Medicine and Health Sciences Commons^™

The Santa Clara, 2014-10-02, Santa Clara University

The Santa Clara

No abstract provided.

Acute Repeated Intracerebroventricular Injections Of Angiotensin Ii Reduce Agonist And Antagonist Radioligand Binding In The Paraventricular Nucleus Of The Hypothalamus And Median Preoptic Nucleus In The Rat Brain, Robert C. Speth, Peter J. Vento, Eduardo J. Carrera, Luz Gonzalez-Reily, Andrea Linares, Kira Santos, Jamala D. Swindle, Derek Daniels

HPD Articles

Angiotensin II (Ang II) stimulates water and saline intakes when injected into the brain of rats. This arises from activation of the AT1 Ang II receptor subtype. Acute repeated injections, however, decrease the water intake response to Ang II without affecting saline intake. Previous studies provide evidence that Ang II-induced water intake is mediated via the classical G protein coupling pathway, whereas the saline intake caused by Ang II is mediated by an ERK 1/2 MAP kinase signaling pathway. Accordingly, the different behavioral response to repeated injections of Ang II may reflect a selective effect on G protein coupling. To …

Analysis Of Candida Albicans Mutants Defective In The Cdk8 Module Of Mediator Reveal Links Between Metabolism And Biofilm Formation, Allia K. Lindsay, Diana K. Morales, Zhongle Liu, Nora Grahl, Anda Zhang, Sven D. Willger, Lawrence C. Myers, Deborah A. Hogan

Dartmouth Scholarship

Candida albicans biofilm formation is a key virulence trait that involves hyphal growth and adhesin expression. Pyocyanin (PYO), a phenazine secreted by Pseudomonas aeruginosa, inhibits both C. albicans biofilm formation and development of wrinkled colonies. Using a genetic screen, we identified two mutants, ssn3Δ/Δ and ssn8Δ/Δ, which continued to wrinkle in the presence of PYO. Ssn8 is a cyclin-like protein and Ssn3 is similar to cyclin-dependent kinases; both proteins are part of the heterotetrameric Cdk8 module that forms a complex with the transcriptional co-regulator, Mediator. Ssn3 kinase activity was also required for PYO sensitivity as a kinase dead mutant maintained …

Sculpting The Illness Experience, Molly Bathje

The Open Journal of Occupational Therapy

Otto Kamensek provided the cover art for the Fall 2014 issue of the Open Journal of Occupational Therapy. “Glimmer of Hope” is part of Otto’s collection “Shard’s, Bone Deep,” which includes hand-built ceramic sculptures that portray his experiences with a lifelong chronic illness. Engaging in ceramic sculpture helps him process the experiences associated with Juvenile Rheumatoid Arthritis and provides a means to support others experiencing chronic illness.

The Significance Of Somatosensory Stimulation To The Hand: Implications For Occupational Therapy Practice, Guy L. Mccormack

The Open Journal of Occupational Therapy

The hands contain numerous nerve endings that are intimately connected to the brain. Mounting evidence supports the concept that willful manipulation of objects contributes to expansion or reorganization of the somatosensory cortex and can produce therapeutic outcomes. In the past decade, research has demonstrated that cortical plasticity can continue throughout adulthood. Brain plasticity is a core principle that demonstrates the ability of the central nervous system to respond to stimuli and modify its structural organization and function as an adaptive response. Occupation-based interventions, which engage the use of the hands, are conceived in this article as a “mindbody” experience because …

The Role Of Reusable Learning Objects In Occupational Therapy Entry-Level Education, Bryan M. Gee, Jane Strickland, Lisa Salazar

The Open Journal of Occupational Therapy

Out of early research, Cisco Systems (1999) have built an impressive foundation that advocates for reusable learning objects (RLOs). As the need for online methods for delivering both formal and informal educational content has increased, the prospect of greater influence through carefully constructed RLOs has grown. RLOs are any digital resource that can be used and reused to enhance online learning. RLOs typically are small, discrete, self-contained digital objects that may be sequenced, combined, and used within a variety of instructional activities. RLOs have been implemented in nursing, pharmacy, and physician assistant programs. However, there is a lack of literature …

Relationships Among Occupation/Activity Patterns, Health And Stress Perceptions, And Life Orientation In Well Adults, Barbara Prudhomme White, Amy Ma, Deborah Whitney

The Open Journal of Occupational Therapy

Background: This study examined the relationships among activity choices, perceived health, stress, and life orientation (optimism-pessimism) in a general population of 675 healthy adults ranging in age from 18-91 years. The objective was to examine assumptions that occupational scientists and practitioners hold regarding the relationships among health factors and engagement in activities/occupations.

Method: The study used four self-report measures, including a customized activity card sort that asked participants about both healthy and unhealthy activity patterns. Responses were then compared with the participants’ perceptions of overall health, stress levels, and degrees of optimism and pessimism (life orientation).

Results: Major findings confirmed …

“Putting The Occupation Back In Occupational Therapy:” A Survey Of Occupational Therapy Practitioners’ Use Of Gardening As An Intervention, Amy Wagenfeld, Ben Atchison

The Open Journal of Occupational Therapy

Background. This study examines how and why occupational therapy practitioners across practice areas use gardening as an intervention. Respondents’ interpretation of the best and least desirable aspects of their facility’s garden and whether they contributed to its design was also examined.

Method. A description and link to a 15-question online survey about gardening as an occupational therapy intervention was emailed to Western Michigan University Occupational Therapy alumni and posted on four OT Connections groups and the AOTA LinkedIn site.

Results. Gardening as an occupational therapy intervention is meaningful and purposeful (93.66%, n = 56), motivating (80%, n = 48), fun …

Home-Based Constraint Induced Movement Therapy Poststroke, Stephen Isbel, Christine Chapparo, David Mcconnell, Judy Ranka

The Open Journal of Occupational Therapy

Background: This study examined the efficacy of a home-based Constraint Induced Movement Therapy (CI Therapy) protocol with eight poststroke survivors.

Method: Eight ABA, single case experiments were conducted in the homes of poststroke survivors. The intervention comprised restraint of the intact upper limb in a mitt for 21 days combined with a home-based and self-directed daily activity regime. Motor changes were measured using The Wolf Motor Function Test (WMFT) and the Motor Activity Log (MAL).

Results: Grouped results showed statistically and clinically significant differences on the WMFT (WMFT [timed items]): Mean 7.28 seconds, SEM 1.41, 95% CI 4.40 – 10.18, …

“I Think Relax, Relax And It Flows A Lot Easier”: Exploring Client-Generated Relax Strategies, Dianne Cirone, Sara E. Mcewen

The Open Journal of Occupational Therapy

Background. Some adult stroke survivors participating in Cognitive Orientation to daily Occupational Performance (CO-OP) treatment programs self-generated relax strategies that have not been explored in previous CO-OP publications. The objective of this study was to describe the process by which adults with stroke used relax strategies and to explore the outcomes associated with their use.

Methods. Secondary analysis of transcripts of intervention sessions from five participants was conducted.

Results. All five participants applied relax strategies after initially observing a breakdown in performance that was attributed to increased fatigue or tension. The relax strategies used by the participants during their occupations …

Introducing Breakouts, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

Sustaining Precarious Transnational Families: The Significance Of Remittances From Canada’S Seasonal Agricultural Workers Program, Don Wells, Janet Mclaughlin, André Lyn, Aaraón Díaz Mendiburo

Health Studies

Accelerating flows of remittances are dwarfing global development aid. This study deepens our understanding of remittance impacts on the families of workers who come to Canada annually for several months under the Seasonal Agricultural Workers Program (SAWP). Interviews with SAWP workers, their spouses, adult children and teachers in Mexico deepen our understanding of the impacts of these remittances. They demonstrate that the remittances are often literally a lifeline to transnational family survival, allowing them to pay for basic needs such as shelter, food, and medical care. Yet, at the same time, the remittances do not allow most of these workers …

Innovations Volume 1: Issue 1, Ron And Kathy Assaf College Of Nursing

Innovations Magazine

No abstract provided.

Analysis Of Differential Mrna And Mirna Expression In An Alzheimer’S Disease Mouse Model, Amanda Hazy, Matthew Dalton

Other Undergraduate Scholarship

Research has shown that changes in gene expression play a critical role in the development of Alzheimer’s Disease (AD). Our project will evaluate genome-wide RNA expression patterns from brain and blood in an AD mouse model. This analysis will provide insight regarding the mechanisms of AD pathology as well as determine a possible diagnostic tool utilizing RNA expression patterns found in the blood as biomarkers for AD.

Integrative Health Studies Newsletter, Ciis

Integrative Health Studies Newsletter

This is the October 2014 issue of the Integrative Health Studies Newsletter at CIIS.

Integrative Health Studies Newsletter, Ciis

Integrative Health Studies Newsletter

This is the October 2014 issue of the Integrative Health Studies Newsletter at CIIS.

Comprehensive School Physical Activity Programs: Characteristics Of Trained Teachers, Erin E. Centeio, Heather Erwin, Darla M. Castelli

Kinesiology, Health and Sport Studies

As public health concerns about physical inactivity and childhood obesity continue to rise, researchers are calling for interventions that comprehensively lead to more opportunities to participate in physical activity (PA). The purpose of this study was to examine the characteristics and attitudes of trained physical education teachers during the implementation of a Comprehensive School Physical Activity Program at the elementary level. Using a collective case study design, interviews, observations, field notes, open-ended survey questions, and an online forum monitoring guided the interpretation of teacher perceptions and development of emergent themes. Qualitative data analysis was conducted for each individual teacher and …

Healthnet News V.29:No.3 Fall 2014, Alberta Richetelle, Wendy Urciuoli

Articles - Patient Care

No abstract provided.

Lower-Extremity Joint Kinematics And Muscle Activations During Semi-Reclined Cycling At Different Workloads In Healthy Individuals, Kamyar Momeni, Pouran D. Faghri, Martinus Evans

Open Access Author Fund Awardees' Articles

Background

A better understanding of lower-extremity muscles’ activation patterns and joint kinematics during different workloads could help rehabilitation professionals with prescribing more effective exercise regimen for elderly and those with compromised muscles. We examined the relative contribution, as well as activation and co-activation patterns, of lower-extremity muscles during semi-reclined cycling at different workloads during a constant cadence.

Methods

Fifteen healthy novice cyclists participated at three 90-second cycling trials with randomly assigned workloads of 0, 50, and 100 W, at a constant cadence of 60 rpm. During all trials, electromyograms were recorded from four lower-extremity muscles: rectus femoris (RF), biceps femoris …

Department Of Surgery Update, October 2014, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, notes and pictures on the postgraduate symposium and more.

Asynchronous Remodeling Is A Driver Of Failed Regeneration In Duchenne Muscular Dystrophy, Sherry Dadgar, Zuyi Wang, Helen Johnston, Akanchha Kesari, Kanneboyina Nagaraju, Yi-Wen Chen, D. Ashley Hill, Terence A. Partridge, Robert J. Freishtat, Javad Nazarian, Jianhua Xuan, Yue Wang, Eric P. Hoffman

Genomics and Precision Medicine Faculty Publications

We sought to determine the mechanisms underlying failure of muscle regeneration that is observed in dystrophic muscle through hypothesis generation using muscle profiling data (human dystrophy and murine regeneration). We found that transforming growth factor β-centered networks strongly associated with pathological fibrosis and failed regeneration were also induced during normal regeneration but at distinct time points. We hypothesized that asynchronously regenerating microenvironments are an underlying driver of fibrosis and failed regeneration. We validated this hypothesis using an experimental model of focal asynchronous bouts of muscle regeneration in wild-type (WT) mice. A chronic inflammatory state and reduced mitochondrial oxidative capacity are …

Lasting Impressions, Fall 2014, College Of Dental Medicine

Newsletters

No abstract provided.

Estimation Of Length Or Height In Infants And Young Children Using Ulnar And Lower Leg Length With Dual-Energy X-Ray Absorptiometry Validation, Lee A. Weidauer, Howard Wey, Hillarie Slater, Laurie Moyer-Mileur, Bonny Specker

Health and Nutritional Sciences Faculty Publications

AIM: We compared the accuracy and reproducibility of using ulnar and lower leg length measurements to predict length and height in infants and children aged 0 to 6 years.

METHOD: Length/height and ulnar and lower leg length were measured in 352 healthy preterm and term-born children (167 males, 185 females) (Mean age= 2.6±1.6 years). Ulna length was measured as the distance between the proximal olecranon process and the distal styloid process of the ulna. Tibia length was measured as the distance from the proximal aspect of the medial condyle and the most distal aspect of the medial malleolus of the …

Physical Activity Change Through Comprehensive School Physical Activity Programs In Urban Elementary Schools, Erin E. Centeio, Nate Mccaughtry, Lila Gutuskey, Alex C. Garn, Cheryl Somers, Bo Shen, Jeffry J. Martin, Noel L, Kulik

Kinesiology, Health and Sport Studies

he impact of Comprehensive School Physical Activity Programs (CSPAPs) on urban children’s, educators’, and parents’ physical activity (PA) is relatively unknown. The purpose of this study was to explore overall changes in student, educator, and parent PA after an 8-month CSPAP-based program. This longitudinal, exploratory study implemented a CSPAP in 20 urban elementary schools, with six randomized for research. In-school PA was measured prepost for all fourth grade students using accelerometers. Parent and educator PA was self-reported using the IPAQ. RM-ANOVAs revealed significant prepost increases in minutes of student MVPA (P < .001). Parents significantly increased PA (P < .01) and although educators’ reported change in PA, it was not statistically significant (P = .50). This study provides unique …

Mid-Atlantic Ethics Committee Newsletter, Fall 2014

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Christina Nelson - Applying John Hagan’S Power-Control Theory To Gender Differences With Drug Abuse, Christina Nelson

Ronald E. McNair Scholars Program 2014

Previous work has indicated that young men and women engage in drug use in different ways and for different reasons. This research tests Hagan’s Power-Control Theory to examine gender differences in adolescent drug use. This study analyzes randomly selected subsample of data from the National Survey on Drug Use and Health (NSDUH). Questions that led this study were: Do patterns of drug abuse differ by gender? To what extent can Hagan’s Power-Control Theory explain this? Control variables looked at gender, age and race. All adolescents were from the ages of 12-17. Dependent variables looked at drug use (ever, yearly, monthly). …

Brittany Bernal - Sensorimotor Adaptation Of Speech Through A Virtually Shortened Vocal Tract, Brittany A. Bernal

Ronald E. McNair Scholars Program 2014

The broad objective of this line of research is to understand how auditory feedback manipulations may be used to elicit involuntary changes in speech articulation. We examine speech sensorimotor adaptation to supplement the development of speech rehabilitation applications that benefit from this learning phenomenon. By manipulating the acoustics of one’s auditory feedback, it is possible to elicit involuntary changes in speech articulation. We seek to understand how virtually manipulating participants’ perception of vowel space affects their speech movements by assessing acoustic variables such as formant frequency changes. Participants speak through a digital audio processing device that virtually alters the perceived …

Olfactory Dysfunction Predicts 5-Year Mortality In Older Adults, Jayant M. Pinto, Kristen E. Wroblewski, David W. Kern, L Phillip Schumm, Martha K. Mcclintock

Psychology & Gerontology Faculty Publications

Prediction of mortality has focused on disease and frailty, although antecedent biomarkers may herald broad physiological decline. Olfaction, an ancestral chemical system, is a strong candidate biomarker because it is linked to diverse physiological processes. We sought to determine if olfactory dysfunction is a harbinger of 5-year mortality in the National Social Life, Health and Aging Project [NSHAP], a nationally representative sample of older U.S. adults. 3,005 community-dwelling adults aged 57–85 were studied in 2005–6 (Wave 1) and their mortality determined in 2010–11 (Wave 2). Olfactory dysfunction, determined objectively at Wave 1, was used to estimate the odds of 5-year, …

Effects Of Yoga On Arm Volume Among Women With Breast Cancer Related Lymphedema: A Pilot Study, Mary Insana Fisher, Betsy Donahoe-Fillmore, Laura Leach, Colleen O'Malley, Cheryl Paeplow, Tess Prescott, Harold L. Merriman

Physical Therapy Faculty Publications

Lymphedema affects 3–58% of survivors of breast cancer and can result in upper extremity impairments. Exercise can be beneficial in managing lymphedema. Yoga practice has been minimally studied for its effects on breast cancer related lymphedema (BCRL). The purpose of this study was to determine the effect of yoga on arm volume, quality of life (QOL), self-reported arm function, and hand grip strength in women with BCRL. Six women with BCRL participated in modified Hatha yoga 3×/week for 8 weeks. Compression sleeves were worn during yoga sessions. Arm volume, QOL, self-reported arm function, and hand grip strength were measured at …

Efficacy Of Transoral Fundoplication For Treatment Of Chronic Gastroesophageal Reflux Disease Incompletely Controlled With High-Dose Proton-Pump Inhibitors Therapy: A Randomized, Multicenter, Open Label, Crossover Study., Karim S. Trad, Gilbert Simoni, William Edris Barnes, Ahmad Bassel Shughoury, Mamoon Raza, Jeffrey Alan Heise, Daniel Gilles Turgeon, Mark Alan Fox, Peter George Mavrelis

Surgery Faculty Publications

Background

The aim of this randomized, crossover study was to determine if transoral fundoplication (TF) could further improve clinical outcomes in partial responders to high-dose (HD) proton-pump inhibitor (PPI) therapy and to evaluate durability of TF.

Methods

In seven United States centers, patients with hiatal hernia ≤2 cm and abnormal esophageal acid exposure (EAE) were randomized to TF (n = 40) or HD PPIs (n = 23) group. At 6-month follow-up, PPI patients underwent crossover. We assessed clinical outcomes 6-month post TF in crossover patients (COP), as compared to 6-month of HD PPI therapy, and 12-month outcomes in patients initially …