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2018

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Articles 12631 - 12660 of 15421

Full-Text Articles in Medicine and Health Sciences

St6gal-I Sialyltransferase Regulates The Activity Of Surface Receptors To Control Cell Signaling In Cancer And Immune Cells, Andrew Holdbrooks Jan 2018

St6gal-I Sialyltransferase Regulates The Activity Of Surface Receptors To Control Cell Signaling In Cancer And Immune Cells, Andrew Holdbrooks

All ETDs from UAB

Among the four classes of biological macromolecules, glycans are essential for proper cellular functioning. However, our knowledge of the contribution of these sugars, including the glycosyltransferases that add them, to cell signaling is limited. This dissertation focuses on the role of the ST6Gal-I sialyltransferase in modulating receptor-mediated signal transduction in cancer and inflammation. ST6Gal-I is a Golgi enzyme that conjugates α2-6-linked sialic acids to N-linked glycans on select glycoproteins. Through its sialylation of surface receptors, ST6Gal-I activity can significantly modify their function. The first section of this dissertation concentrates on the ST6Gal-I-mediated regulation of the signaling pathway of TNFR1, which …

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Novel Mediators Of The Blood Pressure Response To Acute Psychosocial Stress In Health And Disease, Brandon Fox Jan 2018

Novel Mediators Of The Blood Pressure Response To Acute Psychosocial Stress In Health And Disease, Brandon Fox

All ETDs from UAB

Psychosocial stress occurs in response to threatening or uncertainty-provoking stimuli and triggers a complex physiological reaction that facilitates survival and adaptation. In the cardiovascular system, acute psychosocial stress elicits a rapid increase in blood pressure, and importantly, cumulative exposure to psychosocial stress is a risk factor for cardiovascular disease. The present studies examined the impact of psychosocial stress on the cardiovascular system in both health and disease. Circulating endothelin-1 (ET-1) levels are induced by psychosocial stress. We hypothesized that endothelium-derived ET-1 contributes to the pressor response to stress via activation of the endothelin A (ETA) receptor. Vascular endothelium-specific ET-1 knockout …

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The Effect Of Mitochondrial-Derived Ros On Calcium Handling And Cardiac Function In Heart, Kah Yong Goh Jan 2018

The Effect Of Mitochondrial-Derived Ros On Calcium Handling And Cardiac Function In Heart, Kah Yong Goh

All ETDs from UAB

Mitochondria are abundantly present in metabolic active organs such as the heart. The presence of mitochondria are crucial to provide energy in the form of ATP, regulate calcium handling, facilitate cell fate, and are involved in metabolic modulation. In the process of generating ATP through oxidative phosphorylation, mitochondria produce reactive oxygen species (ROS) as a side product. In the heart, mitochondria is a major source of ROS. Under normal conditions, ROS are kept at a physiologically relevant and healthy level. Unfortunately, excessive ROS levels during pathological states, such as pressure overload heart failure, appears as a threat to the whole …

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Resilience In Caregivers Of Partners With Young Onset Dementia: A Concept Analysis, Karie R. Kobiske, Abir K. Bekhet Jan 2018

Resilience In Caregivers Of Partners With Young Onset Dementia: A Concept Analysis, Karie R. Kobiske, Abir K. Bekhet

College of Nursing Faculty Research and Publications

Introduction: Over 200,000 Americans diagnosed with young onset dementia (YOD), dementia diagnosed prior to age 65, are cared for by family members. This can be costly to caregivers’physical and psychological health. Some adapt well to the caregiver role and are said to be resilient. Aim/Question: This paper builds on current understanding of the concept of resilience and applies this to caregivers of partners diagnosed with YOD. Method: Concept analysis. Results: Resilient caregivers exhibit attributes including determination, flexibility, positive thinking, self-efficacy, resourcefulness, social support and spirituality. Discussion: YOD affects caregiver’s health. Much research has been done on interventions for dementia caregivers. …

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Pain And Academic Performance In Youth With Spina Bifida: The Mediating Role Of Neuropsychological Functioning, Diana Margaret Ohanian Jan 2018

Pain And Academic Performance In Youth With Spina Bifida: The Mediating Role Of Neuropsychological Functioning, Diana Margaret Ohanian

Master's Theses

Objective: The current literature has identified few modifiable condition parameters associated with academic performance in youth with spina bifida (SB). Nevertheless, youth with SB are more likely to struggle academically than their typically developing (TD) peers. Therefore, identifying areas for clinical intervention is paramount. Pain, an understudied secondary condition in youth with SB, has been found to be associated with poorer academic performance in TD youth. Further, neuropsychological functioning has been found to be both negatively associated with pain and positively associated with academic outcomes. The aims of this study were to examine (1) the relationship between pain and academic …

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Pomona Large Vessel Occlusion Screening Tool For Prehospital And Emergency Room Settings, Kessarin Panichpisal, Kenneth Nugent, Maharaj Singh, Richard Rovin, Reji P. Babygirija, Yogesh Moradiya, Karen Tse-Chang, Kimberly A. Jones, Katrina J. Woolfolk, Debbie Keasler, Bhupat Desai, Parinda Sakdanaraseth, Paphavee Sakdanaraseth, Alimohammad Moalem, Nazli Janjua Jan 2018

Pomona Large Vessel Occlusion Screening Tool For Prehospital And Emergency Room Settings, Kessarin Panichpisal, Kenneth Nugent, Maharaj Singh, Richard Rovin, Reji P. Babygirija, Yogesh Moradiya, Karen Tse-Chang, Kimberly A. Jones, Katrina J. Woolfolk, Debbie Keasler, Bhupat Desai, Parinda Sakdanaraseth, Paphavee Sakdanaraseth, Alimohammad Moalem, Nazli Janjua

College of Nursing Faculty Research and Publications

Background: Early identification of patients with acute ischemic strokes due to large vessel occlusions (LVO) is critical. We propose a simple risk score model to predict LVO. Method: The proposed scale (Pomona Scale) ranges from 0 to 3 and includes 3 items: gaze deviation, expressive aphasia, and neglect. We reviewed a cohort of all acute stroke activation patients between February 2014 and January 2016. The predictive performance of the Pomona Scale was determined and compared with several National Institutes of Health Stroke Scale (NIHSS) cutoffs (≥4, ≥6, ≥8, and ≥10), the Los Angeles Motor Scale (LAMS), the Cincinnati Prehospital Stroke …

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Addressing Challenges In Gaining Informed Consent For A Research Study Investigating Falls In People With Intellectual Disability, Portia Ho, Caroline Bulsara, Shane Patman, Jenny Downs, Anne-Marie Hill Jan 2018

Addressing Challenges In Gaining Informed Consent For A Research Study Investigating Falls In People With Intellectual Disability, Portia Ho, Caroline Bulsara, Shane Patman, Jenny Downs, Anne-Marie Hill

Nursing Papers and Journal Articles

Background: People with intellectual disability encounter multiple barriers to accessing quality, evidence based health care which is detrimental to their quality of life (Qol) and mortality. Engaging people with intellectual disability when conducting research is vital to address these QoL issues. People with intellectual disability have the right to engage in research pertinent to them but at present, they are under-represented in research and there are limited methods available to ensure that people with intellectual disability are fully supported to provide informed consent. Therefore the aim of this paper is to describe an informed consent process and reflect on the …

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Evolution Of Psychotherapy 2017: Quick Review Of The Conference, Ulkar Isayeva Jan 2018

Evolution Of Psychotherapy 2017: Quick Review Of The Conference, Ulkar Isayeva

Khazar Journal of Humanities and Social Sciences

No abstract provided.

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Structure And Socio-Dynamics Of Chechen Culture, Said Mushajiyev Jan 2018

Structure And Socio-Dynamics Of Chechen Culture, Said Mushajiyev

Khazar Journal of Humanities and Social Sciences

The structure of Chechen culture, which includes various cultural and historical layers (Nakh, Islamic, Russian) is of a symbiotic nature. The ethnic core of culture in the process of formation has accepted and at the same time rejected various civilizational influences.

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9-11 Year Old Students’ Perception Of Violence Reflected In Their Drawings, Melih Burak Ozdemir, Senem Gurkan, Yashar Barut Jan 2018

9-11 Year Old Students’ Perception Of Violence Reflected In Their Drawings, Melih Burak Ozdemir, Senem Gurkan, Yashar Barut

Khazar Journal of Humanities and Social Sciences

Violence, which can be defined as any threat towards the physical and psychological integrity of a human being, can result in fear, anxiety and severe behavior problems on children, whether exposed or witnessed. In this study, it is planned to achieve children’s perception of violence expressed by drawing and obtaining data in this way. In this study, the type of violence children portray in their drawings, how they determine to portray characteristics who perpetrate violence and are exposed to it as well as how is applied are analyzed. To measure how children perceive the violence, they were asked to draw …

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On The Relationships Among Efl Learners' Willingness To Communicate, Communication Apprehension, Self-Perceived Competence And Emotional Intelligence, Saeed Mehrpoor, Neda Soleimani Jan 2018

On The Relationships Among Efl Learners' Willingness To Communicate, Communication Apprehension, Self-Perceived Competence And Emotional Intelligence, Saeed Mehrpoor, Neda Soleimani

Khazar Journal of Humanities and Social Sciences

This study focused on the relationships among language learners' communication-related variables including willingness to start a communication (WTC), self-perceived communication competence (SPCC), communication apprehension (CA) and different subcomponents of emotional intelligence (EI). To this end a battery of questionnaires (WTC=20 items, Personal Report of Communication Apprehension (PRCA=24), SelfPerceived Communication Competence (SPCC =12), Emotional quotient inventory (EQI=133)) were distributed among 340 randomly selected Iranian EFL learners in Yasuj, Iran. Correlation and regression analyses showed that EFL student' EI dimensions were correlated with their WTC, SPCC, and CA. All five EI dimensions were found to be positively and significantly correlated with WTC …

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Addressing Barriers To Quality Of Underutilized Commodities And Services For Prevention And Management Of Pre-Eclampsia And Eclampsia In Kenya, Charity Ndwiga, Pooja Sripad, Charlotte E. Warren Jan 2018

Addressing Barriers To Quality Of Underutilized Commodities And Services For Prevention And Management Of Pre-Eclampsia And Eclampsia In Kenya, Charity Ndwiga, Pooja Sripad, Charlotte E. Warren

Reproductive Health

The Ending Eclampsia Project seeks to increase access to quality, underutilized interventions and commodities for the prevention, detection, and management of pre-eclampsia and eclampsia (PE/E), including promoting correct use of antihypertensive drugs and magnesium sulphate (MgSO4). This final report details the findings of a qualitative study that explored health system bottlenecks that prevent access to quality maternal and newborn health care in two Kenyan counties, Kakamega and Kitui, with a specific focus on PE/E. The study explored policy implementation gaps in Kenya’s newly devolved county government structure, to:1) assess the policy and health system environment for PE/E diagnosis, referral, and …

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How Are Educated Women In Ghana Regulating Fertility Without High Levels Of Modern Contraceptive Use?, Kazuyo Machiyama, Cicely Marston, Nancy Termini Lachance, Terence Adda-Balinia, Placide Tapsoba Jan 2018

How Are Educated Women In Ghana Regulating Fertility Without High Levels Of Modern Contraceptive Use?, Kazuyo Machiyama, Cicely Marston, Nancy Termini Lachance, Terence Adda-Balinia, Placide Tapsoba

Reproductive Health

While Ghana has made striking gains in enabling its women to use family planning to reduce family size—the total fertility rate shifted from 7.0 to 4.2 children per woman from the 1970s to the 2010s—the Strengthening Evidence for Programming on Unintended Pregnancy (STEP UP) studies found that educated women in Ghana are achieving their fertility goals by limited use of highly effective contraceptive methods. Their fertility regulation strategies involve contraceptive method mosaics that have not been captured by the DHS. This evidence summary aggregates research from the STEP UP Research Programme Consortium along with other related evidence to explore this …

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Expanding Access To Family Planning For Married Adolescent Girls In The Urban Slums Of Dhaka, Fauzia Akhter Huda, Nancy Termini Lachance Jan 2018

Expanding Access To Family Planning For Married Adolescent Girls In The Urban Slums Of Dhaka, Fauzia Akhter Huda, Nancy Termini Lachance

Reproductive Health

Early pregnancy is associated with adverse health, social, and economic consequences for girls, and Bangladesh has an adolescent fertility rate that is among the highest in the region. Poor, slum-dwelling girls are especially vulnerable. This policy brief outlines a project that icddr,b, a STEP UP project partner, initiated to test three innovative strategies aiming to support the unmet family planning needs of these girls. This brief concludes with government-level policy and program recommendations based on the evidence of this project for leveraging existing government health programs to better serve the needs of married adolescent girls and reduce their risks of …

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Accelerating Uptake Of Voluntary, Rights-Based Family Planning In Developing Countries, Kazuyo Machiyama, Francis Obare, Venkatraman Chandra-Mouli, Doris Chou, Mario Festin, Rajat Khosla, James Kiarie, Lale Say, Nandita Thatte Jan 2018

Accelerating Uptake Of Voluntary, Rights-Based Family Planning In Developing Countries, Kazuyo Machiyama, Francis Obare, Venkatraman Chandra-Mouli, Doris Chou, Mario Festin, Rajat Khosla, James Kiarie, Lale Say, Nandita Thatte

Reproductive Health

This brief summarizes evidence on the benefits of family planning for girls and women, their children, families, and societies. It also provides evidence on the cost-effectiveness of family planning programs; discusses reasons for unmet need for contraception and identifies ways to reduce unmet need and discontinuation; and describes progress in meeting FP2020 and the Sustainable Development Goals (SDGs). To meet the FP2020 and SDGs, significant investments are required by countries and donors in the following priority areas: sustainable financing, reaching all adolescents, expanding availability of services to the poorest and hard-to-reach populations, improving the quality of services, increasing the range …

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Expanding Contraceptive Choice, Heather Clark, Saumya Ramarao, Catherine Unthank, Kazuyo Machiyama, Nandita Thatte Jan 2018

Expanding Contraceptive Choice, Heather Clark, Saumya Ramarao, Catherine Unthank, Kazuyo Machiyama, Nandita Thatte

Reproductive Health

Expanding the range of contraceptive options helps individuals to make choices appropriate to their needs and circumstances, allows them to switch from one method to another if desired, and reflects a program focus on quality and rights. This policy brief outlines policy and program considerations in order to establish and maintain well-functioning supply chains for an expanded choice of contraceptives: introducing new contraceptive technologies to satisfy the diverse preferences of women and their partners; overcoming access barriers to existing methods such as adverse economic and social circumstances, including gender norms; and maximizing the potential of expanded contraceptive choice by ensuring …

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Ensuring Adequate Financing Of Family Planning Commodities And Services, Moazzam Ali, Benjamin Bellows Jan 2018

Ensuring Adequate Financing Of Family Planning Commodities And Services, Moazzam Ali, Benjamin Bellows

Reproductive Health

Increasing efficient and effective investment in family planning (FP) through the public and private sectors is key to meeting the FP2020 goal of helping 120 million additional women become modern contraceptive users. This policy brief identifies several policy and program considerations to ensure adequate financing of family planning commodities and services: sustained fundraising, pooling, and strategic purchasing; reaching new users and improving continuation rates among current users; and conducting further research on family planning quality performance metrics to test their correlation with higher continuation rates. Future efforts to reduce unmet need for FP must consider consumers’ out-of-pocket costs, programmatic cost-effectiveness, …

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Reducing Early And Unintended Pregnancies Among Adolescents, Francis Obare, Caroline W. Kabiru, Venkatraman Chandra-Mouli Jan 2018

Reducing Early And Unintended Pregnancies Among Adolescents, Francis Obare, Caroline W. Kabiru, Venkatraman Chandra-Mouli

Reproductive Health

Interventions to reduce unmet need for contraception and early and unintended pregnancies among adolescents should be critical components of family planning programs in developing countries. This evidence brief highlights evidence and provides research and program considerations for improving access to family planning and reducing unintended pregnancy. It describes the following five elements that must be in place in order to apply evidence to large-scale, national-level programs: collect, analyze, and use accurate and up-to-date data; formulate or revise national laws and policies; develop national adolescent sexual and reproductive health strategies; implement strategies with careful monitoring; and conduct periodic program reviews.

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Using Evidence To Improve Quality Of Pharmacy-Delivered Medical Abortion, Katharine Footman, Nancy Termini Lachance Jan 2018

Using Evidence To Improve Quality Of Pharmacy-Delivered Medical Abortion, Katharine Footman, Nancy Termini Lachance

Reproductive Health

The goal of family planning and reproductive health operations research is to generate evidence that helps policies and programs maximize access to and quality of services for women and their families. Yet the crucial step of ensuring the utilization of that evidence often receives inconsistent or inadequate attention. The goal of this case study is to document an activity of Marie Stopes International (MSI) in Kenya, part of the STEP UP research program consortium, which resulted in successful evidence utilization. STEP UP research on quality of care for medical abortion, particularly on pharmacy provision of medical abortion, has provided the …

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Assessing The Feasibility And Acceptability Of Community Health Extension Workers To Treat Hypertension Associated With Pregnancy: An Analysis Of Post-Intervention Findings, Salisu Mohammed Ishaku Jan 2018

Assessing The Feasibility And Acceptability Of Community Health Extension Workers To Treat Hypertension Associated With Pregnancy: An Analysis Of Post-Intervention Findings, Salisu Mohammed Ishaku

Reproductive Health

This brief reports on a study that tested the feasibility of tasking community health extension workers (CHEWs) with detecting and managing hypertension, and prescribing an oral antihypertensive drug at primary health care (PHC) facilities in Nigeria as part of a package of care for women with pre-eclampsia and eclampsia (PE/E). This evaluation measured improvements in knowledge retention and increases in early detection, prevention, and management of PE/E. Findings indicate that trained CHEWs working at intervention PHCs can correctly identify, differentiate, and manage normal, mild, moderate, and severe hypertension. These findings are important contributions to implementing Nigeria’s national task-shifting policy at …

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Baseline Evaluation Of Project Mesha In Bihar: Factsheet Results 2017-2018, Population Council Jan 2018

Baseline Evaluation Of Project Mesha In Bihar: Factsheet Results 2017-2018, Population Council

Reproductive Health

This fact sheet presents baseline results for an evaluation survey among women who were the primary decisionmakers in the rearing of goats in Bihar, India. The study underpins the Aga Khan Foundation’s implementation of “Project Mesha,” a community-based program to develop the potential of goat farming among women goat rearers in four blocks of Muzaffarpur district. The aim of the project is to increase the income and empowerment of women goat rearers through the implementation of Project Mesha in JEEViKA-run self-help groups. The fact sheet includes data on demographic and household profiles; goat ownership, rearing, income, and productive resources; access …

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Cesarean Section Deliveries In Egypt: Trends, Practices, Perceptions, And Cost, Nahla G. Abdel-Tawab, Doaa Oraby, Nevine Hassanein, Shatha El-Nakib Jan 2018

Cesarean Section Deliveries In Egypt: Trends, Practices, Perceptions, And Cost, Nahla G. Abdel-Tawab, Doaa Oraby, Nevine Hassanein, Shatha El-Nakib

Reproductive Health

In Egypt, the past decade has witnessed a sharp increase in the prevalence of cesarean section (CS) with the most recent Egypt Demographic and Health Survey documenting a CS rate of 52 percent, suggesting that cesarean delivery might be overused or used for inappropriate indications. This study aimed to explore trends, practices, and costs associated with CS deliveries to women, their families, and the health system, as well as factors that may contribute to increased use of CS in Egypt. Participating physicians and key informants unanimously agreed that the CS mode of delivery was over-used in Egypt. Perceived reasons underlying …

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Changes In Fgm/C In Somaliland: Medical Narrative Driving Shift In Types Of Cutting, Richard A. Powell, Mohamed Yussuf Jan 2018

Changes In Fgm/C In Somaliland: Medical Narrative Driving Shift In Types Of Cutting, Richard A. Powell, Mohamed Yussuf

Reproductive Health

In Somalia, female genital mutilation/cutting (FGM/C) prevalence is nearly universal at 98 percent. This qualitative study sought to explore: 1) views and experiences of married and unmarried men and women on FGM/C and potential changes in its practice; 2) individual, family, and societal factors contributing to any changes, or continuation of FGM/C; 3) the knowledge, views, and experiences of healthcare workers who offer FGM/C services and their role as change agents rather than providers; and 4) how healthcare systems’ capacities can be strengthened for management and prevention. The study finds that normative changes appear to be occurring in Somaliland society …

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Changes In Household Well Being And Resilience: The Role Of Population, Family Planning And Reproductive Health In The Tuungane Project, Kristen P. Patterson Jan 2018

Changes In Household Well Being And Resilience: The Role Of Population, Family Planning And Reproductive Health In The Tuungane Project, Kristen P. Patterson

Reproductive Health

Both the family planning sector and the environmental sector will be interested in this synopsis of findings from a study of the first four years of the Tuungane integrated population, health, and environment (PHE) project in Tanzania. The objectives of the Tuungane Project are to achieve healthier families, healthier forests, and healthier fisheries, using an integrated, cross-sectoral approach. Analyses of the 2011 baseline and 2016 midline quantitative data, and additional qualitative data from 2016, measured the project’s progress and shed light on the contribution of the project interventions to building resilience, and on the links between family planning and other …

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Collaborative Work With Somaliland Stakeholders To Increase Evidence Based Decision Making In Fgm/C, Chantalle Okondo Jan 2018

Collaborative Work With Somaliland Stakeholders To Increase Evidence Based Decision Making In Fgm/C, Chantalle Okondo

Reproductive Health

The Population Council collaborated with partners Orchid Project and Somaliland Family Health Association to pilot a new approach to disseminating research findings in order to increase the impact of evidence-based decisionmaking in program, policy, and investments in female genital mutilation/cutting (FGM/C). This brief reports on a recent workshop that utilized an open space approach to encourage review of recent key evidence on FGM/C in Somaliland; explore UNICEF’s six elements of abandonment and their relevance to the Somaliland context; link research with decisionmaking; and develop action plans. Participants identified six key themes for further reflection: behavioral/social change, medicalization, policy, child rights, …

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Dynamics Of Injectable Contraceptive Use In India, The Evidence Project Jan 2018

Dynamics Of Injectable Contraceptive Use In India, The Evidence Project

Reproductive Health

This brief describes a research study by the Population Council, with support from USAID/India, whose purpose is to provide evidence that can be used to strengthen the family planning program and meet the needs of reversible contraceptive users who want to prevent pregnancy in India. Understanding the experiences of the small but growing population of women choosing the injectable is important as the Government of India continues to roll out injectable contraceptive methods in the public sector. The report’s key recommendations include: disseminating messaging about potential side effects of the injectable, institutionalizing quality of care in pre-service trainings for all …

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Dynamics Of Interval Iud Use In India, The Evidence Project Jan 2018

Dynamics Of Interval Iud Use In India, The Evidence Project

Reproductive Health

The IUD is an important long-acting, reversible contraceptive method, and an alternative to permanent female sterilization that does not carry the risk of regret. In India, as the government aims to expand the basket of reversible method choice available to women, understanding the experiences of those who use the interval IUD is paramount. This brief describes a study by the Population Council, with support from USAID/India, which found that overall there is room to improve the quality of services clients receive. The report recommends disseminating messaging about potential side effects of the IUD, training frontline health workers on four domains …

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Dynamics Of Oral Contraceptive Pill Use In India, The Evidence Project Jan 2018

Dynamics Of Oral Contraceptive Pill Use In India, The Evidence Project

Reproductive Health

The purpose of this brief is to provide evidence that can be used to strengthen the family planning program in India, particularly for community-based and facility-based distribution of oral contraceptive pills (OCPs), use of which remains low despite their availability. Understanding women’s interactions with frontline health workers while obtaining the method and during follow-up counseling can help the Government of India improve its National Family Planning Program. Based on its findings, the report recommends that all providers, especially frontline health workers, receive training focusing on four domains of quality of care: 1) respectful care, 2) counseling to enable appropriate method …

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Dynamics Of Postpartum Iud Use In India, The Evidence Project Jan 2018

Dynamics Of Postpartum Iud Use In India, The Evidence Project

Reproductive Health

Evidence suggests that in India, compared to married women in general, postpartum married women have a much higher need for family planning that remains unmet. India’s postpartum IUD (PPIUD) program aims to help postpartum women space pregnancies and prevent mistimed or unwanted births. The majority of PPIUD users in this study were young, educated, and had one child. Most were involved in making the final decision about which family planning method to use after discussions with the provider, and most had spoken with a frontline health worker at least once about family planning methods in the three months preceding birth …

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Ending Eclampsia: Phc Ph/E_Plus Model, Charlotte E. Warren Jan 2018

Ending Eclampsia: Phc Ph/E_Plus Model, Charlotte E. Warren

Reproductive Health

Pre-eclampsia and eclampsia (PE/E)—life-threatening high blood pressure and excess protein in the urine after 20 weeks gestation—is a leading cause of pregnancy-related deaths. These deaths are preventable, yet essential medicines and tools to treat this disorder are often unavailable in low-resource settings. The Population Council implemented a two-phase intervention involving training, mentoring, and supervising providers at secondary facilities on detection and management of PE/E patients (Phase 1), and training primary health care (PHC) providers to administer a modified loading dose of magnesium sulphate and refer women to secondary health facilities for monitoring (Phase 2). This brief describes the Population Council’s …

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