Medicine and Health Sciences Commons^™

An Introduction To Drugs And The Neuroscience Of Behavior, Adam J. Prus

Books

This up-to-date text provides an introductory overview of the nervous system actions and behavioral effects of the major classes of psychoactive drugs, using pedagogy unique among pharmacology texts to make the topic approachable.

Core Professional Nursing Values As Experienced By Baccalaureate Nursing Students Who Are Men, Bonnie Schmidt

Student Theses, Dissertations and Capstones

Experts have called for greater diversity in the nursing workforce; however, men remain underrepresented in the nursing profession. The presence of cultural dissonance among male nursing students has been documented in prior research but little is known about their values that are culturally influenced. The purpose of this study was to understand and interpret the meaning of core professional nursing values to male baccalaureate nursing students. The research question was: what is the meaning of core professional nursing values to nursing students who are men.

The study setting was an undergraduate baccalaureate school of nursing in the Midwest. Using a …

Lived Experience Of Transitioning To A New Graduate Nurse Following A Prelicensure Hospital-Based Externship Experience, Debra Shipman

Student Theses, Dissertations and Capstones

Forty years after Kramer's (1974) seminal work, Reality Shock, new graduate nurses continue to have difficulty transitioning to the registered nurse (RN) role. The purpose of this phenomenological study explores the lived experience of new graduate nurses who completed a Veterans Affairs externship program in their senior year of nursing coursework and its perceived impact on their successful transition into the practice role 3-24 months following graduation. Benner's (1984) Novice-to-Expert Model, Karmer's (1974) Reality Shock Theory, and Selder's (1989) Life Transition Theory support a framework for this study. Twelve telephone interviews were conducted using van Manen's (1990) method for researching …

Com Outlook Winter 2014, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Cephalometric Regional Superimpositions -- Digital Vs. Analog Accuracy And Precision : 3. The Cranial Base, Douglas Shaw

Student Theses, Dissertations and Capstones

Objective. To assess the accuracy and precision in measurement of pairwise implant displacement across three methods of cranial base superimposition. Background. Cephalometric superimposition is the principal radiographic method used to evaluate changes within the craniofacial skeleton. Many studies have examined the accuracy of software intended to produce cephalometric superimposition. Such studies have utilized anatomic landmarks, selected by the respective software manufacturers, as registration points for constructing superimpositions and their analysis. As a result, these studies are only as accurate as the stability and validity of anatomic registration landmarks used. To our knowledge, no other study has utilized metallic implants to …

In Vitro Comparison Of Microabrasion, Cpp-Acp, Cpp-Acfp And Combination Therapies On The Remineralization Of White Spot Lesions, Tetyana Parsons

Student Theses, Dissertations and Capstones

Objectives: To determine whether treatment of demineralized enamel white spot lesions with CPP-ACP paste, CPP-ACFP paste or microabrasion technique decreases lesion depth in vitro. Additionally, to determine whether treatment of demineralized enamel white spot lesions with microabrasion technique in combination with CPP-ACP paste or CPP-ACFP paste decreases lesion depth greater than any of the three techniques alone. Background: White spot lesions (WSLs) after the removal of orthodontic appliances remain a problem for clinicians and patients. Previous studies suggest that application of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) may promote enamel remineralization. Recently, …

Medical Education Digest, Vol. 16 No. 1 (January/February 2014), Nova Southeastern University

Medical Education Digest

No abstract provided.

The Lli Chronicle Volume 5 Number 1, Nova Southeastern University

Lifelong Learning Institute Newsletters

No abstract provided.

Phytochemistry Of Camptotheca Decaisne, Shiyou Li, Ping Wang

NCPC Publications and Patents

To date, chemical investigations of the genus Camptotheca have been primarily focused on C. acuminata. Total 78 compounds have been isolated from the species, including alkaloids (1-28), ellagic acids (29-40), flavonoids (41-46), sterols (47-48), terpenes (49-55), tannins (56-71), polyphenols and fatty acids (65-72), iridoid (73), lignan (74), polyols (75 and 76), amide (77), and sacchardide (78). The contents of camptothecin (CPT, 1), the major active alkaloid varies significantly with Camptotheca species and varieties, tissue and tree age and seasonal changes. Among all taxa of Camptotheca, C. acuminata var. acuminata has the lowest CPT contents (0.2249-0.3162% in young leaves, and 0.0392- …

Feasibility And Acceptability Of An Early Childhood Obesity Prevention Intervention: Results From The Healthy Homes, Healthy Families Pilot Study, Akilah Dulin Keita, Patricia M. Risica, Kelli L. Drenner, Ingrid Adams, Gemma Gorham, Kim M. Gans

Faculty Publications

Background. This study examined the feasibility and acceptability of a home-based early childhood obesity prevention intervention designed to empower low-income racially/ethnically diverse parents to modify their children’s health behaviors. Methods. We used a prospective design with pre-/posttest evaluation of 50 parent-child pairs (children aged 2 to 5 years) to examine potential changes in dietary, physical activity, and sedentary behaviors among children at baseline and four-month follow-up. Results. 39 (78%) parent-child pairs completed evaluation data at 4-month follow-up. Vegetable intake among children significantly increased at follow-up (0.54 cups at 4 months compared to 0.28 cups at baseline, 𝑃 …

Nebraska Bqa: Antibiotic Use Guidelines, Rob Eirich

Nebraska Beef Quality Assurance Program

Cattlemen have demonstrated a commitment to animal health through vaccination programs developed carefully in cooperation with their veterinarian. When animals must be treated with an antibiotic after disease diagnosis, producers need to follow important antibiotic use guidelines established through the National Beef Quality Assurance (BQA) program.

Nebraska Bqa: Effective Cattle Handling, Rob Eirich

Nebraska Beef Quality Assurance Program

Cattlemen know the importance of proper cattle handling and its effect on animal health and performance. Beef Quality Assurance has been implementing effective cattle handling (low-stress) into educational programs since its establishment in the 1980s.

Nebraska Bqa: Handling Compromised Animals, Rob Eirich

Nebraska Beef Quality Assurance Program

Cattle producers have long recognized the need of proper husbandry and stewardship for the animals entrusted into their care. Best livestock production practices, based on research and sound science, help ensure the well-being, animal health and productivity of cattle.

Calf Branding/Processing Time And Beef Quality Assurance, Rob Eirich

Nebraska Beef Quality Assurance Program

It is spring and that means branding time across cattle country. As producers are finishing calving season and preparing for branding/processing, it is important to review Beef Quality Assurance (BQA) guidelines. Let's take a minute to look at the key BQA principles:

Audits And Assessments In Beef Cattle Production, Rob Eirich

Nebraska Beef Quality Assurance Program

Assessments and audits are becoming a part of doing business in beef cattle production, as we are seeing beef processors implementing third-party audits. Since beginning as the Nebraska Director of Beef Quality Assurance (BQA) in July, I have been studying and gathering information on the National Cattlemen's Beef Association (NCBA) Assessment Guides and third-party audits in the beef industry.

Nebraska Beef Quality Assurance: Focused On The Safety, Wholesomeness And Quality Of Beef

Nebraska Beef Quality Assurance Program

Across the nation, beef producers face the challenge of making a living from the land, while producing safe, wholesome beef. Beef that will provide a great eating experience each and every time for American and International consumers.

South Dakota Animal Disease Research & Diagnostic Laboratory: Annual Report 2014, Animal Disease Research And Diagnostic Laboratory, South Dakota State University

South Dakota Animal Disease Research and Diagnostic Laboratory (ADRDL)

This document is the 2014 annual report of the South Dakota Veterinary and Biomedical Science Department Animal Disease Research and Diagnostic Laboratory.

A New Rhesus Macaque Assembly And Annotation For Next-Generation Sequencing Analyses, Aleksey V. Zimin, Adam S. Cornish, Mnirnal D. Maudhoo, Robert M. Gibbs, Xiongfei Zhang, Sanjit Pandey, Daniel T. Meehan, Kristin Wipfler, Steven E. Bosinger, Zachary P. Johnson, Gregory K. Tharp, Guillaume Marçais, Michael Roberts, Betsy Ferguson, Howard S. Fox, Todd Treangen, Steven L. Salzberg, James A. Yorke, Robert B. Norgren Jr.

Journal Articles: Genetics, Cell Biology & Anatomy

BACKGROUND: The rhesus macaque (Macaca mulatta) is a key species for advancing biomedical research. Like all draft mammalian genomes, the draft rhesus assembly (rheMac2) has gaps, sequencing errors and misassemblies that have prevented automated annotation pipelines from functioning correctly. Another rhesus macaque assembly, CR_1.0, is also available but is substantially more fragmented than rheMac2 with smaller contigs and scaffolds. Annotations for these two assemblies are limited in completeness and accuracy. High quality assembly and annotation files are required for a wide range of studies including expression, genetic and evolutionary analyses.

RESULTS: We report a new de novo assembly of the …

Finding Fault?: Exploring Legal Duties To Return Incidental Findings In Genomic Research, Elizabeth R. Pike, Karen H. Rothenberg, Benjamin E. Berkman

Faculty Scholarship

The use of whole genome sequencing in biomedical research is expected to produce dramatic advances in human health. The increasing use of this powerful, data-rich new technology in research, however, will inevitably give rise to incidental findings (IFs), findings with individual health or reproductive significance that are beyond the aims of the particular research, and the related questions of whether and to what extent researchers have an ethical obligation to return IFs. Many have concluded that researchers have an ethical obligation to return some findings in some circumstances, but have provided vague or context-dependent approaches to determining which IFs must …

Setting The Stage: Enhancing Understanding Of Bioethical Challenges With Theatre, Karen H. Rothenberg

Faculty Scholarship

Theatre provides a dynamic platform to reflect upon the ethical, legal, and social implications of medical innovations and the powerful impact on personal and professional relationships. This article explores the last four to five decades of theatre, which coincide with the evolution of the formal discipline of bioethics and the field of medical humanities, to aid in the understanding of the bioethical challenges we face today and to place them in an historical and societal context. Four plays are discussed that reflect the ethical and legal context of their eras and reveal significant ethical challenges for us to consider.

Protecting Health Privacy In An Era Of Big Data Processing And Cloud Computing, Frank A. Pasquale, Tara Adams Ragone

Faculty Scholarship

This Article examines how new technologies generate privacy challenges for both healthcare providers and patients, and how American health privacy laws may be interpreted or amended to address these challenges. Given the current implementation of Meaningful Use rules for health information technology and the Omnibus HIPAA Rule in health care generally, the stage is now set for a distinctive law of “health information” to emerge. HIPAA has come of age of late, with more aggressive enforcement efforts targeting wayward healthcare providers and entities. Nevertheless, more needs to be done to assure that health privacy and all the values it is …

Is There Chronic Brain Damage In Retired Nfl Players? Neuroradiology, Neuropsychology, And Neurology Examinations Of 45 Retired Players, I. Casson, D. C. Viano, E. M. Haacke, Z. Kou, D. G. Lestrange

Journal Articles

BACKGROUND: Neuropathology and surveys of retired National Football League (NFL) players suggest that chronic brain damage is a frequent result of a career in football. There is limited information on the neurological statuses of living retired players. This study aimed to fill the gap in knowledge by conducting in-depth neurological examinations of 30- to 60-year-old retired NFL players. HYPOTHESIS: In-depth neurological examinations of 30- to 60-year-old retired players are unlikely to detect objective clinical abnormalities in the majority of subjects. STUDY DESIGN: A day-long medical examination was conducted on 45 retired NFL players, including state-of-the-art magnetic resonance imaging (MRI; susceptibility …

Juvenile Myoclonic Epilepsy-What Does The Future Look Like?, C. Harden

Journal Articles

No abstract provided.

Topiramate, Zonisamide And Small For Gestational Age: Maternal Factors, Timing Of Exposure And Baby Fat, C. L. Harden

Journal Articles

No abstract provided.

Consensus On Guidelines For Stereotactic Neurosurgery For Psychiatric Disorders, B. Nuttin, H. Wu, H. Mayberg, M. Hariz, L. Gabriels, T. Galert, R. Merkel, M. Schulder, Y. J. Li, T. Schlaepfer, +24 Additional Authors

Journal Articles

Background For patients with psychiatric illnesses remaining refractory to 'tandard' therapies, neurosurgical procedures may be considered. Guidelines for safe and ethical conduct of such procedures have previously and independently been proposed by various local and regional expert groups. Methods To expand on these earlier documents, representative members of continental and international psychiatric and neurosurgical societies, joined efforts to further elaborate and adopt a pragmatic worldwide set of guidelines. These are intended to address a broad range of neuropsychiatric disorders, brain targets and neurosurgical techniques, taking into account cultural and social heterogeneities of healthcare environments. Findings The proposed consensus document highlights …

Molecular Medicine Commemorates The Career And Science Of Anthony Cerami, K. J. Tracey

Journal Articles

No abstract provided.

Phase I/Ii Study Of Resection And Intraoperative Cesium-131 Radioisotope Brachytherapy In Patients With Newly Diagnosed Brain Metastases., A. G. Wernicke, B. Parashar, D. Nori, K. S. Clifford Chao, P. Christos, I. Kovanlikaya, S. Pannullo, J. A. Boockvar, P. E. Stieg, T. H. Schwartz

Journal Articles

OBJECT: Resected brain metastases have a high rate of local recurrence without adjuvant therapy. Adjuvant whole-brain radiotherapy (WBRT) remains the standard of care with a local control rate > 90%. However, WBRT is delivered over 10-15 days, which can delay other therapy and is associated with acute and long-term toxicities. Permanent cesium-131 ((131)Cs) implants can be used at the time of metastatic resection, thereby avoiding the need for any additional therapy. The authors evaluated the safety, feasibility, and efficacy of a novel therapeutic approach with permanent (131)Cs brachytherapy at the resection for brain metastases. METHODS: After institutional review board approval was …

Sepsis: Current Dogma And New Perspectives, C. S. Deutschman, K. J. Tracey

Journal Articles

Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading cause of morbidity andmortality worldwide. Current immunological mechanisms do not explain the basis of cellular dysfunction and organ failure, the ultimate cause of death. Here we review current dogma and argue that it is time to delineate novel immunometabolic and neurophysiological mechanisms underlying the altered cellular bioenergetics and failure of epithelial and endothelial barriers that produce organ dysfunction and death. These mechanisms might hold the key to future therapeutic strategies.

A Systematic Nomenclature For The Redox States Of High Mobility Group Box (Hmgb) Proteins, D. J. Antoine, H. E. Harris, U. Andersson, K. J. Tracey, M. E. Bianchi

Journal Articles

High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activities, such as inducing chemotaxis or the transcription of cytokines and chemokines, via the interaction with different receptors. The different HMGB1 redox forms can be identified by mass spectrometry in body fluids of patients and may hold promise as biomarkers. We propose here a systematic nomenclature of the different redox forms of HMGB1 and related proteins, to replace the conflicting names used so far by different laboratories.

Perceptions Of Neighborhood Safety And Asthma Among Children And Adolescents In Los Angeles: A Multilevel Analysis, M. Camacho-Rivera, I. Kawachi, G. G. Bennett, S. V. Subramanian

Journal Articles

Background: Research examining the impact of neighborhoods on asthma has shown an increased interest in the role of the psychosocial environment. We examined the associations between various measures of neighborhood safety, individual and family characteristics, and asthma outcomes among children in Los Angeles. Methods: Multilevel logistic regression models were used to analyze data on 3,114 children across 65 neighborhoods from Wave 1 of the Los Angeles Family and Neighborhood Survey (2000 to 2002). Primary caregivers reported asthma outcome and all individual covariates; home environmental characteristics were observed by the interviewer. Results: In fully adjusted models, parents who reported their neighborhood …