Medicine and Health Sciences Commons^™

The Neuroprotective Effects Of Targeted Temperature Management On Post-Cardiac Arrest Patients, Timothy Hovde

Physician Assistant Scholarly Project Posters

Novel methods of ensuring survival following cardiac arrest and resuscitation are of supreme importance to the medical community. Targeted temperature management (TTM) has become increasingly utilized pre-hospital, in emergency departments, and within intensive care units to increase the likelihood of survival to hospital discharge. TTM has further been used to attempt to improve neurological functioning. The efficacy and mechanism behind TTM remains poorly understood. In several patient populations it also remains unproven. The purpose of this study is to assess the physiological mechanism, survival, neurological recovery and methodology of TTM use and implementation.

Literature review was utilized to assess the …

The Impact Of Circadian Misalignment On Cardiometabolic Health, Cynthia Marie Mills

Physician Assistant Scholarly Project Posters

The circadian system is important in all living organisms because it generates a 24-hour rhythm for physiological and behavioral processes enabling anticipation and adaptation to daily changes in the environment. The prevalence of cardiometabolic diseases, which are linked to lifestyle choices, has been rising at an alarming rate. Modernization and globalization are two of many factors to blame for lifestyle changes resulting in circadian disruption. The purpose of this literature review is to explore circadian misalignment with regards to its mechanism and impact on cardiometabolic health and to determine possible interventional measures. The primary focus is on lifestyle change, particularly …

Integrative Medicine In Primary Care, Ashley M. Bjornerud

Physician Assistant Scholarly Project Posters

Integrative medicine (IM) is an approach to care that puts the patient at the center and addresses the full range of physical, emotional, mental, social, spiritual and environmental influences that affect a person’s health (Rakel, 2017). Commonly, IM is associated with complementary and alternative medicine therapies (CAM). These are two separate entities. CAM is one of the modalities used in integrative medicine.

The Safety And Efficacy Of Creatine Supplementation In The General Public, Cody Baxter

Physician Assistant Scholarly Project Posters

The purpose of this study was to determine whether supplementation with creatine monohydrate is efficacious beyond the realm of its most popular use, which is in athletics. This study investigated the safety of creatine supplementation in the general population. References were collected through a review of PubMed and Scopus databases. Initial keywords searched were creatine supplementation and creatine safety. Where possible, trials with human subjects were utilized. Studies focused on creatine’s effects in athletes or weightlifting parameters were eliminated. Topics were further narrowed down by conditions with the most amount of research and medical concerns recognized as common to primary …

Decreased Mortality Of Pulmonary Arterial Hypertension In Duchenne Muscular Dystrophy And Down Syndrome, Mitchell Volin

Physician Assistant Scholarly Project Posters

The genetic cause of significant disorders like Down syndrome (DS) and Duchenne muscular dystrophy (DMD) is well documented. Pulmonary arterial hypertension (PAH), a co-morbid condition, is tied to mortality among these groups. Individuals with the ability to communicate their symptoms and actively participate in treatment are at an advantage with subsequent benefit. DS and DMD significantly decrease physical ability and communication capacity. Genetic research has allowed for earlier identification of, or predisposition for, the development of PAH. Work has also progressed toward manipulation at the genetic level to decrease the severity and even eradicate the cardiopulmonary disorder. This information is …

Chaotic Attractor Hopping Yields Logic Operations., K Murali, Sudeshna Sinha, Vivek Kohar, Behnam Kia, William L Ditto

Faculty Research 2018

Certain nonlinear systems can switch between dynamical attractors occupying different regions of phase space, under variation of parameters or initial states. In this work we exploit this feature to obtain reliable logic operations. With logic output 0/1 mapped to dynamical attractors bounded in distinct regions of phase space, and logic inputs encoded by a very small bias parameter, we explicitly demonstrate that the system hops consistently in response to an external input stream, operating effectively as a reliable logic gate. This system offers the advantage that very low-amplitude inputs yield highly amplified outputs. Additionally, different dynamical variables in the system …

Adam17 Is Essential For Ectodomain Shedding Of The Egf-Receptor Ligand Amphiregulin., Vishnu Hosur, Michelle L Farley, Lisa M. Burzenski, Leonard D. Shultz, Michael V. Wiles

Faculty Research 2018

The epidermal growth factor (EGF)-receptor ligand amphiregulin (AREG) is a potent growth factor implicated in proliferative skin diseases and in primary and metastatic epithelial cancers. AREG, synthesized as a propeptide, requires conversion to an active peptide by metalloproteases by a process known as ectodomain shedding. Although (ADAM17) a disintegrin and metalloprotease 17 is a key sheddase of AREG, ADAM8-, ADAM15-, and batimastat (broad metalloprotease inhibitor)-sensitive metalloproteases have also been implicated in AREG shedding. In the present study, using a curly bare (Rhbdf2^cub ) mouse model that shows loss-of-hair, enlarged sebaceous gland, and rapid cutaneous wound-healing phenotypes mediated by …

The Effect Of Social Vulnerability During The 2014 Ebola Outbreak In Monrovia, Liberia, Mussa Y. Zatreh

Master of Public Health Program Student Publications

Background: Ebola virus disease (EVD) is a dangerous, often fatal disease that spreads through infected bodily fluids. In 2014, an Ebola outbreak swept through West Africa, including Liberia.

Purpose: The purpose of this study is to examine how social vulnerability affected different aspects of life during the 2014 Ebola outbreak in Monrovia, Liberia. The association between vulnerability and hardship that people experience during the outbreak was examined. This was measured by indicator variables for hardship such as availability of food, cash, or medical care. Vulnerability was also compared with EVD knowledge and vigilance.
Method: An additive index for social vulnerability …

Impact Of Air Manganese On Child Neurodevelopment In East Liverpool, Ohio, Erin N. Haynes, Heidi Sucharew, Timothy J. Hilbert, Pierce Kuhnell, Alonzo Spencer, Nicholas C. Newman, Roxanne Burns, Robert Wright, Patrick J. Parsons, Kim N. Dietrich

Epidemiology and Environmental Health Faculty Publications

Background: East Liverpool, Ohio, the site of a hazardous waste incinerator and a manganese (Mn) processor, has had air Mn concentrations exceeding United States Environmental Protection Agency reference levels for over a decade. Save Our County, Inc., a community organization, was formed to address community environmental health concerns related to local industry. Researchers from the University of Cincinnati partnered with Save Our County to determine if air Mn had an impact on the neurocognitive function of children in the community.

Methods: Children 7–9 years of age from East Liverpool and its surrounding communities, were enrolled (N = 106) in the …

Civility And Academic Freedom: Who Defines The Former (And How) May Imperil Rights To The Latter, Theodore W. Mcdonald, James D. Stockton, R. Eric Landrum

Psychological Sciences Faculty Publications and Presentations

An alarming occurrence in academia involves the discipline of faculty, under the guise of violating civility or collegiality codes, for engaging in what should be protected academic free speech. This often occurs when unprincipled and/or corporate-minded administrators seek to punish or dissuade faculty from challenging or questioning their decisions or policy initiatives, or for speaking up about policy violations or lack of due process. The ambiguity of terms such as civility and collegiality, when selectively defined by administrators, can be used to stifle, dissuade or punish academic free speech. Ways to identify and address these problems are presented.

Treatment Of Subacromial Impingement Syndrome In A 53-Year-Old Female: A Case Study, Jarad Syrstad

Physical Therapy Scholarly Projects

Background and Purpose. Subacromial impingement syndrome (SAIS) is a common shoulder pathology. The purpose of this case report is to discuss the outcomes of subsequent physical therapy after operative treatment for SAIS and the clinical decision making involved in seeking surgical intervention.

Case Description. This case report describes a 54 y/o female who participated in eight weeks of physical therapy after undergoing shoulder decompression surgery while failing conservative physical therapy prior to surgical intervention.

Intervention. Physical therapy interventions were designed to strengthen the rotator cuff and shoulder, increase range of motion, decrease pain, and improve functional activity. …

Electromyographic Activity Of Hamstrings And Quadriceps Muscle During Jumping And Landing: Pilot Study, Jayla Greene, Brecca Wahlund, Jay Mittlieder, Adam Lutz

Physical Therapy Scholarly Projects

Background and Purpose. The purpose of this pilot study was to see if there was a difference in amount of electromyographic (EMG) activity in the quadriceps (vastus medialis and vastus lateralis) compared to amount of EMG activity in the hamstrings (biceps femoris and semitendinosus) in active male and female subjects during vertical jumping and landing. In addition, we looked at the amount of knee flexion that occurred in the male and female subjects shortly after landing from a vertical jump.

Methods EMG activity was recorded using a Noraxon TeleMyo DTS telemetry unit with a sampling rate of 1 kHz. EMG …

Dr. Kiran C. Patel College Of Osteopathic Medicine Graduate Programs 2018, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Dr. Kiran C. Patel College Of Osteopathic Medicine Clinical Training Manual, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

The Association Between The Coach-Athlete Relationship And Burnout Among High School Coaches, Scott Westfall, Eric M. Martin, Daniel Gould

Kinesiology Faculty Publications and Presentations

Burnout is a term that continues to raise considerable concern among high school coaches and administrators (Raedeke, 1997) and has shown to have negative effects on coaches and athletes alike (Price & Weiss, 2000; Vealey, Armstrong, & Comar, 1998). While burnout has shown to have significant adverse effects, few studies have examined how the coach-athlete relationship may affect a coach s level of perceived burnout. This study sought to understand if the coach-athlete relationship predicted coach burnout. High school coaches (69 males, 62 females) completed the Coach-Athlete Relationship Questionnaire (CART-Q; Jowett & Ntoumanis, 2004), the Coaching Burnout Questionnaire, a modified …

The 4th International Conference Of The International Association For Music And Medicine (Iamm), Amy Clements-Cortés

Music Faculty Publications

No abstract provided.

Organic Barn Dust Inhibits Surfactant Protein D Production Through Protein Kinase-C Alpha Dependent Increase Of Gpr116, David Schneberger, Jane M. Devasure, Shelley A. Kirychuk, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Prolonged exposure to organic barn dusts can lead to chronic inflammation and a broad range of lung problems over time, mediated by innate immune mechanisms. The immune surfactant or collectin surfactant protein D (SP-D) is a crucial multifunctional innate immune receptor. Little work to date has examined the effect of such collectins in response to organic dusts. We provide evidence here that agricultural organic dusts can inhibit mRNA and protein expression of SP-D in a human alveolar epithelial cell line, and an in vivo mouse model. This inhibition was not a result of lipopolysaccharide (LPS) or peptidoglycans, the two most …

The Clemson Healthcare Work System Ergonomic Assessment Toolkit, Anjali Joseph, Deborah Wingler, Rutali Joshi

Center for Health Facilities Design and Testing

Within the ambulatory care environment, healthcare organizations are challenged to address the rapidly advancing technological demands associated with electronic health records (EHR) when building new facilities or renovating existing infrastructures. The Clemson Healthcare Work System Ergonomic Assessment Toolkit is a tool for evaluating the ergonomics of alternative computer workstation configurations within the broader context of the ambulatory work system which they are placed. The toolkit provides guidance for analyzing the strengths and weaknesses of varying applications of technology integration into ambulatory workspaces to support evidence-based design decisions.

Oral Cancer Has A New Risk Factor: Hpv, Tira Hanrahan, Shillpa Naavaal

Dental Public Health and Policy Publications

No abstract provided.

Guidelines And Recommendations On Yeast Cell Death Nomenclature, Didac Carmona-Gutierrez, Maria Anna Bauer, Andreas Zimmermann, Andrés Aguilera, Nicanor Austriaco, Kathryn Ayscough, Rena Balzan, Shoshana Bar-Nun, Antonio Barrientos, Peter Belenky, Marc Blondel, Ralf J Braun, Michael Breitenbach, William C Burhans, Sabrina Büttner, Duccio Cavalieri, Michael Chang, Katrina F Cooper, Manuela Côrte-Real, Vítor Costa, Christophe Cullin, Ian Dawes, Jörn Dengjel, Martin B Dickman, Tobias Eisenberg, Birthe Fahrenkrog, Nicolas Fasel, Kai-Uwe Fröhlich, Ali Gargouri, Sergio Giannattasio, Paola Goffrini, Campbell W Gourlay, Chris M Grant, Michael T Greenwood, Nicoletta Guaragnella, Thomas Heger, Jürgen Heinisch, Eva Herker, Johannes M Herrmann, Sebastian Hofer, Antonio Jiménez-Ruiz, Helmut Jungwirth, Katharina Kainz, Dimitrios P Kontoyiannis, Paula Ludovico, Stéphen Manon, Enzo Martegani, Cristina Mazzoni, Lynn A Megeney, Chris Meisinger, Jens Nielsen, Thomas Nyström, Heinz D Osiewacz, Tiago F Outeiro, Hay-Oak Park, Tobias Pendl, Dina Petranovic, Stephane Picot, Peter Polčic, Ted Powers, Mark Ramsdale, Mark Rinnerthaler, Patrick Rockenfeller, Christoph Ruckenstuhl, Raffael Schaffrath, Maria Segovia, Fedor F Severin, Amir Sharon, Stephan J Sigrist, Cornelia Sommer-Ruck, Maria João Sousa, Johan M Thevelein, Karin Thevissen, Vladimir Titorenko, Michel B Toledano, Mick Tuite, F-Nora Vögtle, Benedikt Westermann, Joris Winderickx, Silke Wissing, Stefan Wölfl, Zhaojie J Zhang, Richard Y Zhao, Bing Zhou, Lorenzo Galluzzi, Guido Kroemer, Frank Madeo

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differential definition of terms including apoptosis, regulated necrosis, and autophagic …

The Lived Experiences Of Opioid Withdrawal: A Phenomenological Study, Eliza Mall

DNP Research Projects

The United States is in the midst of an opioid overdose epidemic resulting to 40,000 accidental drug overdose deaths. In 2016, the number of deaths related to opioid overdose increased to 116 people per day resulting to $504 billion in economic costs. This research study explored the lived experiences of drug addicts having experienced opioid withdrawal symptoms. Phenomenology is useful in discovering the narrative lived experiences that cannot be obtained in quantitative approach. Six themes emerged to describe the lived experiences of opioid addicts who have undergone withdrawal: (a) Increasing desires that are hard to resist (b) Helplessness and hopelessness …

I Can Do This - Collaboration On A Global Nursing Assignment To Increase The Self-Efficacy Of Pre-Nursing Students For Research Skills, Carol L. Watwood, Mary P. Bennett, Lorraine B. Bormann

Nursing Faculty Publications

Objective –This study asked whether pre-nursing students who took the Nursing 102 (Introduction to Professional Nursing) class, which included information literacy instruction by the Health Sciences Librarian and writing assistance using peer tutors, felt better prepared in basic research skills and a more global understanding of nursing than they did before they took the class. Methods – In Nursing 102, instruction in the skills needed to prepare an APA paper and group presentations on an assigned country were used to increase pre-nursing students’ self-efficacy in basic computer and library skills and global health awareness. In cooperation with the instructors, the …

Job Satisfaction Of Nursing Home Administrators, Cathy Abell

Nursing Faculty Publications

Background: The older adult population, age 65 and older, in the United States has increased 30% since 2005 and is projected to continue to grow. Nursing homes have become the living arrangement for some older adults. Nursing home administrators (NHAs) can play a vital role in the long-term care industry. Job satisfaction is important as it can enhance retention of NHAs.Methods: A purposive sample of NHAs was utilized for this descriptive correlational research study to examine job satisfaction. A researcher developed demographic questionnaire and the Nursing Home Administrator Job Satisfaction Questionnaire (NHA-JSQ), which has six specific domains, were utilized to …

Improving Evidence-Based Practice Skills Of Practicing Registered Nurses, Lora K. Moore

Doctor of Nursing Practice Technical Reports

This study evaluated the effect of an educational intervention on improving evidence-based nursing practice (EBP) skills of practicing nurses. In addition, the effects of educational preparation and years of nursing experienced were examined. Using a quasi-experimental pretest-posttest design, the Evidence Based Practice Questionnaire (EBPQ) was administered to a convenience sample of registered nurses from a large regional hospital. The experimental group completed an online EBP educational intervention, the first control group completed an alternate unrelated educational intervention, and the second control group was not provided any type of educational intervention. No significant differences were noted in EBPQ subscale scores of …

Clinical Features Of Guillain-Barré Syndrome With Vs Without Zika Virus Infection, Puerto Rico, 2016, Emilio Dirlikov, Chelsea G. Major, Nicole A. Medina, Roberta Lugo-Robles, Desiree Matos, Jorge L. Muñoz-Jordan, Candimar Colon-Sanchez, Myriam Garcia, Marangely Olivero-Segarra, Graciela Malave, Gloria M. Rodríguez-Vega, Dana L. Thomas, Stephen H. Waterman, James J. Sejvar, Carlos A. Luciano, Tyler M. Sharp, Brenda Rivera-García

Journal Articles: Epidemiology

Importance: The pathophysiologic mechanisms of Guillain-Barré syndrome (GBS) associated with Zika virus (ZIKV) infection may be indicated by differences in clinical features.

Objective: To identify specific clinical features of GBS associated with ZIKV infection.

Design, Setting, and Participants: During the ZIKV epidemic in Puerto Rico, prospective and retrospective strategies were used to identify patients with GBS who had neurologic illness onset in 2016 and were hospitalized at all 57 nonspecialized hospitals and 2 rehabilitation centers in Puerto Rico. Guillain-Barré syndrome diagnosis was confirmed via medical record review using the Brighton Collaboration criteria. Specimens (serum, urine, cerebrospinal fluid, and saliva) from …

Evidence-Based Guidelines For Supportive Care Of Patients With Ebola Virus Disease, François Lamontagne, Robert A. Fowler, Neill K. Adhikari, Srinivas Murthy, David Brett-Major, Michael Jacobs, Timothy M. Uyeki, Constanza Vallenas, Susan L. Norris, William A. Fischer, Thomas E. Fletcher, Adam C. Levine, Paul Reed, Daniel G. Bausch, Sandy Gove, Andrew Hall, Susan Shepherd, Reed A. Siemieniuk, Marie-Claude Lamah, Rashida Kamara, Phiona Nakyeyune, Moses J. Soka, Ama Edwin, Afeez A. Hazzan, Shevin T. Jacob, Mubarak Mustafa Elkarsany, Takuya Adachi, Lynda Benhadj, Christophe Clément, Ian Crozier, Armando Garcia, Steven J. Hoffman, Gordon H. Guyatt

Journal Articles: Epidemiology

The 2013-16 Ebola virus disease outbreak in west Africa was associated with unprecedented challenges in the provision of care to patients with Ebola virus disease, including absence of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care, and limitations in the provision of supportive medical care. Case fatality rates in west Africa were initially greater than 70%, but decreased with improvements in supportive care. To inform optimal care in a future outbreak of Ebola virus disease, we employed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to develop evidence-based guidelines for the delivery of supportive …

Lead In The Environment, Msn Module, Dawn Blue

Q2S Enhancing Pedagogy

Module for MSN program in toxicology on lead in the environment.

Cognitive Load Theory: Applications In Medical Education, Adam W. Wissman

Technical Communication Capstone Course

This article examines how cognitive load theory can help instructional designers in medical education design material and content to best suit their audience. Through the examination of schema construction, working and long-term memory, biologically primary/secondary knowledge, and novice and experienced learners, this article proposes instructional design best practices. This article separates these best practices into three categories: activities, pre-lecture resources, and teaching strategies, which can be applied to either novice learners or experienced learners.

Co-Occurrence Of Tobacco Product Use, Substance Use, And Mental Health Problems Among Youth: Findings From Wave 1 (2013–2014) Of The Population Assessment Of Tobacco And Health (Path) Study, Kevin P. Conway, Victoria R. Green, Karin A. Kasza, Marushka L. Silveira, Nicolette Borek, Heather L. Kimmel, James D. Sargent, Cassandra A. Stanton, Elizabeth Lambert, Nahla Hilmi, Chad J. Reissig, Kia J. Jackson, Susanne E. Tanski, David Maklan, Andrew J. Hyland, Wilson M. Compton

United States Food and Drug Administration: Publications

Introduction: Cigarette use is associated with substance use and mental health problems among youth, but as- sociations are unknown for non-cigarette tobacco product use, as well as the increasingly common poly-tobacco use.

Methods: The current study examined co-occurrence of substance use and mental health problems across tobacco products among 13,617 youth aged 12–17 years from Wave 1 (2013–2014) of the nationally representative Population Assessment of Tobacco and Health (PATH) Study. Participants self-reported ever cigarette, e-cigar- ette, smokeless tobacco, traditional cigar, cigarillo, filtered cigar, hookah, and other tobacco product use; al- cohol, marijuana, and other drugs; and lifetime substance use, internalizing …

Trends And Economic Drivers For United States Naloxone Pricing, January T 2006 To February 2017, Matthew Rosenberg, Grace Chai, Shekhar Mehta, Andreas Schick

United States Food and Drug Administration: Publications

Anecdotal evidence indicates that naloxone prices have risen in recent years, but limited research has examined the magnitude of these increases and potential causes. We contribute nationally representative evidence to help answer each of these questions, including wholesale pricing data from a proprietary drug sales database span- ning January 2006 to February 2017. We find that all formulations of naloxone increased in price since 2006 except for Narcan Nasal Spray. These cumulative increases totaled 2281% for the 0.4 MG single-dose products, 244% for the 2 MG single-dose products, 3797% for the 4 MG multi-dose products, and 469% for the 0.4 …