Medicine and Health Sciences Commons^™

Development Of Novel Biomarkers In Cancer: Detection Of Circulating Mir-141 As A Potential Prognostic Marker For Prostate Cancer, Jason Cadaoas Gonzales

UNLV Theses, Dissertations, Professional Papers, and Capstones

Prostate cancer (CAP) is the most common epithelial malignancy and the second leading cause of cancer deaths in American men. The identification of predictive and prognostic biomarkers in CAP patients is critical for improving clinical outcomes. Although the measurement of prostate-specific antigen (PSA) and radiographic studies are clinically approved to predict response to therapy, these tests can oftentimes prove to be inadequate in certain patients. Thus, it is important to discover new biomarkers to improve chances of survivability. We and others have shown that longitudinal measurements of circulating tumor cells (CTC) and lactate dehydrogenase (LDH) may aid in predicting response …

Recent Accelerated Second-Degree Baccalaureate Graduates’ Perceptions Of Educational Preparation, Susan Candelaria

UNLV Theses, Dissertations, Professional Papers, and Capstones

As of 2008, the U.S. Department of Labor is predicting a need for greater than one million new registered nurses by the year 2016 (American Associations of Colleges of Nursing [AACN], 2008). One way that nursing schools around the country are dealing with this issue is through the creation of accelerated second-degree programs for non-nursing graduates.

The purpose of this descriptive study was to examine the perceptions of educational preparation of accelerated second-degree baccalaureate graduates, who have been out of school for at least one year, but no longer than four years. The sample consisted of 54 graduates from an …

The Physical Activity Patterns And Constraints Of Diverse Female College Students, Kathleen Victoria Minkel

UNLV Theses, Dissertations, Professional Papers, and Capstones

Diverse college aged females from a public university in the southwest were asked to participate in an online survey to determine their constraints to physical activity, as well as their current activity level. The groups were compared to establish the differences among the minority groups. Raymore, Crawford, and Godbey’s Hierarchical Model of Constraints was used as a framework when creating the survey. Data analysis showed only one significant difference among the racial/ethnic groups, when looking specifically at the intrapersonal, interpersonal, and structural constraints categories. Hispanic women differed significantly from Caucasian women in their perception of interpersonal constraints on their physical …

Application Of A Judgment Model Toward Measurement Of Clinical Judgment In Senior Nursing Students, Tiwaporn Pongmarutai

UNLV Theses, Dissertations, Professional Papers, and Capstones

Clinical judgment, defined as “the application of the nurse’s knowledge and experience in making decisions about client care” (The National Council of State Boards of Nursing, 2005, p. 2), has been recognized as a vital and essential skill for healthcare providers when caring for clients. Undisputedly, nurses represent the largest component of the healthcare profession and, therefore, play a major role in ensuring quality patient care in the United States. Although the concept of clinical judgment in nursing has been discussed for more than three decades, and in spite of numerous efforts to improve student clinical judgment, the recent literature …

The Determinants Of Colorectal Cancer Survival Disparities In Nevada, Lucas N. Wassira

UNLV Theses, Dissertations, Professional Papers, and Capstones

Different population groups across Nevada and throughout the United States suffer disproportionately from colorectal cancer and its after-effects. Overcoming cancer health disparities is important for lessening the burden of cancer. There has been an overall decline in the incidence of and mortality from colorectal cancer (CRC). This is likely due, in part, to the increasing use of screening procedures such as Fecal Occult Blood Test (FOBT) and/or endoscopy, which can reduce the risk of CRC mortality by fifty percent. Nevertheless, screening procedures are routinely used by only fifty percent of Americans aged fifty years and older. Despite overall mortality decreasing …

Vertical Transmission Of West Nile Virus In Culex Spp. Mosquitoes Of Clark County, Nevada, Vivek K. Raman

UNLV Theses, Dissertations, Professional Papers, and Capstones

West Nile Virus (WNV) is an RNA arbovirus that cycles between mosquitoes and birds, but also infects and causes disease in humans, horses and other vertebrate species. Although most infections are asymptomatic, WNV has emerged as the most common cause of epidemic meningoencephalitis in North America and the leading cause of arboviral encephalitis in the United States.

Mosquitoes of the genus Culex are the most active vectors of WNV in North America. Approximately 85% of human WNV infections in the United States occur in late summer with a peak number of cases in August and September. Vertical transmission is defined …

The Relationship Of Snowmobile Year, Track Length, And Riding Terrain To The Occurrence Of Musculosketetal Symptoms In Recreational Snowmobile Drivers, Erica L. Heisler

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this retrospective study was to examine the occurrence of musculoskeletal symptoms in recreational snowmobile drivers and relate them to the manufacture year of the snowmobile, the length of the track, and/or the riding terrain. Participants included 186 males and 57 females (n=243), aged 18 years and older, and were all snowmobile drivers. Subjects were asked to complete either an online survey or a paper survey to gather information about the year of snowmobile they drove, the track length of that snowmobile, the typical riding terrain they drove on, and any musculoskeletal symptoms they developed from driving snowmobile. …

Donepezil And Galanin Interactions In An Animal Model Of Alzheimer’S Disease, Jonathan J. Sabbagh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alzheimer's disease (AD) is a neurodegenerative disorder marked by a progressive loss of cognitive function. One of the neurobiological hallmarks of AD is a progressive loss of cholinergic neurons and a decrease in the amount of acetylcholine in the brain. Pharmacological therapies have targeted the cholinergic system, specifically first-line, palliative treatment using acetylcholinesterase (AChE) inhibitors, such as donepezil. Donepezil has been shown to increase cholinergic tone and ameliorate some of the cognitive deficits in AD patients. Galanin, a neuropeptide that inhibits the evoked release of several neurotransmitters including acetylcholine as well as modulates seveal intracellular cascades, is overexpressed in AD …

Effects Of Environmental Prompts On Stair Usage, Lori Andersen

UNLV Theses, Dissertations, Professional Papers, and Capstones

The objective of this study was to evaluate whether environmental prompts placed in two-story buildings on a university campus would increase stair usage. Three buildings were used. One served as a control, while the other two received an intervention. Participants of three buildings were observed taking the stairs and elevator for seven weeks. Baseline data was collected; signs were introduced, and then removed during this time period. Approximately 2700 observations were collected. Environmental prompts did not appear to increase stair usage. There were significant differences in the amount of stair users between buildings. The stair usage rates of this particular …

Development Of Software To Estimate Pressures On The Residual Limbs Of Amputees By Means Of A Pylon Mounted Transducer, Malli K. Yalamanchili

UNLV Theses, Dissertations, Professional Papers, and Capstones

The alignment of prosthesis has been recognized as one of the main factors that determine successful prosthetic outcomes for trans-tibial amputees. Alignment is defined as the relative position and orientation of the prosthetic components. Misalignment can result in changes in the position and orientation of the joints of the leg and moments experienced by them during gait, increases in energy use, and discomfort or even tissue breakdown at the socket/stump interface. Hence it is very important to align the prosthesis in correct manner. Gait analysis can be used to examine the effects of incorrect alignment of the prosthesis during gait. …

Variability Of Pacing In Marathon Distance Running, Thomas A. Haney Jr.

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purposes of this study were to describe variability of pacing during a marathon and to determine if there is a relationship between variability of pacing and marathon performance. A total of 301 race profiles that contained personal global positioning system (GPS) from the Rock „n‟ Roll Las Vegas (Race 1) and San Diego (Race 2) marathons were downloaded (http://connect.garmin.com) and analyzed. Each marathon finish time was placed into one of three finish time bins: Bin 1: 2.5 – 3.9 hrs, Bin 2: 4.0 – 4.6 hrs, Bin 3: 4.7 – 7.2. The coefficient of variation of velocity (Velcov) was …

Protocol Variation Analysis Of Whole Brain Ct Perfusion In Acute Ischemic Stroke, Peter T. Heiberger

UNLV Theses, Dissertations, Professional Papers, and Capstones

Computed tomography perfusion (CTP) analysis is a rapidly advancing imaging modality that is improving diagnosis of brain abnormalities in patients suffering from hemorrhagic or ischemic stroke, traumatic brain injury, vascular occlusion and numerous other conditions. Through the advancements of computed tomography (CT) imaging, including the introduction of the 320-detector row CT with a 16 centimeter range in the z-axis enabling whole brain CTP, perfusion analysis now has a significantly increased clinical utility that is useful for both diagnosis and treatment of central nervous system (CNS) conditions. This study focuses on the procedural and analytical approach to the diagnostic evaluation of …

Therapist-Initiated Addiction Assessment Procedures Of Marriage And Family Therapists In The Southwest United States, Emire Olmeztoprak

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to examine the addiction assessment procedures of marriage and family therapists. Addiction prevalence rates are growing therefore it is likely that marriage and family therapists will have clients affected by addiction. Undetected addictions can impede treatment and/or prevent the therapist from making appropriate treatment related decisions. Marriage and family therapists in Nevada, Arizona, and New Mexico were invited to complete a web-based survey containing a series of questions about their assessment procedures for addiction as well as a series of demographics questions. The data from the completed surveys was collected and analyzed. The data …

Neutron Flux And Energy Characterization Of A Plutonium-Beryllium Isotopic Neutron Source By Monte Carlo Simulation With Verification By Neutron Activation Analysis, Zachary R. Harvey

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this research was to characterize the neutron energy distribution and flux emitted from the UNLV plutonium-beryllium source, serial number MRC-N-W PuBe 453. This was accomplished through the use of the MCNPX/5 Monte-Carlo particle transport code to simulate radiation interactions within the physical environment of the source and its surroundings. The moderating drum currently containing the source as well as all of the sampling ports were accurately modeled in MCNPX/5. This geometry was then used to simulate the neutron interactions taking place in these geometries. The results of the simulations were then verified by the use of specifically …

Macrophages Loaded With Gold Nanoshells For Photothermal Ablation Of Glioma: An In Vitro Model, Amani Riad Makkouk

UNLV Theses, Dissertations, Professional Papers, and Capstones

The current median survival of patients with glioblastoma multiforme (GBM), the most common type of glioma, remains at 14.6 months despite multimodal treatments (surgery, radiotherapy and chemotherapy). This research aims to study the feasibility of photothermal ablation of glioma using gold nanoshells that are heated upon laser irradiation at their resonance wavelength. The novelty of our approach lies in improving nanoshell tumor delivery by loading them in macrophages, which are known to be recruited to gliomas via tumor-released chemoattractive agents. Ferumoxides, superparamagnetic iron oxide (SPIO) nanoparticles, are needed as an additional macrophage load in order to visualize macrophage accumulation in …

The Live Experience Of Non-Degree Learners From A Time Modified Traditional Baccalaureate In Nursing Program, Stephanie S. Deboor

UNLV Theses, Dissertations, Professional Papers, and Capstones

By the year 2016, it is projected that a million new and replacement nurses will be needed throughout the United States. The traditional 4-year baccalaureate program alone cannot adequately sustain this demand. The immediacy of the current nursing shortage demands our educational systems respond by building and maintaining a workforce that is sufficient to support the health care needs of our society. In an attempt to meet this challenge, nursing schools around the country began exploring the option of creating accelerated programs for those who already possess a bachelor's degree in another field without compromising the integrity and quality of …

The Influence Of Perspective And Gender On The Processing Of Narratives, Jeremy A. Houska

UNLV Theses, Dissertations, Professional Papers, and Capstones

The overarching aim of this research was to examine potential boundary conditions to situation model construction (Experiment 1) and narrative-based persuasion (Experiment 3). Variables such as narrative perspective (i.e., 2nd or 3rd person) and matched characteristics with the reader (i.e., participant-protagonist gender match) were first examined using situation model updating (Experiment 1) and behavioral measures (Experiment 3) as dependent measures. It was expected that situation model updating would be more likely for narratives written in the 2nd person perspective and with a participant-protagonist gender match. It was uncertain, however, for health promotion narratives, whether these manipulations would increase the likelihood …

Comparison Of Body Composition Between Physically Active And Inactive Wheelchair Users, Masaru Teramoto

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to examine the association between regular physical activity and body composition in individuals with physical disabilities. The study was designed to compare body composition parameters between wheelchair users participating in adapted sports programs and those being physically inactive. Male wheelchair users were recruited and classified based on physical activity level (active or inactive) and disability type (paraplegic or quadriplegic). Regional and whole-body percent body fat (%BF), lean body mass (LBM), and bone mineral density (BMD) were assessed by dual-energy X-ray absorptiometry. These variables were then compared among the groups using a two-way between-groups multivariate …

Effects Of Obesity On The Biomechanics Of Children’S Gait At Different Speeds, Philana-Lee Gouws

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of the study was to investigate the relationship between body mass index (BMI) and spatio-temporal gait characteristics of overweight/obese and non-obese school-aged children (12-14 years) at two different walking speeds. Eighty-four overweight/obese (n=28; age: 13.96 ± 0.79 yrs; mass: 74.8 ± 18.21 kg; height: 159.2 ± 7.1 cm and BMI: 29.28 ± 5.64 kg/m2) and non-obese students (n=56; age: 13.72 ± 0.79 yrs; mass: 51.7 ± 10.2 kg; height: 157.8 ± 8.3 cm and BMI: 20.69 ± 2.74 kg/m2) with no present injuries were recruited. Participants were instructed to walk across an electronic walkway in each of two …

Impacts On Maternal Diet In A Transitional Community In Rural Costa Rica: Potential Implications For The Developmental Origins Of Obesity-Related Disorders, Allison Cantor

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis examines maternal diet in a rural, transitional community in Costa Rica. Using cross-cultural categories recognized in the ethnographic literature (i.e. dietary taboos, dietary prescriptions, food cravings and the acknowledgment of a special post-partum period diet), maternal dietary practices were identified in the local community through surveys (n=45) and participant-observation (n=5), and to reflect the actual consumption patterns of pregnant and nursing women in the area, 24-hour diet recalls were administered to 5 pregnant or nursing women. In light of the recent changes that increased tourism has brought to the Monteverde Zone, focus groups were employed to determine impacts …

Experienced Clinician’S Understanding And Approach To Treatment With Male Survivors Of Child Sexual Abuse, Blendine Perreire Hawkins

UNLV Theses, Dissertations, Professional Papers, and Capstones

The number of males abused sexually as children are significant and while the awareness of the needs of this population has increased, the process in treatment has not been sufficiently examined. The purpose of this study was to explore experienced clinicians' approach and understanding within treatment with adult male survivors of child sexual abuse. A qualitative research design was utilized, using purposeful expert sampling procedures. In this study, data was collected from phone interviews with five participants who were identified as highly experienced clinicians in the area of male survivors of child sexual abuse treatment. Using qualitative methods within phenomenological …

Enhanced Food Marketing To Children On The Internet: A Content Analysis, Sarah A. Ochsner

UNLV Theses, Dissertations, Professional Papers, and Capstones

In light of the continuing epidemic of childhood obesity, aggressive food marketing strategies have come under increased scrutiny as a possible contributing factor. It has been acknowledged in numerous studies, that poor nutrient quality of food and beverages dominate children's programming. The growth in child-specific media envoys has further increased favorable opportunities to market food and beverages to children, notably less regulated and parentally unsupervised. According to the U.S. Census Bureau, 65% of children aged 6-11 have home access to the Internet; and today, the majority of food manufacturers operate websites appealing to children. The Institute of Medicine issued a …

The Role Of Visual, Vestibular, And Somatosensory Systems In Postural Balance, Mary Grace Gaerlan

UNLV Theses, Dissertations, Professional Papers, and Capstones

The integration of visual, vestibular, and somatosensory components are used to maintain one's postural balance. Postural control changes over time and body sway increases with age. The different sensory systems begin to develop and refine starting when children are young, while in older adults it begins to decline. Hence, it is important to study the changes that occur in postural balance. There is very little known about balance of younger adults. If balance issues are identified early in adult life it is possible to prevent exacerbation of balance decline as one ages. If nurse practitioners are aware of what dominant …

Lead Risk Hazards In Pre-1978 Childcare Facilities Located In Clark County, Nevada, Usa, Jessica Marie Newberry

UNLV Theses, Dissertations, Professional Papers, and Capstones

The harmful health effects of lead exposure have been known for centuries, yet lead is still produced and utilized in a variety of ways. There have been many movements to rid the environment of this toxic metal in hope to reduce the number of individuals who are and who may potentially be exposed. Lead exposure is responsible for a myriad of negative health effects most notably lowering IQ scores in children. Extensive amounts of data have been collected from areas of the country with known lead hazards, hazards that have been identified through hundreds of thousands of elevated blood lead …

The Relationship Of A Long-Term Exercise Program And Selected Coronary Risk Factors, Maryse Wells

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to investigate body composition and blood pressure as potential risk factors for coronary artery disease after 3 years of participation in a structured exercise program. The sample group was comprised of 21 male participants (66%) and 11 (34%) female participants with a mean age of 55 years who attended the exercise program and completed health and fitness testing annually. Participants did cardiovascular, strength, and flexibility training 5 days a week with an average attendance of 70%. After 3 years, BMI, waist circumference, and percent body fat increased significantly (p < .01); blood pressure levels did not change significantly (p > .05). Low control of diet …

Health Care Access Disparities Among Children Entering Kindergarten In Nevada, Nadia Deashinta

UNLV Theses, Dissertations, Professional Papers, and Capstones

Access to health care is an important factor for the well-being of America's children. The principal goal of this study was examine the 2008-2009 Kindergarten Health Survey data to advance understanding and appreciation of the health status of children in addition to their discrepancies in accessing health care in the state of Nevada (n = 11,073). This dataset serves as a secondary data source to determine whether socio-demographic and medical factors are associated with disparity in accessing health care for children entering kindergarten. This study looked at both independent and combined effects of annual household income, race/ethnicity, primary language spoken …

Factors Associated With Blood Lead Levels Of Children In Southern Nevada, Mackenzie Suzanne Burns

UNLV Theses, Dissertations, Professional Papers, and Capstones

Exposure to lead continues to be a public health concern, particularly for young children. The Centers for Disease Control and Prevention report that approximately 250,000 children currently have blood lead levels (BLLs) above the level at which adverse health effects are apparent and intervention is recommended (10μg/dL). National surveillance data on childhood lead exposure has been collected for children under the age of 6 years old since 1995. However, not until 2006 did a program begin in Nevada (limited to Clark County); therefore, statewide data about childhood lead exposure in Nevada remains limited. The goal of this study was to …

A Grounded Theory Approach To Faculty’S Perspective And Patterns Of Online Social Presence, Rebecca A. Cox-Davenport

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this research study was to generate a grounded theory regarding the patterns and perceptions of nursing faculty in the formation of social processes in an online course. Employing a grounded theory approach, this researcher built upon the theoretical concepts of the Community of Inquiry (CoI) model (Garrison, Anderson, & Archer, 2000). The CoI model illustrates the inner workings of the educational experience. The model consists of three main components: social presence, teaching presence, and cognitive presence. These three elements overlap to demonstrate how each factor influences the other forms of presence. This study sought to better understand …

An Evaluation Of Lead In Imported Candies Within Clark County, Nevada, Usa, Lee Reuben Ibarra

UNLV Theses, Dissertations, Professional Papers, and Capstones

Imported candies from Latin America pose a danger to children because of the potential for those candies to contain harmful levels of lead. This study sought to identify characteristics of imported candies that typically display higher concentrations of lead. This study also explored the Integrated Exposure Uptake Biokinetic model developed by the EPA. Using lead exposure data specific to Clark County, Nevada, the IEUBK model was used to estimate the amounts of candy a child would have to consume in order to raise his blood lead level to over 10µg/dL (the federal allowable limit).

The results showed that candies with …

Oral Cancer In Nevada: A Public Health Perspective, Karl Kingsley

UNLV Theses, Dissertations, Professional Papers, and Capstones

Cancer is the second leading cause of death in the United States, and oral cancer remains the eighth leading cause of cancer death among US males. Although previous epidemiologic studies have found that overall rates of cancer, including oral cancer, have declined in the US in recent decades – these declines are neither uniform nor consistent within this population. Anecdotal evidence has suggested that rates of oral cancer in Nevada are relatively high, although no evidence was available to support these assertions.

Oral Cancer Epidemiology: Based upon this information, a detailed and thorough epidemiologic examination of oral cancer rates in …