Medicine and Health Sciences Commons^™

Blood Volume And Hemoglobin Oxygenation Response Following Electrical Stimulation Of Human Cortex, Minah Suh, Sonya Bahar, Ashesh Mehta, Theodore Schwartz

Physics Faculty Works

No abstract provided.

B Cells At The Interface Of Innate And Adaptive Immunity In Systemic Lupus Erythematosus: Requirements For The Activation Of Autoreactive B Cells In Autoimmune Disease, Sean Ryan Christensen

Yale Medicine Thesis Digital Library

Systemic autoimmune disease is characterized by loss of immunologic tolerance to a restricted set of self-nuclear antigens. These macromolecular complexes can be grouped into two categories: DNA-containing autoantigens such as chromatin, and RNA containing autoantigens such as Smith antigen (Sm) and related ribonucleoprotein complexes. Elucidating the mechanism for selective targeting of these molecules in systemic lupus erythematosus (SLE) may provide clues to the etiology of disease. We hypothesized that Toll-like receptors (TLRs), germline-encoded pattern-recognition receptors of the innate immune system, could dictate target antigen specificity in SLE. Using genetic ablation of various TLRs in murine models of SLE, we have …

[Book Review Of] Physicians' Crusade Against Abortion, By Frederick N. Dyer, Eugene F. Diamond

The Linacre Quarterly

No abstract provided.

Long-Term Follow-Up Of Patients With Clubfeet Treated With Extensive Soft-Tissue Release, Matthew B. Dobbs, Ryan Nunley, Perry L. Schoenecker

Open Access Publications

No abstract provided.

Do Clinical Manifestations Of Systemic Lupus Erythematosus In Pakistan Correlate With Rest Of Asia?, Malik Anas Rabbani, Bilal Karim Siddiqui, Muhammad Hammad Tahir, Bushra Ahmad, A Shamim, Shahid Majid, Syed Sohail Ali, Syed Mansoor Ahmed Shah, Aasim Ahmad

Section of Nephrology

Objective: Systemic Lupus Erythematosus (SLE) is known to be different among people with different racial, geographical and socio-economic back grounds. Asia has diverse ethnic groups broadly, Orientals in the East and Southeast Asia, Indians in South Asia and Arabs in the Middle East. These regions differ significantly from the Caucasians with reference to SLE. The purpose of this study was, therefore, to delineate the clinical pattern and disease course in Pakistani patients with SLE and compare it with Asian data.Methods: Patients with SLE fulfilling the clinical and laboratory criteria of the American Rheumatism Association admitted at the Aga Khan University …

Hypertension And Kidney Disease In Asia, Tazeen H. Jafar

Section of Nephrology

PURPOSE OF REVIEW: Communicable diseases were traditionally the major cause of public health concern in Asian countries, most of which were less developed. With industrialization and associated lifestyle changes during the past few decades, however, noncommunicable diseases similar to those that affect Western societies have emerged in Asian countries. The purpose of the review was to examine recent evidence about the burden and factors associated with hypertension and chronic kidney disease (CKD) in Asian countries.RECENT FINDINGS: Hypertension has become one of the leading causes of mortality in Asia. Although its prevalence continues to rise, it remains under-diagnosed and under-treated. CKD …

Knowledge, Attitude And Misconceptions Regarding Tuberculosis In Pakistani Patients, Javaid Ahmed Khan, Muhammad Irfan, Amna Zaki, Madiha Beg, Syed Fayyaz Hussain, Nadeem Rizvi

Section of Pulmonary & Critical Care

Objective:

To assess knowledge of patients with tuberculosis; about their disease and misconceptions regarding TB.

Methods:

A cross sectional study was conducted at Out-patient clinics of two teaching hospitals (private and public) in Karachi, Pakistan. A questionnaire was filled for the purpose.

Results:

A total of 170 patients were interviewed, 112 from private and 58 from a public sector hospital. Cough, fever, bloody sputum and chest pain were recognized as the common symptoms of TB. Eleven (7%) patients thought TB was not an infectious disease and 18 (10.6%) did not consider it a preventable disease. Contaminated food was considered the …

Level I Fieldwork Today: A Study Of Contexts And Perceptions., Caryn Johnson, Kristie P. Koenig, Catherine Verrier Piersol, Susan E. Santalucia, Wendy Wachter-Schutz

Department of Occupational Therapy Faculty Papers

The last comprehensive examination of the Level I fieldwork experience was performed 15 years ago (Shalik, 1990) and addressed the different types of settings in which fieldwork occurred; amounts and types of supervision; structure and scheduling of the Level I experiences; and the effects of supervising Level I students on productivity. Although every occupational therapy and occupational therapy assistant student encounters a number of Level I fieldwork opportunities, little is available describing the process and contexts of the Level I fieldwork experience today. This study, which examines 1,002 student reports on Level I fieldwork experiences, finds that Level I fieldwork …

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link, Vol. 2, Iss.4, May 2006

Public Health Link

Vol. 2, Iss. 4 of Public Health Link newsletter includes a summary of the retreat to the Franklin Institute, SAPHE's public health week award luncheon and thesis presenters.

Role Of Caveolin-1 In The Regulation Of The Vascular Shear Stress Response, Philippe G. Frank, Michael P. Lisanti

Department of Cancer Biology Faculty Papers

In blood vessels, endothelia are submitted to constant shear effects and are, under normal conditions, capable of responding to any variation in hemodynamic forces. Caveolae — 50- to 100-nm plasma membrane invaginations present at the surface of terminally differentiated cells and particularly enriched in ECs — are composed of a high sphingolipid and cholesterol content and the protein caveolin-1 (Cav-1). Previous studies have suggested that caveolae and endothelial Cav-1 may regulate the vascular response to altered shear stress. In this issue of the JCI, Yu et al. have examined the role of Cav-1/caveolae in the regulation of flow-induced alterations (i.e., …

Passenger Dies When Semi-Truck Trailer Hits Cow In Roadway, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On November 8, 2005, a 26-year-old male laborer who was a passenger in a semi-truck died when the driver swerved to avoid hitting a cow that was standing in the parkway lane. The two employees had been traveling westbound for approximately one hour when the driver noticed a cow in his lane. He swerved to avoid hitting the cow but hit it anyway. The tractor and two trailers jack-knifed, traveled through the median with the cab and trailers flipped onto their right sides, slid across the eastbound lanes, then the cab slammed through the guardrail. The cab came to rest …

Abdominal Pain With Rigidity Secondary To The Anti-Emetic Drug Metoclopramide, Nadeem Ullah Khan, Junaid A. Razzak

Department of Emergency Medicine

We report a case of abdominal pain with rigidity, mimicking an acute abdomen, caused by metoclopramide, a common anti-emetic drug. Extrapyramidal symptoms are commonly reported side-effects of this medication. They generally include involuntary movements of limbs, torticollis, oculogyric crisis, rhythmic protrusion of tongue, trismus, or dystonic reactions resembling tetanus, etc. Abdominal rigidity due to this medication, resembling an acute abdomen, has not been reported previously. This case report illustrates the importance of considering medication side-effects when evaluating a patient with abdominal pain and rigidity.

Ada News - 05/01/2006, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

A Healthcare-Delivery System For The Next Generation

RCHE Publications

On May 2-3, 2006, Purdue University, BlueCross BlueShield Association, and WellPoint, Inc. hosted 24 CEO-level healthcare executives representing a diverse cross section of the healthcare supply chain to design the U.S. healthcare-delivery system for the next generation. Participants were challenged to envision the ideal system for the future, without regard to the constraints of today’s technologies, infrastructure, or financial systems. The Regenstrief Center for Healthcare Engineering at Purdue University was tasked to present the summit discussion in the form of a white paper that represents the view of the summit participants.

When And Where I Enter: Social Determinants Of Mental Health Services Use Among African American Women, Shonreh Doss

Masters Theses & Specialist Projects

African Americans utilize mental health services significantly less frequently than do White-Americans. This study examined the social factors that work to influence the decision to seek services outside of the social circle. Using the National Survey of Black Americans, 4th wave, factors were examined using logistic regression analysis to test the likelihood of accessing the sick role. In addition to the sick role, regression analysis was used to determine the sick role's effect on the decision to seek outside care. Controlling for education, perceived racism, religiosity and employment problems, the findings suggest that life control and socioeconomic status factors influence …

A Randomized Trial Of A Multicomponent Home Intervention To Reduce Functional Difficulties In Older Adults, Laura N. Gitlin, Laraine Winter, Marie P. Dennis, Mary Corcoran, Walter W. Hauck

Center for Applied Research on Aging and Health Research Papers

OBJECTIVES: To test the efficacy of a multicomponent intervention to reduce functional difficulties, fear of falling, and home hazards and enhance self-efficacy and adaptive coping in older adults with chronic conditions.

DESIGN: A prospective, two-group, randomized trial. Participants were randomized to a treatment group or no-treatment group.

SETTING: Urban community-living older people.

PARTICIPANTS: Three hundred nineteen community-living adults aged 70 and older who reported difficulty with one or more activities of daily living.

INTERVENTION: Occupational and physical therapy sessions involving home modifications and training in their use; instruction in strategies of problem-solving, energy conservation, safe performance, and fall recovery techniques; …

The Burden Of Anxiety And Depression Among Patients With Chronic Rheumatologic Disorders At A Tertiary Care Hospital Clinic In Karachi, Pakistan, Abdul Waheed, Kamran Hameed, Abdul Moiz Khan, Junaid Ali Syed, Ahmed Iqbal Mirza

Medical College Documents

Objectives: To study the burden of anxiety and depression as a comorbid among patients of chronic rheumatological disorders and to investigate possible determinants of depression and anxiety.Methods: It was a cross-sectional study conducted at the rheumatology clinic of The Aga Khan University Hospital (AKUH) Karachi, Pakistan. With convenient sampling, 111 patients who fulfilled inclusion/exclusion criteria were screened for anxiety and depression with help of Aga Khan University Anxiety and Depression Scale (AKUADS). The data was entered and analyzed by Statistical Package for Social Sciences (Version 10.0).Results: The population consisted mainly of middle aged (mean age 41) females (80.2%). The most …

Evaluation Of Toxicity Following Electrically Mediated Interleukin-12 Gene Delivery In A B16 Mouse Melanoma Model, Loree Heller, Kathleen Merkler, Jeffrey Westover, Yolmari Cruz, Domenico Coppola, Kaaron Benson, Adil Daud, Richard Heller

Bioelectrics Publications

PURPOSE: Interleukin-12 (IL-12) has potential as an immunotherapeutic agent for the treatment of cancer but is unfortunately associated with toxicity. Delivery of a plasmid encoding IL-12 with electroporation induces an antitumor effect in the B16 mouse melanoma model without serious side effects. To translate this observation to the clinic, an evaluation of toxicity was done in the mouse model.

EXPERIMENTAL DESIGN: Weight change, tumor response, blood chemistry and hematology values, and serum IL-12 levels were evaluated. Multiple tissues were analyzed histopathologically.

RESULTS: A pronounced reduction in tumor volume, including a large percentage of complete regressions, was observed after electrically mediated …

Extra [Corrected] Pulmonary Uptake Of Tc-99m-Maa Perfusion Lung Scan As A Result Of Right To Left Intra Cardiac Shunt, Riffat Hussain, Maseeh-Uz-Zaman, Sohail Abrar Khan, M Nadeem Ahmad

Department of Radiology

Extra pulmonary accumulation of Tc-99m-macroaggregate of albumin (MAA) is rarely seen on perfusion lung scan, and has been reported in less than 4% of a study population of nearly 380 patients. It occurs when the agent bypasses the lungs due to a right to left (R-L) cardiac or pulmonary shunt, when it is shunted to the portal vein before reaching the right atrium and ventricle of the heart, and when the agent is degraded to a submicron particle size. When a pharmaceutical problem is excluded, extra-pulmonary uptake implies unusual hemodynamics with a shunt. A case is reported in which a …

Role Of Focused Appendiceal Computed Tomography In Clinically Equivocal Acute Appendicitis, Kashif Ashraf, Omer Ashraf, Vaqar Bari, Muhammad Zafar Rafique, Muhammad Uzair Usman, Ishtiaq Chisti

Department of Radiology

Objective: To determine the accuracy of FACT (focused appendiceal computed tomography) in evaluation of acute appendicitis.Methods: The study was conducted in Aga Khan University Hospital, Karachi, over a period of one year. Sixty-three patients with clinically equivocal acute appendicitis underwent thin-section non-enhanced helical CT. Axial scans were obtained in a single breath hold from L2 vertebral level to the pubic symphysis with 5-mm collimation and a pitch of 1.5. All scans were obtained without oral, intravenous, or rectal contrast material. Criteria for diagnosis of acute appendicitis included an enlarged appendix (>6 mm diameter) and periappendiceal inflammation. Final diagnoses were …

Gαq And Its AktIons, David M. Harris, Andrea D. Eckhart, Walter J. Koch

Department of Medicine Faculty Papers

No abstract available.

Assessment Of Whole Grain Intake And Health Correlates In An Aging Population, Alexis Howard

Senior Honors Projects

Research suggests that whole grain intake may decrease the risk of heart disease, type II diabetes, hypertension, obesity, and many types of cancer. The overall goal of this work is to increase the health status of an older adult population through comprehensive nutrition risk assessment and exposure to tailored nutrition education interventions. This project involved assisting in baseline and post-intervention assessment of the knowledge, attitude, and intake of whole grain foods within a convenience sample of fifty-eight older adults residing in low-income housing sites across Rhode Island. Anthropometry, including height, weight, waist circumference, and blood pressure was measured, along with …

Oncolog Volume 51, Number 05, May 2006, Sunni Hosemann, Kathryn Carnes, Patrick Hwu Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• A Better Kind of Brain Surgery
• Raloxifene Effective for Breast Cancer Prevention
• House Call: The Many Benefits of Massage
• DiaLog: Cancer Vaccines and Immunotherapy, by Patrick Hwu, MD, Professor and Chair, Melanoma Medical Oncology

Resilience And Quality Of Life In Taiwanese Survivors Of Childhood Cancer, Li-Na Chou Phd, Msn, Rn

Dissertations

Survivors of childhood cancer are at risk to develop physiologic-psychosocial complications that affect their quality of life. This study explored how the independent variables of illness-related risk (ILLRK), individual risks (IRK), protective factors (PF) and resilience (RS) affected the dependent variable---quality of life (QOL)--in Taiwanese survivors of childhood cancer. Triangulated research methodology was employed to (1) identify the statistical relationships between the variables and (2) explore qualitatively what these variables meant to the subjects and how their perceptions further explained the statistical results. Haase's (2004) Adolescent Resilience Model was used as the theoretical framework. Ninety-eight Taiwanese adolescent cancer survivors, diagnosed …

Forensic Nursing: Death Investigation, Lauren Palazzo

Senior Honors Projects

Forensic Nursing is a fairly new exciting nursing specialty. Television shows such as CSI portray forensic nurses and investigators in a less than realistic manner. Forensic nursing and investigation are exciting fields to specialize in, but the role of the forensic nurse and investigator are often misunderstood. For my project I wrote a research paper on forensic nursing, joined the international association of Forensic nurses, attended the international conference in washington dc and set in on a few meetings with a board, including lawyers, represenatives from the rape crisis center, clinical managers from W&I ED, nurses, NP’s, etc. in discussing …

Promoting Equity In Health Information: Partners For Health Information And Health Information Partners (Hips), Richard Billingsley, Betsy Gardiner, Karyn L. Pomerantz, Eduardo Pezo, Patricia Wilson

Himmelfarb Library Faculty Posters and Presentations

In 2004, a community health outreach partnership, funded by the U.S. National Library of Medicine (NLM), was launched. HIPS, Health Information Partners, promoted health literacy and health advocacy for residents of Washington, D.C., who frequented the area community health centers. This poster explores the goals, strategies, and results of the HIPS program.

Changing Space Needs: A First Floor Renovation And Assessing Its Impact On Designing The Electronic Library Of The 21st Century, Anne Linton, Kathe Obrig, Patricia Wilson

Himmelfarb Library Faculty Posters and Presentations

An increase in electronic resources, modification in both usersʼ and staffʼs working space, and an internal initiative to create a single Service Desk, all resulted in the redesign of the Himmelfarb Health Sciences Library's first floor. This poster demonstrates how completion of that project has affected usersʼ perception of the library.

Running Out Of Library Space: Sharing Remote Storage To Increase Cost-Savings And Conserve Space, Kathe Obrig, Vani K. Murthy, Tracie E. Frederic, George P. Paul, Leah Pellegrino

Himmelfarb Library Faculty Posters and Presentations

A cooperative project between two urban academic medical libraries, the Himmelfarb Health Sciences Library (George Washington University Medical Center) and the Dahlgren Medical Library (Georgetown Medical Center), was designed to relocate all pre-1980 bound journal volumes to a remote-storage facility. This poster explores the goals, process, and results, both financially and physically, of the collaborative initiative.

Transforming Nursing Practice For Today's World: Teaching Information Literacy Skills To Nurses As Preparation For Evidence-Based Nursing Practice, Richard Billingsley

Himmelfarb Library Faculty Posters and Presentations

This poster presentation summarizes how combined entities of the George Washington University Medical Center planned, developed, and disseminated instructional programs promoting information literacy skills among professional nurses. The programs served as a precursor for research utilization and the promotion of evidence-based nursing practices (EBNP).

Dental Maturation In Children Treated For Acute Lymphocytic Leukemia, Michael Grey Weathersby

Theses and Dissertations (ETD)

Acute lymphocytic leukemia (ALL) is a life-threatening disease primarily affecting children. Treatment currently consists of chemotherapy sometimes in combination with head irradiation. The literature documents the damage of treatment to the teeth (e.g., congenital absence, microdontia, abnormal crown- root ratios). The present study assessed the effects of treatment for ALL on the tempos of dental maturation (i.e., dental age) in a mixed longitudinal sample of 72 children treated for ALL at St Jude's Children's' Research Hospital, Memphis, Tennessee. Panoramic radiographs had been taken as indicated to assess and maintain dental health in this retrospective study. Dental age was quantified both …