Medicine and Health Sciences Commons^™

Of Predatory Publishers And Spurious Impact Factors, Saba Sohail

Department of Radiology

No abstract provided.

Chlorovirus Pbcv-1 Encodes An Active Copper-Zinc Superoxide Dismutase, Ming Kang, Garry A. Duncan, Charles Kuszynski, George Oyler, Jiayin Zheng, Donald F. Becker, James L. Van Etten

James Van Etten Publications

Superoxide dismutases (SODs) are metalloproteins that protect organisms from toxic reactive oxygen species by catalyzing the conversion of superoxide anion to hydrogen peroxide and molecular oxygen. Chlorovirus PBCV-1 encodes a 187-amino-acid protein that resembles a Cu-Zn SOD with all of the conserved amino acid residues for binding copper and zinc (named cvSOD). cvSOD has an internal Met that results in a 165-amino-acid protein (named tcvSOD). Both cvSOD and tcvSOD recombinant proteins inhibited nitroblue tetrazolium reduction of superoxide anion generated in a xanthine-xanthine oxidase system in solution. tcvSOD was chosen for further characterization because it was easier to produce. Recombinant tcvSOD …

The Scoop, Vol. 1 Issue 5, August 2014, Health Sciences Library

Volume 1

Latest news and events from the Health Sciences Library in our monthly newsletter for August 2014.

In Vivo Processing Of Ceria Nanoparticles Inside Liver: Impact On Free-Radical Scavenging Activity And Oxidative Stress, Uschi M. Graham, Michael T. Tseng, Jacek B. Jasinski, Robert A. Yokel, Jason M. Unrine, Burtron H. Davis, Alan K. Dozier, Sarita S. Hardas, Rukhsana Sultana, Eric A. Grulke, D. Allan Butterfield

Pharmaceutical Sciences Faculty Publications

The cytotoxicity of ceria ultimately lies in its electronic structure, which is defined by the crystal structure, composition, and size. Despite previous studies focused on ceria uptake, distribution, biopersistance, and cellular effects, little is known about its chemical and structural stability and solubility once sequestered inside the liver. Mechanisms will be presented that elucidate the in vivo transformation in the liver. In vivo processed ceria reveals a particle-size effect towards the formation of ultrafines, which represent a second generation of ceria. A measurable change in the valence reduction of the second-generation ceria can be linked to an increased free-radical scavenging …

The Role Of Melanin Concentrating Hormone (Mch) In The Central Chemoreflex: A Knockdown Study By Sirna In The Lateral Hypothalamus In Rats, Ningjing Li, Eugene Nattie, Aihua Li

Dartmouth Scholarship

Melanin concentrating hormone (MCH), a neuropeptide produced mainly in neurons localized to the lateral hypothalamic area (LHA), has been implicated in the regulation of food intake, energy balance, sleep state, and the cardiovascular system. Hypothalamic MCH neurons also have multisynaptic connections with diaphragmatic motoneurons and project to many central chemoreceptor sites. However, there are few studies of MCH involvement in central respiratory control. To test the hypothesis that MCH plays a role in the central chemoreflex, we induced a down regulation of MCH in the central nervous system by knocking down the MCH precursor (pMCH) mRNA in the LHA using …

Vaccines To Combat River Blindness: Expression, Selection And Formulation Of Vaccines Against Infection With Onchocerca Volvulus In A Mouse Model., Jessica A. Hess, Bin Zhan, Sandra Bonne-Annee, Jessica M. Deckman, Maria Elena Bottazzi, Peter J. Hotez, Thomas R R. Klei, Sara Lustigman, David Abraham

Department of Microbiology and Immunology Faculty Papers

Human onchocerciasis is a neglected tropical disease caused by Onchocerca volvulus and an important cause of blindness and chronic disability in the developing world. Although mass drug administration of ivermectin has had a profound effect on control of the disease, additional tools are critically needed including the need for a vaccine against onchocerciasis. The objectives of the present study were to: (i) select antigens with known vaccine pedigrees as components of a vaccine; (ii) produce the selected vaccine antigens under controlled conditions, using two expression systems and in one laboratory and (iii) evaluate their vaccine efficacy using a single immunisation …

El Mal De Chagas Y Su Potencial De Eliminación, Eileen Stillwaggon

Economics Faculty Publications

La Asamblea Mundial de la Salud ha elegido algunas enfermedades como blancos para la eliminación. Hay mucha esperanza y una alta probabilidad de que varias enfermedades, recientemente llamadas desatendidas, sean eliminadas en las próximas décadas. Vamos a presenciar el fin de la transmisión de la dracunculiasis, la filariosis linfática, la poliomielitis, y en las Américas por lo menos, la oncocercosis. Ya se ven éxitos significativos como la cuasi erradicación de la dracunculiasis y paso importantes en contra de otras aflicciones. [Original Spanish version]

The World Health Assembly has chosen some diseases as targets for elimination. There is much …

Development Of A New Polymerase Chain Reaction Assay For The Rapid Detection Of The Oral Pathogenic Bacterium, Selenomonas Noxia, Patrica Cruz-Perez, Arthuro Mehretu, Mark P. Buttner, Katherine M. Howard, Theresa Trice

Environmental & Global Health Faculty Research

Background

In recent studies, periodontal health has been linked to being overweight and/or obese. Among common oral bacteria, Selenomonas noxia has been implicated in converting periodontal health to disease, and Selenomonas species have also been found in gastric ulcers. The objective of this study was to develop and validate a quantitative polymerase chain reaction (qPCR) assay for the specific and rapid detection of S. noxia.

Methods

Two oligonucleotide primer pairs and one probe were designed and tested to determine optimal amplification signal with three strains of S. noxia. The PCR assay was tested against fourteen non-target organisms, including …

Oncolog, Volume 59, Number 08, August 2014, Kathryn L. Hale, Bryan Tutt, Sunita Patterson, R. Molar-Candanosa

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Immune Checkpoint Inhibitors Show Promise Against Metastatic Renal Cell Carcinoma, Other Difficult-to-Treat Cancers: A decade ago, oncologists had little to offer most patients with metastatic renal cell carcinoma (RCC). However, a breakthrough discovery that has already changed the treatment of metastatic melanoma is showing promise against other metastatic cancers-including metastatic RCC-and giving patients new hope for long-term survival
• Clinical Study Offers Definitive Local Treatment of Bone Metastases from Breast Cancer: Metastatic breast cancer carries a poor prognosis, and most systemic treatments for metastatic disease aim to slow its progression rather than to cure it. In a select group of patients, …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 2014), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 2014 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Message from the President
• PCOM Updates
• Commencement 2014
• Development News
• Considerations for Healthcare Education
• Diversity and Healthcare Disparities: Remembering the Children
• Instructional Strategies in Continuity Care Education
• Competency-based Assessment: Practicing Emergency Care from the Start
• Health Information Technology Advances Innovative Clinical Teaching Model
• Curbing Healthcare Provider Shortages in the South with New Residency Programs
• Class Notes
• Reunion Weekend
• In Memoriam
• My Turn Essay

Rapid Repeat Pregnancy Among Women Seeking Pregnancy Termination: A Descriptive Study, Katharine White Md, Peter St. Marie Bs, Alison Mitchell Bs, Abigail Hatch, Erin Amato, Elizabeth Lynch Bs

All Scholarly Works

No abstract provided.

Single Incision Laparoscopic Appendectomy Utilizing Glove Port In Pediatric Patients. A Retrospective Chart Review, Michael Tirabassi Md, Carmen Mora Md, Kevin Moriarty Md, David Tashjian Md, Gregory Banever Md, Stanley Konefal Md, Kyle Douglas

All Scholarly Works

No abstract provided.

A Prospective Study Of The Management Of Mild Traumatic Brain Injuries Without Neurosurgical Consultation, Jeffry Nahmias Md, Robert Gaffey

All Scholarly Works

No abstract provided.

Premature Discontinuation Rates Of Larc Methods Of Contraception: A Descriptive Study, Cunningham Cassidy, Katharine White Md, Annie Fu

All Scholarly Works

No abstract provided.

Department Of Surgery Update, August 2014, Wright State University Department Of Surgery

Department of Surgery Updates

A two page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, announcements, committee meetings, scholarly activity and more.

Vital Signs, Fall 2014, Boonshoft School Of Medicine

Vital Signs

A sixty-four page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Mismatch In Ed And Discharge Diagnoses Of Chf, Howard Smithline Md, Sunjin Oh, Nicholas Cormier

All Scholarly Works

No abstract provided.

Induced Hypothermia And Its Effects On Cardiac Arrhythmias, Shatoyia Barlow

HIM 1990-2015

The purpose of this integrated review of the literature was to determine the relationship between therapeutic hypothermia and cardiac arrhythmias. The reviewed literatures were English based articles from year 2003-2013. Relevant information from the American Heart Association and the International Liaison Committee on Resuscitation was used to further enhance research results. The results of this literature review showed hypothermia treatment propensity to prolong QT interval without precipitating life-threatening arrhythmias. Although arrhythmias can be potentially increased under induced hypothermia, it has been shown that treatment is easier while under hypothermic conditions. The reviewed research also shows that hypothermia treatment should be …

Identifying Populations At Risk For Infection After Knee Arthroplasty: An Integrated Literature Review, Christian Coker

HIM 1990-2015

The purpose of this integrated review of the literature was to explore the postsurgical infection complications commonly occurring in individuals undergoing total knee replacement surgery, and the relationship of co-morbidities, lifestyle choices, and genetics on the risk for complication. A comprehensive search of the literature focusing on the patient surgical site infection and total knee replacement surgery using the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Medical Literature On-line (MEDLINE). Initial searches revealed 80 results. Upon closer scrutiny, duplicates were removed, as well as those not relevant to infection in total knee arthroplasty. This resulted in a …

The Use Of Drug Therapy For Attention Deficit Hyperactivity Disorder (Adhd) In The Management Of Oppositional Defiant Disorder (Odd): A Literature Review, Shaina Flowers

HIM 1990-2015

Children with oppositional defiant disorder (ODD) and a concurrent Axis I diagnosis are often prescribed drug therapy for attention deficit hyperactivity disorder (ADHD) to manage disruptive behavior. However, ODD symptoms tend to be poorly controlled, raising questions about the effectiveness of drug therapy in children with the condition. Safety and long term consequences of pharmacological agents for ODD are important factors clinicians must consider before initiating treatment. The purpose of this literature review is to examine the pharmacodynamics and efficacy of drug therapy used for ODD in school-age children and adolescents. Additionally, awareness of poor behavior patterns and recognition of …

The Acquisition Of Student Nurses' Knowledge Of Genetics And Genomics And Attitudes Toward The Application Of Their Knowledge In Clinical Practice, Theresa Munroe

HIM 1990-2015

BACKGROUND: Nurses have the opportunity to bring a unique perspective to genetic and genomic healthcare through their emphasis of health promotion, prevention, screening, caring, and patient, family, and community relationships. Nurses are expected to have genetic and genomic knowledge that can be integrated into clinical practice. However, researchers today are finding nursing students are not competent or comfortable in the clinical applications of genetics and genomics, even though these students will soon be working in healthcare as it advances in these fields. The purpose of this research was to evaluate the genetic and genomic knowledge of nursing undergraduate students and …

The Effect Of Dietary Interventions On Fetal Birth Weights In Pregnant Adolescents: A Systematic Review, Seeta Nath

HIM 1990-2015

Nutrition status during adolescent pregnancy and childbearing is a complex, multifaceted condition that can impact the health status of the teen mother and her baby. Adolescent mothers are at higher risk for low birth weight infants because of the unique dietary requirements needed to accommodate for both the growth needs of the adolescent mother and her unborn child. The purpose of this research was to examine dietary interventions that have the greatest effect on fetal birth weight outcomes in adolescent mothers. Secondly, this study explored dietary nutrients effective in reducing the likelihood of complications commonly associated with low birth weight …

The Use Of Mobile Applications In Preventive Care And Health-Related Conditions: A Review Of The Literature, Naomi Ringer

HIM 1990-2015

The purpose of this review of literature was to understand the role of mobile device applications in health related conditions and to analyze their effects on health outcomes related to the management of chronic illnesses. Implications for future use of applications in client-centered care and interpretation of the data by health care providers was also explored. Peer-reviewed, English-language research articles published from 2008 to present were included for synthesis. Study results revealed positive outcomes when health-related mobile applications were used in practice and support clinicians' use of mobile applications as a tool for monitoring symptoms and communicating with individuals. The …

My Child Has What? The Most Effective Means Of Communication When Delivering A Difficult Diagnosis To The Parents Of A Pediatric Patient, Nidhi Sethi

HIM 1990-2015

For the healthcare provider, disclosing a pediatric patient's difficult diagnosis in the form of an acute or chronic condition to the parents is a challenging task. Healthcare providers often feel unprepared when relaying the news of such diagnosis, and the parents feel equally unprepared upon receiving it (Pririe, 2012). This systematic literature review examined the various communication techniques used in the past, and the techniques' effectiveness in increasing parental satisfaction when first learning of the child's diagnosis. A scarce number of studies related to the most effective techniques were found in the literature, and even fewer were found that evaluated …

The Fatherhood Factor: The Impact Of The Father-Child Relationship On The Social, Interpersonal, And Recidivism Risk Factors Of Previously Incarcerated Men, Larissa A. Maley

Seton Hall University Dissertations and Theses (ETDs)

Of the men who return home from prison, nearly 7 out of 10 will be re-arrested and sent back within 3 years of their release (Travis, Solomon, & Waul, 2001). This trend has large- scale implications, not just for individuals, but for their families and communities as well. Clearly, understanding the factors that contribute to a man’s success or failure in staying out of prison is extremely important in constructing policy and programs to assist these at-risk individuals and communities. Of the few studies that have explored the lives of previously incarcerated men, some have found fatherhood to be a …

Detection Of Dementia Risk In Primary Care: Preliminary Investigation Of A Composite Dementia Risk Score In Veterans, Jonathan Deright

Dissertations - ALL

Dementia is becoming a significant public health concern as the United States population rapidly ages. Veterans, accounting for a substantial portion of the United States population, may be at even higher risk for developing dementia as they generally have more risk factors for dementia than the general population. The current study sought to develop a modifiable composite dementia risk score, based on routinely gathered data from the primary care setting, that would predict an individual's risk for developing dementia in 10 years. A composite risk score--based on age, hypercholesterolemia, hypertension, current smoking, alcohol use disorder, and pulse pressure--was created using …

New Dentist News (August 2014), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

Association Of Cardiorespiratory Fitness And Adiposity With Inflammatory Biomarkers In Young Adults, Eunduck Park

Dissertations and Theses (Open Access)

Background: Low grade systemic inflammation plays a key role in atherosclerosis, and C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF -a), markers of systemic inflammation, are associated with cardiovascular events and adiposity. Cardiorespiratory fitness has shown health benefits by reducing circulating levels of inflammatory markers. However, it remains uncertain whether the negative association between cardiorespiratory fitness and inflammatory biomarkers is due to cardiorespiratory fitness itself or results from lower levels of adiposity. Moreover, the evidence examining the interaction between cardiorespiratory fitness and adiposity in inflammation in young adults is lacking.

Purpose: The aims of this study were …

Once-Weekly Exenatide As Adjunct Treatment Of Type 1 Diabetes Mellitus In Patients Receiving Continuous Subcutaneous Insulin Infusion Therapy, Andrea N. Traina, Melinda E. Lull, Adrian C. Hui, Toni M. Zahorian, Jane Lyons-Patterson

Pharmacy Faculty/Staff Publications

Objective

The use of once-weekly exenatide in type 2 diabetes mellitus is well supported, but little is known about its effectiveness in type 1 diabetes. The objective of this study was to determine the clinical efficacy of once-weekly exenatide on glycemic control in patients with type 1 diabetes when added to basal-bolus insulin therapy.

Methods

For this retrospective study, patients with type 1 diabetes, aged 18 years and older, receiving continuous subcutaneous insulin infusion, using a continuous glucose monitoring device or regularly measuring blood glucose levels and receiving 2 mg of exenatide once weekly for at least 3 months were …

Towards Image-Guided Pediatric Atrial Septal Defect Repair, Fuad Mefleh

All Dissertations

Congenital heart disease occurs in 107.6 out of 10,000 live births, with Atrial Septal Defects (ASD) accounting for 10\% of these conditions. Historically, ASDs were treated with open heart surgery using cardiopulmonary bypass, allowing a patch to be sewn over the defect. In 1976, King et al. demonstrated use of a transcatheter occlusion procedure, thus reducing the invasiveness of ASD repair. Localization during these catheter based procedures traditionally has relied on bi-plane fluoroscopy; more recently trans-esophageal echocardiography (TEE) and intra-cardiac echocardiography (ICE) have been used to navigate these procedures. Although there is a high success rate using the transcatheter occlusion …