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Full-Text Articles in Medicine and Health Sciences
Genetic Influences On The Dynamics Of Pain And Affect In Fibromyalgia, Howard A. Tennen, Jonathan Covault
Genetic Influences On The Dynamics Of Pain And Affect In Fibromyalgia, Howard A. Tennen, Jonathan Covault
UCHC Articles - Research
Objective The purpose of the present investigation was to determine if variation in the catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genes is associated with pain-related positive affective regulation in fibromyalgia (FM). Design Forty-six female FM patients completed an electronic diary that included daily assessments of positive affect and pain. Between- and within-person analyses were conducted with multilevel modeling. Main Outcome Measure Daily positive affect was the primary outcome measure. Results Analyses revealed a significant gene × experience interaction for COMT, such that individuals with met/met genotype experienced a greater decline in positive affect on days …
Tender Point Count, Pain, And Mobility In The Older Population: The Mobilize Boston Study, Suzanne G. Leveille, Laura H.P. Eggermont
Tender Point Count, Pain, And Mobility In The Older Population: The Mobilize Boston Study, Suzanne G. Leveille, Laura H.P. Eggermont
Suzanne G. Leveille
Abstract: Prevalence of tender points (TP), and widespread pain and fibromyalgia, as well as the relationship between TP and widespread pain and mobility, was examined in 585 community-dwelling older adults (mean age 78.2 years, 63.4% female). Pain was based on location (none, single site, multisite, widespread). Mobility was measured by the Short Physical Performance Battery (SPPB), gait speed, and self-reported (S-R) mobility difficulty. Tender-point count and health characteristics (ie, BMI, chronic conditions, analgesic use, number of medications, depression, and blocks walked per week) were assessed. Several participants had 3 or more TP (22.1%) although prevalence of criteria-based fibromyalgia was low …