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2018

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Articles 1981 - 2010 of 15422

Full-Text Articles in Medicine and Health Sciences

Building A Medical Library From The Ground Up: Lessons Learned, Molly Montgomery Oct 2018

Building A Medical Library From The Ground Up: Lessons Learned, Molly Montgomery

Pacific Northwest Chapter of MLA Annual Meeting

How to you go from zero to (librarian) hero by developing a medical library in less than six months? How far out of your comfort zone do you have to be in order to go from being mainly an instruction/reference librarian to making systems decisions, building up an ILS, and wrestling with interlibrary loan? Attend this session to learn the strategies, skills, and coping mechanisms used to build up a medical library for Idaho’s first medical school.


The Nnlm And All Of Us Research Program Partnership: Transforming, Translating And Transcending Health Disparities Through Health Literacy, Michele Spatz Oct 2018

The Nnlm And All Of Us Research Program Partnership: Transforming, Translating And Transcending Health Disparities Through Health Literacy, Michele Spatz

Pacific Northwest Chapter of MLA Annual Meeting

The National Institutes of Health has launched an ambitious longitudinal research project called the All of Us Research Program (https://allofus.nih.gov/). Part of the Precision Medicine Initiative, All of Us seeks to engage one million or more volunteers living in the U.S. to contribute their health data over many years to improve health outcomes, fuel the development of new, more precise medical treatments, catalyze a new era of evidence-based preventive care and close the health disparities gap.


Ada News - 10/15/2018, American Dental Association, Publishing Division Oct 2018

Ada News - 10/15/2018, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Staff Member Recognized For Leadership, College Of Education And Human Development Oct 2018

Staff Member Recognized For Leadership, College Of Education And Human Development

Family and Consumer Sciences News

KALAMAZOO, Mich.—Western Michigan University's multicultural affairs director, Diana Hernández, received El Concilio's 2018 Quetzalcoatl Award in recognition of her stature as a professional Latinx leader who has been working, contributing, supporting and advocating for the well-being of the Latinx community in Kalamazoo


What's Happening: October 15, 2018, Maine Medical Center Oct 2018

What's Happening: October 15, 2018, Maine Medical Center

What's Happening

No abstract provided.


Determinants Of Uncontrolled Hypertension In Rural Communities In South Asia-Bangladesh, Pakistan, And Sri Lanka, Tazeen Jafar, Mihir Gandhi, Imtiaz Jehan, Aliya Naheed, H Asita De Silva, Hunaina Shahab, Dewan Alam, Nathasha Luke, Ching Wee Lim Wee Lim, Cobra-Bps Study Group Oct 2018

Determinants Of Uncontrolled Hypertension In Rural Communities In South Asia-Bangladesh, Pakistan, And Sri Lanka, Tazeen Jafar, Mihir Gandhi, Imtiaz Jehan, Aliya Naheed, H Asita De Silva, Hunaina Shahab, Dewan Alam, Nathasha Luke, Ching Wee Lim Wee Lim, Cobra-Bps Study Group

Community Health Sciences

Background: Uncontrolled blood pressure (BP) is a leading risk factor for death and disability in South Asia. We aimed to determine the cross-country variation, and the factors associated with uncontrolled BP among adults treated for hypertension in rural South Asia.
Methods: We enrolled 1718 individuals aged ≥40 years treated for hypertension in a cross-sectional study from rural communities in Bangladesh, Pakistan, and Sri Lanka. Multivariable logistic regression model was used to determine the factors associated with uncontrolledBP (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg).
Results: Among hypertensive individuals, 58.0% (95% confidence interval 55.7, 60.4) had uncontrolled BP: 52.8% …


Leukemia Inhibitory Factor Modulates The Peripheral Immune Response In A Rat Model Of Emergent Large Vessel Occlusion, Stephanie M. Davis, Lisa A. Collier, Edric D. Winford, Christopher C. Leonardo, Craig T. Ajmo Jr., Elspeth A. Foran, Timothy J. Kopper, John C. Gensel, Keith R. Pennypacker Oct 2018

Leukemia Inhibitory Factor Modulates The Peripheral Immune Response In A Rat Model Of Emergent Large Vessel Occlusion, Stephanie M. Davis, Lisa A. Collier, Edric D. Winford, Christopher C. Leonardo, Craig T. Ajmo Jr., Elspeth A. Foran, Timothy J. Kopper, John C. Gensel, Keith R. Pennypacker

Neurology Faculty Publications

Background: The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a cytokine that promotes neural cell survival through upregulation of antioxidant enzymes, promotes an anti-inflammatory phenotype in several types of immune cells. The goal of this study was to determine whether LIF treatment modulates the peripheral immune response after stroke.

Methods: Young male (3 month) Sprague-Dawley rats underwent sham surgery or permanent middle cerebral artery occlusion (MCAO). Animals were administered LIF (125 μg/kg) or …


Using Drosophila Behavioral Assays To Characterize Terebrid Venompeptide Bioactivity, Anders Eriksson, Prachi Anand, Juliette Gorson, Corina Grijuc, Elina Hadelia, James C. Stewart, Mandë Holford, Adam Claridge-Chang Oct 2018

Using Drosophila Behavioral Assays To Characterize Terebrid Venompeptide Bioactivity, Anders Eriksson, Prachi Anand, Juliette Gorson, Corina Grijuc, Elina Hadelia, James C. Stewart, Mandë Holford, Adam Claridge-Chang

Publications and Research

The number of newly discovered peptides from the transcriptomes and proteomes of animal venom arsenals is rapidly increasing, resulting in an abundance of uncharacterized peptides. There is a pressing need for a systematic, cost effective, and scalable approach to identify physiological effects of venom peptides. To address this discovery-to-function gap, we developed a sequence driven:activity-based hybrid approach for screening venom peptides that is amenable to large-venom peptide libraries with minimal amounts of peptide. Using this approach, we characterized the physiological and behavioral phenotypes of two peptides from the venom of predatory terebrid marine snails, teretoxins Tv1 from Terebra variegata and …


Unlv School Of Medicine: Rethinking Governance, Planning, And Economic Impact, The Lincy Institute Oct 2018

Unlv School Of Medicine: Rethinking Governance, Planning, And Economic Impact, The Lincy Institute

Brookings Scholar Lecture Series

The launch of the UNLV School of Medicine presented a unique opportunity for Southern Nevada to address two critical issues: the absence of adequate healthcare services for a region of more than 2.2 million people, and the economic impact of a new medical school resulting in an expanded regional health care economy. A collaborative process that engages local, state, and private sector interests is essential to the development of the UNLV School of Medicine and the expansion of an effective, efficient, and profitable healthcare economy.

In this colloquium The Lincy Institute released new health policy publications prepared with the support …


Low-Cost, Low Fidelity Meat Model To Teach Ultrasound Guided Nerve Blocks, Morgan Oakland, Shruti Chandra, Carl Alsup Oct 2018

Low-Cost, Low Fidelity Meat Model To Teach Ultrasound Guided Nerve Blocks, Morgan Oakland, Shruti Chandra, Carl Alsup

Department of Emergency Medicine Faculty Papers

Audience: The target audience of this workshop is emergency medicine residents; however, it is appropriate for all level of learners from medical students to faculty.

Introduction: Pain control is a major focus in the emergency department. Regional anesthesia is a rapidly growing alternative to opioid analgesia or procedural sedation. Nerve blocks are useful in many procedures and are relevant to some of our most common chief complaints. Ultrasound guided regional anesthesia has been shown to be highly successful with minimal complications, and has been shown to reduce the need for supplemental anesthesia such as sedation and narcotics.1 Ultrasound guidance …


Effects Of Opaque, Weighted Bottles On Maternal Sensitivity And Infant Intake, Alison K. Ventura, Alexandra Hernandez Oct 2018

Effects Of Opaque, Weighted Bottles On Maternal Sensitivity And Infant Intake, Alison K. Ventura, Alexandra Hernandez

Kinesiology and Public Health

Caregivers' abilities to assess how much is in the bottle may lead to encouragement of infant bottle emptying and overfeeding. The present study assessed whether use of opaque, weighted bottles (as compared with conventional, clear bottles) improves feeding outcomes. Mothers with infants <32 weeks of age (n = 76) were assessed on two separate days. Mothers fed their infants from an opaque, weighted bottle on 1 day and a clear bottle on the other; conditions were counterbalanced. Blinded raters certified in the Nursing Child Assessment Feeding Scale scored all videos to determine maternal sensitivity. Infant intake was assessed by weighing the bottle before and …


Perioperative Genitourinary Infection Associated With Sodium-Glucose Co-Transporter 2 Inhibitor Use., Stephen Melnick, Priya Rajagopalan, Theresa Lynn, Anthony Donato Oct 2018

Perioperative Genitourinary Infection Associated With Sodium-Glucose Co-Transporter 2 Inhibitor Use., Stephen Melnick, Priya Rajagopalan, Theresa Lynn, Anthony Donato

Reading Hospital Internal Medicine Residency

Context: Sodium-glucose co-transporter 2 (SGLT-2) inhibitors are a novel treatment approved for type 2 diabetes mellitus to lower hyperglycemia, systolic blood pressure, and promote weight loss. Commonly reported serious adverse events include increased mycotic urogenital infections, orthostatic hypotension, and normoglycemic ketoacidosis. Case report: We present a case of a 47-year old man with a history of type 2 diabetes mellitus initiated on the SGLT-2 inhibitor canagliflozin preoperatively before a penile implant, who presented with late postoperative MRSA bacteremia and scrotal abscess requiring implant extraction. Conclusion: As the SGLT-2 inhibitors are gaining in popularity, prescribers must be aware …


Week Of October 15, 2018, New York Medical College Oct 2018

Medical School Watercooler Newsletter - October 14, 2018, Lindsey Lyle Oct 2018

Medical School Watercooler Newsletter - October 14, 2018, Lindsey Lyle

Watercooler Newsletter

This is the October 14, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

  • November Med School Café – 'Gout'
  • Dr. Natalie Fox Named Assistant Administrator, Chief Nursing Officer for USA Physicians Group
  • COM Research Forum Submission Deadline Extended


Dti Metrics For Multi-Site/Multi-Scanner Study Of Adult Cervical Spinal Cord, Devon M. Middleton, Phd, Joshua Fisher, Bs, Adam E. Flanders, Md, Feroze Mohamed, Phd, John H. Wu, Md, Laura Krisa, Phd, Mark Elliot, Phd, Scott H. Faro, Md, Jessica Evans, Bs Oct 2018

Dti Metrics For Multi-Site/Multi-Scanner Study Of Adult Cervical Spinal Cord, Devon M. Middleton, Phd, Joshua Fisher, Bs, Adam E. Flanders, Md, Feroze Mohamed, Phd, John H. Wu, Md, Laura Krisa, Phd, Mark Elliot, Phd, Scott H. Faro, Md, Jessica Evans, Bs

Department of Radiology Posters

Background and Objective

A major variable in DTI spinal cord studies is the diversity in MRI scanner vendor and field strength. While there are several techniques proven to acquire DTI data, there are no standardized accepted methods for acquisition and processing. As more medical systems are utilizing this technology to evaluate the spinal cord, it is important to study the reproducibility of the DTI metrics among various scanner platforms, coil configurations and software implementations to determine the variance in obtaining normative spinal cord DTI data. This preliminary data for a multi-site DTI study examines the effects of these different MR …


The Smarxt Media Literacy Program: Improving Evidence-Based Prescribing Among Medical Students, Bethany D. Corbin, Jason B. Colditz, Galen E. Switzer, Jaime E. Sidani, Patricia M. Klatt, Ted Schaffer, Brian A. Primack Oct 2018

The Smarxt Media Literacy Program: Improving Evidence-Based Prescribing Among Medical Students, Bethany D. Corbin, Jason B. Colditz, Galen E. Switzer, Jaime E. Sidani, Patricia M. Klatt, Ted Schaffer, Brian A. Primack

Journal of Media Literacy Education

Many prescriptions written are not evidence-based, resulting in unnecessary morbidity and mortality. Media literacy may help medical trainees optimize evidence-based decision-making. In this study, we aimed to assess feasibility, acceptability, and initial efficacy of a media literacy prescribing program. We recruited 30 medical students, who completed animated video modules about pharmaceutical marketing and prescribing. We used a process evaluation and open-ended items to assess feasibility and acceptability, and knowledge tests before and after the intervention to assess efficacy. The program was feasible to implement and well-accepted. Knowledge and attitude targets around evidence-based prescribing and drug marketing improved after the intervention.


Screening Mammography Use In Older Women According To Health Status: A Systematic Review And Meta-Analysis, Joshua Demb, Tomi Akinyemiju, Isabel Allen, Tracy Onega, Robert A. Hiatt, Dejana Braithwaite Oct 2018

Screening Mammography Use In Older Women According To Health Status: A Systematic Review And Meta-Analysis, Joshua Demb, Tomi Akinyemiju, Isabel Allen, Tracy Onega, Robert A. Hiatt, Dejana Braithwaite

Epidemiology and Environmental Health Faculty Publications

Background: The extent to which screening mammography (SM) recommendations in older women incorporate life expectancy factors is not well established.

Objective: The objective of this review was to evaluate evidence on SM utilization in older women by life expectancy factors.

Data sources: We searched Medline, Embase and Web of Science from January 1991 to March 2016.

Study selection: We included studies examining SM utilization in women ages ≥ 65 years that measured life expectancy using comorbidity, functional limitations or health or prognostic status.

Data extraction and synthesis: ORs and 95% CIs were extracted and grouped by life expectancy category. Findings …


Effects Of Hearing Loss On General Cognitive Health And Social Auditory Lifestyle Within The Older Population, Sawyer Milam, Scott Seeman Oct 2018

Effects Of Hearing Loss On General Cognitive Health And Social Auditory Lifestyle Within The Older Population, Sawyer Milam, Scott Seeman

AuD Capstone Projects - Communication Sciences and Disorders

Hearing loss is a common medical condition associated with the elderly. Its impact on general cognitive health has been extensively studied, along with its association with social auditory lifestyle. Hearing loss has been associated with a decline in both aspects (Lin, 2011a; Wu and Bentler, 2012), however, studies involving all three of these factors have yet to be performed. Further research is needed to encompass how these three facets, when combined, affect the elderly population. A literature review of 21 articles was conducted in order to reveal how hearing loss is associated with general cognitive health and social auditory lifestyle.


Qualitative Case Study Of Needle Exchange Programs In The Central Appalachian Region Of The United States, Stephen M. Davis, Danielle Davidov, Alfgeir L. Kristjansson, Keith Zullig, Adam Baus, Melanie Fisher Oct 2018

Qualitative Case Study Of Needle Exchange Programs In The Central Appalachian Region Of The United States, Stephen M. Davis, Danielle Davidov, Alfgeir L. Kristjansson, Keith Zullig, Adam Baus, Melanie Fisher

Clinical and Translational Science Institute

Background

The Central Appalachian region of the United States is in the midst of a hepatitis C virus epidemic driven by injection of opioids, particularly heroin, with contaminated syringes. In response to this epidemic, several needle exchange programs (NEP) have opened to provide clean needles and other supplies and services to people who inject drugs (PWID). However, no studies have investigated the barriers and facilitators to implementing, operating, and expanding NEPs in less populous areas of the United States.

Methods

This qualitative case study consisted of interviews with program directors, police chiefs, law enforcement members, and PWID affiliated with two …


Brownsfields To Greenfields: Environmental Justice Versus Environmental Gentrification, Juliana A. Maantay, Andrew Maroko Oct 2018

Brownsfields To Greenfields: Environmental Justice Versus Environmental Gentrification, Juliana A. Maantay, Andrew Maroko

Publications and Research

Gentrification is a growing concern in many urban areas, due to the potential for displacement of lower-income and other vulnerable populations. This process can be accelerated when neighborhood “greening” projects are undertaken via governmental or private investor efforts, resulting in a phenomenon termed environmental or “green” gentrification. Vacant land in lower-income areas is often improved by the existing community through the creation of community gardens, but this contributes to these greening efforts and paradoxically may spur gentrification and subsequent displacement of the gardens’ stewards and neighbors. “Is proximity to community gardens in less affluent neighborhoods associated with an increased likelihood …


The Santa Clara, 2018-10-11, Santa Clara University Oct 2018

The Santa Clara, 2018-10-11, Santa Clara University

The Santa Clara

No abstract provided.


Self-Reported Vs. Measured Height, Weight, And Bmi In Young Adults, Melissa D. Olfert, Makenzie L. Barr, Camille M. Charlier, Oluremi A. Famodu, Wenjun Zhou, Anne E. Mathews, Carol Byrd-Bredbenner, Sarah E. Colby Oct 2018

Self-Reported Vs. Measured Height, Weight, And Bmi In Young Adults, Melissa D. Olfert, Makenzie L. Barr, Camille M. Charlier, Oluremi A. Famodu, Wenjun Zhou, Anne E. Mathews, Carol Byrd-Bredbenner, Sarah E. Colby

Clinical and Translational Science Institute

Self-reported height and weight, if accurate, provide a simple and economical method to track changes in body weight over time. Literature suggests adults tend to under-report their own weight and that the gap between self-reported weight and actual weight increases with obesity. This study investigates the extent of discrepancy in self-reported height, weight, and subsequent Body Mass Index (BMI) versus actual measurements in young adults. Physically measured and self-reported height and weight were taken from 1562 students. Male students marginally overestimated height, while females were closer to target. Males, on average, closely self-reported weight. Self-reported anthropometrics remained statistically correlated to …


Evaluation Of Innovative Medical School Facilities And Consultant Recommendations, Tripp Umbach Oct 2018

Evaluation Of Innovative Medical School Facilities And Consultant Recommendations, Tripp Umbach

Lincy Institute Reports and Briefs

In August 2018, The Lincy Institute1 retained Tripp Umbach2 to provide consultation to evaluate and identify best practices for medical school facilities and development models as the University of Nevada Las Vegas (UNLV) and the community embarks on the development of a home for the UNLV School of Medicine. To complete this assignment, Tripp Umbach completed a comprehensive process involving secondary data analysis and actively sought and received input from stakeholders including leadership at The Lincy Institute, UNLV School of Medicine, previous Tripp Umbach clients, leading design professionals with experience developing medical schools, and potential donors to the proposed project. …


Cd133 Expression In Glioblastoma Multiforme: A Literature Review, Syed Ijlal Ahmed, Gohar Javed, Altaf Ali Laghari, Syeda Beenish Bareeqa, Saba Farrukh, Shajeeah Zahid, Syeda Sana Samar, Kashif Aziz Oct 2018

Cd133 Expression In Glioblastoma Multiforme: A Literature Review, Syed Ijlal Ahmed, Gohar Javed, Altaf Ali Laghari, Syeda Beenish Bareeqa, Saba Farrukh, Shajeeah Zahid, Syeda Sana Samar, Kashif Aziz

Section of Neurosurgery

Glioblastoma, also known as glioblastoma multiforme (GBM), is the most common primary brain tumor. Extensive research has been carried out to discover the factors associated with the course and progression of GBM. CD133 is a glycoprotein antigen found in normal and malignant tissues. CD133 has been recognized as a marker for the growth of cancer cells. The association between this tissue marker and GBM is being investigated. The aim of this review was to evaluate the role of CD133 as a tumor marker for the prognosis of GBM.


Integration Of Postpartum Care Into Child Health And Immunization Services In Burkina Faso: Findings From A Cross-Sectional Study, Danielle Yugbaré Belemsaga, Anne Goujon, Aristide Bado, Seni Kouanda, Els Duysburgh, Marleen Temmerman, Olivier Degomme Oct 2018

Integration Of Postpartum Care Into Child Health And Immunization Services In Burkina Faso: Findings From A Cross-Sectional Study, Danielle Yugbaré Belemsaga, Anne Goujon, Aristide Bado, Seni Kouanda, Els Duysburgh, Marleen Temmerman, Olivier Degomme

Department of Obstetrics & Gynaecology

Background: The Missed Opportunities for Maternal and Infant Health (MOMI) project, which aimed at upgrading maternal and infant postpartum care (PPC), implemented a package of interventions including the integration of maternal PPC in infant immunization services in 12 health facilities in Kaya Health district in Burkina Faso from 2013 to 2015. This paper assesses the coverage and the quality of combined mother-infant PPC in reproductive, maternal, newborn and child health services (RMNCH).
Methods: We conducted a mixed methods study with cross-sectional surveys before and after the intervention in the Kaya health and demographic surveillance system. On the quantitative side, two …


Investigating Mpm-Iii, Sofa And Delta Sofa Scoring Systems As Predictors Of Mortality At A Tertiary Hospital In Nairobi, Kenya: A Retrospective Cohort Study, Lilian Lukoko Oct 2018

Investigating Mpm-Iii, Sofa And Delta Sofa Scoring Systems As Predictors Of Mortality At A Tertiary Hospital In Nairobi, Kenya: A Retrospective Cohort Study, Lilian Lukoko

Master of Medicine in Anaesthesiology

Background: Despite major advances, management of critically ill patients worldwide is associated with high mortality rates. Assessment of disease severity is crucial in the analysis of ICU mortality. Although a variety of severity of illness scoring systems have been developed for this assessment and validated across Europe and the USA, few studies exist to show support of their utilization in African countries. There is conflicting evidence regarding the most reliable severity of illness scoring system suitable for resource limited countries as their mortality predictive values differ with different populations. SOFA is already in use at the AKUHN ICU and has …


Source Of Stress In Sport: A Rasch Calibration, Christine Williams, Ramona Stone, Seungho Ryu Oct 2018

Source Of Stress In Sport: A Rasch Calibration, Christine Williams, Ramona Stone, Seungho Ryu

Public Health Sciences Faculty Publications

The purpose of this study was to assess the psychometric properties of a stress in sport inventory by determining optimal categorization and model-data fit, and calibrate the sources of stress items associated with individual and team sport athletes using Rasch modeling. The study examines the intensity level of various sources of acute stress experienced by competitive athletes. The Sources of Stress in Sport Inventory (SSSI) was generated to measure intensity level of perceived stress in sport. A total of 336 college-aged males (N=167) and females (N=169) who previously competed in high school or college sports participated. Function of the rating …


Impact Of The Use Of Local Fidaxomicin Treatment Algorithms For Managing Clostridium Difficile Infection In Hospitalized Patients In Southeastern United States, Jonathan C. Cho, Sandy J. Estrada, Jamie J. Kisgen, Angelina Davis, Laura Puzniak Oct 2018

Impact Of The Use Of Local Fidaxomicin Treatment Algorithms For Managing Clostridium Difficile Infection In Hospitalized Patients In Southeastern United States, Jonathan C. Cho, Sandy J. Estrada, Jamie J. Kisgen, Angelina Davis, Laura Puzniak

Pharmacy Faculty Publications and Presentations

Background: Clostridium difficile-associated diarrhea (CDAD) is a major public health threat that results in increased length of stay, hospital readmissions, deaths, and economic burden. CDAD treatment is often guided by severity of disease. Although various tools exist to determine CDAD severity, real-world data evaluating the use of such tools in treatment algorithms are sparse. Methods: A local CDAD treatment pathway was developed independently to guide fidaxomicin prescribing at wellStar Health System (WellStar) and at Lee Health (LH) and Sarasota Memorial Hospital (SMH). Each algorithm was designed locally by the stewardship pharmacist and was utilized to identify patients at high risk …


Metformin Clinical Trial In Hpv+ And Hpv- Head And Neck Squamous Cell Carcinoma: Impact On Cancer Cell Apoptosis And Immune Infiltrate., Joseph M. Curry, Jennifer Johnson, Mehri Mollaee, Patrick Tassone, Dev Amin, Alexander Knops, Diana Whitaker Menezes, My Mahoney, Andrew P. South, Ulrich Rodeck, Tingting Zhan, Larry A. Harshyne, Nancy Philp, Adam J. Luginbuhl, David Cognetti, Madalina Tuluc, Ubaldo E. Martinez-Outshoorn, Md Oct 2018

Metformin Clinical Trial In Hpv+ And Hpv- Head And Neck Squamous Cell Carcinoma: Impact On Cancer Cell Apoptosis And Immune Infiltrate., Joseph M. Curry, Jennifer Johnson, Mehri Mollaee, Patrick Tassone, Dev Amin, Alexander Knops, Diana Whitaker Menezes, My Mahoney, Andrew P. South, Ulrich Rodeck, Tingting Zhan, Larry A. Harshyne, Nancy Philp, Adam J. Luginbuhl, David Cognetti, Madalina Tuluc, Ubaldo E. Martinez-Outshoorn, Md

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Background: Metformin, an oral anti-hyperglycemic drug which inhibits mitochondrial complex I and oxidative phosphorylation has been reported to correlate with improved outcomes in head and neck squamous cell carcinoma (HNSCC) and other cancers. This effect is postulated to occur through disruption of tumor-driven metabolic and immune dysregulation in the tumor microenvironment (TME). We report new findings on the impact of metformin on the tumor and immune elements of the TME from a clinical trial of metformin in HNSCC. Methods: Human papilloma virus-(HPV-) tobacco+ mucosal HNSCC samples (n = 12) were compared to HPV+ oropharyngeal squamous cell carcinoma (OPSCC) samples (n …


Paradigm Shift In Anti-Coagulating Patients With Non-Valvular Atrial Fibrillation, Bushra Moiz Oct 2018

Paradigm Shift In Anti-Coagulating Patients With Non-Valvular Atrial Fibrillation, Bushra Moiz

Department of Pathology and Laboratory Medicine

No abstract provided.