Medicine and Health Sciences Commons^™

Effects Of A Community Population Health Initiative On Blood Pressure Control In Latinos, James R Langabeer, Timothy D Henry, Carlos Perez Aldana, Larissa Deluna, Nora Silva, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

Background Hypertension remains one of the most important, modifiable cardiovascular risk factors. Yet, the largest minority ethnic group (Hispanics/Latinos) often have different health outcomes and behavior, making hypertension management more difficult. We explored the effects of an American Heart Association-sponsored population health intervention aimed at modifying behavior of Latinos living in Texas. Methods and Results We enrolled 8071 patients, and 5714 (65.7%) completed the 90-day program (58.5 years ±11.7; 59% female) from July 2016 to June 2018. Navigators identified patients with risk factors; initial and final blood pressure ( BP ) readings were performed in the physician's office; and interim …

Dental Hygiene Protocol Used By Nurses In The Hospital Setting A Pilot Survey, Tsenre M. Vigil

Dental Hygiene ETDs

Oral care is often dismissed or undervalued in the overall health and wellness of individuals and can be detrimental to patients in hospital-like settings. Although dental hygienists are educated to practice in alternative practice settings like pediatric offices, hospitals, nursing homes, schools and federally qualified health centers they are underutilized in such arenas. The purpose of this study is to learn about the University of New Mexico Hospital’s (UNMH) current oral hygiene care practices and protocols, nurses’ values and interests in inter-professional collaboration with a dental hygienist.

A feedback survey was created and intended recipients included all UNMH nurses regardless …

Redox-Sensitive, Cholesterol-Bearing Pegylated Poly(Propyleneimine)-Based Dendrimersomes For Drug And Gene Delivery To Cancer Cells, Partha Laskar, Sukrut Somani, Najla Altwaijry, Margaret Mullin, Deborah Bowering, Monika Warzecha, Patricia Keating, Rothwelle J. Tate, Hing Y. Leung, Christine Dufès

School of Medicine Publications

Stimuli-responsive nanocarriers have attracted increased attention as materials that can facilitate drug and gene delivery in cancer therapy. The present study reports the development of redox-sensitive dendrimersomes comprising disulfide-linked cholesterol-bearing PEGylated dendrimers, which can be used as drug and gene delivery systems. Two disulfide-linked cholesterol-bearing PEGylated generation 3 diaminobutyric polypropylenimine dendrimers have been successfully synthesized via an in situ two-step reaction. They were able to spontaneously self-assemble into stable, cationic, nanosized vesicles (or dendrimersomes) with lower critical aggregation concentration values for high-cholesterol-bearing vesicles. These dendrimersomes were able to entrap both hydrophilic and hydrophobic dyes, and they also showed a redox-responsive …

Orotic Aciduria, Aliah L. Fonteh

Fidei et Veritatis: The Liberty University Journal of Graduate Research

Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid. Orotic acid is commonly produced by this reaction in erythrocytes, hepatocytes, and kidney cells. Chemical modification of orotic acid in the pyrimidine pathway will generate nucleotides involved in DNA and RNA synthesis. Orotic aciduria can occur as a secondary manifestation due to a defect in an enzyme or transporter within the urea cycle, due to competitive inhibition by anti-cancer drugs such as allopurinol and 6-azauridine, or …

Use Of Hearing Protection In Neonatal Intensive Care Unit Patients: A Systematic Review Of The Evidence, Nathalie Chouery, Kathleen T. Dunckley

Journal of Early Hearing Detection and Intervention

Neonatal intensive care unit (NICU) settings present neonates with many environmental hazards, including exposure to dangerous sound intensity levels. Noise levels in NICUs worldwide overwhelmingly exceed the recommendations for safe exposure by the American Academy of Pediatrics. Environmental modifications and staff behavioral changes have proved ineffective to sufficiently reduce infant noise exposure. A systematic review of the literature was undertaken to answer if earmuffs improves physiologic stability, behavioral response, and sleep behavior, which are markers of stress response in NICU patients. Seven databases were searched for pertinent records using a specific search protocol. Seven studies met the review’s inclusion criteria …

Hispanic Parents’ Beliefs, Attitudes And Perceptions Toward Pediatric Hearing Loss: A Comprehensive Literature Review, Ana Caballero, Karen F. Munoz, Jared Schultz, Laurel Graham, Alex Meibos

Journal of Early Hearing Detection and Intervention

Objective: The purpose of this review was two-fold: (a) to understand research findings about Hispanic parents’ beliefs, attitudes, and perceptions related to hearing loss after having children who are deaf or hard of hearing, and (b) to inform future research needs that could expand audiologists’ ability to provide patient-centered care with this population.

Design: A comprehensive review of the literature was used to identify relevant articles for the review.

Study Sample: Five research articles met the inclusion criteria.

Results: Three primary themes emerged: (1) deafness causality, parents tended to describe the cause of the hearing loss in terms of religion …

Progress In Documented Early Identification And Intervention For Deaf And Hard Of Hearing Infants – Cdc’S Hearing Screening And Follow-Up Survey, United States, 2006–2016, Krishnaveni Subbiah, Craig A. Mason, Marcus Gaffney, Scott D. Grosse

Journal of Early Hearing Detection and Intervention

The national EHDI 1-3-6 goals state that all infants should be screened for hearing loss before 1 month of age; with diagnostic testing before 3 months of age for those who do not pass screening; and early intervention (EI) services before 6 months of age for those with permanent hearing loss. This report updates previous summaries of progress on these goals by U.S. states and territories. Data are based on the Hearing Screening and Follow-up Survey (HSFS) conducted annually by the Centers for Disease Control and Prevention for the years 2006–2016. Trends were assessed using 3-year moving averages, with rates …

Dual-Display Laparoscopic Laser Speckle Contrast Imaging For Real-Time Surgical Assistance, Jaepyeong Cha, Corey Zheng, Lung Wai Lau

Pediatrics Faculty Publications

Laser speckle contrast imaging (LSCI) utilizes the speckle pattern of a laser to determine the blood flow in tissues. The current approaches for its use in a clinical setting require a camera system with a laser source on a separate optical axis making it unsuitable for minimally invasive surgery (MIS). With blood flow visualization, bowel viability, for example, can be determined. Thus, LSCI can be a valuable tool in gastrointestinal surgery. In this work, we develop the first-of-its-kind dual-display laparoscopic vision system integrating LSCI with a commercially available 10mm rigid laparoscope where the laser has the same optical axis as …

Ada News - 11/05/2018, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: November 5, 2018, Maine Medical Center

What's Happening

No abstract provided.

Tri-Ponderal Mass Index In Survivors Of Childhood Brain Tumors: A Cross-Sectional Study., E Danielle Sims, Kuan-Wen Wang, Adam Fleming, Donna L Johnston, Shayna M Zelcer, Shahrad Rod Rassekh, Sarah Burrow, Lehana Thabane, M Constantine Samaan

Paediatrics Publications

Survivors of childhood brain tumors (SCBT) face a higher risk of cardiometabolic disorders and premature mortality compared to the general population. Excess adiposity is a known risk factor for these comorbidities. However, while SCBT have higher adiposity compared to healthy controls, measuring adiposity in clinical practice involves access to specialized equipment and may impact busy clinical services. Tri-ponderal Mass Index (TMI; kg/m

Impact Of Precision Medicine On Drug Repositioning And Pricing: A Too Small To Thrive Crisis, Venkataswarup Tiriveedhi

Biology Faculty Research

The pricing of targeted medicines continues to be a major area of contention in healthcare economics. This issue is further complicated by redefining the role of molecular testing in precision medicine. Currently, whilst pricing of clinical laboratory diagnostics is cost-based, drug pricing is value-based. The pricing for molecular testing is under pressure to change the traditional business model, for it has a critical subsidiary role in determining the final value of targeted medicines. The market size for drugs is reduced by molecular testing when patients with the same disease are stratified based on their genetics, it is critical to determine …

Role Of Noise And Parametric Variation In The Dynamics Of Gene Regulatory Circuits., Vivek Kohar, Mingyang Lu

Faculty Research 2018

Stochasticity in gene expression impacts the dynamics and functions of gene regulatory circuits. Intrinsic noises, including those that are caused by low copy number of molecules and transcriptional bursting, are usually studied by stochastic simulations. However, the role of extrinsic factors, such as cell-to-cell variability and heterogeneity in the microenvironment, is still elusive. To evaluate the effects of both the intrinsic and extrinsic noises, we develop a method, named sRACIPE, by integrating stochastic analysis with random circuit perturbation (RACIPE) method. RACIPE uniquely generates and analyzes an ensemble of models with random kinetic parameters. Previously, we have shown that the gene …

A Randomized Control Trial Of Anti-Inflammatory Regional Hypothermia On Urinary Continence During Robot-Assisted Radical Prostatectomy., Linda M Huynh, Douglas Skarecky, James R Porter, Christian Wagner, Jorn Witt, Timothy Wilson, Clayton Lau, Thomas E Ahlering

Articles, Abstracts, and Reports

The present study seeks to present a single-blind, randomized control trial of a hypothermic anti-inflammatory device, the endorectal cooling balloon (ECB), to assess whether regional hypothermia could improve 90-day and time to pad-free continence following robot-assisted radical prostatectomy (RARP). Five high-volume surgeons at three institutions had patients randomized (1:1) to regional hypothermia with ECB versus control. Patients were blinded to device use, as it was inserted and removed intraoperatively. Knowledge of device use was restricted to the operating room personnel only; recovery room and ward nursing staff were not informed of device use and instructed to indicate such if a …

Kinetics Of Dextromethorphan-O-Demethylase Activity And Distribution Of Cyp2d In Four Commonly-Used Subcellular Fractions Of Rat Brain, Barent N. Dubois, Farideh Amirrad, Reza Mehvar

Pharmacy Faculty Articles and Research

The purpose of this study was to compare the enzymatic kinetics and distribution of cytochrome P450 2D (CYP2D) among different rat brain subcellular fractions.

Rat brains were used to prepare total membrane, crude mitochondrial, purified mitochondrial, and microsomal fractions, in addition to total homogenate. Michaelis–Menten kinetics of the brain CYP2D activity was estimated based on the conversion of dextromethorphan (DXM) to dextrorphan using UPLC-MS/MS. Protein levels of CYP2D and subcellular markers were determined by Western blot.

Microsomal CYP2D exhibited high affinity and low capacity, compared with the mitochondrial CYP2D that had a much lower (∼50-fold) affinity but a higher (∼six-fold) …

What Conditions Enable Decentralization To Improve The Health System? Qualitative Analysis Of Perspectives On Decision Space After 25 Years Of Devolution In The Philippines, Harvy Joy Liwanag, Kaspar Wyss

Ateneo School of Medicine and Public Health Publications

Background

Decentralization is promoted as a strategy to improve health system performance by bringing decision-making closer to service delivery. Some studies have investigated if decentralization actually improves the health system. However, few have explored the conditions that enable it to be effective. To determine these conditions, we have analyzed the perspectives of decision-makers in the Philippines where devolution, one form of decentralization, was introduced 25 years ago.

Methods

Drawing from the “decision space” approach, we interviewed 27 decision-makers with an average of 23.6 years of working across different levels of the Philippine government health sector and representing various local settings. …

A Xenopus Oocyte Model System To Study Action Potentials, Aaron Corbin-Leftwich, Hannah E Small, Helen H Robinson, Carlos A. Villalba-Galea, Linda M Boland

School of Pharmacy Faculty Articles

Action potentials (APs) are the functional units of fast electrical signaling in excitable cells. The upstroke and downstroke of an AP is generated by the competing and asynchronous action of Na+- and K+-selective voltage-gated conductances. Although a mixture of voltage-gated channels has been long recognized to contribute to the generation and temporal characteristics of the AP, understanding how each of these proteins function and are regulated during electrical signaling remains the subject of intense research. AP properties vary among different cellular types because of the expression diversity, subcellular location, and modulation of ion channels. These complexities, in addition to the …

Serous Cystadenoma Of Pancreas : A Clinicopathologic Experience Of 23 Cases From A Major Tertiary Care Center, Muhammad Usman Tariq, Zubair Ahmad, Jamshid Abdul Ghafar, Nasir Ud Din

Department of Pathology and Laboratory Medicine

Background: Serous cystadenomas of pancreas are rare benign epithelial neoplasms, which predominantly occur in the pancreatic body and tail of elderly females. Majority of these tumors have microcystic appearance. Macrocystic and solid variants have also been described. A number of more aggressive cystic pancreatic lesions are included in the differential diagnosis. Distinction from such lesions is important for optimal management.
Objective: Our aim was to study the clinical and histological features of serous cystadenomas which would be helpful in making their correct diagnosis and understanding their behavior.
Methods: We reviewed 23 cases of serous cystadenomas diagnosed in our institution between …

The Life She Deserves: Medical Marijuana In The United States, John Hudak, George Burroughs, Maritza Bermudez

Brookings Scholar Lecture Series

Brookings Mountain West offered an event titled, "The Life She Deserves: Medical Marijuana in the United States on Monday, November 5, 2018. This event featured a viewing of the film, and was followed by a panel discussion with John Hudak, George Burroughs, and Maritza Bermudez. “The Life She Deserves” is an intimate portrait of Jennifer Collins and her family’s struggle to find a treatment to control her debilitating epilepsy. Because her legal pharmaceutical treatments cause severe side effects, Jennifer and her mother move across the country to access medical marijuana. The therapy provides Jennifer and her family with the relief …

The Validity Of The Push Band 2.0 During Vertical Jump Performance, Jason P. Lake, Simon Augustus, Kieran Austin, Peter Mundy, John J. Mcmahon, Paul Comfort, Guy G. Haff

Research outputs 2014 to 2021

The Push Band has the potential to provide a cheap and practical method of measuring velocity and power during countermovement vertical jumping (CMJ). However, very little is known about whether it conforms to laboratory-based gold standards. The aim of this study was to assess the agreement between peak and mean velocity and power obtained from the belt-worn Push Band, and derived from three-dimensional motion capture, and vertical force from an in-ground force platform. Twenty-two volunteers performed 3 CMJ on a force platform, while a belt-worn Push Band and a motion capture system (a marker affixed to the Push Band) simultaneously …

Human-Like Hyperplastic Prostate With Low Zip1 Induced Solely By Zn Deficiency In Rats., Louise Y. Fong, Ruiyan Jing, Karl J. Smalley, Zi-Xuan Wang, Cristian Taccioli, Sili Fan, Hongping Chen, Hansjuerg Alder, Kay Huebner, John L. Farber, Oliver Fiehn, Carlo M. Croce

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Prostate cancer is a leading cause of cancer death in men over 50 years of age, and there is a characteristic marked decrease in Zn content in the malignant prostate cells. The cause and consequences of this loss have thus far been unknown. We found that in middle-aged rats a Zn-deficient diet reduces prostatic Zn levels (P = 0.025), increases cellular proliferation, and induces an inflammatory phenotype with COX-2 overexpression. This hyperplastic/inflammatory prostate has a human prostate cancer-like microRNA profile, with up-regulation of the Zn-homeostasis-regulating miR-183-96-182 cluster (fold change = 1.41-2.38; P = 0.029-0.0003) and down-regulation of the Zn …

Medical School Watercooler Newsletter - November 4, 2018, Lindsey Lyle

Watercooler Newsletter

This is the November 4, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Health Physicians Group Welcomes New Urologists
• USA College of Medicine Expands Intramural Grants Program
• Mark Your Calendar: Lunch and Learn Sessions for Faculty

Microbial Diversity In Urban Environments: Concern For Antibiotic Resistance, Ality Aghedo, Mangala Tawde, Nazrul I. Khandaker

Publications and Research

We are almost oblivious to the presence of microorganisms in our daily lives, but they exist and come into contact with us all the time. While some bacteria are harmless, and even beneficial, other bacteria can cause infections. A common treatment to bacterial infections is antibiotics and the success of an antibiotic depends on the resistance of the bacteria to the antibiotic. We conducted experiments to identify the types of bacteria that can be found on surfaces or within soil environments that come into contact with a vast number of people on a daily basis and how this can affect …

Molecular Modulation Of Osteoblasts And Osteoclasts In Type 2 Diabetes, Selvalakshmi Rathinavelu, Crissy Guidry-Elizondo, Jameela Banu

Health & Biomedical Sciences Faculty Publications

Diabetes is a common disease affecting majority of populations worldwide. Since 1980, there has been an increase in the number of people diagnosed as prediabetic and diabetic. Diabetes is characterized by high levels of circulating glucose and leads to most microvascular and macrovascular complications such as retinopathy, nephropathy, neuropathy, stroke, and myocardial infarction. Bone marrow vascular disruption and increased adiposity are also linked to various complications in type II diabetes mellitus. In addition to these complications, type 2 diabetic patients also have fragile bones caused by faulty mineralization mainly due to increased adiposity among diabetic patients that affects both osteoblast …

School‐Level Body Mass Index Shapes Children's Weight Trajectories, Ashley W. Kranjac

Sociology Faculty Articles and Research

BACKGROUND

Embedded within children's weight trajectories are complex environmental contexts that influence obesity risk. As such, the normative environment of body mass index (BMI) within schools may influence children's weight trajectories as they age from kindergarten to fifth grade.

METHODS

I use 5 waves of the ECLS‐K—Kindergarten Class 1998‐1999 data and a series of multilevel growth models to examine whether attending schools with higher overall BMI influences children's weight status over time.

RESULTS

Results show that, net of child, family, and school sociodemographic characteristics, children who attend schools with higher rates of obesity have increased weight compared to children who …

Barriers To Change For Augmentative And Alternative Communication Use, Lauren E. Brown

Scholars Week

Title: BARRIERS TO CHANGE FOR AUGMENTATIVE AND ALTERNATIVE COMMUNICATION USE

Keywords: speech language pathology, augmentative and alternative communication, counseling, readiness to change, self-efficacy

In recent literature, there has been a marked increase in importance placed upon understanding what factors both positively and negatively impact the progress made by a client and that client’s family in response to speech and language therapy. Today, clinicians prioritize evidence based practice (EBP) when making clinical decisions, focusing on not only clinical expertise and best evidence, but also client and caregiver perspectives, or preferences (ASHA, 2018). In consideration of EBP for augmentative and alternative communication …

International Service Project Supporting Children's Sensory/Emotional Needs, Susan Jeantete, Suzanne Trotter, Andrea Cline, Kiersten Svatos

Occupational Therapy Collection

Background:

Health care providers in the United States must be prepared to collaborate inter-professionally for optimal care with culturally diverse populations. As of 2016, more than a quarter of the overall U.S. population was made up of immigrants and their U.S. born children (Zong, Batalova, & Hallock, 2017). International service-learning experiences have been used across a variety of health care educational programs, some providing inter-professional rehabilitation services, to help prepare students to work with individuals from varying cultures (Buff et al., 2015; Mu et al., 2016). Field immersion experiences can support the development of cultural competency in health care students, …

Restoration Of Left Ventricular Function Following Lvad Implantation – Remission Or Recovery? A Case Series., Shiksha Joshi, Mariah Barlow, Maya Guglin

The VAD Journal

Background

A wide range of left ventricular (LV) recovery rates on left ventricular assist device (LVAD) support have been reported. In this case series, we summarize our experience with LVAD explantation for presumed LV recovery.

Case series

Out of 240 patients who received an LVAD implant in our program since its inception, we explanted/inactivated the pump for presumed LV recovery in only three patients. All three of these patients had relapse of cardiomyopathy within 6 months of explantation.

Conclusion

Our experience does not support the existence of LV recovery following LVAD implantation as a common phenomenon. Improvement in LV function …

Resistance Training Volume Load With And Without Exercise Displacement, W. Guy Hornsby, Jeremy A. Gentles, Paul Comfort, Timothy J. Suchomel, Satoshi Mizuguchi, Michael H. Stone

ETSU Faculty Works

Monitoring the resistance training volume load (VL) (sets × reps × load) is essential to managing resistance training and the recovery–adaptation process. Subjects: Eight trained weightlifters, seven of which were at national level, participated in the study. Methods: VL was measured both with (VLwD) and without (VL) the inclusion of barbell displacement, across twenty weeks of training, in order to allow for comparisons to be made of these VL calculating methods. This consisted of recording the load, repetition count, and barbell displacement for every set executed. Comparisons were made between VL and VLwD for individual blocks of training, select training …

Performance Of Prostate Cancer Recurrence Nomograms By Obesity Status: A Retrospective Analysis Of A Radical Prostatectomy Cohort., Charnita Zeigler-Johnson, Aaron Hudson, Karen Glanz, Elaine Spangler, Knashawn H Morales

Department of Medical Oncology Faculty Papers

BACKGROUND: Obesity has been associated with aggressive prostate cancer and poor outcomes. It is important to understand how prognostic tools for that guide prostate cancer treatment may be impacted by obesity. The goal of this study was to evaluate the predicting abilities of two prostate cancer (PCa) nomograms by obesity status.

METHODS: We examined 1576 radical prostatectomy patients categorized into standard body mass index (BMI) groups. Patients were categorized into low, medium, and high risk groups for the Kattan and CaPSURE/CPDR scores, which are based on PSA value, Gleason score, tumor stage, and other patient data. Time to PCa recurrence …