Medicine and Health Sciences Commons^™

Morbidity Burden And Community-Based Palliative Care Are Associated With Rates Of Hospital Use By People With Schizophrenia In The Last Year Of Life: A Population-Based Matched Cohort Study, Katrina Spilsbury, Lorna Rosenwax, Kate Brameld, Brian Kelly, Glenn Arendts

Health Sciences Papers and Journal Articles

Objective: People with schizophrenia face an increased risk of premature death from chronic diseases and injury. This study describes the trajectory of acute care health service use in the last year of life for people with schizophrenia and how this varied with receipt of community based specialist palliative care and morbidity burden.

Method: A population-based retrospective matched cohort study of people who died from 01/01/ 2009 to 31/12/2013 with and without schizophrenia in Western Australia. Hospital inpatient, emergency department, death and community-based care data collections were linked at the person level. Rates of emergency department presentations and hospital admissions over …

Mechanical Suppression Of Osteolytic Bone Metastases In Advanced Breast Cancer Patients: A Randomised Controlled Study Protocol Evaluating Safety, Feasibility And Preliminary Efficacy Of Exercise As A Targeted Medicine, Nicolas H. Hart, Daniel A. Galvao, Christobel Saunders, Dennis R. Taaffe, Kynan T. Feeney, Nigel A. Spry, Daphne Tsoi, Hilary Martin, Raphael Chee, Tim Clay, Andrew D. Redfern, Robert U. Newton

Health Sciences Papers and Journal Articles

Background: Skeletal metastases present a major challenge for clinicians, representing an advanced and typically incurable stage of cancer. Bone is also the most common location for metastatic breast carcinoma, with skeletal lesions identified in over 80% of patients with advanced breast cancer. Preclinical models have demonstrated the ability of mechanical stimulation to suppress tumour formation and promote skeletal preservation at bone sites with osteolytic lesions, generating modulatory interference of tumour-driven bone remodelling. Preclinical studies have also demonstrated anti-cancer effects through exercise by minimising tumour hypoxia, normalising tumour vasculature and increasing tumoural blood perfusion. This study proposes to explore the promising …

The Imprint Of Childhood Abuse On Trauma-Related Shame In Adulthood, Joan A. Reid

Dignity: A Journal of Analysis of Exploitation and Violence

Research has consistently linked residual trauma-related shame among child sexual abuse (CSA) survivors to sexual revictimization, health risk behaviors, and poorer response to mental health treatment. However, questions remain regarding the imprint of childhood maltreatment on trauma-related shame including which CSA characteristics or types of childhood maltreatment contribute to residual shame in adulthood. Using data drawn from a prospective study of 174 primarily African American women with histories of CSA and a matched comparison group, this study explores whether specific characteristics of CSA (familial CSA, CSA with penetration, force used by CSA perpetrator), repeat sexual victimization in adolescence, childhood physical …

Learning To Fill The Labor Niche: Filipino Nursing Graduates And The Risk Of The Migration Trap, Yasmin Y. Ortiga

Research Collection School of Social Sciences

Overseas recruitment has become a common strategy in filling nurse shortages within U.S. health institutions, sparking the proliferation of nursing programs in the Philippines. Export-oriented education exacerbates a mismatch, however, between available jobs (in both the Philippines and the United States) and the number of nursing graduates, thus increasing joblessness and underemployment among Filipino youth. Pursing higher education as a means to migrate also puts Filipino students at risk of getting caught in a migration trap, where prospective migrants obtain credentials for overseas work yet cannot leave when labor demands or immigration policies change. Such problems highlight the complicated impact …

Accelerating Kenya’S Progress To 2030: Understanding The Determinants Of Under-Five Mortality From 1990 To 2015, Emily C. Keats, William Macharia, Neha S. Singh, Nadia Akseer, Nirmala Ravishankar, Anthony Ngugi, Arjumand Rizvi, Emma Nelima Khaemba, John Tole, Zulfiqar Ahmed Bhutta

Paediatrics and Child Health, East Africa

Introduction: Despite recent gains, Kenya did not achieve its Millennium Development Goal (MDG) target for reducing under-five mortality. To accelerate progress to 2030, we must understand what impacted mortality throughout the MDG period.

Methods: Trends in the under-five mortality rate (U5MR) were analysed using data from nationally representative Demographic and Health Surveys (1989–2014). Comprehensive, mixed-methods analyses of health policies and systems, workforce and health financing were conducted using relevant surveys, government documents and key informant interviews with country experts. A hierarchical multivariable linear regression analysis was undertaken to better understand the proximal determinants of change in U5MR over the MDG …

Personality Oriented Job Analysis To Identify Non-Cognitive Factors For A Doctor Of Physical Therapy Program In The United States, Maureen A. Conard, Kristin Schweizer

Psychology Faculty Publications

It aimed to conduct a personality oriented job analysis to identify non-cognitive factors that may predict successful performance or performance difficulties in doctorate in physical therapy (DPT) students. The study employed focus groups and a survey with 9 DPT subject matter experts. Focus group participants including 3 DPT faculty members and 4 recent graduates of the DPT program identified 22 non-cognitive factors. Out of them, 15 factors were possibly associated with successful performance and 7 factors were possibly associated with performance difficulties. The questionnaire employing the Combination Job Analysis Method resulted in 12 factors which could be used in selection, …

Using Simulated Family Presence To Decrease Agitation In Older Hospitalized Delirious Patients: A Randomized Controlled Trial, Christine M. Waszynski, Kerry A. Milner, Ilene Staff, Sheila L. Molony

Nursing Faculty Publications

Background: Simulated family presence has been shown to be an effective nonpharmacological intervention to reduce agitation in persons with dementia in nursing homes. Hyperactive or mixed delirium is a common and serious complication experienced by hospitalized patients, a key feature of which is agitation. Effective nonpharmacological interventions to manage delirium are needed.

Objectives: To examine the effect of simulated family presence through pre-recorded video messages on the agitation level of hospitalized, delirious, acutely agitated patients.

Design: Single site randomized control trial, 3 groups x 4 time points mixed factorial design conducted from July 2015 to March 2016.

Setting: Acute care …

Non-Congenital Severe Ocular Complications Of Zika Virus Infection, Mussaret B. Zaidi, C Gustavo De Moraes, Michele Petitto, Juan B. Yepez, Anavaj Sakuntabhai, Etienne Simon-Loriere, Matthieu Prot, Claude Ruffie, Susan S. Kim, Gladys E. Maestre

School of Medicine Publications

In 2016, during a major Zika virus (ZIKV) outbreak in Maracaibo, Venezuela, a 49-year-old woman and an unrelated 4-year-old boy developed bilateral optic neuritis 2–3 weeks after presenting an acute febrile illness characterized by low-grade fever, rash and myalgia [1]. Both patients presented sudden, painless bilateral loss of vision with no corneal or uveal abnormalities. Fundoscopic examination revealed oedema of the optic nerve and optic disc pallor. Optical coherence tomography confirmed bilateral optic nerve head swelling in the case of the adult, but it was not carried out in the child. Automated perimetry performed in the adult revealed bilateral diffuse …

Kaposi Sarcoma Incidence In Females Is Nearly Four-Fold Higher In The Lower Rio Grande Valley Compared To The Texas Average, Wendy Innis-Whitehouse, Xiaohui Wang, Nicolas Restrepo, Carlos Salas, Katia Moreno, Alvaro Restrepo, Megan Keniry

School of Medicine Publications

The Lower Rio Grande Valley (LRGV) is located on U.S.-Mexican border with a population that is 90% Hispanic[1]. Comprised of Hidalgo, Cameron, Starr and Willacy counties, this region has the highest poverty rate and one of the highest incidences of Type 2 diabetes in the United States[2],[3],[4]. Previous studies demonstrated a high prevalence of Human Herpes Virus 8 (HHV8) in the LRGV[5],[6],[7]. HHV8 infection has been causally linked to Kaposi Sarcoma (KS)[8]. Here, we retrospectively examine the incidence of KS in the LRGV in a set of HIV-negative Hispanic patients. Strikingly, the incidence of KS was higher in LRGV women …

Interpretation Bias Toward Ambiguous Information In Burnout And Depression, Renzo Bianchi, Eric Laurent, Irvin Sam Schonfeld, Jay Verkuilen, Chantal Berna

Publications and Research

Burnout has been defined as a job-related syndrome combining pervasive fatigue and loss of motivation. In recent years, evidence has mounted that burnout may reflect a depressive condition. In this study, we expanded on past investigations of burnout-depression overlap by focusing on interpretation biases toward ambiguous information among the two entities. We conducted a web-based study involving 1056 participants (83% female; mean age: 42.87). Burnout symptoms were assessed with the Shirom-Melamed Burnout Measure and depressive symptoms with the PHQ-9. The Ambiguous Scenarios Test (AST), a measure of interpretation bias validated among dysphoric individuals, was the outcome of interest. The AST …

Burnout Research: Eyes Wide Shut, Irvin Sam Schonfeld, Eric Laurent, Renzo Bianchi

Publications and Research

In a study published in a recent issue of Critical Care Medicine, Colville and Smith (2017) found modest overlap between burnout and depression and assumed that burnout and depression are distinct entities. For four reasons, we think that the study is seriously flawed. First, Colville and Smith assessed burnout symptoms with an abbreviated version of the Maslach Burnout Inventory (MBI), the psychometric properties of which are unclear. Second, they used clinically and theoretically arbitrary cutoff scores for categorizing burnout, a modus operandi that, unfortunately, has become commonplace in studies of medical professionals. Third, participants could be categorized as “burned out” …

Burnout-Depression Overlap: Nomological Network Examination And Factor-Analytic Approach, Renzo Bianchi, Irvin Sam Schonfeld

Publications and Research

Burnout has been defined as a condition in which individuals are left exhausted by a long-term confrontation with unmanageable job stressors. The question of whether burnout reflects anything other than depressive responses to unresolvable stress remains an object of debate. In this 911-participant study (83% female; mean age: 42.36), we further addressed the issue of burnout-depression overlap. Burnout was assessed with the exhaustion subscale of the Maslach Burnout Inventory-General Survey (MBI-GS) and depression with the PHQ-8. The relationships of burnout and depression with three jobrelated variables – illegitimate work tasks, work-nonwork interference, and job satisfaction – and three “context-free” variables …

Pap Utilization Survey In Nueva Vida, Nicaragua: Professional And Health Promotoras Partnership, Olushola O. Ogunleye, Bethesda J. O'Connell, Megan A. Quinn, Lea C. Florence, Kaitlyn Shirely

Journal of Social, Behavioral, and Health Sciences

Cervical cancer is the second most common cancer affecting women in developing countries and accounted for 84% of the global incidence of cervical cancer in 2012. Nicaragua is one country illustrating this disparity, with an annual cervical cancer mortality six times the U.S. rate. This may be explained by lack and poor utilization of effective screening programs, especially the Papanicolaou, or Pap, smear. This study resulted from a partnership formed by faculty and students from two U.S. universities and a Nicaraguan nonprofit organization to conduct projects to benefit a community in Nicaragua. To promote a free Pap smear program provided …

A Systematic Review Of Non-Pharmacological Interventions To Improve Nighttime Sleep Among Residents Of Long-Term Care Settings, Elizabeth Capezuti, Rana Sagha Zadeh, Kevin Pain, Aleksa Basara, Nancy Ziyan Jiang, Ana C. Krieger

Publications and Research

Background: Disturbances in sleep and circadian rhythms are common among residents of long-term care facilities. In this systematic review, we aim to identify and evaluate the literature documenting the outcomes associated with non-pharmacological interventions to improve nighttime sleep among long-term care residents.

Methods: The Preferred Reporting Items for Systematic Reviews guided searches of five databases (MEDLINE, Embase, CINAHL, Scopus, and Cochrane Library) for articles reporting results of experimental or quasi-experimental studies conducted in long-term care settings (nursing homes, assisted-living facilities, or group homes) in which nighttime sleep was subjectively or objectively measured as a primary outcome. We categorized each intervention …

The Science Of Neurobiology Of Sexual Assault Trauma And The Utah Legal System, Donna Kelly, Julie L. Valentine

Faculty Publications

Sexual assault triggers a cascade of physiological responses in victims, commonly referred to as the neurobiology of sexual assault trauma. Victims often report the inability to move or resist, memory loss, and loss of our altered feelings of consciousness – reactions which often negatively impact the perception of their credibility. Recently, the criminal justice system has begun to connect these normal, physiological responses in understanding common victim behaviors and responses. As knowledge of the neurobiology of sexual assault trauma disseminates throughout the criminal justice system, it is readily apparent that education, new protocols, and trauma informed interview techniques are required. …

Identity Practice: A Study Of Bangladeshi Immigrants Leisure Subculture And Identity Practices In Tallinn, Estonia, Aminul Islam

Khazar Journal of Humanities and Social Sciences

This paper addressed Game gathering in Tallinn, Estonia from the perspective of leisure subculture among Bangladeshi immigrants. By describing Identity and status practices, this paper figured how it is implemented through their leisure practices. This study also addressed the fact that leisure subculture is very important for the immigrants in order to get out of their stressful life as for many of them migration itself can be traumatic fact. Through ethnography this paper came up with the conclusion that leisure subculture provides a social cohesion which leads the immigrants to practice their different identity and status from within the community. …

The Advantages And Disadvantages Of Body Language In Intercultural Communication, Miramar Damanhouri

Khazar Journal of Humanities and Social Sciences

This study is an attempt to explore the advantages and disadvantages of non-verbal communication, specifically body language, in intercultural settings, and the extent to which non-verbal factors contribute to the success of communication , by interviewing 31 English language instructors at the English language Institute at King Abdulaziz University. The instructors came from different cultural backgrounds and their length of stay in Saudi Arabia varies from 1 year to more than 7 years. The findings show that although the main function of body language in an intercultural setting is to clarify meaning when language is a barrier, the difference in …

A Comparison Of The Antimicrobial Efficacy Of Silver Diamine Fluoride And Silver Nitrate: An Ex Vivo Study, Reham M. Alnajjar

Theses and Dissertations

A comparison of the antimicrobial efficacy of silver diamine fluoride and silver nitrate on various cariogenic bacteria: an ex vivo study By: Reham AlNajjar, D.D.S.

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University. Virginia Commonwealth University, 2019

Thesis Advisor: William Dahlke, D.M.D., Associate Professor and Chair of Pediatric Dentistry, School of Dentistry

Purpose: The use of silver-based antimicrobials is an emerging method for the treatment of dental caries. In this study, the authors compare the efficacy of the two most prominent silver- based therapeutics, silver diamine …

Design, Synthesis And Biological Evaluation Of Inhibitors Against Both Human And Mouse Microsomal Prostaglandin E2 Synthase-1 Enzymes, Kai Ding

Theses and Dissertations--Chemistry

As the principal pro-inflammatory prostanoid, prostaglandin E₂ (PGE₂) serves as mediator of pain and fever in inflammatory reactions. The biosynthesis of PGE₂ starts from arachidonic acid (AA). Cyclooxygenase (COX)-1 and/or COX-2 converts AA to prostaglandin H₂ (PGH₂), and PGE₂ synthases transform PGH₂ to PGE₂. Current mainstream approach for treating inflammation-related symptoms remains the application of traditional non-steroidal anti-inflammatory drugs (tNSAIDs) and selective COX-2 inhibitors (coxibs). As both categories shut down the biosynthesis of all downstream prostanoids, their application renders several deleterious effects including gastrointestinalulceration and cardiovascular risk. Microsomal prostaglandin …

A Breast Prosthesis Infection Update: Two-Year Incidence, Risk Factors And Management At Single Institution, Ashley Nadia Boustany, Shady Elmaraghi, Nneamaka Agochukwu, Benjamin Cloyd, Adam J. Dugan, Brian Rinker

Surgery Faculty Publications

Background: Infection following augmentation and prosthetic-based breast reconstruction can cause significant physical and psychological distress for patients. It may delay adjuvant therapies and compromise aesthetic outcomes. The aim of this study is to identify modifiable risk factors for infection and identify common bacterial isolates to achieve optimal outcomes for patients.

Methods: A retrospective cohort study was performed for patients undergoing implant-based breast reconstruction over a 2-year period. In each case, we documented demographics, co-morbidities, complications and antibiotic use. We reviewed treatments, infectious species cultured where applicable and all outcomes.

Results: A total of 292 patients met the inclusion criteria. Fifty-five …

Women And The Experience Of Pain And Opioid Use Disorder: A Literature-Based Commentary, Andrew L. Koons, Marna R. Greenberg Do, Mph, Facep, Robert D. Cannon Do, Gillian A. Beauchamp Md

Department of Emergency Medicine

It is generally understood that pain experience and opioid abuse have relied on male-dominated models. However, sex and gender play a role in both pain experience and opioid use disorder.

Using the previously validated Texas Tech University Health Sciences Center Sex and Gender Specific Health PubMed Advanced Search Tool, the authors used pertinent literature to develop this literature-based commentary on sex and gender differences in pain experience and opioid use disorder. Women report their experience of pain more frequently, have increased rates of diagnoses related to pain, have increased pain sensitivity, and have a variable response to pain and analgesia. …

The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 67, Issue 1, Winter 2018

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

This issue includes:

• Dean's Column
• Findings: "Living Electrodes" may change neurological device design
• Ch-ch-ch-changes: Jefferson's realignment of departments and programs
• The Difference Alumni Make: A message from Elizabeth Dale
• A Fighting Chance: Harrisburg's boxing scene has an unlikely ally in cardiologist Andrew Foy, MD '08
• Alumni Weekend
• 2017 Jefferson Gala: Gathering to celebrate our shared success
• Time Capsule
• The Shot Doc: Meet Herb Magee, head coach of Jefferson's men's basketball team, the Rams
• Going the Distance: Students bring compassion into the clinic in Nicaragua's remote mountains
• On Campus
• Stephanie Moleski, MD '05: Jefferson doctor moves from board room to exam …

Multifunctional Nanocomposites In Coating Technology: Synthesis, Characterization, Formulation, Evaluation And Application, Sudeshna Chakraborty

Graduate Research Theses & Dissertations

Application of Nanomaterials using nanotechnology has gained significant

attention in the coating industry in recent years. Their application has had a great

impact, particularly in the 3C industries (computer, communication, and construction).

Incorporation of nanomaterials into polymer carriers through a systematic approach to

coating processes can enhance various physical properties, such as mechanical,

optical, electrical and thermal properties. The current dissertation focused on the

synthesis and characterization of new nanomaterials like mesoporous silica or

nanocomposites like copper-doped zinc oxide that can be used in the coating to study

thermal cooling performance and enhancement of thermal conductivity. New thermal

devices will …

Investigating The Effects Of Orientation Control Of Graphene Nanoplatelet Suspensions By A Magnetic Field On The Viscosity Of A Nanofluid System, Radhika Iyer

Graduate Research Theses & Dissertations

In this investigation, the rheological behavior of paraffin oil containing diamagnetic suspensions is characterized under varying magnetic field conditions. The particles suspended in the white paraffin oil at mass concentrations of 0.1, 0.3, 0.5, 0.7 and 1% m/m are two-dimensional graphene nanoplatelets with an average thickness of 2 – 8 nm. Rheological experiments were conducted using a Brookfield DV2T viscometer with a modified cylindrical spindle over the range of shear rates between 192 s-1 to 1928 s-1. A Neodymium N42 ring magnet with a surface strength of 1.32 T generated the magnetic field conditions for the rheological experiments and was …

Design And Analysis Of Curcumin Conjugated Poly(Beta-Amino Ester) Networks For Controlled Release In Oxidative Stress Environments, Carolyn T. Jordan

Theses and Dissertations--Chemical and Materials Engineering

Oxidative stress, the imbalance of free radical generation with antioxidant defenses, leads to cellular inflammation, apoptosis and cell death. This compromised environment results in debilitating diseases, such as oral mucositis (OM), atherosclerosis, and ischemia/reperfusion injury. Antioxidant therapeutics has been a proposed strategy to ameliorate these imbalances and maintain homeostatic environments. However, the success of these approaches, specifically curcumin, has been limited due to characteristics such as hydrophobicity and high reactivity when released as bolus doses to contest to oxidative stress induced diseases. The development of a controlled release system to aid in protection of the antioxidant capacity of curcumin, as …

The Development Of Microfluidic Devices For The Production Of Safe And Effective Non-Viral Gene Delivery Vectors, Jason Matthew Absher

Theses and Dissertations--Chemical and Materials Engineering

Including inherited genetic diseases, like lipoprotein lipase deficiency, and acquired diseases, such as cancer and HIV, gene therapy has the potential to treat or cure afflicted people by driving an affected cell to produce a therapeutic protein. Using primarily viral vectors, gene therapies are involved in a number of ongoing clinical trials and have already been approved by multiple international regulatory drug administrations for several diseases. However, viral vectors suffer from serious disadvantages including poor transduction of many cell types, immunogenicity, direct tissue toxicity and lack of targetability. Non-viral polymeric gene delivery vectors (polyplexes) provide an alternative solution but are …

The Role Of Contact And Empathy In Stigma Toward Individuals With Mental Illness Among Mental Health And Non-Mental Health Professionals, Quincy A. Knolhoff

Masters Theses

This study was designed to help identify the factors that predict people's stigmatized attitudes toward individuals with mental illness. Corrigan (2002) suggested that stigmatized beliefs about individuals with mental illness may be detrimental to the potential recovery of these individuals, their self-esteem, empowerment, and their integration into society. One factor that has been found to reduce this stigma is personal contact with mentally ill individuals (Corrigan et al., 2002). Additionally, research has shown that empathy and principled moral reasoning are negatively correlated with prejudice, or stigma (McFarland, 2010). The current study examined level of contact, employment in a mental health …

Social Anxiety And Problematic Drinking In College Students: Examining Potential Mediators, Carissa Gutsmiedl

Masters Theses

Social anxiety and problematic drinking are among the most prevalent disorders present in the college population. Having one or both of these disorders while in college can be detrimental to academic performance and can increase dropout rates. Social anxiety has been found to precede problematic drinking in previous research. The purpose of this study was to help determine what variables may explain this relationship (i.e., mediators). The current study tested whether emotion regulation difficulties, drinking motives, alcohol outcome expectancies, and self-discrepancy mediated the relationship between social anxiety and problematic drinking among college undergraduates (N = 135). Results indicated that emotion …

A Qualitative Case Study On Best Practices Of Emotional Support Animal Policies, Jordan E. Dadez

Masters Theses

This study sought to understand the best practices and protocols of Emotional Support Animal policies in residential life. A qualitative case study was conducted to provide insight on the best practices of residential life Emotional Support Animal Policies. Four participants from institutions with established policies were interviewed to gain understanding of these protocols and policies, what is involved in the approval and accommodations process, and what challenges the participants face. The results showed a need to evaluate and change the current process that most institutions utilize for Emotional Support Animal approval. The approval process and accommodations process are two separate …

Is The Relationship Between College Drinking Behaviors And Social Anxiety Mediated By Alcohol Expectancies And Traumatic Life Experiences?, Cortney Lin Kingsmill

Masters Theses

The relationship between alcohol consumption and social anxiety is difficult to understand, as there have been mixed findings in the research. In general, a positive correlation has been found between the two, with a focus on the mediating effect of alcohol outcome expectancies. Both positive expectancies and trauma have been correlated positively with social anxiety and drinking behavior. This paper reviews the literature and examines the relationship between social anxiety and alcohol consumption. A mediated model between these two variables with the mediators being alcohol expectancies and traumatic experiences was proposed, but this model did not fit the date. Specifically, …