Medicine and Health Sciences Commons^™

Elderly Foot Care, Helen Chu

International Conference: Overcoming Challenges in Active Ageing

No abstract provided.

Occupational Therapy For The Elderly, Heung Ian, Irene Chan

International Conference: Overcoming Challenges in Active Ageing

No abstract provided.

Physiotherapy To Enhance Active Ageing, Yee Hung, Priscilla Poon

International Conference: Overcoming Challenges in Active Ageing

No abstract provided.

Using Progesterone As An Indicator Of Ovarian Response To Stimulation In Cattle, Kayla Mariah Kauffman

Animal Science

No abstract provided.

Resolution Of Central Nervous System Astrocytic And Endothelial Sources Of Ccl2 Gene Expression During Evolving Neuroinflammation, Bandana Shrestha, Shujun Ge, Joel S. Pachter

UCHC Articles - Research

Background

The chemokine CCL2 is a critical mediator of neuroinflammation in diseases such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). CCL2 drives mononuclear cell infiltration into the central nervous system (CNS), alters expression and distribution of microvascular endothelial tight junction proteins, and disrupts the blood–brain and blood-spinal cord barriers. Immunohistochemistry has consistently revealed astrocytes to be a source of this chemokine during neuroinflammation, while providing less uniform evidence that CNS endothelial cells may also express CCL2. Moreover, the relative contributions of these cell types to the CNS pool of CCL2 during MS/EAE are unclear and …

Smoking Cessation In Primary Care At The Sequatchie County Health Department: A Practice Change Proposal, Joy Hamilton

DNP Research Projects

No abstract provided.

Do Not Judge A Kidney By Its Pelvis: A Rare Case Of An Unobstructed Dilated Renal Pelvis, Aaron D. Martin, Craig A. Peters

Urology Faculty Publications

We present a rare case of an unobstructed dilated renal pelvis in a newborn female. Prenatal imaging documented a large abdominal cyst in a stable fetus. Postnatal imaging confirmed persistence of this large cyst but with an unclear etiology. The child was taken to surgery by the pediatric surgeons with concern for a possible harmful nonurologic diagnosis. Intraoperative findings were that of a severely dilated renal pelvis; however, in the absence of an expected ureteropelvic junction obstruction. Reduction pyeloplasty without interference of the ureteropelvic junction proved successful.

Update On Hyperlipidemia Guidelines, Drew Keister Md

Department of Family Medicine

No abstract provided.

Information Mastery Open Workshop, Drew Keister Md

Department of Family Medicine

No abstract provided.

Characterization Of A Novel Influenza Virus In Cattle And Swine: Proposal For A New Genus In The Orthomyxoviridae Family, Ben M. Hause, Emily A. Collin, Runxia Liu, Bing Huang, Zizhang Sheng, Wuxun Lu, Dan Wang, Eric A. Nelson, Feng Li

Veterinary and Biomedical Sciences Faculty Publications

We have recently reported the isolation of a novel virus, provisionally designated C/swine/Oklahoma/1334/2011 (C/OK), with 50% overall homology to human influenza C viruses (ICV), from a pig in Oklahoma. Deep RNA sequencing of C/OK virus found a matrix 1 (M1) protein expression strategy that differed from that of ICV. The novelty of C/OK virus prompted us to investigate whether C/OK virus could exist in a nonswine species. Significantly, we found that C/OK virus was widespread in U.S. bovine herds, as demonstrated by reverse transcription (RT)-PCR and serological assays. Genome sequencing of three bovine viruses isolated from two herds in different …

Anterior Talofibular Ligament Abnormality On Routine Magnetic Resonance Imaging Of The Ankle, Patrick Kane, Md, David Pedowitz, Md, Adam C C. Zoga, Md, Steven M. Raikin, Md

Rothman Institute Conference Posters

The anterior talo­fibular ligament (ATFL) extends from the anteroinferior border of the ­fibula to the talar neck. Primary restraint to ankle inversion in plantar‑exion. Injury (acute or chronic) can be diagnosed with physical exam, stress X-Rays, ultrasound or magnetic resonance imaging (MRI).

Purpose:

MRI abnormalities in asymptomatic individuals known in other areas of orthopaedics (shoulder and spine). Purpose of our study: determine the prevalence of ATFL abnormalities found on MRI in asymptomatic individuals. Asymptomatic individuals - those undergoing MRI for pathology unrelated to lateral ankle trauma, instability, or inversion injuries.

A Clinical Decision Support Tool To Predict The Risk Of Failure In Patients With Femoroacetabular Impingement Undergoing Hip Preservation Surgery, Claudio Diaz-Ledezma, Md, Mitchell Maltenfort, Phd, Lesley Walinchus, Bs, Benjamin Hendy, Bs, Thomas Novack, Bs, Javad Parvizi, Md, Frcs

Rothman Institute Conference Posters

In modern orthopaedics, risk prediction scores can help discriminate between ideal and poor candidates for a specifi­c therapeutic intervention. We consider these tools useful during the process of shared medical decision-making1. To our knowledge, such a strategy has never been explored in the ­field of hip preservation surgery.

The aim of our study is to generate a clinical decision support tool to predict risk of failure after hip preservation surgery among patients with femoroacetabular impingement (FAI).

Trends In Antibiotic Resistance In Coagulase-Negative Staphylococci In The United States, 1999 To 2012, Larissa S. May, Eili Y. Klein, Richard E. Rothman, Ramanan Laxminarayan

Emergency Medicine Faculty Publications

Coagulase-negative staphylococci (CoNS) are important bloodstream pathogens that are typically resistant to multiple antibiotics. Despite the concern about increasing resistance, there have been no recent studies describing the national prevalence of CoNS pathogens. We used national resistance data over a period of 13 years (1999 to 2012) from The Surveillance Network (TSN) to determine the prevalence of and assess the trends in resistance for Staphylococcus epidermidis, the most common CoNS pathogen, and all other CoNS pathogens. Over the course of the study period, S. epidermidis resistance to ciprofloxacin and clindamycin increased steadily from 58.3% to 68.4% and from 43.4% to …

Long-Term Safety Of Ospemifene (52-Week Extension) In The Treatment Of Vulvar And Vaginal Atrophy In Hysterectomized Postmenopausal Women, James A. Simon, David J. Portman, R. Garn Mabey, The Ospemifene Study Group

Obstetrics and Gynecology Faculty Publications

Objective

To examine the long-term safety of oral ospemifene, a non-estrogen tissue-selective estrogen agonist/antagonist, for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy (VVA) due to menopause.

Study design

This multicenter, long-term, open-label, safety extension study was conducted in women without a uterus aged 40–80 years (N = 301) who received oral ospemifene 60 mg/day for 52 weeks. Participants either continued their 60-mg/day ospemifene dose from the initial 12-week pivotal efficacy study or switched from blinded placebo or ospemifene 30 mg/day to open-label ospemifene 60 mg/day. The 52-week open-label extension period plus initial …

Editorial Comment: Health-Related Quality Of Life In Hemodialysis Patients: An Iranian Multi-Center Study, Ehsan Nobakht, Scott D. Cohen

Medicine Faculty Publications

No abstract provided.

Child And Adolescent Psychiatrists' Attitudes And Practices Prescribing Second Generation Antipsychotics, Angie Mae Rodday, Susan K. Parsons, Christoph U. Correll, Adelaide S. Robb, Bonnie T. Zima, Tully S. Saunders, Laurel K. Leslie

Psychiatry and Behavioral Sciences Faculty Publications

Objective: The purpose of this study was to examine psychiatrists' attitudes and practices in prescribing second-generation antipsychotics (SGA) to children and adolescents (referred to here as “children”) and identify factors associated with off-label SGA use.

Methods: A survey was mailed to a national, randomly selected sample of 1600 child and adolescent psychiatrists identified by the American Medical Association. Multivariable logistic regression was used to identify factors, including psychiatrists' characteristics, practice characteristics, and psychiatrists' attitudes, that are associated with off-label SGA use (i.e., SGAs used in children with attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, or nonbipolar mood disorders).

Results: …

Why Hospital Improvement Efforts Fail: A View From The Front Line., Paul D. Longenecker, Clinton O. Longenecker

Health and Sport Sciences Faculty Scholarship

In the 21st century, healthcare executives are facing changes of unprecedented magnitude in virtually every area, affecting their ability to compete. That hindrance brings with it a greater need for rapid and effective organizational change and improvement. Yet changes in the U.S. healthcare delivery system have historically been criticized as slow and less than effective in responding to the changes necessary for rapid performance improvement. To that end, the purpose of this applied research study was to help healthcare executives better understand the barriers to effective organizational change and improvement from the perspective of frontline leaders. Focus groups were conducted …

Genome Of The Human Hookworm Necator Americanus, Yat T. Tang, Xin Gao, Bruce A. Rosa, Sahar Abubucker, Kymberlie Hallsworth-Pepin, Peter J. Hotez, Jeffrey M. Bethony, +23 Additional Authors

Microbiology, Immunology, and Tropical Medicine Faculty Publications

The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and mortality during pregnancy in women. We report sequencing and assembly of the N. americanus genome (244 Mb, 19,151 genes). Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms. N. americanus has undergone a considerable and unique expansion of immunomodulator proteins, …

In Vitro Interaction Of Pseudomonas Aeruginosa With Human Middle Ear Epithelial Cells, Rahul Mittal, M'Hamed Grati, Robert Gerring, Patricia Blackwelder, Denise Yan, Jian-Dong Li, Xue Zhong Liu

Marine & Environmental Sciences Faculty Articles

Background: Otitis media (OM) is an inflammation of the middle ear which can be acute or chronic. Acute OM is caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis whereas Pseudomonas aeruginosa is a leading cause of chronic suppurative otitis media (CSOM). CSOM is a chronic inflammatory disorder of the middle ear characterized by infection and discharge. The survivors often suffer from hearing loss and neurological sequelae. However, no information is available regarding the interaction of P. aeruginosa with human middle ear epithelial cells (HMEECs).

Methodology and Findings: In the present investigation, we demonstrate that P. …

Health Insurance Coverage Of Low-Income Rural Children Increases And Is More Continuous Following Chip Implementation, Erika C. Ziller Phd

Access / Insurance

Key Findings: Prior to CHIP, low-income rural and urban children had comparable rates of public coverage and uninsurance, including chronic (a year or more) uninsurance; By the time CHIP was fully implemented, uninsured rates had declined so much among low-income rural children that they were lower than among urban children; In addition to lower uninsured rates in a given month, low-income rural children experienced dramatic increases in the continuity of their health insurance coverage following CHIP. Controlling for child and family characteristics, low-income rural children have more continuous coverage post-CHIP than do their urban counterparts.

Mental Health In Mississippi: Analysis And Recommendations, Harvard Law School Mississippi Delta Project

Delta Directions: Publications

Thousands of Mississippians struggle with some type of mental illness, and their experiences illustrate that mental health is more than just a medical issue. Mental health has a profound impact on Mississippi’s economy and overall standard of living; it is deeply connected to education, unemployment rates, crime, drug use, and public assistance. Given the far-­‐reaching impact of mental health, it is important that all stakeholders (e.g., mental health professionals, state legislators, local policymakers, educators, attorneys), have access to detailed information about the current state of Mississippi’s mental health system as well as an in-­‐depth analysis of the system’s most pressing …

Statin Therapy, Fitness, And Mortality Risk In Middle-Aged Hypertensive Male Veterans, Peter F. Kokkinos, Charles O. Faselis, Jonathan Myers, John Peter Kokkinos, Michael N. Doumas, Andreas Pittaras, Raya Kheirbek, Athanasios Manolis, Demosthenes Panagiotakos, Vasilios Papademetriou, Ross D. Fletcher

Medicine Faculty Publications

BACKGROUND

Hypertension often coexists with dyslipidemia, accentuating cardiovascular risk. Statins are often prescribed in hypertensive individuals to lower cardiovascular risk. Higher fitness is associated with lower mortality, but exercise capacity may be attenuated in hypertension. The combined effects of fitness and statin therapy in hypertensive individuals have not been assessed. Thus, we assessed the combined health benefits of fitness and statin therapy in hypertensive male subjects.

METHODS

Peak exercise capacity was assessed in 10,202 hypertensive male subjects (mean age = 60.4±10.6 years) in 2 Veterans Affairs Medical Centers. We established 4 fitness categories based on peak metabolic equivalents (METs) achieved …

Strad Pseudokinases Regulate Axogenesis And Lkb1 Stability, Biliana O. Veleva-Rotse, James L. Smart, Annette F. Baas, Benjamin Edmonds, Zi-Ming Zhao, Allyson Brown, Lillian R. Klug, Kelly Hansen, Gabrielle Rielly, Alexandria P. Gardner, Krishnaveni Subbiah, Eric A. Gaucher, Hans Clevers, Anthony P. Barnes

Faculty Publications - Department of Biological & Molecular Science

No abstract provided.

Results Of The Kentucky Worksite Assessment: Utilization Of The Cdc’S Health Scorecard, Cecilia M. Watkins, Grace Lartey, Gretchen Macy, Vijay Golla, Teresa Lovely

Public Health Faculty Publications

Study Objectives and Research Approach

A Health Impact Assessment (HIA) conducted in 2011-2012 of a proposed Kentucky Worksite Wellness Tax Credit highlighted gaps in the data available on worksite wellness programs in the Commonwealth of Kentucky.

Conducting a state-wide assessment of worksite wellness programs was a recommendation that resulted from this HIA.

The purpose of the assessment is to:

1) Identify the number of comprehensive worksite health promotion programs in Kentucky.

2) Determine the health needs of worksites in Kentucky.

By Identifying current wellness practices in Kentucky, better tools and support can be provided at a state level to assist …

44th Annual Wku Student Research Conference, Scott Lyons, Chair, Student Research Council

Student Research Conference Select Presentations

Abstracts available as a separate download on bottom of page.

Faculty Attitudes Towards Integrating Technology And Innovation, Colleen Marzilli, Julie Delello, Shelly Marmion, Rochell Mcwhorter

Nursing Faculty Publications and Presentations

Technological innovation is an important aspect of teaching and learning in the 21st century. This article examines faculty attitudes toward technology use in the classroom at one regional public university in the United States. Building on a faculty-led initiative to develop a Community of Practice for improving education, this study used a mixed-method approach of a faculty-developed, electronic survey to assess this topic. Findings from 72 faculty members revealed an overall positive stance toward technology in the classroom and the average faculty member utilized about six technology tools in their courses. The opportunities, barriers and future uses for technologies in …

Chhs March/April 2014 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

Medical Education Digest, Vol. 16 No. 2 (March/April 2014), Nova Southeastern University

Medical Education Digest

No abstract provided.

Role Of Erk1, 2, And 5 In Dopamine Neuron Survival During Aging, Mayur S. Parmar, Juliann D. Jaumotte, Stephanie L. Wyrostek, Michael J. Zigmond, Jane E. Cavanaugh

HPD Articles

Extracellular signal-regulated kinases (ERKs) 1, 2, and 5 have been shown to play distinct roles in proliferation, differentiation, and neuronal viability. In this study, we examined ERK1, 2, and 5 expression and activation in the substantia nigra (SN), striatum (STR), and ventral tegmental area (VTA) during aging. An age-related decrease in phosphorylated ERK5 was observed in the SN and STR, whereas an increase in total ERK1 was observed in all 3 regions. In primary cultures of the SN and VTA, inhibition of ERK5 but not ERK1 and 2 decreased dopamine neuronal viability significantly. These data suggest that ERK5 is essential …

Molecular Pap Biomarkers For Cervical Cancer Risk Assessment In Thinprep® Clinical Specimens, Jennifer Taylor

Graduate School of Biomedical Sciences Theses and Dissertations

Approximately 500,000 patients are diagnosed with cervical cancer worldwide each year, thus making it the second most common cause of cancer-related deaths in women. Persistent high-risk human papillomavirus (HR-HPV) infections induce cervical dysplasia by increasing the expression of two viral oncogenes, E6 and E7. Utilization of the Papanicolaous smear test (Pap test) has contributed to a decrease in morbidity and mortality of cervical cancer; however, subjective analysis of cell morphology with a limited amount of cells has led to a substantial rate of false positive and false negative diagnoses. A more objective and sensitive diagnostic tool for the detection of …