Medicine and Health Sciences Commons^™

Screening The Safety Net, Babette L. Southard Mrs

Electronic Theses and Dissertations

Safety net clinics across the country struggle with a lack of resources to tackle the needs presented. Screening programs set up for children and elderly have proven to be effective in triaging need, prioritizing care, and maximizing resources. These programs do not currently exist for working uninsured adults. Research was initiated to answer the question: Does the screening process improve patient care for the community clinic? During a 6-week pilot study a licensed dental hygienist performed 30 screenings in the community clinic setting. Findings were recorded and coded according to patient’s level of need identified. Pre- and posttest data for …

Relationship Between A Measure Of Social And Emotional Development And Early Communication Development In Young Children With Cleft Palate, Jenna L. Pugh

Electronic Theses and Dissertations

This study was an examination of responses to a standardized assessment of social-emotional behaviors and correlation with speech and language development in young children with cleft palate and/or lip. Twenty-eight participants aged 14-35 months with nonsyndromic cleft palate and or lip were included in this study. The Infant-Toddler Social and Emotional Assessment (ITSEA) was used to identify emerging social and emotional behaviors. Descriptive analysis of ITSEA results was completed. Pearson correlation coefficient and effect size estimates were calculated between ITSEA domain raw scores and measures of speech and language development. A small proportion of participants (14%) showed ITSEA scores beyond …

Regulating Rsma Expression In Pseudomonas Aeruginosa, Sean D. Stacey

Electronic Theses and Dissertations

Pseudomonas aeruginosa, a Gram-negative bacillus, commonly infects immunocompromised individuals and uses a variety of virulence factors to persist in these hosts. The posttranscriptional regulator, RsmA, plays a role in the expression of many virulence factors in P. aeruginosa. RsmA up regulates virulence factors used in colonizing hosts. However, regulation of rsmA is not well elucidated. Transposon mutagenesis was performed on P. aeruginosa containing a transcriptional rsmA-lacZ fusion to answer this question. Mutants were screened via β-galactosidase assay and transposon insertions identified via arbitrary PCR. A probable MFS transporter, we named mtpX, was one significant transposon mutant identified. …

Systemic Leptin Modulates The Expression Of E-Cadherin, Β-Catenin In The Ovary Of Dietary-Induced Obese Infertile Rats, Olufunke A. Sokan

Electronic Theses and Dissertations

One of the numerous complications of obesity is infertility. Leptin has been shown to reverse infertility; however, exact mechanism is poorly understood. Recent evidence indicates Ecadherin/ β-catenin complex, which is a structural constituent of adherens junction, is expressed in the rat ovary during folliculogenesis. We hypothesized that systemic leptin modulates the expression of E-cadherin and β-catenin in dietary-induced obese infertile rats to reverse infertility. Female Sprague-Dawley rats were fed either regular chow diet (RCD) (n=6) or high fat diet (HFD) (n=14). Oestrus cycles were monitored daily until their cycles became irregular. 100 ug/ml of leptin was given intraperitoneally to HFD-fed …

Exercise Participation During Weight Loss On A High Protein – Low Carbohydrate Diet Plan In Females Aged 15-25 Years, Margaret Mobley-Meulman

Electronic Theses and Dissertations

Weight gain due to poor diet and lack of exercise is responsible for over 300,000 deaths each year (U.S. Department of Health and Human Services, 2010). Obese adults have an increased risk for serious health conditions including high blood pressure and cholesterol, type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis, sleep apnea, respiratory problems, and certain cancers (National Cancer Institute, 2012). Participation in exercise can help control weight, strengthen muscles and bones, and reduce the incidence of cardiac events, stroke, hypertension, type 2 diabetes, colon and breast cancers, osteoporotic fractures, gallbladder disease, obesity, depression, anxiety, and delay mortality …

Unpacking The Temperament Weight Relationship: The Mediating Role Of Food Preferences, Sarah A. Berry

Electronic Theses and Dissertations

The current study examined the mediating role of possible food preferences on the temperamentweight relationship among 18-month-old toddlers. Parents of 37 typically developing toddlers completed the Early Childhood Behavior Questionnaire (ECBQ). During a lab visit toddlers’ weight and recumbent length were measured and recorded. Toddlers also completed a sequential touching task to examine their ability to categorize a healthy group of foods and an unhealthy group of foods. The only temperament measure found to associate with both child weight status and food categorization was inhibitory control. Toddlers’ food categorization was not found to mediate the relationship between inhibitory control and …

Efficacy Of Partial Rom Squat In Maximal Strength Training, Caleb Bazyler

Electronic Theses and Dissertations

Eighteen well trained males (1RM Squat: 150.57 ± 26.79 kg) were assigned to two groups: full ROM training (control) and full ROM with partial ROM training (CP) for the seven-week training intervention. There was a significant time effect (p

Bioengineering The Expression Of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, And C-Reactive Protein In Yeast, Eliot T. Smith

Electronic Theses and Dissertations

The yeasts Pichia pastoris and Kluyveromyces lactis were used to express several recombinant human proteins for further biochemical characterization. Two substitution variants of recombinant human enteropeptidase light chain (rhEPL) were engineered to modify the extended substrate specificity of this serine protease. Both were secreted as active enzymes in excess of 1.7 mg/L in P. pastoris fermentation broth. The substitution variant rhEPL R96Q showed significantly reduced specificities for the preferred substrate sequences DDDDK and DDDDR; however, the rhEPL Y174R variant displayed improved specificities for these substrate sequences relative to all other reported variants of this enzyme. The neutrophil serine proteases human …

The Relationship Of Stress Levels To Wellness Practices Among U.S. Radiologic Technology Program Directors, Jesse D. Pennington

Electronic Theses and Dissertations

The purpose of this modified replication study is to examine the relationship between the stress levels and the wellness practices of U.S. radiologic technology program directors and to determine if correlations exist between wellness practices and stress levels of the group. Additionally, relaxation activities and the feelings, characteristics, and symptoms associated with stress were considered. The design of the study was ex post facto correlational. The population of the study was U.S. radiologic technology program directors working in JRCERT accredited programs. The electronic instrument was distributed to 635 program directors through e-mail, with 424 (66.7%) usable returns. Significant associations were …

Random Mutagenesis Of The Aspergillus Oryzae Genome Results In Fungal Antibacterial Activity, Cory A. Leonard, Stacy D. Brown, James Russell Hayman

ETSU Faculty Works

Multidrug-resistant bacteria cause severe infections in hospitals and communities. Development of new drugs to combat resistant microorganisms is needed. Natural products of microbial origin are the source of most currently available antibiotics. We hypothesized that random mutagenesis of Aspergillus oryzae would result in secretion of antibacterial compounds. To address this hypothesis, we developed a screen to identify individual A. oryzae mutants that inhibit the growth of Methicillin-resistant Staphylococcus aureus (MRSA) in vitro. To randomly generate A. oryzae mutant strains, spores were treated with ethyl methanesulfonate (EMS). Over 3000 EMS-treated A. oryzae cultures were tested in the screen, and one isolate, …

Alternative Ear-Canal Measures Related To Absorbance, S. T. Neely, S. Stenfelt, Kim S. Schairer

ETSU Faculty Works

Abstract:

Several alternative ear-canal measures are similar to absorbance in their requirement for prior determination of a Thévenin-equivalent sound…

Power And Explosiveness: First Step(S), Michael H. Stone, Kimitake Sato

ETSU Faculty Works

Power (along with Impulse) is arguably the most import characteristic for an athlete to develop. Power (particularly peak power) has strong relationships with sports performance such as lifting, throwing, sprinting, jumping and agility. Development of power is best accomplished by a progressive sequence that is characterized by successive phases that increased work capacity, muscle cross-section area, maximum strength and task specific power. Furthermore, evidence indicates that for power development, weaker athletes benefit as much or more from the development of strength through basic strength training than from power training.

Audiology Services At Remote Area Medical Expeditions In Southern Appalachia, Marc A. Fagelson

ETSU Faculty Works

This presentation summarizes the preparation for, and execution of, audiology series provided by East Tennessee State University's Audiology, Program at Remote Area Medical (RAM) expeditiors in the Southern Appalachian region. In 2010 and 2012, ETSU audiology faculty and students evaluatd 281 patients and subsequently fit 178 hearing aids.

Does Structured Quality Improvement Training For Residents Increase Qi In Practice?, Ivy A. Click, Jeri Ann Basden, Fred Tudiver

ETSU Faculty Works

East Tennessee State University implemented quality improvement (QI) training for second-year family medicine residents in 2009. Results in 2011 indicated training increased scores in QI skill assessments as well as self-efficacy in QI. With residents who completed the training now in practice, does the increase in knowledge and skill translate to increased QI in practice? A survey of graduates compares frequency of QI cycles and self-assessment of QI skills among graduating classes, those receiving QI training and those graduating before training began. Residents that completed the QI curriculum rated their training higher; however residents that did not receive training were …

Balance And Gait Among A Community Dwelling Older Adult Population Using Nintendo Wii Bowling Game., Carly Hutchins

Undergraduate Honors Theses

Due to the increase in the aging population older adults are looking for ways to stay fit and active in their later years. Such activities need to be fun, easy to operate, and encourage socialization. The Nintendo Wii© Bowling provides these features for the aging population. Participants in this quantitative pilot study had the opportunity to play the Nintendo Wii© Bowling Game twice a week for six weeks to see if their balance and mobility would improve when compared with the pre and post scores from the Performance Oriented Mobility Assessment (POMA). The participant’s scores on the Performance Oriented Mobility …

Nursing Student's Perceptions Of Cultural Competency., Caitlin Malcolm

Undergraduate Honors Theses

As the United States population becomes more culturally diverse, it has become a priority for health care professionals to competently provide culturally sensitive care. Cultural competency is required in baccalaureate (BSN) programs, mandated by collegiate nursing accrediting agencies. Although BSN programs have integrated cultural competency education into their core curricula, little data has been collected evaluating outcomes and effectiveness. Using a 36 question survey, students in all levels of a selected BSN program were asked questions regarding cultural competency and attitudes towards cultural care. The ANOVA and a Tukey Kramer analyses were performed with an alpha coefficient of 0.05 and …

Dose Creep: Is It Real Or Imagined?, Cody Baker

Undergraduate Honors Theses

Two types of patient-centered care in the radiology profession are service and safety. Service relates to the technologist being a patient advocate by effectively communicating, building relationships and providing care. Two types of safety in the radiologic sciences profession relate to contrast media and radiation safety. The focus of this study was on radiation safety. The project was designed to evaluate exposure indicator values from radiographic procedures performed by junior and senior radiography students during the month of March 2013. The mean exposure indicator values for radiographic procedures were evaluated by all students and then by student rank (juniors and …

Electromyographical Analysis Of Barefoot Squat: A Clinical Perspective., Sarah E. Brown

Undergraduate Honors Theses

The purpose of this study was to compare muscle activation in eight superficial lower limb muscles during execution of barbell back squats while in barefoot and athletic shoe conditions. It was hypothesized that greater muscle activity would be seen when squats were performed in barefoot conditions. Six participants were included in the study (means: 21.33±1.53 years, 170.45±11.33cm height, 69.85±12.46kg mass, 3.4±1.40 years training). Each met specific inclusion criteria. Participants came in three separate days for data collection (Day 1 – 1 repetition maximum [1RM] was determined, Day 2 – maximum voluntary contraction tests were held, Day 3 – squat tests …

Nursing Students' Perceptions Of Uncivil Behavior In The Classroom Setting., Jessica Marie Stamey

Undergraduate Honors Theses

There is an increase in uncivil student behaviors in the classroom setting including inattention, lying, cheating, and plagiarism. The purpose of this quantitative descriptive study was to determine behaviors that undergraduate nursing students perceived as uncivil in the classroom. The research question was, “How do undergraduate nursing students perceive uncivil behavior in the classroom?” A convenience sample using cluster sample method of all five undergraduate baccalaureate nursing student cohorts from a College of Nursing in Appalachia were invited to complete the researcher’s edited version of the Incivility in Nursing Education (INE) survey. There were 526 undergraduate nursing students enrolled in …

Test Anxiety And Nursing Students., Brad Moore

Undergraduate Honors Theses

Test anxiety has been a problem for many individuals not only in the workforce, but also in many schools and colleges (Driscoll, Evans, Ramsey & Wheeler 2009). According to Driscoll et al., when compared to high school students and the general public (17%), nursing students are shown to have over double (55-60%) the rate of moderately high to high test anxiety. Cognitive test anxiety can account for a 7 to 8% drop in test grades, which can drop test score’s an entire letter grade (Cassady & Johnson, 2001). The purpose of this research is to explore the level of test …

Analysis Of The Role Of D2 Receptors In Methylphenidate-Induced Conditioned Place Preference., Chase M. Duty

Undergraduate Honors Theses

ADHD is one of the most commonly diagnosed disorders during adolescence. Recently, significant increases in the diagnosis of ADHD have caused the prescription of the ADHD medication methylphenidate (MPH) to increase. MPH is a psychostimulant that blocks the dopamine transporter, which is responsible for dopamine reuptake at the synapse. The blockade of the dopamine transporter results in an increase in the availability of dopamine in the synaptic cleft. This increase of dopamine accounts for the addictive properties of a MPH due to strong effects on portions of the brain’s drug-reward pathway, including the striatum and nucleus accumbens. In this study, …

Differences And Similarities In Rural Residents’ Health And Cardiac Risk Factors, Florence M. Weierbach, Bernice Yates, Melody Hertzog, Bunny Pozehl

ETSU Faculty Works

Purpose: The current U.S. population exceeds three hundred million with approximately 20% living in non-urban rural areas. A higher percentage of rural residents have diagnosed heart disease and report poorer health compared to non-rural residents; however, it is not known whether risk factor modification for heart disease and health status differ based on degree of rurality. The purposes of this study were: 1) to compare differences in health status and cardiac risk factors between cardiac patients living in large and small/isolated rural areas, and 2) to compare the health status of rural cardiac patients with a national sample. Method: A …

Genetic Imbalances In Endometriosis Detected By Oligonucleotide-Array Based Comparative Genomic Hybridization, Natalie Burke

Electronic Theses and Dissertations

Endometriosis is one of the most common gynecological diseases as it is thought to affect up to 15% of the female population. Characterized by the growth and proliferation of endometrial tissue outside of the uterine cavity, it is a complex condition with varying degrees of severity and can affect multiple regions of the body with symptoms ranging from a total lack of symptoms to debilitating pain and infertility. The most accepted theory of how endometriosis initiates is that of retrograde menstruation; however, approximately 90% of women with unobstructed fallopian tubes are thought to have some menstrual debris in the peritoneal …

Self-Management Of Diabetes In Low-Income Appalachian Women., Erin Austin

Undergraduate Honors Theses

Diabetes mellitus is a major health concern and the number of Americans diagnosed with the disease is quickly increasing, affecting all aspects of an individual’s life and requiring significant self-involvement. Little is known about how low-income Appalachian women with Type 2 Diabetes Mellitus (T2DM) manage their diabetes from day-to-day. This population struggles to effectively manage the illness as they desire for many reasons. The purpose of this study is to better understand the experiences of Appalachian women in self-managing diabetes so that health care providers can better meet the social and cultural needs of this unique population.

This study used …

The Study Of The Effect Of Two Flavone Isomers Derived From Gnaphalium Elegans And Achyrocline Bogotensis In Breast Cancer., Jessica J. Walker

Undergraduate Honors Theses

Flavonoids are ubiquitous to all terrestrial plants and many are known to have anti-tumor activities. In this research project we studied the differential cytotoxic effects of two flavone isomers on human breast cancer cells (BT-474, SKBR-3, and MCF-7) and normal breast cells as a control (MCF-10A). The basis of the relationships between chemical structures, type and position of substituent groups and the effects these compounds exert specifically on cancer cells are not completely elucidated. These flavones are derived from plants native of Colombia, South America. These plants of the family Asteraceae, genera Gnaphalium and Achyrocline are reputed to have anti-cancer …

Preventing Skin Cancer In Adolescent Girls Through Intervention With Their Mothers, Mary K. Baker

Electronic Theses and Dissertations

Indoor tanning (IT) before the age of 35 increases one’s risk for melanoma by 75%, and epidemiological data show a 6.1% annual increase in the incidence of melanomas in white women younger than age 44 in the US. Population-based studies reveal that 15% of adolescents and 8% to 14% of their primary caregivers have engaged in IT in the past year.

The compelling case for IT being a significant risk factor for melanoma, together with the high rates of IT in teen girls and their mothers, provided a strong rationale for conducting an antitanning intervention directed at mother-daughter dyads. This …

Examining Stage At Diagnosis And Survival In Three Cancers With Definitive Screening Guidelines For Average-Risk Adults: The Role Of Marital Status, David J. Blackley

Electronic Theses and Dissertations

Each year there are more than 350 000 new cases and nearly 100 000 deaths attributed to colorectal, female breast, and cervical cancer in the United States. Screening tests can reduce morbidity and mortality associated with these cancers. Patient marital status has been associated with health outcomes, but no study has focused on the relationship of marriage with disease stage and survival for the 3 cancers with established screening guidance. It is critical to identify special populations that may be at risk for poor cancer outcomes.

The objective of this study was to examine the relationship of marital status with …

Comparison Of Obesity Bias, Attitudes, And Beliefs Among Undergraduate Dietetic Students, Dietetic Interns, And Practicing Registered Dietitians, Sarah E. Welborn

Electronic Theses and Dissertations

The obesity epidemic in the United States is increasing, and health concerns are also on the rise as they are directly related to obesity. Even though the majority of Americans are overweight or obese, prejudice and weight bias continue to be prevalent and socially accepted in a culture that tolerates discrimination towards these individuals. Health care providers, including registered dietitians, are not exempt from instigating bias towards obese patients causing a decrease in the level of care that they receive. The main purpose of this study was to compare attitudes, beliefs, and bias concerning obesity among undergraduate dietetic students, dietetic …

Practice Characteristics Of Graduates Of East Tennessee State University Quillen College Of Medicine: Factors Related To Career Choices In Primary Care, Ivy A. Click

Electronic Theses and Dissertations

The nation is facing a physician shortage, specifically in relation to primary care and in rural underserved areas. The most basic function of a medical school is to educate physicians to care for the national population. The purpose of this study was to examine the physician practicing characteristics of the graduates of East Tennessee State University Quillen College of Medicine including factors that influence graduates’ specialty choices and practice locations, especially those related to primary care. Secondary data for this study were collected from the college’s student database system and the American Medical Association Physician Masterfile. The study population included …

Ovarian Modifications In Mice Exposed To Whole-Body Irradiation., Jacob Marion Poole

Undergraduate Honors Theses

This experiment was designed to determine the involvement of varying levels of whole-body irradiation on ovarian follicular and corpora luteal development in mice. Previous research has indicated reduced counts of ovarian follicles and corpora lutea in mice flown in space. These differences may be the result of microgravity, increased exposure to radiation, or some combination of both. Fifty-six mice were divided into three groups (apocynin-treated, nox2 knockout, and wild-type control) before exposure to 0 Gy, 0.5 Gy, or 2.0 Gy radiation. The tissues were harvested, preserved, run through the appropriate paraffin embedding procedures, serially sectioned, mounted on microscope slides, and …