUVEC cells were used as proteasome reporter cells. Direct binding studies used purified 19S, 20S, …

Susceptibility Genes To Plant Viruses, Hernan Garcia-Ruiz

Nebraska Center for Virology: Faculty Publications

Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication and movement and by the balance between plant defense and viral suppression of defense responses. Host factors may have antiviral or proviral activities. Proviral factors condition susceptibility to viruses by participating in processes essential to the virus. Here, we review current advances in the identification and characterization of host factors …

Medical School Watercooler Newsletter - September 9, 2018, Lindsey Lyle

Watercooler Newsletter

This is the September 9, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Welcomes Nephrologist Dr. Emad Al Jaber to Internal Medicine
• Dr. James Toldi Joins USA Family Medicine
• Richard Trieu Participates in NIDDK Medical Student Research Program in Diabetes
• Pediatrics Grand Rounds Set for Sept. 21
• Dr. Perkins Receives HRSA Grant for Opioid Misuse Training
• USA Welcomes Cardiologist Dr. Farnoosh Rahimi to Internal Medicine
• USA Hosts Southern All of Us Network Regional Meeting

Pepducin-Mediated Cardioprotection Via Β-Arrestin-Biased Β2-Adrenergic Receptor-Specific Signaling, Laurel A. Grisanti, Toby P. Thomas, Rhonda L. Carter, Claudio De Lucia, Erhe Gao, Walter J. Koch, Jeffrey L. Benovic, Douglas G. Tilley

Department of Biochemistry and Molecular Biology Faculty Papers

Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro; thus, we hypothesize that this pathway can mitigate cardiomyocyte death at the time of reperfusion to better preserve function. However, a lack of efficacious βarr-biased orthosteric small molecules has prevented investigation into whether this pathway relays protection against ischemic injury in vivo. We recently demonstrated that the pepducin ICL1-9, a small lipidated peptide fragment designed from the first intracellular loop of β2AR, allosterically engaged pro-survival signaling cascades in a βarr-dependent manner in …

Pregnancy Anxiety Predicts Shorter Gestation In Latina And Non-Latina White Women: The Role Of Placental Corticotrophin-Releasing Hormone, Isabel F. Ramos, Christine M. Guardino, Maxwell Mansolf, Laura M. Glynn, Curt A. Sandman, Calvin J. Hobel, Christine Dunkel Schetter

Psychology Faculty Articles and Research

Objective

Previous research has shown that a woman’s anxiety about her pregnancy predicts gestational length. Placental corticotrophin-releasing hormone (CRH) is a stress-responsive peptide proposed as a mechanism. We examined placental CRH as a physiological mediator of the association between pregnancy anxiety and gestational length in Latina and non-Latina White women to replicate evidence of associations between pregnancy anxiety, placental CRH and gestational length; to test whether placental CRH levels or changes mediate effects of pregnancy anxiety on gestational length; to examine ethnic differences in pregnancy anxiety, placental CRH, and gestational length; and to explore whether the effects of pregnancy anxiety …

Exposure To Household Air Pollution From Biomass Cookstoves And Blood Pressure Among Women In Rural Honduras: A Cross‐Sectional Study, Bonnie N. Young, Maggie L. Clark, Sarah Rajkumar, Megan L. Benka-Coker, Annette Bachand, Robert D. Brook, Tracy L. Nelson, John Volckens, Stephen J. Reynolds, Christian L'Orange, Nicholas Good, Kirsten Koehler, Sebastian Africano, Anibal B. Osorto Pinel, Jennifer L. Peel

Health Sciences Faculty Publications

Growing evidence links household air pollution exposure from biomass cookstoves with elevated blood pressure. We assessed cross‐sectional associations of 24‐hour mean concentrations of personal and kitchen fine particulate matter (PM2.5), black carbon (BC), and stove type with blood pressure, adjusting for confounders, among 147 women using traditional or cleaner‐burning Justa stoves in Honduras. We investigated effect modification by age and body mass index. Traditional stove users had mean (standard deviation) personal and kitchen 24‐hour PM2.5 concentrations of 126 μg/m3 (77) and 360 μg/m3 (374), while Justa stove users’ exposures were 66 μg/m3 (38) and 137 μg/m3(194), respectively. BC concentrations were …

A Modified Access Technique Of Impella 5.0 Axillary Artery Insertion, Abdallah Alameddine, Brian J. Binnall, Eric Dibiasio-White, Khaled Alameddine

The VAD Journal

The conventional method for the axillary artery insertion of Impella 5.0 is a non-tunneling route of the side-graft. We present an alternative technique in order to facilitate device insertion and to ensure protection from potential wound contamination. The technique consists of exiting the graft separately and away from the main incision with an intact skin and subcutaneous fat between the two sites. By proper isolation of the main wound, the risk of infection can thus be largely mitigated. Furthermore, this technique allows a better landing entry angle of graft insertion; the resulting smoother curve trajectory leads to facile device insertion, …

"Born Out Of Fear": A Grounded Theory Study Of The Stigma Of Bipolar Disorder For New Mothers, Walker Ladd Ph.D.

The Qualitative Report

Childbirth is an established trigger for the onset of bipolar disorders (BD) in the postpartum period, causing significant pathology and disability. Research has shown that the stigma of mental illness for new mothers is a powerful obstacle to care, preventing women from accessing critical treatment and social support. However, the majority of research has examined the relationship between the stigma and postpartum depression, leaving a gap in knowledge regarding stigma and postpartum bipolar disorder. The problem addressed in this grounded theory study was the lack of knowledge regarding the stigma of a diagnosis of bipolar disorder (BD) in the first …

Intravenous Immunoglobulin Is A Treatment Option For Refractory Dermatomyositis In Adult Patients, Adrianna D M Clapp

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Dalakas MC, Illa I, Dambrosia JM, et al. A controlled trial of high-dose intravenous immune globulin infusions as treatment for dermatomyositis. N Engl J Med. 1993;329:1993-2000. doi: 10.1056/nejm199312303292704.

Autologous Blood Patch After Ct-Guided Lung Biopsy Might Reduce Pneumothorax Requiring Chest Tube Placement, Tiffani Strickland

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Malone LJ, Stanfill RM, Wang H, Fahey KM, Bertino RE. Effect of intraparenchymal blood patch on rates of pneumothorax and pneumothorax requiring chest tube placement after percutaneous lung biopsy. American Journal of Roentgenology. 2013;200(6):1238-1243. doi: 10.2214/ajr.12.8980.

Icatibant Is Not An Appropriate Treatment Option For Ace-Inhibitor Induced Angioedema Of The Head And Neck, Faiz Khaja

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Sinert T, Levy P, Bernstein JA, et al. Randomized trial of icatibant for angiotensin-converting enzyme inhibitor-induced upper airway angioedema. J Allergy Clin Immunol Pract. 2017;5(5):1402-9. doi: 10.1016/j.jaip.2017.03.003

Capsid Structure Of Dsrna Fungal Viruses, Daniel Luque, Carlos P. Mata, Nobuhiro Suzuki, Said A. Ghabrial, José R. Castón

Plant Pathology Faculty Publications

Most fungal, double-stranded (ds) RNA viruses lack an extracellular life cycle stage and are transmitted by cytoplasmic interchange. dsRNA mycovirus capsids are based on a 120-subunit T = 1 capsid, with a dimer as the asymmetric unit. These capsids, which remain structurally undisturbed throughout the viral cycle, nevertheless, are dynamic particles involved in the organization of the viral genome and the viral polymerase necessary for RNA synthesis. The atomic structure of the T = 1 capsids of four mycoviruses was resolved: the L-A virus of Saccharomyces cerevisiae (ScV-L-A), Penicillium chrysogenum virus (PcV), Penicillium stoloniferum virus F (PsV-F), and Rosellinia necatrix …

Scientific, Paranormal, And Spiritual Frames In Alternative Medicine, Charles F. Emmons

Friday Forum

Although the term “integrative medicine” is being used to refer to the merging of complementary and alternative medicine (CAM) with standard biomedicine, there are some spiritual and paranormal frames for alternative medicine that are only partially integrated into standard medicine if at all. This study examines the orientations of some alternative practitioners and clients/users in the U.S. and the UK in terms of their views of science, spirituality and the paranormal.

The Continual Threat Of Influenza Virus Infections At The Human–Animal Interface: What Is New From A One Health Perspective?, E. S. Bailey, J. Y. Choi, J. K. Fieldhouse, L. K. Borkenhagen, J. Zemke, D. Zhang, G. C. Gray

Public Health

No abstract provided.

Correction: Secukinumab In The Treatment Of Psoriatic Arthritis: Efficacy And Safety Results Through 3 Years From The Year 1 Extension Of The Randomised Phase Iii Future 1 Trial., Philip Mease, A Kavanaugh, A Reimold

Articles, Abstracts, and Reports

No abstract provided.

Effects Of Beta Blockers And Ace Inhibitors After Left Ventricular Assist Device Implantation, Gaurang Vaidya, Emma Birks, Jessica Pillarella, Benjamin Salgado, Rajakrishnan Vijayakrishnan, Andrew Lenneman, Mark Slaughter, Dmitry Abramov

The VAD Journal

Purpose: While Beta blockers(BB) and Angiotensin system blockers(ACEinh/ARB) are important components in advanced heart failure therapy, their use after left ventricular assist device (LVAD) implantation remains controversial. Concern has been raised about possible adverse effects of BB on right ventricular(RV) function while tolerance and efficacy/outcome data for ACEinh are lacking. This study aimed to characterize the use of medical therapy post-LVAD implantation and to evaluate its safety and efficacy. Methods: Demographic, clinical and echocardiographic variables of patients implanted with a continuous-flow LVAD between 2012 and 2015 at a single center were retrospectively reviewed. Mortality and heart failure(CHF) hospitalizations were followed …