Medicine and Health Sciences Commons^™

Livin' Right! Morning, Noon, And Night: A Multi-Disciplinary Wellness Camp [For] Children With Obesity Issues, Lynne R. Bradbury

Occupational Therapy Capstones

The prevalence of childhood obesity is rapidly increasing in the United States and the percentage of overweight or obese children in South Dakota exceeds the objective set by the U.S. Department of Health and Human Services (2000). An extensive review of literature was completed on the prevalence and characteristics of obesity in children as well as interventions such as a multi-disciplinary team approach and family involvement. A review of the use of measurement tools both for screening and outcome measures was also conducted. There are significant health and societal impacts that accompany the increasing prevalence of obesity in our communities. …

Children With Limb Deficiency: The Impacts Of Using A Prosthetic For Functional Independence, Kirsten Brandt, Michelle Grimes

Occupational Therapy Capstones

Many emotions, questions, and concerns may arise for parents and caregivers upon learning that their child has a limb deficiency. Educational resources for parents of children with limb deficiencies may be lengthy, time consuming to find and read, and full of medical jargon. The purpose of this scholarly project was to develop an educational booklet that is concise and easy to read for parents and caregivers of children with limb deficiencies.

An extensive literature review was conducted addressing the physical and psychological impacts children with limb deficiencies experience during daily activities. Parents with children who have limb deficiencies, individuals with …

School-Based Practice: Integrating The Occupational Therapy Practice Framework, Nancy M. Daly

Occupational Therapy Capstones

Occupational therapists in school-based practice frequently experience change due to the evolution of the profession and education reform. This project examines the impact of these changes relative to the integration of client-centered and occupation-based services in contemporary educational practice. Occupational therapists have identified significant barriers that impact the efficiency and effectiveness of service delivery. This paper, through the review of current occupational therapy and special education literature, explores the integration of collaboration, client-centered occupation-based care, and service delivery. The increasing requirements for accountability and professional standards define documentation needs. Findings indicate a need for school-based occupational therapists to have processes …

Eating Disorder Programming In Four-Year College Recreation Wellness Centers, Tiffany Jean Anderson, Amanda Lynn Gulka

Physical Therapy Scholarly Projects

Eating disorders are more prevalent in the college-age group when compared to the lifetime prevalence. Because of this increased prevalence, college recreation/wellness center staff should be aware of their clients in terms of the increased risk for eating disorders. College wellness/recreation centers, while serving the campus community, also serve the individuals within this community diagnosed with or at-risk for an eating disorder. Through survey research, we show who is employed at wellness/recreation centers, what type of training they receive regarding eating disorder, how this training is provided along with its content, and what method of public awareness on eating disorders …

Muscle Activation In Individuals Who Are Status-Post A Stroke During Over Ground, Treadmill, And Body Weight Supported Gait: A Comparative Study, Rhonda L. Breitbach, Kelly L. Malmin, Beth M. Nordmark, Jennifer A. Pederson

Physical Therapy Scholarly Projects

Purpose: The purpose of this study was to evaluate individuals who are status post stroke during ambulation over ground, on a treadmill without support, and on a treadmill with partial body weight support (PBWS) to determine if there are any differences in muscle activation of major muscle groups in the lower extremity.

Subjects: Two subjects were recruited for this study. Subjects were included if they were over the age of 50 years, could fulfill a two-hour time commitment, and walk independently with or without the use of an assistive device. Subjects were excluded if they have had surgery or an …

An Electromyographic Study Of Upper Trapezius, Lower Trapezius, And Serratus Anterior Muscle Activity During Traditional And Modified Muscle Testing Positions, Jace Everett, Mike Fowler, Jason Haak, Robby Luck

Physical Therapy Scholarly Projects

Purpose: The purpose of this study is to assess the muscle activity of the shoulder joint force couple induced by the upper trapezius, lower trapezius, and serratus anterior to determine if they are more effectively recruited during the traditional exercise position of forward shoulder elevation in 145° of shoulder abduction versus a modified position of shoulder external rotation while in 80° of shoulder abduction and 90° of elbow flexion

Methods: Nine participants took part in this randomized study in which EMG data was collected during 4 exercise trials of 10 repetitions each on the right shoulder. EMG activity was monitored …

Balance Comparison Of Open- And Closed-Back Shoes, Tiffany Hemberger, Sara Henderson, Eric Loiland

Physical Therapy Scholarly Projects

A growing number of healthcare professionals have been choosing to wear an open-back shoe rather than a traditional closed-back shoe in the workplace. Healthcare professionals incorporate dynamic balance and quick reactions during direct patient interaction. The purpose of the study was to determine if dynamic balance would be affected in healthcare professionals when wearing open-back shoes versus closed-back shoes.

Thirty-two healthcare professionals or students of healthcare professions (28 females and 4 males) were recruited for this study. Subjects ranged in age from 20 to 62 years (mean age 28.2 years), with the majority being physical therapists or physical therapy students. …

Role Of Z-Coilª Shoes On Plantar Pressure Forces During Short Distance Walking, Tyler Volle, Michael Rider, Brett Jenks, Benjamin Deubner

Physical Therapy Scholarly Projects

Purpose: The Z-CoiL ® company has marketed a shoe that is advertised to decrease pressure and attenuation of forces on the foot, ankle, and other lower extremity joints. Evidence based studies, however, are lacking in support of this claim. The purpose of this study was to compare the peak pressure distributed onto the bottom of the foot from heel strike to midstance when walking bare foot, using a personal athletic shoe, and using a Z-CoiL ® shoe.

Subjects: Thirty subjects without any current history of orthopedic pathologies were examined in this study. Fourteen subjects were excluded from final data analysis, …

Statins And The Vasculopathy Of Systemic Sclerosis: Potential Therapeutic Agents?, Chris T. Derk, Sergio A. Jimenez

Department of Medicine Faculty Papers

It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth factors. As a result of the action of these cytokines and growth factors, chemoattraction of fibroblasts into the vessel wall and transdifferentiation of resident fibroblasts and smooth muscle cells into myofibroblasts occur leading to fibrosis and exaggerated collagen deposition in the vessel wall. To date, the therapeutic options for the vasculopathy of systemic sclerosis have been limited to drugs that cause vasodilation and inhibit platelet aggregation …

Virginia Dental Journal (Vol. 83, No. 2, 2006)

Virginia Dental Journal

No abstract provided.

Coping Processes Of Couples Experiencing Infertility, Brennan Peterson, Christopher R. Newton, Karen H. Rosen, Robert S. Shulman

Psychology Faculty Articles and Research

This study explored the coping processes of couples experiencing infertility. Participants included 420 couples referred for advanced reproductive treatments. Couples were divided into groups based on the frequency of their use of eight coping strategies. Findings suggest that coping processes, which are beneficial to individuals, may be problematic for one's partner. Couples where men used high amounts of distancing, while their partner used low amounts of distancing, reported higher levels of distress when compared to couples in the other groups. Conversely, couples with women who used high amounts of self-controlling coping, when paired with men who used low amounts of …

Identification Of Novel Allosteric Regulators Of Human Erythrocyte Pyruvate Kinase, Shilpa S. Kharalkar

Theses and Dissertations

Erythrocyte pyruvate kinase (R-PK) is a key glycolytic enzyme catalyzing the transphosphorylation of phosphoenolpyruvate (PEP) and ADP to pyruvate and ATP respectively3,4. The substrate PEP and product pyruvate of this reaction are involved in a number of energetic and biosynthetic pathways; hence a tight regulation of R-PK activity is crucial not only for glycolysis, but also for the entire cellular metabolism. Deficiency of R-PK is one of the most common enzymatic defects of RBC, and may be caused by mutations of the PK-LR (pyruvate kinase liver red blood cell) gene31, 32. Clinically, R-PK deficiency manifests itself as a chronic life-long …

Influence Of Anti-Cd44 On Murine B Cell Activation, Tiana L. Wyant

Theses and Dissertations

Lymphocyte activation and trafficking are indispensable to the immune system. CD44, an adhesion molecule, plays important roles in T cell activation, lymphocyte homing/trafficking, and tumor metastasis. Although the functions of CD44 have been shown in T cells and other leukocytes, little is known about its role in B cells. The effects of CD44 cross-linking on murine B cell activation via CD40L/IL-4 was explored using the anti-CD44 mAbs RK3G9 and IM7. Immobilized RK3G9 and IM7 could strongly inhibit B cell proliferation and Ig production, with IgE inhibition being prominent. Soluble anti-CD44 had no effect. The inhibitory effect of RK3G9 was not …

Utilization Of The Center For The Advancement Of Education Educational Outcomes, Revised Version 2004: Report Of The 2005 American College Of Clinical Pharmacy Educational Affairs Committee, Susan P. Bruce, Amy Bower, Emily Hak, Amy H. Schwartz, Aacp Educational Affairs Committee

School of Pharmacy Faculty Articles

In response to the release of the Center for the Advancement of Pharmaceutical Education (CAPE) Educational Outcomes1 revised version in May 2004, the 2004–2005 American College of Clinical Pharmacy (ACCP) Educational Affairs Committee was charged by then-president Barbara G. Wells, PharmD, with reviewing the updated document and recommending strategies for pharmacy educators to apply the information. The recommendations contained in this document focus on guiding curricular development, helping students connect what they learn in the classroom and experiential setting to the practice of pharmacy, educating external audiences about the role of the pharmacist, assessing the new outcomes, and determining the …

Medications That Should Not Be Crushed, K. Shaver, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

Over-The-Counter Supplements For Cholesterol Lowering, K. M. Shields, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

Topical Treatment Of Chronic Wounds, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

Intercellular Spreading Of Porphyromonas Gingivalis Infection In Primary Gingival Epithelial Cells, Özlem Yilmaz, Philippe Verbeke, Richard J. Lamont, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Porphyromonas gingivalis, an important periodontal pathogen, is an effective colonizer of oral tissues. The organism successfully invades, multiplies in, and survives for extended periods in primary gingival epithelial cells (GECs). It is unknown whether P. gingivalis resides in the cytoplasm of infected cells throughout the infection or can spread to adjacent cells over time. We developed a technique based on flow cytofluorometry and fluorescence microscopy to study propagation of the organism at different stages of infection of GECs. Results showed that P. gingivalis spreads cell to cell and that the amount of spreading increases gradually over time. There was a …

Characterization And Functional Analysis Of A Newly Identified Human Mt5-Mmp Transcript Variant Isolated From Multipotent Nt2 Cells, Heather Hamilton Ross

Theses and Dissertations

Membrane-type 5 matrix metalloproteinase (MT5-MMP) is unique among MMP family members as it is predominately expressed in the CNS. Its expression is ubiquitous during brain development and restricted to regions of neurogenesis and neuroplasticity in the adult. MT5-MMP is a mediator of pericellular proteolysis and is thought to have a functional impact on neurite outgrowth. The studies presented in this work were designed to examine MT5-MMP expression in cultured NT2 cells, a model of newogenesis and neuronal differentiation, and in adult neurogenic brain regions. We further sought to overexpress MT5-MMP and test the hypothesis that it plays a role in …

An Evaluation Of Hospital Capital Investment After The Balanced Budget Act, Tae Hyun Kim

Theses and Dissertations

Capital investments in the latest medical equipment and the replacement of aging facilities are important hospital decisions because they may have a significant influence on operating efficiencies and quality of care. However, hospitals experienced a minimal growth rate in capital expenditures which contributed to the aging of the hospital industry's asset base during the late 1990's and early 2000's. One of the underlying reasons behind this lack of growth might be the financial stresses that hospitals were facing after the Balanced Budget Act (BBA) of 1997, which significantly reducedMedicare reimbursement and had an adverse impact on the financial viability of …

Developmental Expression Of Calcium-Binding Proteins In The Avcn And Mntb Of Normal Hearing And Congenitally Deaf Mice, John L. Roebel

Browse all Theses and Dissertations

This experiment analyzes synaptic differences in the central auditory pathway between normal hearing and congenitally deaf (dn/dn) mice, and provides valuable insight into central changes that correspond with human congenital deafness. Specifically, this experiment analyzes developmental expression of the Calcium (Ca2+)-binding proteins Calretinin (CR), Calbindin D-28k (CB) and Parvalbumin (PV) in large excitatory synapses in the anteroventral cochlear nucleus (AVCN) and the medial nucleus of the trapezoid body (MNTB) of normal and dn/dn mice. Immunofluorescence imaging with primary antibodies detecting CR, CB or PV was used to analyze the expression of each at 9 days, 13 days, 20 days, 30 …

Clinical Presentation Of Acute Coronary Syndrome: Does Age Make A Difference? Implications For Emergency Nursing, Iesiah M. Harris

Browse all Theses and Dissertations

Accurately recognizing symptoms of Acute Coronary Syndrome (ACS) presents a challenge to Emergency Department (ED) nurses and physicians. Due to the variety of clinical presentations in patients, ACS is frequently missed diagnosed. Studies demonstrate that many patients present with atypical symptoms and presentation varies based on gender. There is, however, a paucity of studies on the presentation of ACS in the elderly. With the older American population growing at exponential rates, it is imperative that studies are conducted to better comprehend ACS clinical presentation in the elderly. By 2020, it is anticipated, that 20% of the population will be 65 …

The Relationship Between Lactic Acid, Reactive Oxygen Species And The Hypoxia-Induced Acidification Seen In Chemosensitive Neurons Of The Nucleus Tractus Solitarius (Nts), Trevor Downing

Browse all Theses and Dissertations

The NTS is one of many sites of chemoreception meaning that it responds to changes in CO2 and pH. NTS neurons also acidify approximately 0.13 pH units in response to hypoxia. Experiments involved brainstem slices exposed to a control hypoxic bout followed by hypoxia in conjunction with different drugs. The drugs included fluorocitrate, 4-hydroxycinnamate, oxygen-glucose deprivation and iodoacetate. Iodoacetate produced the strongest blunting of the hypoxia-induced acidification and decreased the response by ~53%. Results from the studies using the superoxide probe DHE showed an increase in the levels of ROS during the hypoxic exposure prior to reoxygenation. Two ROS scavengers …

Development Of An Audio Visual Tool For Medical Training At Kennedy Space Center, Rimawi, Nidal El

Browse all Theses and Dissertations

As part of an effort to improve efficiency of space-flight medical support at Kennedy Space Center, a training video was created to replace a series of lectures given before a launch or landing of the Space Shuttle. The video was designed to familiarize volunteer physicians from around the country with the specific emergency response protocols for a Space Shuttle launch or landing emergency at Kennedy Space Center. The methods used were consistent with standard film making techniques as outlined in several film making texts. The Production was divided into three phases; A pre-production phase wherein the research, screenwriting and production …

Role Of Ict Malaria Immunochromatographic Test For Rapid Diagnosis Of Malaria, Mahadev S. Harani, M.Asim Beg, Lubna Khaleeq,, Salman Adil, Ghulam Nabi Kakepoto, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Objective: To evaluate the sensitivity and specificity of immunochromatographic test (ICT) malaria p.f/p.v using microscopy as the gold standard diagnosis. Methods: Five hundred and sixty patients of both sexes and all age groups with clinical suspicion of malaria were studied. Venous blood was collected for microscopy and ICT. Thick and thin films prepared and stained with Leishman's stain were examined. ICT malaria test was performed and interpreted according to manufacturer's instructions. Data was analyzed using Epi-6.
Results: A total of 560 cases were studied, 339 males and 221 females with age ranges between 2 to 73 years. …

Fludarabine Induced Autoimmune Haemolytic Anaemia In A Patient With Chronic Lymphocytic Leukaemia, Naveen Naz Syed, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Autoimmune haemolytic anaemia following fludarabine is an uncommon complication and previously treated patients are at higher risk. We describe a case of 57- year old lady with chronic lymphocytic leukaemia; she received intermittent courses of alkylating agents and purine analogue, fludarabine. Reintroduction of fludarabine for her relapsing disease induced autoimmune haemolytic anaemia. Numbers of cases have been reported regarding autoimmune haemolytic anaemia following fludarabine administration, but none have been published from our part of the world. Normally T-cell suppresses autoreactive lymphocytes that can produce autoantibodies. Suppression of T-cells by fludarabine, in addition to the underlying disease process appears to be …

Significance Of Cytogenetic Abnormalities In Acute Myeloid Leukaemia, Mahadev S. Harani, Salman Adil, Ghulam Nabi Kakepoto, Zahida Khilji, Usman Shaikh, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Objective: To evaluate the role of karyotype in acute myeloid leukaemia (AML) as a predictor of response to induction chemotherapy.
Methods: A cross-sectional study was carried out at the department of Pathology and Oncology, Aga Khan University Karachi from January 2003 to January 2005. Newly diagnosed patients with denovo AML admitted to the hospital were included in the study. Diagnosis of AML was based on FAB criteria, immunophenotyping and cytogenetic studies. They were treated according to standard protocols (combination of anthracycline and cytarabine -3+7) and those who had acute promyelocytic leukaemia additionally received all- trans retinoic acid (ATRA). …

Clinico-Pathologic Features Of Chronic Myeloid Leukemia And Risk Stratification According To Sokal Score, Naveen Naz Syed, Mikal Usman, Gulnaz Khaliq, Salman Adil, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

To compile the clinical and haematological parameters of chronic myeloid leukemia (CML) and risk stratification according to Sokal score in our population. A descriptive analysis. The Aga Khan University Hospital, during the period from August 1997 to August 2005. All patients with diagnosis of chronic myeloid leukemia treated as outpatient in haematology clinic, or admitted in haem-oncology wards in The Aga Khan University Hospital were included. Records were retrospectively analyzed for clinicopathologic features. Risk groups were assigned as per Sokal scoring. During the 8 years study period, 245 patients with chronic myeloid leukemia were analyzed, the median age of presentation …

Blood And Body Fluid Exposure And Risk To Health Care Workers, Afia Zafar

Department of Pathology and Laboratory Medicine

No abstract provided.

Screening For Cystic Fibrosis: The Importance Of Using The Correct Tools, Uzma Shah, Tariq Moatter

Department of Pathology and Laboratory Medicine

Background: Cystic Fibrosis (CF) is a potentially lethal genetic disorder. The most frequent mutation worldwide in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene is designated as the Delta F508 mutation. This mutation was found in only 33% of Pakistani patients studied. Since the common Pakistani mutations remain to be identified, appropriate screening tools are required to identify disease. Sweat chloride determinations remain the gold standard for diagnosing CF. This study was done to emphasize the importance of using the correct tests.
Methods: The study was conducted at the Aga Khan University Hospital. The CFTR delta F508 mutation was tested …