Medicine and Health Sciences Commons^™

Compliance And Appropriateness Of Driver Vision Regulations In Ireland, Ciara Mchugh, Nabin Paudel, James Loughman, Matthew Sheehan

Other

Driving is a highly complex task which relies heavily on vision for successful execution. There are currently 2,820,528 holders of driving licences in Ireland. Holders of a driving license must meet the standards for vision as set out by the Road Safety Authority Slainte agus Tiomáint document. Visual acuity and Visual Field measurements are specified as the minimum standard. If there is reason to believe that these measurements are inadequate, it is required that the subject undergo a more detailed examination. Currently, drivers must undergo a vision screening when applying for their first license, and additional vision screening is not …

A Neural Network Based Model Effectively Predicts Enhancers From Clinical Atac-Seq Samples., Asa Thibodeau, Asli Uyar, Shubham Khetan, Michael L. Stitzel, Duygu Ucar

Faculty Research 2018

Enhancers are cis-acting sequences that regulate transcription rates of their target genes in a cell-specific manner and harbor disease-associated sequence variants in cognate cell types. Many complex diseases are associated with enhancer malfunction, necessitating the discovery and study of enhancers from clinical samples. Assay for Transposase Accessible Chromatin (ATAC-seq) technology can interrogate chromatin accessibility from small cell numbers and facilitate studying enhancers in pathologies. However, on average, ~35% of open chromatin regions (OCRs) from ATAC-seq samples map to enhancers. We developed a neural network-based model, Predicting Enhancers from ATAC-Seq data (PEAS), to effectively infer enhancers from clinical ATAC-seq samples by …

Predominance Of Triple Wild-Type And Igf2r Mutations In Mucosal Melanomas., Yuuki Iida, Matthew P Salomon, Keisuke Hata, Kevin Tran, Shuichi Ohe, Chester Griffiths, Sandy C Hsu, Nellie Nelson, Dave S B Hoon

Articles, Abstracts, and Reports

BACKGROUND: Primary mucosal melanoma (MM) is a rare subtype of melanoma that arises from melanocytes in the mucosa. MM has not been well profiled for mutations and its etiology is not well understood, rendering current treatment strategies unsuccessful. Hence, we investigated mutational landscape for MM to understand its etiology and to clarify mutations that are potentially relevant for MM treatment.

METHODS: Forty one MM and 48 cutaneous melanoma (CM) tissues were profiled for mutations using targeted deep next-generation sequencing (NGS) for 89 cancer-related genes. A total of 997 mutations within exons were analyzed for their mutational spectrum and prevalence of …

Forecast Or Fall: Prediction's Importance To Postural Control, Chris J. Dakin, David A.E. Bolton

Kinesiology and Health Science Faculty Publications

To interact successfully with an uncertain environment, organisms must be able to respond to both unanticipated and anticipated events. For unanticipated events, organisms have evolved stereotyped motor behaviors mapped to the statistical regularities of the environment, which can be trigged by specific sensory stimuli. These 'reflexive' responses are more or less hardwired to prevent falls and represent, maybe, the best available solution to maintaining posture given limited available time and information. With the gift of foresight, however, motor behaviors can be tuned or prepared in advance, improving the ability of the organism to compensate for, and interact with, the changing …

The Impact Of Disease-Modifying Therapy Access Barriers On People With Multiple Sclerosis: Mixed-Methods Study., Kristina F. Simacek, John J. Ko, Debbie Moreton, Stefan Varga, Kristen Johnson, Bozena J. Katic

College of Population Health Faculty Papers

BACKGROUND: In the United States, people with relapsing-remitting multiple sclerosis (RRMS) can face difficulty accessing disease-modifying therapies (DMTs) because of insurance, pharmacy, or provider policies. These barriers have been associated with poor adherence and negative health outcomes.

OBJECTIVE: The goals of this study were to describe the overall occurrence of difficulties and delays associated with gaining access to DMTs among people with RRMS, to assess DMT adherence during periods of reduced access, and to contextualize the patients' journey from receipt of a prescription for DMT to obtaining and taking their medication when faced with access barriers.

METHODS: We recruited US-based …

Rumah Sakit Syariah Strategi Pemasaran Vs Syiar, Mala Hayati, Wahyu Sulistiadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The phenomenon of sharia awareness among the people of Indonesia, moves the economy in various aspects of people's lives, including the health service sector. The community begins to choose products that are not only quality from the medical side, but also get psychosocial safe services framed with Islamic values. Very open market opportunities to capture these symptoms. Sharia hospitals try to answer this challenge by packaging Islamic values into their service standards. Literature studies sourced from various scopus indexed international journals and google scholar. The concept of sharia hospitals that carry spiritual values is in line with the marketing 3.0 …

Kaposi’S Sarcoma-Associated Herpesvirus Seropositivity Is Associated With Type 2 Diabetes Mellitus: A Case–Control Study In Xinjiang, China, Meng Cui, Qiwen Fang, Jun Zheng, Zhanjun Shu, Yin Chen, Yage Fan, Juan Zhao, Charles Wood, Tiejun Zhang, Yan Zeng

Nebraska Center for Virology: Faculty Publications

Objective: To assess the potential relationship between Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and type 2 diabetes mellitus (DM-2) in Xinjiang, China.

Methods: A case–control study of consecutively included DM-2 patients and normal controls was conducted among the Uygur and Han populations in Xinjiang Uygur Autonomous Region, China. Blood samples were collected and KSHV seroprevalence, antibody titers, and viral load were investigated. Logistic regression analysis and multiple linear regression analysis were applied to explore determinants of the main outcome measures.

Results: A total of 324 patients with DM-2 and 376 normal controls were included. The seroprevalence of KSHV was 49.1% (95% …

Variasi Biaya Sectio Caesaria Di Rumah Sakit Indonesia, Tetriadi Tetriadi, Atik Nurwahyuni

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Pricing / variation of costs is one of the strategic steps that must be taken because it refers to costs incurred, both marginal and total costs, including indirect costs (overhead costs). Cesarean section (SC) surgery is one of the most common actions performed in the operating room which also requires careful planning of service costs, so that the appropriate price setting for the hospital can do activities without reducing service quality. This paper aims to look at the different costs of SC in Indonesia based on the class / level of the hospital and hospital ownership, whether the hospital is …

Metode Pendekatan Top-Down Dan Bottom-Up: Strategi Marketing Penetapan Harga Di Pelayanan Kesehatan, Muchtar Muchtar, Wahyu Sulistiadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The marketing mix consists of product, price, place and promotion. Pricing in health services is an important mix that can be done through the top-down and bottom-up approach. The purpose of this paper is to review the differences between the top-down and bottom-up approaches to pricing health services. Method: This literature review is conducted in December 2018. Research related to the top-down and bottom-up approaches to pricing health services is sought by using valid keywords, including top down approaches, bottom-up approaches and costing through PubMed, Science Direct and EBSCO. Results & Discussion: A total of 10 papers were selected for …

The Impact Of Medical Tourism Industry For The Hospital Services And Marketing Activities: A Systematic Review, Nadya Aviliyani Taufik, Wahyu Sulistiadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The relationship between the health industry and tourism has produced what is called medical tourism which is one of the largest and fastest growing service industries in the world and is a profitable business for the destination country. To capture the many medical tourists it is necessary to recognize the vital factors that influence the decision of medical tourists to choose the destination country by implementing marketing strategies and good health services. Using Systematic Review with PRISMA method retrieved from online database such as PubMed, and Google Scholar using a keyword “Medical tourism” AND “hospital services” AND “marketing”. The end …

Identifikasi Faktor–Faktor Yang Berpengaruh Terhadap Medical Tourism Pada Rumah Sakit Di Indonesia, Ayu Nadya Kusumawati

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Medical tourism is an activity carried out by an individual to get a health service or medical care abroad. In the effort to develop the health system and competition and the impact of health globalization, it does not rule out the possibility that medical tourism raises intense competition among hospitals in providing quality services and superior service products provided by hospitals in attracting foreign patients to come get treatment. Objective of this research is to determined factors that affect hospital to be medical tourism’s aim. Methods in this research is literature review from international journals. The results is hospital needs …

Hubungan Bauran Pemasaran (Marketing Mix) Dengan Loyalitas Pelanggan: Systematic Review, Leawaty Leawaty, Wahyu Sulistiadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Marketing activities in the business era are now an important factor for maintaining and developing a business. The higher the level of competition in the business, requires management to innovate in maintaining its customers. This activity is to create loyal customers. Customer loyalty is very important for the continuity of a business. To find out the marketing mix relationship with customer loyalty. Preferred Reporting Items for Systematic Reviews and Meta Analyzes (PRISMA) are evidence-based methods for conducting systematic reviews. Based on the results of the research at the Pulmo Clinic of Paru Batu Hospital, several conclusions can be obtained that …

Analisis Produk Layanan Rumah Sakit Dalam Lingkup Bauran Pemasaran, Rahmawati Rahmawati

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Hospitals as large service institutions, are required to be able to fulfill public health services well, this is due to a lot of competition and if they do not pay attention to these demands, it will be difficult to maintain their survival. Some breakthroughs in health services are a necessity especially to bridge the level of social differences in health services on the one hand to find the right form of funding efficiency for the community on the other hand. For this reason, the hospital must be able to develop a marketing strategy through an effective and efficient marketing mix …

Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements For Nad+ Synthesis, Laura Palzer, Jessica J. Bader, Frances Angel, Megan Witzel, Sydney Blaser, Alexis Mcneil, Miles K. Wandersee, N. Adrian Leu, Christopher J. Lengner, Clara E. Cho, Kevin D. Welch, James B. Kirkland, Ralph G. Meyer, Mirella L. Meyer-Ficca

Animal, Dairy, and Veterinary Science Faculty Publications

NAD⁺ is essential for redox reactions in energy metabolism and necessary for DNA repair and epigenetic modification. Humans require sufficient amounts of dietary niacin (nicotinic acid, nicotinamide, and nicotinamide riboside) for adequate NAD⁺ synthesis. In contrast, mice easily generate sufficient NAD⁺ solely from tryptophan through the kynurenine pathway. We show that transgenic mice with inducible expression of human alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) become niacin dependent similar to humans when ACMSD expression is high. On niacin-free diets, these acquired niacin dependency (ANDY) mice developed reversible, mild-to-severe NAD⁺ deficiency, depending on the nutrient composition of the diet. NAD deficiency …

An Examination Of The Relationship Between Health Literacy And Dietary Practices Among College Students: A Test Of The Integrated Model Of Health Literacy, Alison B. Oberne

USF Tampa Graduate Theses and Dissertations

Overweight and obesity continue to plague Americans and contribute to decreased quantity and quality of life. Americans of all ages experience overweight and obesity; however, increasing rates occur during young adulthood. Young adults develop dietary practice behaviors that persist into adulthood and can contribute to weight-related chronic diseases. Approximately half of all young adults are enrolled in college, and, approximately 38% of college students are either overweight or obese.

Dietary practices are health behaviors that can either increase or decrease risk for overweight and obesity. Much research has explored predictors of dietary practices among college students; however, there is a …

Development And Internal Validation Of The Multivariable Cipher (Collaborative Integrated Pregnancy High-Dependency Estimate Of Risk) Clinical Risk Prediction Model, Beth A. Payne, Helen Ryan, Jeffrey Bone, Laura A. Magee, Alice B. Aarvold, J. Mark Ansermino, Zulfiqar Ahmed Bhutta, Mary Bowen, J. Guilherme Cecatti, Cynthia Chazotte

Department of Paediatrics and Child Health

Background: Intensive care unit (ICU) outcome prediction models, such as Acute Physiology And Chronic Health Evaluation (APACHE), were designed in general critical care populations and their use in obstetric populations is contentious. The aim of the CIPHER (Collaborative Integrated Pregnancy High-dependency Estimate of Risk) study was to develop and internally validate a multivariable prognostic model calibrated specifically for pregnant or recently delivered women admitted for critical care.
Methods: A retrospective observational cohort was created for this study from 13 tertiary facilities across five high-income and six low- or middle-income countries. Women admitted to an ICU for more than 24 h …

Mediterranean Diet Adherence And Rate Of Cerebral Aβ-Amyloid Accumulation: Data From The Australian Imaging, Biomarkers And Lifestyle Study Of Ageing, Stephanie Rainey-Smith, Yian Gu, Samantha Gardener, James D Doecke, Victor L Villemagne, Belinda M Brown, Kevin Taddei, Simon M Laws, Hamid R. Sohrabi, Michael Weinborn, David Ames, Christopher Fowler, S Lance Macaulay, Paul Maruff, Colin L Masters, Olivier Salvado, Christopher C Rowe, Nikolaos Scarmeas, Ralph N. Martins

Research outputs 2014 to 2021

Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer's disease (AD) risk. However, no study to-date has examined the relationship between MeDi adherence and accumulation of cerebral Aβ-amyloid (Aβ; a pathological hallmark of AD) in older adults. Cognitively normal healthy control participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing completed the Cancer Council of Victoria Food Frequency Questionnaire at baseline, which was used to construct a MeDi score for each participant (score range 0-9; higher score indicating higher adherence). Cerebral Aβ load was quantified by Pittsburgh Compound B positron emission …

Determining The Efficacy Of Fifa 11+ In Reducing Acl Injury In Female Soccer Players, John Hallmark

Celebration of Learning

Objective-This study aims to identify the relationship between the Fifa 11+ program and the angle of valgus deformity at the knee. Background-200,000 ACL tears are reported each year. Previous studies have linked valgus motion of the knee to an increased rate of ACL injury and females exhibit a 4-6x increased risk for ACL injury. Fifa 11+ has shown promise in studies done on professional soccer teams yet remains untested in a younger population. Methods-This prospective cohort study of 300 consented female soccer players will use Noraxon as a tool for the measurement of valgus angle at the …

What's Happening: October 29, 2018, Maine Medical Center

What's Happening

No abstract provided.

Analysis Of The Patient Information Quality And Readability On Esophagogastroduodenoscopy (Egd) On The Internet, P. Priyanka, Yousaf B. Hadi, G. J. Reynolds

Clinical and Translational Science Institute

Objective. Patients are increasingly using the Internet to inform themselves of health-related topics and procedures, including EGD. We analyzed the quality of information and readability of websites afer a search on 3 diferent search engines. Methods. We used an assessment tool for website quality analysis that we developed in addition to using validated instruments for website quality, Global Quality Score (GQS) and Health on Net (HON) certifcation. Te readability was assessed using Flesch-Kincaid Reading Ease (FRE) and Flesch-Kincaid Grade level (FKG). 30 results of each search terms ‘EGD’ and ‘Upper Endoscopy’ from Google and 15 each from Bing and Yahoo …

Impact Of Legalizing Recreational Cannabis Sales On Cannabis Exposure Calls To Poison Centers 2008-2017, Gillian A. Beauchamp Md, Robert G. Hendrickson Md, B. Zane Horowitz Md, Daniel A. Spyker Md, Phd

Department of Emergency Medicine

No abstract provided.

Glimepiride Administered In Chow Reversibly Impairs Glucose Tolerance In Mice, Dana M. Niedowicz, Sabire Özcan, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Sulfonylureas are a class of antidiabetes medications prescribed to millions of individuals worldwide. Rodents have been used extensively to study sulfonylureas in the laboratory. Here, we report the results of studies treating mice with a sulfonylurea (glimepiride) in order to understand how the drug affects glucose homeostasis and tolerance. We tested the effect of glimepiride on fasting blood glucose, glucose tolerance, and insulin secretion, using glimepiride sourced from a local pharmacy. We also examined the effect on glucagon, gluconeogenesis, and insulin sensitivity. Unexpectedly, glimepiride exposure in mice was associated with fasting hyperglycemia, glucose intolerance, and decreased insulin. There was no …

Patient Barriers For Weight Management Among African American Women, Owen Bowie, Jennifer Kusch, George L. Morris Iii, Tracy Flood, Jessica Gill, Renee E. Walker, Ron A. Cisler, Jennifer T. Fink

Journal of Patient-Centered Research and Reviews

Purpose: The primary aim of this study was to assess the perceptions of local African American women who are overweight or obese using semi-structured focus groups to identify barriers to weight management and factors that support strategy success. The secondary aim of this study was to determine recommendations for patient-centered weight management interventions established specifically for African American women in the Milwaukee-area community.

Methods: Three semi-structured focus groups to explore barriers to weight management were performed among women patients. Participants (N = 41) were recruited via email, postal mail, and phone as available from an academic medical center in Milwaukee, …

Adapting Boot Camp Translation Methods To Engage Clinician/Patient Research Teams Within Practice-Based Research Networks, Lyle J. Fagnan, Matthew J. Simpson, Jeanette M. Daly, Leann C. Michaels, David L. Hahn, Barcey T. Levy, Douglas H. Fernald, John M. Westfall, Donald E. Nease Jr.

Journal of Patient-Centered Research and Reviews

Purpose: Boot camp translation is a proven process to engage community members and health professionals in translating and disseminating evidence-based “best practices” models for health prevention and chronic illness care. Primary care practice improvement studies, particularly involving patient-driven change, as seen with self-management support (SMS), require engaged practice teams that include patients. Models of engagement such as boot camp translation may be effective.

Methods: Four geographically dispersed practice-based research networks (PBRNs) from the Meta-LARC consortium engaged 16 practices to form SMS implementation teams involving a clinician, care manager, and 2 patients in each team. Our study adapted the boot camp …

Conference Proceedings: Aurora Scientific Day 2018

Journal of Patient-Centered Research and Reviews

This journal supplement includes selected abstracts from among the more than 50 presented at the 44th annual Aurora Scientific Day research symposium. Held May 25, 2018, in Milwaukee, Wisconsin, Aurora Scientific Day provides a forum for original research conducted by faculty, fellows, residents, and other allied health professionals affiliated with Aurora Health Care, an integrated health system with hospitals and clinics in Wisconsin and Illinois.

Rationale, Design And Methods Of "Set The Rules": A Tailored Peer-To-Peer Health Information Intervention, Jennifer R. Warren, Brandi M. White

Health and Clinical Sciences Faculty Publications

Ensuring equitable access to health information is one strategy to promote health equity for underserved communities, especially for low-income African Americans (AAs). Childcare centers are one viable site to deliver health information to address this disparity. This paper describes the methods used in a community-based participatory research project with a childcare facility that aimed to reduce environmental tobacco smoke (ETS) exposure among low-income AA children. Through collaboration and multiple data collection methods, partners identified communication strategies to overcome informational barriers. These initial findings indicated a peer-to-peer health information intervention, entitled “Set the Rules”, as the best strategy to increase awareness. …

Preliminary Scale Of Reference Values For Evaluating Reactive Strength Index-Modified In Male And Female Ncaa Division I Athletes, Christopher J. Sole, Timothy J. Suchomel, Michael H. Stone

ETSU Faculty Works

The purpose of this analysis was to construct a preliminary scale of reference values for reactive strength index-modified (RSImod). Countermovement jump data from 151 National Collegiate Athletic Association (NCAA) Division I collegiate athletes (male n = 76; female n = 75) were analyzed. Using percentiles, scales for both male and female samples were constructed. For further analysis, athletes were separated into four performance groups based on RSImod and comparisons of jump height (JH), and time to takeoff (TTT) were performed. RSImod values ranged from 0.208 to 0.704 and 0.135 to 0.553 in males and females, respectively. Males had greater RSImod …

Stress-Induced Heat Shock Protein 40 And Immune Function In Altered Gravity, Amber M. Paul, Brooke D. Shepard, Sharmila Bhattacharya

Publications

In space, astronauts are more susceptible to pathogens, viral reactivation and immunosuppression, which poses limits to their health and the mission. Interestingly, during space flight, stress-inducible heat shock proteins (HSP) are robustly induced, and the overexpression of HSPs have been implicated in immune dysregulation, therefore HSPs may be critically involved in regulating immune homeostasis. HSP40/DNAJ1 plays a major role in proper protein translation and folding. Its loss of function has been implicated in susceptibility to microbial infection, while its overexpression has been implicated in autoimmunity, collectively suggesting its complicated, but necessary, role in maintaining immunological function. To determine the role …

Implementing Community-Created Self-Management Support Tools In Primary Care Practices: Multimethod Analysis From The Insttepp Study, Douglas H. Fernald, Matthew J. Simpson, Donald E. Nease Jr., David L. Hahn, Amanda E. Hoffmann, Leann C. Michaels, Lyle J. Fagnan, Jeanette M. Daly, Barcey T. Levy

Journal of Patient-Centered Research and Reviews

Purpose: With one-half of Americans projected to be living with at least one chronic condition before 2020, enhancing patient self-management support (SMS) may improve health-related behaviors and clinical outcomes. Routine SMS implementation in primary care settings is difficult. Little is known about the practice conditions required for successful implementation of SMS tools.

Methods: Four primary care practice-based research networks (PBRNs) recruited 16 practices to participate in a boot camp translation process to adapt patient-centered SMS tools. Boot camp translation sessions were held over a 2-month period with 2 patients, a clinician, and a care manager from each practice. Qualitative case …

How To Translate Self-Management Support Tools Into Clinical Practice, Matthew J. Simpson, Jeanette M. Daly, Douglas H. Fernald, John M. Westfall, Leann C. Michaels, Barcey T. Levy, David L. Hahn, Lyle J. Fagnan, Donald E. Nease Jr.

Journal of Patient-Centered Research and Reviews

Purpose: Patient self-management is an inevitable part of the work of being a patient, and self-management support (SMS) has become increasingly important in chronic disease management. However, the majority of SMS resources available in the Agency for Healthcare Research and Quality SMS Resource Library were developed without explicit collaboration between clinicians and patients.

Methods: Translation of SMS tools derived from the library into primary care practices occurred utilizing boot camp translation in four different practice-based research networks (PBRNs). The typical model of boot camp translation was adapted for the purpose of the Implementing Networks’ Self-management Tools Through Engaging Patients and …