Medicine and Health Sciences Commons^™

Near-Infrared Imaging Of Adoptive Immune Cell Therapy In Breast Cancer Model Using Cell Membrane Labeling, Fatma M. Youniss, Gobalakrishnan Sundaresan, Laura J. Graham, Li Wang, Collin R. Berry, Gajanan K. Dewkar, Purnima Jose, Harry D. Bear, Jamal Zweit

Radiology Publications

The overall objective of this study is to non-invasively image and assess tumor targeting and retention of directly labeled T-lymphocytes following their adoptive transfer in mice. T-lymphocytes obtained from draining lymph nodes of 4T1 (murine breast cancer cell) sensitized BALB/C mice were activated in-vitro with Bryostatin/Ionomycin for 18 hours, and were grown in the presence of Interleukin-2 for 6 days. T-lymphocytes were then directly labeled with 1,1-dioctadecyltetramethyl indotricarbocyanine Iodide (DiR), a lipophilic near infrared fluorescent dye that labels the cell membrane. Assays for viability, proliferation, and function of labeled T-lymphocytes showed that they were unaffected by DiR labeling. The DiR …

Headaches And Hemiparesis In An Immunocompetent Inmate, Andrea Gilbert Jelinek, Christine Fuller, Ahmet Baykal, Kimberly Stogner-Underwood, Hope Richard, Knarik Arkun

Pathology Publications

This is a case of a 22 year-old African American male inmate with no significant past medical history who regularly cleaned moldy bathrooms and showers during his incarceration. The patient presented with progressive development of left-sided weakness, dizziness, headaches, and vomiting over a two month period. In summary, we report this case to boost awareness of the potential for CNS phaeohyphomycosis infection to present as a clinical and radioimaging mimic of high grade glioma. Our patient, a previously healthy adult, is one of less than a dozen cases of cerebral phaeohyphomycosis due to Bipolaris documented in the literature, and is …

How Effective Is Capitation At Reducing Health Care Costs?, David P. Paul Iii, Jennifer Brunoni, Tasha Dolinger, Irina Walker, Danielle Wood, Alberto Coustasse

Management Faculty Research

Due to skyrocketing healthcare costs in the U.S., several strategies, including capitation, have been utilized to reduce overall cost. Capitation has helped to contain costs by placing a limit on the amount of reimbursement that is offered to the provider for specific types of patients and care. In order for physicians to improve their profitability under capitation, their practices must become more cost efficient. The purpose of this research was to analyze the effects of capitation on the overall reduction of healthcare cost.

Financial Advantages Of Hospitals’ Relationships With Accountable Care Organizations, David P. Paul Iii, Rodrigo Carmago, Thaisa Carmago, Stacie Deslich, Alberto Coustasse

Management Faculty Research

Accountable care organizations are groups of providers who agree to accept the responsibility for elevating the health status of a defined group of patients, with the goal of enabling people to take charge of their health and enroll in shared decision-making with providers. The large initial investment required (estimated at $1.8 million) to develop an ACO implies that the participation of large health care organizations, especially hospitals and health systems, is required for success. Findings of the study suggest that ACOs based in a larger hospital organizations are more likely to meet CMS criteria for formation because of financial and …

The Business Case For The Efficiency And Effectiveness Of Tele-Intensive Care Units, David P. Paul, Deanna Bailey, Alesia Hairston, Stacie Deslich, Alberto Coustasse

Management Faculty Research

A tele-Intensive Care Unit (tele-ICU) is the use of telemedicine in an Intensive Care Unit (ICU) setting, using technology to provide care to critically ill patients by off-site clinical resources. This literature review examined a large number of studies of the implementation of tele-ICU systems in hospitals. Generally, implementation of a tele-ICU system was associated with cost savings, shorter lengths of stay, and decreased mortality. Implementation of tele-ICUs is initially relatively expensive but result in cost savings and better clinical outcomes. Intensivists working these systems are used more effective providing better clinical outcomes for patients at lower costs for hospitals.

Early Mobilization In Icu Patients, Alex Hunter, Leslie Johnson, William Willis, Alberto Coustasse

Management Faculty Research

Introduction: Bed rest or immobilization is frequently part of treatment for patients in the intensive care unit with critical illness. The average intensive care unit length of stay was 3.3 days and for every day spent in an intensive care unit bed, the average patient spent an additional 1.5 days in a non-intensive care unit bed. Daily costs have increased more than 30% from 2000-2005 with an average daily cost of $3518. Weaning from mechanical ventilation has been correlated with increased intensive care unit and hospital length of stay. Mechanical ventilation has been correlated with the development of intensive care …

Medical Education, Pdas And Smartphones: Welcome To The 21st Century, David P. Paul, Nicole Moussa, Sara Asad, Brad Pershing, Alberto Coustasse

Management Faculty Research

PDAs and Smartphones allow medical professionals to access medical information more easily than ever before. This literature review examines use of these devices and associated “apps” in medical education, finding widespread use by medical students, residents, and faculty. Surprisingly, little generational bias was noted.

Chromatin Structure In Situ: The Contribution Of Dna Ultrastructural Cytochemistry, Massimo Derenzini, Ada L. Olins, Donald E. Olins

Pharmaceutical Sciences Faculty Publications

Ultrastructural studies conducted in situ using conventional transmission electron microscopy have had relatively little impact on defining the structural organization of chromatin. This is due to the fact that in routine transmission electron microscopy, together with the deoxyribonucleoprotein, many different intermingled substances are contrasted, masking the ultrastructure of chromatin. By selective staining of DNA in thin sections, using the Feulgen-like osmium-ammine reaction, these drawbacks have been overcome and worthwhile data have been obtained both on the gross morphology and the ultrastructural-functional organization of chromatin in situ. In the present study these results are reviewed and discussed in light of recent …

Disseminating An Evidence-Based Course To Teach Self-Management Of Auditory Hallucinations, M Buffum, Robin Buccheri, L Trygstad, G Dowling

Nursing and Health Professions Faculty Research and Publications

This multi-site project extended course dissemination of the 10-session Behavioral Management of Auditory Hallucinations Course to U.S. Department of Veterans Affairs (VA) mental health outpatient settings. The VA Quality Enhancement Research Initiative (QUERI) model and Rogers' theory of diffusion of innovations served as the theoretical framework. The course was taught to mental health professionals using teleconferencing, electronic media, and monthly conference calls across 24 VA mental health outpatient sites. Twenty course leaders provided feedback. One hundred percent reported being better able to communicate with patients about their voices and 96% reported improved understanding of the voice-hearing experience. Thirty-three course participants …

Clinical Leadership And Asymmetric Information: The Impact Of Physician Advice On Smoking Cessation, Courtney Keeler

Nursing and Health Professions Faculty Research and Publications

A knowledge gradient exists between experts in a given field and consumers of that knowledge. When the need arises, not knowing the best path, an average individual typically relies on the advice of an expert. Given the steep knowledge gradient between patient and provider, clinicians play an essential role in the clinical setting, acting as both a health leader and a health facilitator; however, this asymmetric information implies that clinical providers face an acute pressure not only to advise but to advise correctly. This paper explores the importance of physician advice within the context of smoking cessation, addressing two specific …

Trauma And Violence Exposure Among Asian American And Pacific Islander Children, Dhara Thakar Meghani, Pratyusha Tummala-Narra, Asian American Psychological Association

Nursing and Health Professions Faculty Research and Publications

No abstract provided.

Seizure Detection, Seizure Prediction, And Closed-Loop Warning Systems In Epilepsy, S Ramgopal, S Thome-Souza, M Jackson, N E. Kadish, I Sanchez Fernandez, J Klehm, William Bosl, C Reinsberger, S Schachter, T Loddenkemper

Nursing and Health Professions Faculty Research and Publications

Nearly one-third of patients with epilepsy continue to have seizures despite optimal medication management. Systems employed to detect seizures may have the potential to improve outcomes in these patients by allowing more tailored therapies and might, additionally, have a role in accident and SUDEP prevention. Automated seizure detection and prediction require algorithms which employ feature computation and subsequent classification. Over the last few decades, methods have been developed to detect seizures utilizing scalp and intracranial EEG, electrocardiography, accelerometry and motion sensors, electrodermal activity, and audio/video captures. To date, it is unclear which combination of detection technologies yields the best results, …

Nonviolent Communication Training Increases Empathy In Baccalaureate Nursing Students: A Mixed Method Study, Marcianna Nosek, Elizabeth Joy Gifford, Brendan Kober

Nursing and Health Professions Faculty Research and Publications

Background: Ineffective communication among healthcare team members is associated with decreased collaborative efforts and adverse patient outcomes. The impact of empathy on collaboration with colleagues and patient interaction has been previously demonstrated. Studies have yet to measure the impact of (Nonviolent Communication [NVC]) on empathy in nursing students.

Purpose: The purpose of this mixed methods study was to test a communication intervention (NVC) with baccalaureate student nurses to examine its effect on empathy.

Methods: A mixed methods single group pre/post test design incorporating the Interpersonal Reactivity Index (IRI) to measure empathy was used. A paired samples t test was calculated …

Creating A Strategic Partnership For Educating Nurse Practitioner Students About Sexual Health, Stefan Rowniak

Nursing and Health Professions Faculty Research and Publications

Sexual health is an essential and often neglected component of primary care. Nurse practitioners are ideal members of the healthcare team to be providing sexual health information, diagnoses, and treatments. Unfortunately, this is an area that has been lacking in the education of all healthcare providers. This paper describes a program that incorporates sexual health into the curriculum for nurse practitioner students through collaboration between the university school of nursing and the local health department. Given the increasing shortage of clinical sites and the need to train nurse practitioners to be competent in the delivery of sexual health, this is …

Morquio A Syndrome-Associated Mutations: A Review Of Alterations In The Galns Gene And A New Locus-Specific Database, A Morrone, A Caciotti, R Atwood, K Davidson, C Du, Patricia Francis-Lyon, P Harmatz, M Mealiffe, S Mooney, T R. Oron, A Ryles, K A. Zawadzki, N Miller

Nursing and Health Professions Faculty Research and Publications

Morquio A syndrome (mucopolysaccharidosis IVA) is an autosomal recessive disorder that results from deficient activity of the enzyme N-acetylgalactosamine-6-sulfatase (GALNS) due to alterations in the GALNS gene, which causes major skeletal and connective tissue abnormalities and effects on multiple organ systems. The GALNS alterations associated with Morquio A are numerous and heterogeneous, and new alterations are continuously identified. To aid detection and interpretation of GALNS alterations, from previously published research, we provide a comprehensive and up-to-date listing of 277 unique GALNS alterations associated with Morquio A identified from 1,091 published GALNS alleles. In agreement with previous findings, most reported GALNS …

Clinical Nurse Leaders In The Community: Building An Academic Faculty Practice Partnership, Chenit Ong-Flaherty

Nursing and Health Professions Faculty Research and Publications

The Affordable Care Act (ACA) emphasis on preventive care and primary health has given community organizations and outpatient care environments renewed attention. Nursing has been offered the opportunity to lead healthcare into a new era. One of the two new nursing programs to be given life in this movement is the Clinical Nurse Leader (CNL). The CNL is a graduate level educated nurse who specializes in healthcare systems leadership, a facilitator of care in the complex healthcare environments of today. They are equipped to see the wider and broader perspective of things, assess needs, research the best interventions for problems …

Complement Expression In The Retina Is Not Influenced By Short-Term Pressure Elevation, Konstantin Astafurov, Cecilia Q. Dong, Lampros Panagis, Gautam Kamtham, Lizhen Ren, Anna Rozenboym, Tarique D. Perera, Jeremy D. Coplan, John Danias

Publications and Research

Purpose: To determine whether short-term pressure elevation affects complement gene expression in the retina in vitro and in vivo.

Methods: Muller cell (TR-MUL5) cultures and organotypic retinal cultures from adult mice and monkeys were sub- jected to either 24-h or 72-h of pressure at 0, 15, 30, and 45 mmHg above ambient. C57BL/6 mice were subjected to microbead-induced intraocular pressure (IOP) elevation for 7 days. RNA and protein were extracted and used for analysis of expression levels of complement component genes and complement component 1, q subcomponent (C1q) and comple- ment factor H (CFH) immunoblotting. …

Differences Between Children With Fetal Alcohol Spectrum Disorders And Attention Deficit Hyperactivity Disorders: Rural Social Work Implications For Prevention, Assessment And Treatment, Susan M. Ryan, George S. Leibowitz, Jeanne M. Nauheimer, Paul Force-Emery Mackie

Social Work Department Publications

This literature review examined nine quantitative research studies published between 1992-2013 that compared children with Fetal Alcohol Spectrum Disorders (FASD) and Attention Deficit Hyperactivity Disorder (ADHD) to identify: (a) the differences between these children (e.g., intellectual, behavioral); and (b) the diagnostic tools that may be used to distinguish between them, thereby providing a differential diagnosis. Special focus was placed on rural treatment implications. These studies revealed differences between the intellectual, executive functioning, adaptive behavior, motor, and behavioral skills of children with FASD and ADHD. This review identified neurodevelopmental assessments used in these nine research studies that appear to support learning …

An Anatomical, Biochemical, Biophysical And Quantum Basis For The Unconscious Mind, James L. Oschman, Maurie D. Pressman

International Journal of Transpersonal Studies

This article suggests that it may now be possible to develop some theoretical and experimental bases for organic substructures involved in psychological phenomena including the unconscious. Our inquiry arose from mutual interest in the mechanisms involved in peak athletic and artistic performances and in deep therapeutic encounters. We are referring to a state of consciousness is often described by performers as “the zone.” This is a state in which individuals or groups function at an extraordinary level of perception and coordination; or a state in which therapists develop a deep connection with their clients’ repressed feelings or traumatic memories. Here …

The Seasons Of Wellbeing As An Evolutionary Map For Transpersonal Medicine, Donald M. Epstein, Simon A. Senzon, Dan Lemberger

International Journal of Transpersonal Studies

The four Seasons of Wellbeing (Discover, Transform, Awaken, and Integrate) refer to distinct rhythms, periods, and factors that influence the accessibility of an individual’s resources during the journey of life. Each season is explicitly and implicitly related to an individual’s experience, focus, and capacity for self-organizational states. Each can be used to understand, organize, and foster behavior change, positive growth, transformation, and human development. A genealogy of the seasons is described, emphasizing the empirical and theoretical foundations of Reorganizational Healing and its roots in models such as Grof ’s Systems of Condensed Experiences (or COEX Systems) and Wilber’s Integral Theory …

A Possible Mechanism Of Action For The Placebo Response: Human Biofield Activation Via Therapeutic Ritual, Marie G. Brook, Randy Fauver

International Journal of Transpersonal Studies

The lack of an identified mechanism of action for the placebo response contributes to its perception as clinically unimportant in Western medicine and minimizes its value as a contributing factor to the effectiveness of both conventional and alternative medical treatments. The therapeutic ritual is one of the principle contributors to the placebo response. Two key elements predicting salutogenic outcomes in both the placebo response and therapeutic ritual are patient meaning making and the patient/healer relationship. A detailed examination of human biofield dynamics shows its role in storing, communicating, and regulating the flow of information associated with healing in Western and …

Ayurvedic Psychology: Ancient Wisdom Meets Modern Science, Daniel Rhoda

International Journal of Transpersonal Studies

Ayurveda is a holistic medical system based on ancient Indian texts that utilizes natural treatments, botanical medicines, and lifestyle and dietary practices to promote healing of the body, mind, senses, and spirit. Interest in Ayurveda has grown in the United States over the last two decades, as consumers, therapists, scientists, and health regulators have recognized its holistic and preventative benefits. According to Ayurveda, every human being is composed of a unique proportion of these elemental energies, a foundational theory in Ayurveda known as tridosha. The three doshas (vata, pitta, kapha) represent three psychobiological constitutional types that govern …

Donut Hole Summer 2014, Medicare Donations & Design Committee

Donut Hole Newsletter

No abstract provided.

Measuring Hiv Stigma At The Family Level: Psychometric Assessment Of The Chinese Courtesy Stigma Scales (Ccsss), Hongjie Liu, Yongfang Xu, Yehuan Sun, Levent Dumenci

Social and Behavioral Sciences Publications

Courtesy stigma is the stigmatization a person perceives or experiences due to their association with a stigmatized individual or group. Most HIV-related stigma scales have been developed for people living with HIV/AIDS (PLWHAs), but not for their HIV-uninfected family members. To date, few measurement scales have been designed to measure the degree of stigma among both PLWHAs and their HIV-uninfected family members at the family level. We developed a set of courtesy stigma scales and estimated their reliability and validity from 256 PLWHAs and 256 of their HIV-uninfected family members. Exploratory and confirmatory factor analyses were performed in two independent …

Interlinking Of Hypoxia And Estrogen In Thyroid Cancer Progression, S Rajoria, E Hanly, A Nicolini, A L. George, J Geliebter, E J. Shin, R Suriano, A Carpi, R K. Tiwari

NYMC Faculty Publications

Estrogen aids in neo-vascularization of various tumors during hypoxic conditions, however the role of estrogen within the hypoxic environment of thyroid cancer is not known. In a series of experimentations, using human thyroid cancer cells, we observed that estrogen and hypoxia modulate the hypoxia inducible factor-1 (HIF-1) signaling which is abrogated by the anti-estrogen fulvestrant and the HIF-1 inhibitor YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole). Furthermore, we found that the conditioned medium from estrogen treated thyroid cancer cells lead to enhanced migration and tubulogenesis of human umbilical vein endothelial cells (HUVECs) which is abrogated by HIF-1 inhibitor. These findings, in addition to our previous …

The Helminthological Society Of Washington 2013 Anniversary Award: Larry S. Roberts, Sherman S. Hendrix

Center for Brain, Biology, and Behavior: Faculty Publications

Dr. Roberts was born in the great state of Texas, and much of his early life is murky, but snakes are often mentioned. Larry received his Bachelor’s degree at Southern Methodist University; his Master of Science at the University of Illinois; and his Doctorate in the Department of Pathobiology at the Johns Hopkins School of Hygiene and Public Health. Larry’s doctoral research, published in Experimental Parasitology, documented the early development and crowding effect of the tapeworm, Hymenolepis diminuta, in the rat small intestine. His publication on this subject opened the door to the golden age of cestode physiology and biochemistry …

Can Helmet Design Reduce The Risk Of Concussion In Football?, Steven Rowson, Stefan M. Duma, Richard M. Greenwald, Jonathan Beckwith, Jeffrey J. Chu, Kevin M. Guskiewicz, Jason P. Mihalik, Joe Crisco, Bethany J. Wilcox, Thomas W. Mcallister, Arthur C. Maerlender, Steven P. Broglio, Brock Schnebel, Scott Anderson, P. Gunnar Brolinson

Center for Brain, Biology, and Behavior: Faculty Publications

Of all sports, football accounts for the highest incidence of concussion in the US due to the large number of athletes participating and the nature of the sport. While there is general agreement that concussion incidence can be reduced through rule changes and teaching proper tackling technique, there remains debate as to whether helmet design may also reduce the incidence of concussion. A retrospective analysis was performed of head impact data collected from 1833 collegiate football players who were instrumented with helmet-mounted accelerometer arrays for games and practices. Data were collected between 2005 and 2010 from 8 collegiate football teams: …

Winning And Losing: Differences In Reward And Punishment Sensitivity Between Smokers And Nonsmokers, Laura E. Martin, Lisa S. Cox, William M. Brooks, Cary R. Savage

Center for Brain, Biology, and Behavior: Faculty Publications

Background: Smokers show increased brain activation in reward processing regions in response to smoking-related cues, yet few studies have examined secondary rewards not associated with smoking (i.e., money). Inconsistencies exist in the studies that do examine secondary rewards with some studies showing increased brain activation in reward processing brain regions, while others show decreased activation or no difference in activation between smokers and nonsmokers. Aims: The goal of the current study is to see if smokers process the evaluation and delivery of equally salient real world rewards similarly or differently than nonsmokers. Methods: The current study employed functional magnetic resonance …

Introduction To Special Topic Section: Toward A Transpersonal Medicine, Randy Fauver

International Journal of Transpersonal Studies

NA

Spontaneous/Radical Remission Of Cancer: Transpersonal Results From A Grounded Theory Study, Kelly A. Turner

International Journal of Transpersonal Studies

This grounded theory study aimed to collect hypotheses for spontaneous or radical remission (RR) of cancer, which is a remission that occurs without medical treatment, or with medical treatment considered inadequate to produce the remission. Interviews were conducted with 20 RR survivors and 50 non-conventional healers from 11 countries. Results showed that three underlying beliefs emerged: 1. Cancer thrives under certain conditions; 2. Illness represents blockage; and 3. A body-mind-spirit interaction exists. Six factors believed to be possible causes of RR also emerged: 1. Diet change; 2. Deepening spirituality; 3. Increasing happiness; 4. Releasing suppressed emotions; 5. Taking supplements; and …