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Full-Text Articles in Medicine and Health Sciences
2-[18f]-Fluoro–2-Deoxy-D-Glucose Positron Emission Tomography In The Evaluation Of Breast Lesions And Axillary Involvement: A Comparison With Mammography And Histopathological Diagnosis, Oğuz Hançerli̇oğullari, Nuri̇ Arslan, Semi̇h Görgülü, Mehmet Fati̇h Can, Hani̇fe Asli Ayan Eke, Semra İnce, Erkan Öztürk, Ramazan Yildiz, Mehmet Ali̇ Özgüven
2-[18f]-Fluoro–2-Deoxy-D-Glucose Positron Emission Tomography In The Evaluation Of Breast Lesions And Axillary Involvement: A Comparison With Mammography And Histopathological Diagnosis, Oğuz Hançerli̇oğullari, Nuri̇ Arslan, Semi̇h Görgülü, Mehmet Fati̇h Can, Hani̇fe Asli Ayan Eke, Semra İnce, Erkan Öztürk, Ramazan Yildiz, Mehmet Ali̇ Özgüven
Turkish Journal of Medical Sciences
The objective of this prospective study was to evaluate the potential role of 2-[18f]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) in the differentiation of malignant and benign breast masses and the evaluation of axillary lymph node involvement. The secondary objective of this study was to assess the value of FDG PET in the initial staging of patients with breast cancer. Materials and methods: We evaluated 82 lesions in 79 consecutive patients (mean age of 54.4 ± 13.0; age range: 25-82 years) with FDG PET. While ultrasounds were performed in all cases, of the 79 patients, 72 had mammography and 58 had …
Radioimmunotherapy Of Mice Bearing Breast Tumors With ^{177}Lu-Labeled Trastuzumab, Samira Rasaneh, Hossein Rajabi, Shahram Akhlaghpoor, Shahab Sheybani
Radioimmunotherapy Of Mice Bearing Breast Tumors With ^{177}Lu-Labeled Trastuzumab, Samira Rasaneh, Hossein Rajabi, Shahram Akhlaghpoor, Shahab Sheybani
Turkish Journal of Medical Sciences
In the present study, we investigated the therapeutic efficacy of trastuzumab labeled with lutetium-177 (^{177}Lu) in mice bearing breast tumors. Materials and methods: Trastuzumab was labeled with ^{177}Lu via DOTA as a chelator. In vitro and in vivo quality control tests of incorporated activity, immunoreactivity, stability of ^{177}Lu-trastuzumab, biodistribution, and imaging studies were performed. Therapeutic efficacy and dosimetry studies were carried out in mice with breast tumors. Results: The good in vitro and in vivo quality control results suggested that ^{177}Lu-trastuzumab could be used as a radioimmunotherapy agent. Reductions of 81% and 98% in the mean tumor volume for the …
Analysis Of Promoter Methylation Of Dickkopf1 (Dkk1) Gene In Breast Cancer, Muradi̇ye Acar, Tülün Çora, Hati̇ce Toy, Hasan Acar
Analysis Of Promoter Methylation Of Dickkopf1 (Dkk1) Gene In Breast Cancer, Muradi̇ye Acar, Tülün Çora, Hati̇ce Toy, Hasan Acar
Turkish Journal of Medical Sciences
Breast cancer is the most common malignancy in women worldwide. The Dickkopf1 (DKK1) gene product is a potent inhibitor of the Wnt pathway. DKK1 methylation status and its protein expression were examined in normal and cancer tissues of breast cancer patients. Materials and methods: We examined methylation changes in 83 tumor and adjacent normal tissues, and also in 9 normal breast tissues from unaffected women (no breast cancer history) as controls. DKK1 promoter methylation was assessed by methylation-specific polymerase chain reaction. Immunohistochemical staining was used to investigate DKK1 protein expression in the 9 controls and in 70 out of the …