Medicine and Health Sciences Commons^™

Novel Antioxidant Properties Of Doxycycline, Dahn L. Clemens, Michael J. Duryee, Cleofes Sarmiento, Andrew Chiou, Jacob D. Mcgowan, Carlos D. Hunter, Sarah L. Schlichte, Jun Tian, Lynell W. Klassen, James R. O'Dell, Geoffrey M. Thiele, Ted R. Mikuls, Matthew C. Zimmerman, Daniel R. Anderson

Journal Articles: Cellular & Integrative Physiology

Doxycycline (DOX), a derivative of tetracycline, is a broad-spectrum antibiotic that exhibits a number of therapeutic activities in addition to its antibacterial properties. For example, DOX has been used in the management of a number of diseases characterized by chronic inflammation. One potential mechanism by which DOX inhibits the progression of these diseases is by reducing oxidative stress, thereby inhibiting subsequent lipid peroxidation and inflammatory responses. Herein, we tested the hypothesis that DOX directly scavenges reactive oxygen species (ROS) and inhibits the formation of redox-mediated malondialdehyde-acetaldehyde (MAA) protein adducts. Using a cell-free system, we demonstrated that DOX scavenged reactive oxygen …

Preliminary Understanding Of Complexities In Swimming Performance Of Common Minnow (Cyprinidae) Taxa, Crystal Nichols, Austin Smith, Stephen Huelsman, Cara Schemmel, Jason C. Doll, Stephen J. Jacquemin

Biological Sciences Faculty Publications

Understanding swimming performance of native freshwater fishes has implications for ecology, conservation, and management. In particular, this type of information has practical importance for improving the understanding of fish dispersal, occurrence, migration, and invasive potential. The objective of this study was to characterize swimming performance of 2 taxa from the comparatively understudied minnow family (Cyprinidae) and test for potential drivers as a function of total length, sex, habitat, morphology, or some combination. The study assessed Spotfin Shiner (Cyprinella spiloptera; n = 66) and Bluntnose Minnow (Pimephales notatus; n = 24) populations from an ontogenic range of male and …

Baseline Patient Characteristics Associated With Response To Biologic Therapy In Patients With Psoriatic Arthritis Enrolled In The Corrona Psoriatic Arthritis/Spondyloarthritis Registry., Philip Mease, Chitra Karki, Mei Liu, Arthur Kavanaugh, Christopher T Ritchlin, Doquyen Hoa Huynh, Jacqueline B Palmer, Jeffrey D Greenberg

Articles, Abstracts, and Reports

Objectives: To compare baseline characteristics between patients with psoriatic arthritis (PsA) who achieved and did not achieve minimal disease activity (MDA) with biologic therapy in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis Registry.

Methods: Patients with PsA aged ≥18 years enrolled between March 2013 and March 2016 who were receiving biologics at enrolment (baseline), not in MDA and had ≥2 follow-up visits were included. Patients were classified as those who remained on their index biologic and achieved MDA at the second follow-up visit (MDA achievers (MDA-A)) and those who did not (MDA non-achievers (MDA-NA)). Demographics, clinical characteristics, patient-reported outcomes and medication history …

Relationship Between Diet And Learning Differences In Children, Amelia Hamilton, Ramona Stone

Public Health Sciences Student Work

There is growing recognition that learning disabilities are associated with a variety of factors, including diet. Prior research showed that children in need of special education services eat less home prepared meals and more non-home-prepared meals, which can lead to obesity, inadequate diet, and lethargy. Additional research along with parental health education to promote healthy nutritional decisions and skills for preparing meals is necessary.

Overweight And Underserved In Children: A Contemporary American Paradox, Elyse J. Barletta-Sherwin, Ramona Stone

Public Health Sciences Student Work

• Childhood overweight and obesity trends are serious problems placing children at greater risks for adverse health outcomes and developmental issues.

• Between 2011 and 2014, obesity prevalence hovered near 17% for children 6-12 years.

• As of 2014, an estimated 14% of U.S. households were labeled food insecure, with 7.9 million children living within these underserved domains. In recent years, there has been growing concern that food insecurity and overweight and obesity conditions may be associated with each other, especially amongst children.

Effects Of Kernel Processing At Harvest Of Brown Midrib Corn Silage On Finishing Performance Of Steers, Lauren A. Ovinge, F. Henry Hilscher, Curtis J. Bittner Bittner, Bradley M. Boyd, John N. Anderson, Galen E. Erickson

Nebraska Beef Cattle Reports

A 2 × 3 factorial finishing study evaluated kernel processing in three corn silage hybrids on finishing performance of yearling steers fed 40% silage. The three hybrids included a control corn silage (CON), a brown midrib (bm3), and a brown midrib with a softer endosperm (bm3-EXP). No interactions were observed between hybrids and kernel processing (P > 0.45). Feeding both bm3 hybrids increased dry matter intake and average daily gain over CON (P < 0.01). Cattle fed bm3-EXP and bm3 had lower feed to gain than CON (P = 0.04), with no differences between the two brown midrib hybrids. Feeding silage that has undergone kernel processing decreased dry matter intake with similar average daily gain, which decreased feed to gain by 2.6% at 40% inclusion compared to non-processed silage (P = 0.10). The improvement in silage is calculated to be 6.5% (2.6/40) when kernel processing was utilized as compared to not kernel processing the corn silage hybrids.

American Nursing Students' Immersion Experience In Ghana: A Qualitative Study, Srijana Bhandari

All Graduate Theses, Dissertations, and Other Capstone Projects

Health care providers are more than ever challenged to care for patients due to multicultural nature of American society. Studies report that health care disparities widely exist in our health care system and patients of different racial and cultural backgrounds do not receive adequate health care. Nurses are in the position to prevent and eliminate such disparities by providing individualized care to these patients. Nurses must be well equipped with knowledge and training to deliver care that is relevant and within the cultural context of patients they encounter. Studies have identified study abroad program as one of the approaches to …

The Harsh Reality: A Feminist Perspective On The Experiences Of Women Coaching Male Athletes, Emilee Shearer

All Graduate Theses, Dissertations, and Other Capstone Projects

This study, using a qualitative approach, examines the impact of patriarchy on females who coach a male-dominated sports team. The purpose of the study is to identify and examine the experiences of females who coach a male-dominated sports team in order to have a better understanding of the impact of the gender binary and patriarchy in the sport field. A qualitative approach was used in this study to gain an understanding of the individual and commonality of the experiences of women coaches. There were five female coaches interviewed; one was a high school basketball coach, two were high school football …

Outcomes Of Cataract Surgery At Teaching Hospital In Karachi, Shaukat Ali Chhipa, Mustafa Kamal Junejo

Section of Ophthalmology

Objective: To assess outcomes of cataract surgery at a tertiary care hospital in Karachi.
Methods: This retrospective study was conducted at Aga Khan University Hospital, Karachi, and comprised data of patients who underwent cataract surgery from January 2011 to December 2015. The data was collected using guidelines based on World Health Organisation systems for quality monitoring. Postoperative follow-up was done at 1 day, 1 week, 4 weeks and after 12 weeks. Visual acuity was recorded as good (6/6-6/18), borderline (6/18-6/60) and poor (<6/60). Intraoperative and postoperative complications were also noted.
Results: Of the 570 patient chartsreviewed, 527(92.45%) were included in the study. Among them, 302(57.4%) were females …

Llusd Articulator - Volume 29, Number 1, Loma Linda University School Of Dentistry, So Ran Kwon, Abhishek Batra, Trina Kindred, Kayla Perez-Ortiz, Min Wang, Euni Cho, Udochukwu Oyoyo

Articulator (Dentistry)

Contents:

4 | Dean’s brown bag
6 | Robert Smith’s generous gift
8 | Inaugural RDAEF class graduates
10 | Zambian miracle
13 | Mark Estey new academic dean
17 | Esther Valenzuela assistant dean
18 | Graham Stacey retires
20 | One Homecoming Number 2
26 | Fostering LLUSD student research
34 | Student research winners
42 | LLUSD at ASDR
46 | News

Describing Independent And Chain Pharmacies Within The Kentucky Medicaid Network, Kimber Woodrum

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The shift in healthcare towards cost-savings mechanisms is hindering business operations of pharmacies in Kentucky, especially independent pharmacies. Independent pharmacists have reported that the operations of pharmacy benefit managers within Kentucky Medicaid networks have created financial hardships for their pharmacies and there is a threat of closure that could be associated with a potential access barrier to pharmacy services for Medicaid beneficiaries. During legislative meetings, much focus was on this issue and several bills are currently being drafted to correct this issue. It is important to define independent pharmacy and describe, geographically and in terms of utilization, chain and independent …

Retrospective Policy Analysis On The Efficacy Of The Army Hearing Program, Ahmad Brandelle Alexander

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The present study (1) examined the Army Hearing Program (AHP) and (2) provided a retrospective policy analysis on several of the policies embedded within the AHP, more specifically the hearing readiness policy, to determine their efficacy and impact regarding noise-induced hearing loss (NIHL). The Beaufort Longest Framework was the analytic framework for this project. It was also used to structure the writing and formatting of this report. An extensive literature review of Army Medical Department (AMEDD) journals and Public Health journals were used in addition to several published Army Regulations and Pamphlets for guidance within conducting the Methods section of …

Select Antimicrobial Resistance Trends In Kentucky’S Bovine Population And Antibiogram Development, Jessica Morehouse

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction: Antimicrobial resistance (AMR) is a complex problem that affects all of society and is driven by many interconnected factors. It is important to monitor AMR trends in veterinary medicine to accurately pursue appropriate antibiotic treatment of ill animals. Antibiogram development is also an important tool in guiding the veterinary practitioner in treating empirically or while a culture and susceptibility is being performed.

Methods: This study compared bacterial susceptibility in voluntary samples submitted to the University of Kentucky Veterinary Diagnostic Laboratory and the Murray State University Breathitt Veterinary Center between 2012 and 2017. Equality of proportions was used to compare …

Overdose Prevention And Naloxone Distribution In Jefferson County, Brittany Coleman

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The United States in battling an opioid epidemic, and rates of overdose fatality have soared to record highs. Kentucky is among the states with highest rates of opioid overdose fatality, and Jefferson County is responsible for about a quarter of all cases. Overdose Prevention and Naloxone Distribution (OPND) programs have been shown to decrease fatality rates by providing a medication that literally reverses opioid overdose. The programs provide other services such as education and connection to recovery facilities.

Currently, the Kentucky Harm Reduction Coalition provides naloxone kits to the residents of Jefferson County, but they do not have a regular …

Assessment Of Clinical And Blood Gas Parameters In Healthy And Diarrhoeic Calves, Patrick Dillane

Theses

Neonatal calf diarrhoea (NCD) is a major problem to calf health worldwide. Metabolic acidosis, electrolyte imbalances are common complications of NCD, consequently, blood gas analysis is regarded as the gold standard test to assess of severity of these abnormalities in diarrhoeic calves. The objective of this research was to develop blood gas reference ranges for neonatal calves accounting for influencing physiological and environmental factors. As this disease is commonly treated by primary producers, previously published clinical assessment scoring chart was also analysed and compared to gold standard blood gas, in addition to next- generation biomarkers for severity diagnosis for NCD. …

The Effects Of A Cognitive Training Program For Cognitively Intact Older Adults, Caroline Kinskey

All Graduate Theses, Dissertations, and Other Capstone Projects

Cognitive training is a term used to describe programs that provide guided practice on tasks requiring different cognitive abilities such as memory or language. It is assumed that regular practice will improve or maintain functioning in a particular cognitive domain (e.g., memory) and those results will generalize beyond the context of training. Results have been mixed in the existing literature that has evaluated the potential benefits of cognitive training on cognitive and emotional functioning in cognitively intact older adults. This study investigated the effectiveness of a cognitive training program for older adults with no to very minimal cognitive decline. Nine …

How Graduate Experience Changes Beliefs In Working With Culturally And Linguistically Diverse Populations: A Survey Study, Stephanie Bove

All Graduate Theses, Dissertations, and Other Capstone Projects

Speech-language pathologists work in a variety of settings that require savvy transitions between patients from many cultures and backgrounds. Graduate students may get little practice working with culturally and linguistically diverse populations depending upon where they perform their practicum and internships. Researchers at a mid-western university developed a survey to collect student perspectives regarding cultural competence. A single cohort received the survey at three intervals to track a change in responses from the beginning of their first year of graduate school through their clinical fellowship. Students took a Multicultural Issues class between their first and second survey responses. Data collected …

Pre-Sleep Routines In Adult Normal Sleepers, Jean Koketsu

Occupational Therapy Doctorate Capstone Projects

Sleep is the most important restorative occupation, and pre-sleep routines, which precede sleep, have not been explored in normal adult sleepers. Routines are an important construct in occupational therapy, but it is not well-researched.

The purpose of this project is to add to the body of knowledge regarding pre-sleep routines through description by normal sleepers. This research can inform occupational therapists in regard to the usual patterns and dynamics of pre-sleep routines. Open systems theory, a grounded theory approach, and graphic and interview methods were used in this qualitative study.

Participants were 16 adults, between the ages of 23 and …

Cognitive And Metacognitive Factors In Reading Comprehension For Occupational Therapy Assistant Students, Cynthia L. Meyer

Occupational Therapy Doctorate Capstone Projects

Difficulties with reading comprehension among occupational therapy assistant (OTA) students can diminish their ability to understand didactic textual information limiting clinical performance and can impact OTA attrition rates and limit graduate success when completing the national certification examination.

Participants were one cohort of OTA students from a rural public community college.

This was a convergent mixed-method design (Creswell & Creswell, 2018). The students’ perceptions of cognitive and metacognitive factors affecting reading and the students’ preferences for cognitive and metacognitive strategies were assessed through a 59-item survey assessment combining the Text-Learning Strategies Inventory (TLSI) (Merchie, Van Keer, & Vandevelde, 2014), the …

Perceptions Of Atp Certified Occupational Therapy Practitioners On Assistive Technology Education In Occupational Therapy Programs, Karen M. Dishman Otd, Otr, Atp

Occupational Therapy Doctorate Capstone Projects

This capstone project focused on identifying which categories of assistive technology (AT) that practitioners perceived to be needed in entry-level master’s occupational therapy (OT) programs; and validating the need for post-professional AT training and post-professional AT certificate programs. For this capstone project, a survey approach was used as the data collection method. The purpose of the survey was to determine perceptions of OT practitioners on AT education received during their entry-level OT program. The survey was returned by 148 occupational therapy practitioners certified as assistive technology professionals (ATP) by the Rehabilitation and Engineering Society of North America (RESNA). Results indicated …

Occupational Therapy Intervention For Project Search Interns With Autism Spectrum Disorder: Potential For Improved Transition Outcomes, Jessie L. Bricker

Occupational Therapy Doctorate Capstone Projects

As the prevalence of autism spectrum disorders (ASD) continues to rise, it is increasingly important to address the needs of adults with ASD as they transition into the work world. Project SEARCH, an internationally recognized program, has been successful in assisting individuals with disabilities in attaining competitive employment. Yet even in this program model, individuals with ASD have lower employment outcomes than individuals in other disability categories. The purpose of this action research study was to explore the needs of individuals with high functioning autism spectrum disorder (HFASD) within the Project SEARCH program from their own perspectives, and to examine …

The Adaptation To Head And Neck Cancer In The Veteran Population, Diane Marie Sobecki-Ryniak

Wayne State University Dissertations

ABSTRACT

ADAPTATION TO HEAD AND NECK CANCER IN THE VETERAN POPULATION: A PILOT STUDY

By

DIANE SOBECKI-RYNIAK

December 2018

Advisor: Dr. Margaret Campbell

Major: Nursing

Degree: Doctor of Philosophy

Post-traumatic stress disorder in the head and neck cancer veteran population may present a challenge to adaptation during diagnosis and treatment of illness. The evaluation of post traumatic stress disorder, anxiety, depression and quality of life were examined and correlated against symptom occurrence and triggering of post traumatic symptoms across experiences. A significant correlation between PTSD-C and PTSD-S was found (r = 0.91, p = 0.001); there was a non-significant correlation …

Lgb Help-Seeking For Mental Health And Substance Abuse Services In Rural Northern Michigan, Jennifer Towns

Walden Dissertations and Doctoral Studies

Lesbian, gay, and bisexual (LGB) individuals are often exposed to stressors based on their nonheterosexual status; they may have unique needs related to help-seeking for mental health in a rural area where more people identify as religious or as politically conservative. To date, there have been no studies on the mental health help-seeking experiences of LGB individuals in rural Northern Michigan. This qualitative, single case study was completed to explore the help-seeking experiences of 10 LGB individuals who were recruited through criterion and snowball sampling. In-depth, semi structured interviews were conducted. Transcribed interview data were entered into Nvivo software for …

Differential Treatment Outcome Factors For Custodial And Noncustodial Mental Health Care Programs, Sheila Fay Waters

Walden Dissertations and Doctoral Studies

Researchers have suggested that jails and prisons in the United States are becoming the new mental health clinics, contributing to the phenomenon of mass incarceration and costing upwards of $15 billion per year in public revenue. The problem is no conclusive evidence exists that treatment in these custodial environments is more effective than that provided by noncustodial programs; especially for substance users. Additionally, the continuing incarceration of people with mental health problems by the hundreds of thousands poses a difficult ethical dilemma regarding why this population does not receive noncustodial or hospital treatment instead. The study addressed the research question …

Policy Addressing Family Presence During Resuscitation, Crystal Emanuel-Hayes

Walden Dissertations and Doctoral Studies

When hospitals became the primary care setting for very ill patients, visiting hours and restrictions related to family presence during resuscitation (FPDR) became common. During medical crises that occur in hospital settings, families are separated from loved ones because family members may impair resuscitation efforts or such efforts might psychologically traumatize family members. Various national health care organizations have endorsed family presence during resuscitation; however, practices preventing family presence persist. This project used evidence from the peer-reviewed literature to develop a healthcare institution policy that addresses family presence during resuscitation. Theories, concepts, and models that guided this DNP project included: …

Nursing Pain Management In An Emergency Room With Hallway Overflow, Zaida Ruiz

Walden Dissertations and Doctoral Studies

Overcrowded emergency rooms (ERs) decrease the flow of nursing care creating a delay in nurse-administered pain management leaving patients in pain. The project-focused question asked if ER nurses felt that overcrowding in the ER led to inadequate pain management and if a clinical practice guideline (CPG) could be developed to promote effective pain management in the setting. Callista Roy's theory of human adaptation was used to guide the project. To prepare for CPG development, data from a simple random selection of 10 nurses who had worked in the ER for a minimum of 6 months was obtained from the practice …

Nurses' Perception Of Their Role In Patient Safety, Janeane Walker

Walden Dissertations and Doctoral Studies

Despite efforts to ensure patient safety in the United States, patients are being harmed by preventable errors. There is a gap in the literature from the nurse's perspective as to why medical errors continue to occur despite having evidence-based safety strategies available. The purpose of this constructivist grounded theory study was to develop a theory explaining nurses' perception of their role in patient safety and why medical errors are still occurring despite implementation of evidence-based safety strategies. The systems engineering initiative for patient safety (SEIPS) model provided the conceptual framework for the study. Data collection included interviews with 11 nurses …

Amputee Social Support: A Quantitative Investigation Of Peer-To-Peer And Group Influence, Dirrick Anthony Williams

Walden Dissertations and Doctoral Studies

Previous research has indicated that vascular disease, trauma, and cancer lead to amputations and that 1.7 million Americans are living with an amputation. The social problem of this study is that amputees have limited places to obtain social support. Alderfer's Existence, Relatedness, and Growth Theory provided the foundation for this research. The current study examined the following questions. First, does type of social support impact amputee perceived social support satisfaction? Second, does type of social support impact life satisfaction? Survey methodology was used following attendance at either peer-to-peer or group support. A purposeful sample of 184 participants were assessed using …

Strategies For Healthcare Payer Information Technology Integration After Mergers And Acquisitions, Kishore Maranganti

Walden Dissertations and Doctoral Studies

Despite the high rate of failure in merger and acquisition (M&A) transactions, many organizations continue to rely on M&As as their primary growth strategy and to address market competition. The purpose of this qualitative single case study was to explore strategies managers from a large healthcare payer in the midwestern United States used to achieve operational and strategic synergies during the postacquisition information technology (IT) integration phase. Haspeslagh and Jemison's acquisition integration approaches model was the conceptual framework for the study. Methodological triangulation was established by analyzing the data from the semistructured interviews of 6 senior executives and 6 IT …

Screening And Educating Military Veterans About Post-Traumatic Stress Disorder, Jane Egbufoama

Walden Dissertations and Doctoral Studies

Veterans are at increased risk for developing mental illnesses because of separation from families, distressing experiences in the military, and previous injury to the brain. Approximately 30% of U.S. veterans returning from war suffer from post-traumatic stress disorder (PTSD). The incidence of acute PTSD is reduced when victims are aware of the condition and its associated factors. Through education and screening, the project bridged the gap between deployment of military veterans and treatment of PTSD in this population by addressing whether screening veterans and providing an educational process affected veterans' early PTSD recognition and treatment. The project study addressed the …